Cartilage injuries in the pediatric knee:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Philadelphia, PA
Saunders
2012
|
| Series: | Orthopedic clinics of North America
43,2 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibiliographical references and index Articular cartilage development: a molecular perspective -- Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice -- Effect of exercise on articular cartilage -- Imaging of osteochondritis dissecans -- Epidemiology, pathogenesis, and imaging of arthritis in children -- Acute traumatic and sports-related osteochondral injury of the pediatric knee -- "One step" treatment of juvenile osteochondritis dissecans in the knee: clinical results and T2 mapping characterization -- Clinical relevance of scaffolds for cartilage engineering -- Implantaion of orthobiologic, biodegradable scaffolds in osteochondral repair |
| Physical Description: | X S., S. 155 - 267 zahlr. Ill., graph. Darst. 27 cm |
| ISBN: | 9781455739059 1455739057 |
Staff View
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| 245 | 1 | 0 | |a Cartilage injuries in the pediatric knee |c guest ed. Harpal K. Gahunia ; Paul S. Babyn |
| 264 | 1 | |a Philadelphia, PA |b Saunders |c 2012 | |
| 300 | |a X S., S. 155 - 267 |b zahlr. Ill., graph. Darst. |c 27 cm | ||
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| 490 | 1 | |a Orthopedic clinics of North America |v 43,2 | |
| 500 | |a Includes bibiliographical references and index | ||
| 500 | |a Articular cartilage development: a molecular perspective -- Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice -- Effect of exercise on articular cartilage -- Imaging of osteochondritis dissecans -- Epidemiology, pathogenesis, and imaging of arthritis in children -- Acute traumatic and sports-related osteochondral injury of the pediatric knee -- "One step" treatment of juvenile osteochondritis dissecans in the knee: clinical results and T2 mapping characterization -- Clinical relevance of scaffolds for cartilage engineering -- Implantaion of orthobiologic, biodegradable scaffolds in osteochondral repair | ||
| 650 | 4 | |a Knee / Wounds and injuries | |
| 650 | 4 | |a Pediatric orthopedics | |
| 650 | 4 | |a Cartilage / Wounds and injuries | |
| 650 | 4 | |a Wounds and injuries / Diagnosis | |
| 700 | 1 | |a Gahunia, Harpal K. |e Sonstige |4 oth | |
| 700 | 1 | |a Babyn, Paul S. |e Sonstige |0 (DE-588)131871919 |4 oth | |
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Record in the Search Index
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| adam_text | Titel: Cartilage injuries in the pediatric knee
Autor: Gahunia, Harpal K
Jahr: 2012
Cartilage Injuries in the Pediatric Knee
Contents
Preface ix
Harpal K. Gahunia
Articular Cartilage Development: A Molecular Perspective 155
Facundo Las Heras, Harpal K. Gahunia, and Kenneth P.H. Pritzker
In this article, development of articular cartilage and endochondral ossification is
reviewed, from the perspective of both morphologic aspects of histogenesis and
molecular biology, particularly with respect to key signaling molecules and extracel-
lular matrix components most active in cartilage development. The current under-
standing of the roles of transforming growth factor (3 and associated signaling
molecules, bone morphogenic proteins, and molecules of the Wnt-p catenin system
in chondrogenesis are described. Articular cartilage development is a highly con-
served complex biological process that is dynamic and robust in nature, which pro-
ceeds well without incident or failure in all joints of most young growing individuals.
Structural and Functional Maturation of Distal Femoral Cartilage and Bone During
Postnatal Development and Growth in Humans and Mice 173
Elaine F. Chan, Ricky Harjanto, Hiroshi Asahara, Nozomu Inoue, Koichi Masuda,
William D. Bugbee, Gary S. Firestein, Harish S. Hosalkar, Martin K. Lotz, and Robert L. Sah
The size and shape of joints markedly affect their biomechanical properties, but the
macroscopic 3-dimensional (3-D) mechanism and extent of cartilage and joint mat-
uration during normal growth are largely unknown. This study qualitatively illustrates
the development of the bone-cartilage interface in the knee during postnatal growth
in humans and C57BL76 wild-type mice, quantitatively defines the 3-D shape using
statistical shape modeling, and assesses growth strain rates in the mouse distal
femur. Accurate quantification of the cartilage-bone interface geometry is imperative
for furthering the understanding of the macroscopic mechanisms of cartilage matu-
ration and overall joint development.
Effect of Exercise on Articular Cartilage 187
Harpal K. Gahunia and Kenneth P.H. Pritzker
This review primarily focuses on how the macromolecular composition and architec-
ture of articular cartilage and its unique biomechanical properties play a pivotal role
in the ability of articular cartilage to withstand mechanical loads several magnitudes
higher than the weight of the individual. Current findings on short-term and long-term
effects of exercise on human articular cartilage are reviewed, and the importance of
appropriate exercises for individuals with normal and diseased or aberrated carti-
lage is discussed.
Imaging of Osteochondritis Dissecans 201
Aiden Moktassi, Charles A. Popkin, Lawrence M.White, and M. Lucas Murnaghan
Osteochondritis dissecans (OCD) is a localized process that affects the subchondral
bone and can progress to the overlying articular cartilage. The cause of this lesion
remains elusive. With the vague clinical symptoms and signs of OCD, imaging plays
Contents
a vital role in making the diagnosis and helping with the prognosis of OCD lesions.
This article reviews current imaging modalities for the assessment of OCD including
conventional radiography, nuclear medicine, computed tomography (CT), CT ar-
thrography, magnetic resonance (MR) and MR arthrography. The role of imaging
in evaluating healing of the OCD and articular congruity after surgical and nonsurgi-
cal management is discussed.
Epidemiology, Pathogenesis, and Imaging of Arthritis in Children 213
Ricardo Restrepo and Edward Y. Lee
duvenile idiopathic arthritis is a broad term used to describe a series of chronic
arthritis occurring in children younger than 16 years of age. Even though the cause
is not fully understood, several clues regarding the pathogenesis have been found.
Diagnosis of the different types of juvenile idiopathic arthritis is made clinically, and
imaging plays a role in answering specific questions pertaining to disease classifica-
tion, staging, and outcome of treatment options.
Acute Traumatic and Sports-Related Osteochondral Injury of the Pediatric Knee 227
Dennis E. Kramer and J. Lee Pace
Adolescents are predisposed to osteochondral (OC) injuries in the knee. The medial
facet of the patella, the femoral trochlea, and the lateral femoral condyle are the most
common sites of injury. Most of these injuries are classically traumatic but noncon-
tact injuries. Surgery is warranted in most cases of OC fracture. Depending on size,
condition, and location of the lesion, options include OC fragment reduction and in-
ternal fixation or excision and cartilage resurfacing. Understanding of how to diag-
nose and treat OC fractures will help optimize outcomes.
One Step Treatment of Juvenile Osteochondritis Dissecans in the Knee: Clinical
Results and T2 Mapping Characterization 237
Francesca Vannini, Milva Battaglia, Roberto Buda, Marco Cavallo, and Sandro Giannini
Osteochondritis dissecans (OCD) is an increasingly common cause of knee pain
and dysfunction among skeletally immature and young adult patients. An ideal
treatment strategy with an optimal surgical technique to repair the osteochondral
lesions in these patients is still controversial. The goal of this study is to evaluate
and report the clinical and MRI findings for the treatment of OCD in the pediatric
knee with bone marrow-derived cell transplantation by using a one-step surgical
technique.
Clinical Relevance of Scaffolds for Cartilage Engineering 245
Thomas F. LaPorta, Alexander Richter, Nicholas A. Sgaglione, and Daniel A. Grande
The repair of articular cartilage defects in patients knees presents a particular chal-
lenge to the orthopedic surgeon because cartilage lacks the ability to repair or re-
generate itself. Various cartilage repair techniques have not produced a superior
or uniform outcome, which has led to a new generation of cartilage repair based
on tissue-engineering strategies and the use of biological scaffolds. Clinical ad-
vances have been made regarding the regeneration of articular cartilage, and con-
tinue to be made toward the achievement of a suitable treatment method for
resurfacing osteochondral defects, through cartilage tissue engineering and the
use of pluripotent cells seeded on bio-scaffolds.
Contents
Implantation of Orthobiologic, Biodegradable Scaffolds in Osteochondral Repair 255
James H.P. Hui, Kizher S. Buhary, and Ashwin Chowdhary
The treatment of articular cartilage lesions is complicated, but novel tissue engineer-
ing approaches seem to improve the outcome. A tissue engineering approach is less
invasive and reduces surgical time, periosteal hypertrophy, and morbidity. Cell-
based therapies using scaffolds have advantages compared with microfrac-
ture techniques, but the efficacy and cost-effectiveness need to be investigated.
Second-generation cell-based therapies have lower morbidity and the ease of the
technique is not significantly different from that of first-generation autologous chon-
drocyte implantation techniques. Third-generation cell-based therapies such as the
use of tissue engineered scaffolds need to be studied in more detail.
Index 263
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| isbn | 9781455739059 1455739057 |
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| physical | X S., S. 155 - 267 zahlr. Ill., graph. Darst. 27 cm |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Saunders |
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| series | Orthopedic clinics of North America |
| series2 | Orthopedic clinics of North America |
| spelling | Cartilage injuries in the pediatric knee guest ed. Harpal K. Gahunia ; Paul S. Babyn Philadelphia, PA Saunders 2012 X S., S. 155 - 267 zahlr. Ill., graph. Darst. 27 cm txt rdacontent n rdamedia nc rdacarrier Orthopedic clinics of North America 43,2 Includes bibiliographical references and index Articular cartilage development: a molecular perspective -- Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice -- Effect of exercise on articular cartilage -- Imaging of osteochondritis dissecans -- Epidemiology, pathogenesis, and imaging of arthritis in children -- Acute traumatic and sports-related osteochondral injury of the pediatric knee -- "One step" treatment of juvenile osteochondritis dissecans in the knee: clinical results and T2 mapping characterization -- Clinical relevance of scaffolds for cartilage engineering -- Implantaion of orthobiologic, biodegradable scaffolds in osteochondral repair Knee / Wounds and injuries Pediatric orthopedics Cartilage / Wounds and injuries Wounds and injuries / Diagnosis Gahunia, Harpal K. Sonstige oth Babyn, Paul S. Sonstige (DE-588)131871919 oth Orthopedic clinics of North America 43,2 (DE-604)BV000001089 43,2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108169&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cartilage injuries in the pediatric knee Orthopedic clinics of North America Knee / Wounds and injuries Pediatric orthopedics Cartilage / Wounds and injuries Wounds and injuries / Diagnosis |
| title | Cartilage injuries in the pediatric knee |
| title_auth | Cartilage injuries in the pediatric knee |
| title_exact_search | Cartilage injuries in the pediatric knee |
| title_full | Cartilage injuries in the pediatric knee guest ed. Harpal K. Gahunia ; Paul S. Babyn |
| title_fullStr | Cartilage injuries in the pediatric knee guest ed. Harpal K. Gahunia ; Paul S. Babyn |
| title_full_unstemmed | Cartilage injuries in the pediatric knee guest ed. Harpal K. Gahunia ; Paul S. Babyn |
| title_short | Cartilage injuries in the pediatric knee |
| title_sort | cartilage injuries in the pediatric knee |
| topic | Knee / Wounds and injuries Pediatric orthopedics Cartilage / Wounds and injuries Wounds and injuries / Diagnosis |
| topic_facet | Knee / Wounds and injuries Pediatric orthopedics Cartilage / Wounds and injuries Wounds and injuries / Diagnosis |
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