Induced pluripotent stem cells:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York, NY [u.a.]
Springer
2012
|
| Series: | SpringerBriefs in stem cells
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VIII, 73 S. |
| ISBN: | 1461422051 9781461422051 |
Staff View
MARC
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Record in the Search Index
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| adam_text | Contents
1
Introduction
........................................ 1
References
.......................................... 2
2
Pluripotent Cells
..................................... 5
2.
і
Different Pluripotent Cells
........................... 5
2.2
Transcriptional Networks and Signaling Pathways
of Plunpotency
................................... 6
2.2.1
Transcriptional Network of Pluripotency
............ 8
References
.......................................... 9
3
Induced Pluripotent Stem Cells (iPSCs)
.................... 11
3.1
Generation the First iPSCs
........................... 11
3.2
Reprogramming
................................... 12
3.2.1
Factor Delivery into Target Cells
................. 12
References
.......................................... 17
4
Molecular Mechanisms of Pluripotency
..................... 21
4.1
Steps in Reprogramming
............................ 21
4.1.1
Increase in the Cell Cycle Rate
.................. 21
4.1.2
Morphological Changes
........................ 22
4.1.3
Late Events Toward Pluripotency
................. 22
4.2
Mechanisms in Reprogramming
....................... 23
4.2.1
Genetic Factors
.............................. 23
4.2.2
Signaling Pathways
........................... 24
4.3
Dynamics of Direct Reprogramming
.................... 25
4.4
Epigenetic Modifications
............................ 26
4.5
Similarities and Differences Between iPSCs and ESCs
....... 27
References
.......................................... 29
viii Contents
5
Modeling Disease in a Dish
.............................. 33
5.1
Disease-Specific iPSCs
.............................. 34
5.2
Choosing Cell Sources
.............................. 34
5.3
Identification of iPSC Colonies
........................ 40
5.4
Characterization of Genetic Mutation
.................... 42
5.5
iPSCs Differentiation into Desired Cell Types
............. 42
References
.......................................... 44
6
Challenges to Therapeutic Potential of hiPSCs
............... 51
6.1
Is Reprogramming Necessary for Regenerative Therapies?
..... 53
References
.......................................... 55
7
New Approach to Understand the Biology of Stem Cells
........ 57
7.1
Health Versus Disease
.............................. 59
7.2
Changed Paradigm: Reprogramming as Rare
But Robust Process
................................ 61
7.3
From Reductionism to Wholeness
...................... 62
7.4
More Future Considerations
.......................... 66
References
.......................................... 68
8
Conclusion
.......................................... 69
About the Author
....................................... 71
Index
................................................ 73
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| physical | VIII, 73 S. |
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| spelling | Yildirim, Sibel Verfasser aut Induced pluripotent stem cells Sibel Yildirim New York, NY [u.a.] Springer 2012 VIII, 73 S. txt rdacontent n rdamedia nc rdacarrier SpringerBriefs in stem cells Therapie (DE-588)4059798-2 gnd rswk-swf Forschung (DE-588)4017894-8 gnd rswk-swf Stammzelle (DE-588)4665329-6 gnd rswk-swf Stammzelle (DE-588)4665329-6 s Forschung (DE-588)4017894-8 s DE-604 Therapie (DE-588)4059798-2 s b DE-604 Erscheint auch als Online-Ausgabe 978-1-4614-2206-8 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024999664&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yildirim, Sibel Induced pluripotent stem cells Therapie (DE-588)4059798-2 gnd Forschung (DE-588)4017894-8 gnd Stammzelle (DE-588)4665329-6 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4017894-8 (DE-588)4665329-6 |
| title | Induced pluripotent stem cells |
| title_auth | Induced pluripotent stem cells |
| title_exact_search | Induced pluripotent stem cells |
| title_full | Induced pluripotent stem cells Sibel Yildirim |
| title_fullStr | Induced pluripotent stem cells Sibel Yildirim |
| title_full_unstemmed | Induced pluripotent stem cells Sibel Yildirim |
| title_short | Induced pluripotent stem cells |
| title_sort | induced pluripotent stem cells |
| topic | Therapie (DE-588)4059798-2 gnd Forschung (DE-588)4017894-8 gnd Stammzelle (DE-588)4665329-6 gnd |
| topic_facet | Therapie Forschung Stammzelle |
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