Renal cell carcinoma: translational biology, personalized medicine, and novel therapeutic targets
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XI, 327 S. Ill., graph. Darst. |
| ISBN: | 1461423996 9781461423997 |
Internformat
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| 245 | 1 | 0 | |a Renal cell carcinoma |b translational biology, personalized medicine, and novel therapeutic targets |c Robert A. Figlin ..., ed. |
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Datensatz im Suchindex
| _version_ | 1804149111928127488 |
|---|---|
| adam_text | Contents
Part I Biology of Renal Cell Carcinoma
1
The Genetic Basis of Kidney Cancer and Implications
for Targeted Therapies
.......................................................................... 3
Laura S. Schmidt, Ramaprasad Srinivasan,
and W.
Marston Linehan
2
Molecular Biology of Clear Cell Renal Carcinoma
............................ 27
WilliamG. Kaelin Jr.
3
HIF Biology in RCC: Implications for Signaling,
Disease Progression, and Treatment
..................................................... 49
W. Kimryn
Radimeli
4
Tissue
Biomarkers
in Renal Cell Carcinoma:
Intermediate
Endpoints in
the Selection
of Targeted Agents for RCC
.................................................................. 69
Brittany
Bahamern
and
Sabina Signoretti
5
Molecular Characterization of Renal Cell Carcinoma
....................... 91
Bin
Tean
Teh, Leslie J.
Färber,
and Kyle Furge
Part II Current and Future Molecular Targets for RCC
6
Targeting the VEGF Pathway in Renal Cell Carcinoma
.................... 115
Cristina Suarez
and Brian I. Rini
7
Angiopoietins and Other Non-VEGF Antiangiogenic
Targets in Advanced Renal Cell Carcinoma
........................................ 135
C. Lance Cowey and Thomas E. Hutson
8
Research Translation and Personalized Medicine
.............................. 161
James Brugarolas
vu
viii Contents
9
Epigenetic
Targeting
and Histone Deacetylase
Inhibition in RCC
.................................................................................. 193
Swathi Ramakrishnan and Roberto
Pili
10
С
-MET
as a Novel Target for the Treatment
of Renal Cell Carcinoma
....................................................................... 213
Hema Vankayala, Patricia LoRusso, and Ulka Vaishampayan
11
Characterizing and Modulating the Tumor
Microenvironment in
Renal Cell Carcinoma:
Potential Therapeutic Strategies
........................................................... 239
Sumanta Kumar Pal, Karen Reckamp,
Hua Yu,
and Robert A. Figlin
12
Carbonic Anhydrase IX: Its Role as
a Biomarker,
Diagnostic, and Therapeutic Target
in Renal Cell Carcinoma
....................................................................... 253
E. Oosterwijk,
A.B.
Stillebroer, and P.F.A. Mulders
13
Presurgical Therapy for Renal Cell Carcinoma
and Implications for Window-of-Opportunity Trials
......................... 271
Hyung L. Kim, Edwin M. Posadas, and Robert A. Figlin
14
Mechanisms of Resistance to VEGF-Directed Therapy
and Implications for Future Trial Design
............................................ 283
James W.
Mier
15
Vaccine-Based Immunotherapy and Targeting
the Tumor
Microenvironment in
Renal Cell Carcinoma
................... 305
Johannes Vieweg
Index
................................................................................................................ 323
Robert
A. Figlin
·
W. Kimryn Rathmell
■
Brian I. Rini Editors
Renal Cell
Carcinoma
Translational
Biology, Personalized
Medicine,
and Novel Therapeutic Targets
This volume examines every major topic area in the modern era of renal carcinoma
biology and treatment. The unique and intricate genetics of this cancer are highly distinct
from most other tumors, and the advances made in this cancer beyond VHL biology-
have been intrinsically driven by discoveries from familial renal cell carcinomas linked
with newer large scale genomic efforts in sporadic disease. These genetic findings tuel
strategies to analyze and define sporadic tumors for greater accuracy in prognosis and
prediction of response to therapy.
Additional topics include major new therapeutic strategies that harness these biological
discoveries, in particular angiogenic, energy metabolism, chromatin remodeling,
tumor microenvironment, and classical signaling pathways. This text will bring all
of these avenues of investigation together for readers interested in understanding the
dynamics of this field in the last decade and anticipating a continued steep trajectory
in advancements toward the cure of this disease in its many manifestations.
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| indexdate | 2024-07-10T00:17:50Z |
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| isbn | 1461423996 9781461423997 |
| language | English |
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| spelling | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets Robert A. Figlin ..., ed. New York, NY [u.a.] Springer 2012 XI, 327 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medizin Medicine Oncology Toxicology Therapie (DE-588)4059798-2 gnd rswk-swf Biologie (DE-588)4006851-1 gnd rswk-swf Hypernephrom (DE-588)4161076-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hypernephrom (DE-588)4161076-3 s Biologie (DE-588)4006851-1 s Therapie (DE-588)4059798-2 s DE-604 Figlin, Robert A. Sonstige oth Erscheint auch als Online-Ausgabe 978-1-4614-2400-0 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024999657&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024999657&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets Medizin Medicine Oncology Toxicology Therapie (DE-588)4059798-2 gnd Biologie (DE-588)4006851-1 gnd Hypernephrom (DE-588)4161076-3 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4006851-1 (DE-588)4161076-3 (DE-588)4143413-4 |
| title | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets |
| title_auth | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets |
| title_exact_search | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets |
| title_full | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets Robert A. Figlin ..., ed. |
| title_fullStr | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets Robert A. Figlin ..., ed. |
| title_full_unstemmed | Renal cell carcinoma translational biology, personalized medicine, and novel therapeutic targets Robert A. Figlin ..., ed. |
| title_short | Renal cell carcinoma |
| title_sort | renal cell carcinoma translational biology personalized medicine and novel therapeutic targets |
| title_sub | translational biology, personalized medicine, and novel therapeutic targets |
| topic | Medizin Medicine Oncology Toxicology Therapie (DE-588)4059798-2 gnd Biologie (DE-588)4006851-1 gnd Hypernephrom (DE-588)4161076-3 gnd |
| topic_facet | Medizin Medicine Oncology Toxicology Therapie Biologie Hypernephrom Aufsatzsammlung |
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