Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
2011
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 169 S. Ill., graph. Darst. 21 cm |
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MARC
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| 100 | 1 | |a Endstrasser, Nina |d 1981- |e Verfasser |0 (DE-588)1017707898 |4 aut | |
| 245 | 1 | 0 | |a Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten |c vorgelegt von Nina Endstrasser |
| 264 | 1 | |c 2011 | |
| 300 | |a 169 S. |b Ill., graph. Darst. |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a München, Univ., Diss., 2011 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-024699375 | ||
Record in the Search Index
| _version_ | 1804148770622930944 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
I.
EINLEITUNG
.............................................................................................................................................................................
7
1
SCHIZOPHRENIE
.....................................................................................................................................................................
7
1.1
E
INFUEHRUNG
......................................................................................................................................................................
7
1.2
H
ISTORISCHER
R
UECKBLICK
...................................................................................................................................................
7
1.3
K
LASSIFIKATION
DER
S
CHIZOPHRENIE
..................................................................................................................................
9
1.4
E
PIDEMIOLOGIE
...............................................................................................................................................................
10
1.5
AETIOPATHOGENESE
............................................................................................................................................................
10
1.5.1
GENETISCHE
FAKTOREN
..........................................................................................................................................
11
1.5.2
NEUROPATHOLOGISCHE
BEFUNDE
..........................................................................................................................
12
1.5.3
ERWORBENE
HIRNSCHAEDIGUNGEN
.........................................................................................................................
13
1.5.4
BIOCHEMISCHER
BEFUND:
YYDIE
DOPAMINHYPOTHESE .
.....................................................................................
13
1.5.5
PSYCHOSOZIALE
FAKTOREN
.....................................................................................................................................
14
1.5.6
IMMUNOLOGISCHE
PARAMETER.
............................................................................................................................
14
2
EINFUEHRUNG
IN
DIE
IMMUNOLOGIE
............................................................................................................................
17
2.1
D
AS
ANGEBORENE
UND
DAS
ERWORBENE
I
MMUNSYSTEM
..................................................................................................
17
2.2
M
ONOZYTEN
/
M
AKROPHAGEN
.........................................................................................................................................
19
2.2.1
URSPRUNG
...............................................................................................................................................................
19
2.2.2
MORPHOLOGIE
.......................................................................................................................................................
21
2.2.3
FUNKTIONEN
...........................................................................................................................................................
21
2.2.4
MONOZYTENAKTIVIERUNG
VIA
CD14
UND
LPS
.....................................................................................................
23
2.3
Z
YTOKINE
..........................................................................................................................................................................
25
2.3.1
INTERLEUKIN
10
(IL-10)
........................................................................................................................................
29
2.3.2
TUMOR-NEKROSE-FAKTOR-ALPHA
(TNF-A)
..........................................................................................................
30
2.4
Z
ELLULAERE
O
BERFLAECHENMOLEKUELE
................................................................................................................................
33
2.4.1
TOLL-LIKE-REZEPTOREN
...........................................................................................................................................
33
2.4.2
HUMAN
LEUKOCYT
ANTIGEN
(HLA-SYSTEM)
.......................................................................................................
37
3
PSYCHONEUROIMMUNOLOGIE
(PNI)
...........................................................................................................................
39
3.1
U
RSPRUNG
........................................................................................................................................................................
39
3.2
D
AS
Z
YTOKIN
-N
ETZWERK
..................................................................................................................................................
39
3.3
K
LINISCHE
N
ACHWEISE
.....................................................................................................................................................
41
3.4
PNI
UND
PSYCHIATRISCHE
ERKRANKUNGEN
......................................................................................................................
43
4
ZIELSETZUNG
......................................................................................................................................................................
45
II
.
MATERIAL
UND
METHODEN
.....................................................................................................................................
47
5
MATERIAL
..............................................................................................................................................................................
47
5.1
P
ATIENTEN
-
UND
K
ONTROLLKOLLEKTIV
.............................................................................................................................
47
5.1.1
PSYCHOPATHOLOGISCHE
ANALYSE
..........................................................................................................................
48
5.2
VERBRAUCHSMATERIALIEN
UND
L
ABORGERAETE
..................................................................................................................
52
5.3
A
NTIKOERPER
......................................................................................................................................................................
53
6
METHODEN
...........................................................................................................................................................................
54
6.1
B
LUTPROBENENTNAHME
....................................................................................................................................................
54
6.2
LPS-S
TIMULATION
.............................................................................................................................................................
54
6.3
F
LUORESZENZFAERBUNG
......................................................................................................................................................
55
6.3.
1
EXTRAZELLULAERE
ANALYSE
........................................................................................................................................
56
6.3.2
INTRAZELLULAERE
ANALYSE
........................................................................................................................................
58
6.4
D
URCHFLUSSZYTOMETRIE
..................................................................................................................................................
60
6.4.
1
GRUNDLAGEN
DER
DUCHFLUSSZYTOMETRIE
............................................................................................................
60
6.4.2
DURCHFUEHRUNG
DER
MESSUNGEN
.........................................................................................................................
65
6.4.3
MESSDATENDARSTELLUNG
.......................................................................................................................................
65
6.4.4
DATENAUSWERTUNG
...............................................................................................................................................
66
6.5
M
ETHODEN
STATISTISCHER
A
USWERTUNG
.......................................................................................................................
70
III.
ERGEBNISSE...........................................................................................................................................
71
7
MONOZYTENVERTEILUNG
.................................................................................................................................................
71
7.1
R
ELATIVE
M
ONOZYTENZAHL
(%)
..............................................................................................................................
71
7.2
A
BSOLUTE
M
ONOZYTENZAHL
................................................................................................................................
74
8
EXTRAZELLULAERE
MONOZYTENANALYSE
....................................................................................................................
77
8.1
E
XPRESSION
VON
TLR-4
OHNE
S
TIMULATION
DURCH
LPS
.................................................................................................
77
8.2
E
XPRESSION
VON
TLR-4
MIT
S
TIMULATION
DURCH
LPS
....................................................................................................
80
8.3
A
NALYSE
DER
TLR-4
POSITIVEN
M
ONOZYTEN
...................................................................................................................
83
8.3.1
TLR^+
/
CD14+
/
LPS-/ZELLEN
.........................................................................................................................
83
8.3.2
TLR-4+/CD14+/LPS+/ZELLEN
........................................................................................................................
85
8.4
E
XPRESSION
VON
HLA-DR
OHNE
S
TIMULATION
DURCH
LPS
.............................................................................................
87
8.5
E
XPRESSION
VON
HLA-DR
MIT
S
TIMULATION
DURCH
LPS
................................................................................................
89
8.6
A
NALYSE
DER
HLA-DR
POSITIVEN
M
ONOZYTEN
...............................................................................................................
91
8.6.1
HLA-DR+
/
CD14+
/
LPS
/
ZELLEN
.....................................................................................................................
91
8.6.2
HLA-DR+
/
CD14+
/
LPS+
/
ZELLEN
....................................................................................................................
93
8.7
A
NALYSE
DER
TLR-4
UND
HLA
-
DR
-
POSITIVEN
MONOZYTEN
......................................................................................
95
8.7.
1
TLR-4+
/
HLA-DR+
/
LPS-/ZELLEN
..................................................................................................................
95
8.7.2
TLR-4+/HLA-DR+/LPS+/ZELLEN
..................................................................................................................
97
9
INTRAZELLULAERE
MONOZYTENANALYSE
.....................................................................................................................
99
9.1
E
XPRESSION
VON
TNF-A
OHNE
S
TIMULATION
DURCH
LPS
...............................................................................................
99
9.2
E
XPRESSION
VON
TNF-A
MIT
S
TIMULATION
DURCH
LPS
.................................................................................................
102
9.3
E
XPRESSION
VON
IL-10
OHNE
S
TIMULATION
DURCH
LPS
...............................................................................................
105
9.4
E
XPRESSION
VON
IL-10
MIT
S
TIMULATION
DURCH
LPS
...................................................................................................
107
9.5
A
NALYSE
DER
TNF-A
UND
IL-10
POSITIVEN
M
ONOZYTEN
.........................................................................................
109
10
UNTERSUCHUNG
DER
AUSWIRKUNG
VERSCHIEDENER
PARAMETER
AUF
DIE
IMMUNZELLEN
................
113
11
UNTERSUCHUNG
DER
AUSWIRKUNG
DER
PSYCHOPATHOLOGIE
AUF
DIE
IMMUNZELLEN
......................
115
IV.
DISKUSSION
....................................................................................................................................................................
117
12
METHODIK
DER
STUDIE
...............................................................................................................................................
117
12.1
U
NTERSUCHUNGSKOLLEKTIV
...........................................................................................................................................
117
12.2
U
NTERSUCHUNGSMETHODIK
..........................................................................................................................................
118
12.3
M
ONOZYTEN
..................................................................................................................................................................
119
12.4
HLA-DR
........................................................................................................................................................................
120
12.5
T
OLL
-
LIKE
-R
EZEPTOREN
..................................................................................................................................................
122
12.6
Z
YTOKINE
........................................................................................................................................................................
125
13
INTERPRETATION
DER
MONOZYTENANALYSE
.......................................................................................................
133
V.
ZUSAMMENFASSUNG
...................................................................................................................................................
135
VI.
LITERATURVERZEICHNIS
..............................................................................................................................................
137
VII.
ABBILDUNGSVERZEICHNIS
.........................................................................................................................................
156
VIII.
TABELLENVERZEICHNIS
...............................................................................................................................................
159
IX.
DANKSAGUNG
................................................................................................................................................................
168
X.
LEBENSLAUF
....................................................................................................................................................................
169
|
| any_adam_object | 1 |
| author | Endstrasser, Nina 1981- |
| author_GND | (DE-588)1017707898 |
| author_facet | Endstrasser, Nina 1981- |
| author_role | aut |
| author_sort | Endstrasser, Nina 1981- |
| author_variant | n e ne |
| building | Verbundindex |
| bvnumber | BV039839452 |
| ctrlnum | (OCoLC)775126558 (DE-599)DNB1017708053 |
| discipline | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV039839452 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:12:25Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024699375 |
| oclc_num | 775126558 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 |
| owner_facet | DE-19 DE-BY-UBM DE-12 |
| physical | 169 S. Ill., graph. Darst. 21 cm |
| publishDate | 2011 |
| publishDateSearch | 2011 |
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| spelling | Endstrasser, Nina 1981- Verfasser (DE-588)1017707898 aut Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten vorgelegt von Nina Endstrasser 2011 169 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2011 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024699375&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Endstrasser, Nina 1981- Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten |
| subject_GND | (DE-588)4113937-9 |
| title | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten |
| title_auth | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten |
| title_exact_search | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten |
| title_full | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten vorgelegt von Nina Endstrasser |
| title_fullStr | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten vorgelegt von Nina Endstrasser |
| title_full_unstemmed | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten vorgelegt von Nina Endstrasser |
| title_short | Durchflusszytometrische Analyse LPS-stimulierter und unstimulierter Monozyten schizophren erkrankter Patienten |
| title_sort | durchflusszytometrische analyse lps stimulierter und unstimulierter monozyten schizophren erkrankter patienten |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024699375&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT endstrassernina durchflusszytometrischeanalyselpsstimulierterundunstimuliertermonozytenschizophrenerkrankterpatienten |