Multiple sclerosis as a neuronal disease (Elsevier Academic Press, 2005)
This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis * Places MS in a new and important perspective that promises to open up new therapeutic avenues * Superbly illustrated and referenced
Includes bibliographical references and index
Structure, molecular organization, and function of myelinated axons -- Neuronal concomitants of demyelination -- Multiple sclerosis as a neurodegenerative disease -- Measurement of neuronal changes in the clinical domain -- Cellular and molecular mechanisms of axonal degeneration in multiple sclerosis -- Other aspects of neuronal injury in multiple sclerosis -- Lessons from the peripheral nervous system -- Prognosis, reparative mechanisms, and therapeutic approaches