Silicon nanowire transistor arrays for biomolecular detection:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Jülich
Forschungszentrum, Zentralbibliothek
2011
|
| Series: | Schriften des Forschungszentrums Jülich
Reihe Schlüsseltechnologien ; Bd. 29 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| ISBN: | 9783893367399 |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | IMAGE 1
CONTENTS
ABSTRACT I
ZUSAMMENFASSUNG III
CONTENTS V
CHAPTER 1. INTRODUCTION 1
CHAPTER 2. FUNDAMENTALS 7
2.1. THE ISFET AS LABEL-FREE BIOSENSORS 7
2.1.1. ISFET: STRUCTURE, OPERATION AND CHARACTERISTICS 7
2.1.2. THE OXIDE-LIQUID INTERFACES 14
2.1.3. ISFET RESPONSES TO BIOMOLECULAR BINDING 19
2.2. SILICON NANOWIRE (SINW) FET BIOSENSORS 24
2.3. NANOFABRICATION TECHNIQUES 29
2.3.1. NANOIMPRINT LITHOGRAPHY 29
2.3.2. ANISOTROPIE SI ETCH USING TMAH 32
CHAPTER 3. MATERIALS AND METHODS 35
3.1. SINW FABRICATIONS 35
3.1.1. SENSOR DESIGNS 36
3.1.2. IMPRINT MOLD FABRICATION 38
3.1.3. CHIP PROCESSING 40
3.2. CHIP PACKAGING AND MICROFLUIDIC FABRICATION 45
3.3. MEASUREMENT SETUP AND ELECTRONIC CHARACTERIZATIONS 47
3.4. SURFACE CLEANING AND MODIFICATION FOR BIOMOLECULAR BINDING 50
3.5. PH SENSITIVITY EXPERIMENTS 52
3.6. DETECTION OF CA 2+ IONS BY SINWS 53
3.7. POLYELECTROLYTES MULTILAYER BUILD UP ON SINWS DEVICES 54
V
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1018002898
DIGITALISIERT DURCH
IMAGE 2
3.8. DETECTION OF BIOTIN-STREPTAVIDIN BINDING BY SINW 57
3.9. DETECTION OF DNA BY SINWS 59
CHAPTER 4. CHARACTERIZATION OF THE SINW DEVICES 63
4.1. STRUCTURES AND TOPOGRAPHY OF THE SINW ARRAYS 63
4.2. ELECTRONIC CHARACTERIZATION OF THE SINW ARRAYS 69
4.2.1. BACK-GATE CHARACTERISTICS 69
4.2.2. FRONT-GATE CHARACTERISTICS 76
4.2.3. INFLUENCE OF THE CONTACT LINES RESISTANCE EFFECT TO THE SINW
ARRAYS
CHARACTERISTICS 85
4.2.4. COUPLING OF BACK-AND FRONT-GATE 87
4.2.5. SIGNAL RELIABILITY 90
4.2.6. TRANSFER FUNCTIONS OF THE SINWS 93
4.3. SUMMARY AND DISCUSSION 94
CHAPTER 5. APPLICATIONS OF THE SINW ARRAYS AS BIOCHEMICAL SENSORS 97
5.1. PH SENSITIVITY OF THE SINWS 98
5.2. DETECTION OF CA 2+ IONS BY THE SINW DEVICES 105
5.3. POTENTIOMETRIC DETECTION OF POLY D LYSINE (PDL) MOLECULES ON THE
SINW DEVICES
107
5.4. POTENTIOMETRIC DETECTION OF POLYELECTROLYTES MULTILAYER BUILD UP ON
THE SINW.... 110
5.5. DETECTION OF BIOTIN-STREPTAVIDIN BINDING BY THE SINW DEVICES 114
5.6. DETECTION OF DNA IMMOBILIZATION AND HYBRIDIZATION 117
5.7. SUMMARY AND DISCUSSION 125
CHAPTER 6. CONCLUSION AND OUTLOOK 129
6.1. CONCLUSIONS 129
6.2. OUTLOOKS 132
APPENDICES 135
A. CHIP DESIGNS AND FABRICATION PROCESS 135
VI
IMAGE 3
A.I. CHIPS DESIGN 135
A.2. FABRICATION PROCESS FLOWS 139
A.3 LIST OF EQUIPMENT AND CHEMICAL USED IN SINW FABRICATION 144
B. CHEMICAL AND BUFFER SOLUTIONS USE FOR BIOMOLECULAR SENSING 146
B.I. PHOSPHATE BUFFER SALINE (PBS) 146
B.2. PHOSPHATE BUFFER SOLUTION FOR DNA IMMOBILIZATION 146
B.3. DNA SEQUENCE 147
B.4. LIST OF CHEMICALS 147
C. ABBREVIATIONS 147
REFERENCES 151
ACKNOWLEDGEMENTS 169
CURRICULUM VITAE 171
PERSONAL INFORMATION 171
EDUCATION AND RESEARCH 171
PUBLICATIONS 172
VU
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| spelling | Vu, Xuan Thang Verfasser (DE-588)1018167137 aut Silicon nanowire transistor arrays for biomolecular detection Xuan Thang Vu Jülich Forschungszentrum, Zentralbibliothek 2011 txt rdacontent n rdamedia nc rdacarrier Schriften des Forschungszentrums Jülich : Reihe Schlüsseltechnologien Bd. 29 Zugl.: Aachen, Techn. Hochsch., Diss., 2011 (DE-588)4113937-9 Hochschulschrift gnd-content Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien ; Bd. 29 (DE-604)BV023237997 29 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024647636&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Vu, Xuan Thang Silicon nanowire transistor arrays for biomolecular detection Schriften des Forschungszentrums Jülich |
| subject_GND | (DE-588)4113937-9 |
| title | Silicon nanowire transistor arrays for biomolecular detection |
| title_auth | Silicon nanowire transistor arrays for biomolecular detection |
| title_exact_search | Silicon nanowire transistor arrays for biomolecular detection |
| title_full | Silicon nanowire transistor arrays for biomolecular detection Xuan Thang Vu |
| title_fullStr | Silicon nanowire transistor arrays for biomolecular detection Xuan Thang Vu |
| title_full_unstemmed | Silicon nanowire transistor arrays for biomolecular detection Xuan Thang Vu |
| title_short | Silicon nanowire transistor arrays for biomolecular detection |
| title_sort | silicon nanowire transistor arrays for biomolecular detection |
| topic_facet | Hochschulschrift |
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