Nanotechnology of the life sciences: 9 Tissue, cell and organ engineering
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| Format: | Book |
| Language: | English |
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Weinheim
Wiley-VCH-Verl.
2011
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| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 519 S. Ill., graph. Darst. |
| ISBN: | 9783527331390 |
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| 245 | 1 | 0 | |a Nanotechnology of the life sciences |n 9 |p Tissue, cell and organ engineering |c ed. by Challa S. S. R. Kumar |
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IMAGE 1
VIL
CONTENTS
PREFACE XV
LIST OF AUTHORS XIX
1 NANOTECHNOLOGY AND TISSUE ENGINEERING: THE SCAFFOLD BASED APPROACH 1
LAKSHMI S. NAIR, SUBHABRATA BHATTACHARYYA, AND CATO T. LAURENCIA
1.1 OVERVIEW 1
1.2 INTRODUCTION 1
1.3 THE IMPORTANCE OF SCAFFOLDS IN TISSUE ENGINEERING 4 1.4 STRUCTURE
AND FUNCTIONS OF NATURAL EXTRACELLULAR MATRIX 12 1.5 APPLICATIONS OF
NANOTECHNOLOGY IN DEVELOPING SCAFFOLDS FOR TISSUE ENGINEERING 21
1.5.1 POLYMERIC NANOFIBER SCAFFOLDS 23 1.5.1.1 TOP-DOWN APPROACHES IN
DEVELOPING SCAFFOLDS FOR NANO-BASED TISSUE ENGINEERING 24 1.5.1.2
BOTTOM-UP APPROACHES IN DEVELOPING SCAFFOLDS FOR NANO-BASED TISSUE
ENGINEERING 33 1.6 CELL BEHAVIOR TOWARDS NANO-BASED MATRICES 39 1.7
APPLICATIONS OF NANO-BASED MATRICES AS SCAFFOLDS FOR TISSUE ENGINEERING
43
1.7.1 STEM CELL ADHESION AND DIFFERENTIATION 43 1.7.2 NEURAL TISSUE
ENGINEERING 47 1.7.3 CARDIAC AND BLOOD VESSEL TISSUE ENGINEERING 49 1.7A
BONE, LIGAMENT AND CARTILAGE TISSUE ENGINEERING 54 1.8 CONCLUSIONS 55
REFERENCES 56
2 POLYMERIC NANOFIBERS IN TISSUE ENGINEERING 66 SEOW HOON SAW, KAREN
WANG, THOMAS YONG, AND SEERAM RAMAKRISHNA
2.1 OVERVIEW 66
2.2 INTRODUCTION 67
2.2.1 HISTORY OF TISSUE ENGINEERING AND NANOFIBERS 67 2.3 CLASSIFICATION
OF NANOFIBERS 69 2.3.1 SYNTHETIC POLYMERS 69 2.3.2 BIOPOLYMERS 69
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1014987946
DIGITALISIERT DURCH
IMAGE 2
VIII CONTENTS
2.3.3 COPOLYMERS 70
2.3.4 COMPOSITE POLYMERS 70 2.4 NANOFIBER FABRICATION 70 2.4.1 DRAWING
71
2.4.2 TEMPLATE SYNTHESIS 71 2.4.3 PHASE SEPARATION 72 2.4.4
SELF-ASSEMBLY 73 2.4.5 ELECTROSPINNING 73 2.5 DEGRADATION AND ABSORPTION
KINETICS OF NANOFIBER SCAFFOLDS COMPARED
WITH CONVENTIONAL SCAFFOLDS 74 2.6 ADVANTAGES AND DISADVANTAGES OF
NANOFIBER SCAFFOLDS COMPARED WITH OTHER CONVENTIONAL SCAFFOLDS 76 2.7
BIOCOMPATIBILITY OF NANO-STRUCTURED TISSUE ENGINEERED IMPLANTS 82
2.8 APPLICATIONS OF POLYMERIC NANOFIBERS IN TISSUE ENGINEERING 87 2.8.1
OPHTHALMOLOGY 89 2.8.2 LIVER 93
2.8.3 NERVE 93
2.8.4 SKIN 99
2.8.5 BONE AND CARTILAGE 102 2.8.6 HEART AND VASCULAR GRAFTS 205 2.8.7
STEM CELLS 109
2.9 INNOVATIONS IN NANOFIBER SCAFFOLDS 213 2.10 CONCLUSION 115
REFERENCES 116
3 ELECTROSPINNING TECHNOLOGY FOR NANOFIBROUS SCAFFOLDS IN TISSUE
ENGINEERING 135
WAN-JU LI, RABIE M. SHANTI, AND ROCKY S. TUAN
3.1 INTRODUCTION 135
3.2 NANOFIBROUS SCAFFOLDS 138 3.2.1 FABRICATION METHODS FOR NANOFIBROUS
SCAFFOLDS 238 3.2.1.1 PHASE SEPARATION 238 3.2.1.2 SELF-ASSEMBLY 238
3.2.1.3 ELECTROSPINNING 239 3.2.2 THE ELECTROSPINNING PROCESS 240
3.2.2.1 HISTORY 240 3.2.2.2 SETUP 242
3.2.2.3 MECHANISM AND WORKING PARAMETERS 242 3.2.3 PROPERTIES OF
ELECTROSPUN NANOFIBROUS SCAFFOLDS 144 3.2.3.1 ARCHITECTURE 244 3.2.3.2
POROSITY 245
3.2.3.3 MECHANICAL PROPERTIES 146 3.3 CURRENT DEVELOPMENT OF ELECTROSPUN
NANOFIBROUS SCAFFOLDS IN TISSUE ENGINEERING 146 3.3.1 EVIDENCE
SUPPORTING THE USE OF NANOFIBROUS SCAFFOLDS IN TISSUE
ENGINEERING 146
IMAGE 3
CONTENTS IX
3.3.1.1 NANOFIBROUS SCAFFOLDS ENHANCE ADSORPTION OF CELL ADHESION
MOLECULES 246
3.3.1.2 NANOFIBROUS SCAFFOLDS INDUCE FAVORABLE CELL-ECM INTERACTION 247
3.3.1.3 NANOFIBROUS SCAFFOLDS MAINTAIN CELL PHENOTYPE 248 3.3.1.4
NANOFIBROUS SCAFFOLDS SUPPORT DIFFERENTIATION OF STEM CELLS 249 3.3.1.5
NANOFIBROUS SCAFFOLDS PROMOTE IN VIVO-LIKE 3D MATRIX ADHESION AND
ACTIVATE CELL SIGNALING PATHWAY 250 3.3.2 BIOMATERIALS ELECTROSPUN INTO
NANOFIBROUS SCAFFOLDS 252 3.3.2.1 NATURAL POLYMERIC NANOFIBROUS
SCAFFOLDS 252 3.3.2.2 SYNTHETIC POLYMERIC NANOFIBROUS SCAFFOLDS 262
3.3.2.3 COMPOSITE POLYMERIC NANOFIBROUS SCAFFOLDS 266 3.3.2.4
NANOFIBROUS SCAFFOLDS COATED WITH BIOACTIVE MOLECULES 268
3.3.3 ENGINEERED TISSUES USING ELECTROSPUN NANOFIBROUS SCAFFOLDS 169
3.3.3.1 SKIN 169 3.3.3.2 BLOOD VESSEL 170 3.3.3.3 CARTILAGE 171 3.3.3.4
BONE 172 3.3.3.5 MUSCLE 173
3.3.3.6 LIGAMENT 275 3.3.3.7 NERVE 175 3.4 CURRENT CHALLENGES AND FUTURE
DIRECTIONS 176 3.5 CONCLUSION 177
REFERENCES 177
4 NANOFIBROUS SCAFFOLDS AND THEIR BIOLOGICAL EFFECTS 188 LAURA A. SMITH,
JONATHAN A. BECK, AND PETER X. MA
4.1 OVERVIEW 188
4.2 INTRODUCTION 188
4.3 METHODS OF FORMATION 190 4.3.1 ELECTROSPINNING 190 4.3.2
SELF-ASSEMBLY 193 4.3.3 PHASE SEPARATION 194
4.4 NANOFIBROUS COMPOSITE SCAFFOLDS 198 4.4.1 INORGANIC COMPOSITES 199
4.4.2 SURFACE MODIFICATION 200 4.4.3 FACTOR DELIVERY SCAFFOLDS 201 4.5
BIOLOGICAL EFFECTS OF NANOFIBERS 202
4.5.1 ATTACHMENT 202 4.5.2 PROLIFERATION 203 4.5.3 DIFFERENTIATION 203
4.5.4 MIGRATION 204 4.6 TISSUE FORMATION 205
4.6.1 CONNECTIVE TISSUE 205 4.6.1.1 LIGAMENTS 205 4.6.1.2 CARTILAGE 205
4.6.1.3 BONE 206
IMAGE 4
X CONTENTS
4.6.2
4.6.3 4.6.3.1 4.6.3.2 4.6.4 4.7
NEURAL TISSUE 207 CARDIOVASCULAR TISSUE CARDIAC MUSCLE 208 BLOOD VESSEL
208
LIVER TISSUE 208 CONCLUSION 209 REFERENCES 220
208
5 NANOPHASE BIOMATERIALS FOR TISSUE ENGINEERING 216 RAMALINGAM MURUGAN
AND SEERAM RAMAKRISHNA 5.1 INTRODUCTION: PROBLEMS WITH CURRENT THERAPIES
216 5.2 TISSUE ENGINEERING: A POTENTIAL SOLUTION 219 5.3 STEM CELLS: THE
ESSENTIALS 220 5.4 NANOBIOMATERIALS: A NEW GENERATION SCAFFOLDING
MATERIAL 223
5.4.1 CHARACTERISTICS OF SCAFFOLD 225 5.4.2 TYPES OF SCAFFOLDING
MATERIALS 227 5.4.2.1 CERAMIC NANOBIOMATERIALS 227 5.4.2.2 POLYMERIC
NANOBIOMATERIALS 234
5.5 NANOFIBROUS SCAFFOLD PROCESSING: CURRENT SCENARIOS 237 5.5.1
SELF-ASSEMBLY 237 5.5.2 PHASE SEPARATION 239 5.5.3 ELECTROSPINNING - A
NEW APPROACH 240
5.5.3.1 EXPERIMENTAL SYSTEM 240 5.5.3.2 SPINNING MECHANISM 241 5.5.3.3
ELECTROSPUN NANOFIBROUS SCAFFOLDS 243 5.6 CELL-MATRIX (SCAFFOLD)
INTERACTIONS 244
5.6.1 CELL-CERAMIC SCAFFOLD INTERACTIONS 244 5.6.2 CELL-POLYMER SCAFFOLD
INTERACTIONS 247 5.7 CONCLUDING REMARKS 248 ACKNOWLEDGMENTS 249
ABBREVIATIONS 249 GLOSSARY 250 REFERENCES 252
6 ORTHOPEDIC TISSUE ENGINEERING USING NANOMATERIALS 257 MICHIKO SATO AND
THOMAS]. WEBSTER 6.1 PREFACE 257
6.2 INTRODUCTION: PROBLEMS WITH CURRENT IMPLANTS 258 6.3 A POTENTIAL
SOLUTION: NANOTECHNOLOGY 259 6.3.1 CURRENT RESEARCH EFFORTS TO IMPROVE
IMPLANT PERFORMANCE TARGETED AT THE NANOSCALE 260
6.3.1.1 CERAMIC NANOMATERIALS 262 6.3.1.2 METAL NANOMATERIALS 270
6.3.1.3 POLYMERIC NANOMATERIALS 270 6.3.1.4 COMPOSITE NANOMATERIALS 274
IMAGE 5
CONTENTS XI
6.3.2 IN VIVO COMPARED WITH IN VITRO STUDIES 276
6.4 CONSIDERATIONS AND FUTURE DIRECTIONS 278 ACKNOWLEDGMENTS 279
REFERENCES 279
7 HYDROXYAPATITE NANOCRYSTALS AS BONE TISSUE SUBSTITUTE 283 NORBERTO
ROVERI AND BARBARA PALAZZO
7.1 OVERVIEW 283
7.2 INTRODUCTION 284
7.3 BIOGENIC HYDROXYAPATITE: BONE AND TEETH 284 7.4 BIOMIMETIC
HYDROXYAPATITE: POROUS AND SUBSTITUTED APATITES 288 7.5 BIOLOGICALLY
INSPIRED HYDROXYAPATITE: HA-COLLAGEN COMPOSITES AND COATINGS 292
7.6 FUNCTIONALIZED HYDROXYAPATITE: HA NANOCRYSTALS - BIOACTIVE MOLECULES
296 7.7 CONCLUSION AND FUTURE CHALLENGES 301 ACKNOWLEDGMENTS 301
REFERENCES 302
8 MAGNETIC NANOPARTICLES FOR TISSUE ENGINEERING 308 AKIRA ITO AND
HIROYUKI HONDA
8.1 INTRODUCTION 308
8.2 MESENCHYMAL STEM CELL ISOLATION AND EXPANSION 310 8.2.1 MSC
EXPANSION USING MCLS 310 8.2.2 MSC ISOLATION AND EXPANSION USING AMLS
313 8.3 MAG-SEEDING 316
8.4 CONSTRUCTION OF 3D TISSUE-LIKE STRUCTURE 318 8.4.1 CELL SHEET
ENGINEERING USING RGD-MCLS 318 8.4.2 CONSTRUCTION OF A KERATINOCYTE
SHEET USING MCLS 322
8.4.3 DELIVERY OF MAG-TISSUE ENGINEERED RPE SHEET 323 8.4.4 CONSTRUCTION
OF A LIVER-LIKE STRUCTURE USING MCLS 326 8.4.5 CONSTRUCTION OF TUBULAR
STRUCTURES USING MCLS 328 8.5 CONCLUSION 330
REFERENCES 332
9 APPLICATIONS AND IMPLICATIONS OF SINGLE-WALLED CARBON NANOTUBES IN
TISSUE ENGINEERING 338
PETER S. MCFETRIDGE AND MATTHIAS U. NOLLERT
9.1 INTRODUCTION 338
9.2 ELECTROMAGNETIC FIELDS FOR TISSUE REGENERATION 339 9.3 TISSUE
ENGINEERING 340
9.4 SWNT PREPARATION: PURIFICATION AND FUNCTIONALIZATION 342 9.5
SPECIFIC APPLICATIONS OF CARBON NANOTUBES IN TISSUE ENGINEERING 352 9.6
CONCLUSIONS 355
REFERENCES 355
IMAGE 6
XII I CONTENTS
10 NANOPARTICLES FOR CELL ENGINEERING - A RADICAL CONCEPT 362
BEVERLY A. RZIGALINSKI, IGOR DANELISEN, ELIZABETH T. STRAWN, COURTNEY A.
COHEN,
AND CHENGYA LIANG
10.1 INTRODUCTION AND OVERVIEW 362
10.2 FREE RADICALS AND OXIDATIVE STRESS 362 10.2.1 SOURCES OF
INTRACELLULAR FREE RADICALS 362 10.2.2 OXIDATIVE STRESS 364 10.2.3
OXIDATIVE STRESS AND DISEASE 365 10.3 A NANOTECHNOLOGICAL APPROACH TO
OXIDATIVE STRESS 366
10.3.1 RARE EARTH OXIDE NANOPARTICLES - CERIUM 367 10.3.1.1 BIOLOGICAL
EFFECTS OF CERIUM 369 10.3.1.2 BIOLOGICAL EFFECTS OF CERIUM OXIDE
NANOPARTICLES 370 10.3.1.3 OTHER OXIDE NANOPARTICLES 373 10.3.1.4
FULLERENE DERIVATIVES AND CARBON NANOTUBES 373 10.4 NANO-PHARMACOLOGY
374
10.4.1 ABSORPTION 375 10.4.1.1 AGGLOMERATION 376 10.4.1.2 DOSE 376
10.4.2 DISTRIBUTION, METABOLISM, AND EXCRETION 377
10.5 NANOPARTIDE ANTIOXIDANTS AND TREATMENT OF DISEASE 377 10.6
TOXICOLOGY 379 10.7 SUMMARY 380
REFERENCES 380
11 NANOPARTICLES AND NANOWIRES FOR CELLULAR ENGINEERING 388 JESSICA O.
WINTER
11.1 INTRODUCTION 388
11.2 BIOLOGICAL OPPORTUNITIES AT THE NANOSCALE 389 11.2.1 NANOSTRUCTURES
AND CELLS 389 11.2.2 NANOPARTICLE AND NANOWIRE SYNTHESIS FOR BIOLOGICAL
SYSTEMS 390 11.2.2.1 NANOPARTICLE SYNTHESIS 390 11.2.2.2 NANOWIRE
SYNTHESIS 393 11.2.3 SURFACE PASSIVATION STRATEGIES 394 11.2.4
BIOCONJUGATION 395 11.2.4.1 CONJUGATION STRATEGIES TO PROMOTE
NON-SPECIFIC CELLULAR AFFINITY 396
11.2.4.2 BIOMOLECULAR RECOGNITION 397 11.2.4.3 CONJUGATION STRATEGIES
FOR ANTIBODY-MEDIATED RECOGNITION 397 11.2.4.4 CONJUGATION STRATEGIES
FOR PROTEIN- AND PEPTIDE-MEDIATED RECOGNITION 398
11.2.5 TOXICITY (SEE ALSO VOLUME 5 OF THIS SERIES) 399 11.3
NANOSTRUCTURES TO MODIFY CELL ADHESION AND MIGRATION 400 11.3.1 CELL
ADHESION AT THE NANOSCALE 402 11.3.2 CELL ADHESION AND NANOSCALE
PHYSICAL TOPOGRAPHY 402 11.3.3 CELL ADHESION AND NANOSCALE CHEMICAL
PATTERNS 405
IMAGE 7
CONTENTS XIII
11.3.4 CYTOSKELETAL MANIPULATION 406
11.3.5 FUTURE APPLICATIONS OF NANOSTRUCTURES FOR CELL ADHESION AND
MIGRATION 407 11.3.5.1 FUTURE PHYSICAL NANOSTRUCTURES FOR CELL ADHESION
408 11.3.5.2 FUTURE CHEMICAL PATTERNS FOR CELL ADHESION 409 11.3.5.3
ACTIVE INVESTIGATION OF THE CYTOSKELETON 422
11.4 NANOSTRUCTURE CELLULAR ENTRY 422 11.4.1 BIOLOGY OF MOLECULAR
DELIVERY 422 11.4.2 NANOSTRUCTURE ENDOCYTOTIC DELIVERY 422
11.4.3 OTHER METHODS OF CELLULAR ENTRY 415 11.4.4 NANOPARTICLE
INTRACELLULAR SENSING 426 11.4.4.1 SEMICONDUCTOR QUANTUM DOTS 426
11.4.4.2 MAGNETIC NANOPARTICLES 428 11.4.5 FUTURE DIRECTIONS 429
11.4.5.1 NANOSTRUCTURE INTRACELLULAR DELIVERY 429 11.4.5.2 INTRACELLULAR
SENSING 420 11.5 INTRACELLULAR TRANSPORT OF NANOSTRUCTURES 421 11.5.1
BIOLOGY OF INTRACELLULAR TRANSPORT 422 11.5.2 ACTIN-BASED NANOSTRUCTURE
TRANSPORT 423 11.5.3 MICROTUBULE-BASED NANOSTRUCTURE TRANSPORT 424
11.5.4 FUTURE DIRECTIONS 424 11.6 BIOMOLECULE DELIVERY USING
NANOSTRUCTURES 425
11.6.1 BIOLOGY OF CONTROLLED DELIVERY 425 11.6.1.1 DRUG DELIVERY 425
11.6.1.2 GENE THERAPY 426
11.6.2 DRUG DELIVERY 426 11.6.2.1 CELL TARGETING IN VIVO 426 11.6.2.2
DRUG DELIVERY FOR CANCER TREATMENT 427 11.6.3 GENE THERAPY 432 11.6.3.1
SILICA NANOCARRIERS 432
11.6.3.2 GOLD NANOCARRIERS 433 11.6.3.3 MAGNETIC NANOCARRIERS 433 11.6.4
FUTURE DIRECTIONS 434
11.6.4.1 DRUG DELIVERY 434 11.6.4.2 GENE THERAPY 436 11.7 PROTEIN
MANIPULATION 437
11.7.1 BIOLOGY OF PROTEIN MANIPULATION 438 11.7.2 MANIPULATION OF FREE
PROTEINS: ENZYMES 438 11.7.3 MANIPULATION OF BOUND PROTEINS: RECEPTORS
AND ION CHANNELS 439 11.7.4 FUTURE DIRECTIONS 440 11.8 SUMMARY AND
CONCLUSIONS 441 11.8.1 SUMMARY 441 11.8.2 CONCLUSIONS 443
REFERENCES 444
IMAGE 8
XIV CONTENTS
12 NANOENGINEERING OF BIOMATERIAL SURFACES 462
ASHWATH JAYAGOPAL AND VENKATRAM PRASAD SHASTRI 12.1 INTRODUCTION 462
12.2 CONVENTIONAL PHOTOLITHOGRAPHY 462 12.3 ELECTRON-BEAM LITHOGRAPHY
466 12.4 SOFT LITHOGRAPHY 468
12.5 POLYMER-DEMIXED NANOTOPOGRAPHIES 472 12.6 STAR-SHAPED AND OTHER
NOVEL POLYMER STRUCTURES 474 12.7 VAPOR DEPOSITION 476
12.8 SELF-ASSEMBLY 479 12.9 PARTICLE BLASTING 482 12.10 ION BEAM AND
PLASMA-GUIDED SURFACE ENGINEERING 483 12.11 SOL-GEL TECHNOLOGY 486 12.12
NANOLITHOGRAPHY 487 12.13 LASER-GUIDED STRATEGIES 489 12.14 RAPID
PROTOTYPING TECHNIQUES 492 12.15 CONCLUSIONS 496
ACKNOWLEDGMENTS 496 REFERENCES 497
INDEX 506 |
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| spelling | Nanotechnology of the life sciences 9 Tissue, cell and organ engineering ed. by Challa S. S. R. Kumar Weinheim Wiley-VCH-Verl. 2011 XXI, 519 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Kumar, Challa S. S. R. (DE-588)129740470 edt (DE-604)BV039691867 9 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024540725&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nanotechnology of the life sciences |
| title | Nanotechnology of the life sciences |
| title_auth | Nanotechnology of the life sciences |
| title_exact_search | Nanotechnology of the life sciences |
| title_full | Nanotechnology of the life sciences 9 Tissue, cell and organ engineering ed. by Challa S. S. R. Kumar |
| title_fullStr | Nanotechnology of the life sciences 9 Tissue, cell and organ engineering ed. by Challa S. S. R. Kumar |
| title_full_unstemmed | Nanotechnology of the life sciences 9 Tissue, cell and organ engineering ed. by Challa S. S. R. Kumar |
| title_short | Nanotechnology of the life sciences |
| title_sort | nanotechnology of the life sciences tissue cell and organ engineering |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024540725&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV039691867 |
| work_keys_str_mv | AT kumarchallassr nanotechnologyofthelifesciences9 |