Growth factors and their receptors in cell differentiation, cancer and cancer therapy:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2011
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| Ausgabe: | 1. ed. |
| Schriftenreihe: | Elsevier insights
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 347 S. graph. Darst. |
| ISBN: | 9780123878199 0123878195 |
Internformat
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Datensatz im Suchindex
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| adam_text | Titel: Growth factors and their receptors in cell differentiation, cancer and cancer therapy
Autor: Sherbet, Gajanan V.
Jahr: 2011
Contents
Preface xi
Abbreviations xiii
Introduction xvii
1. Convergence of Growth-Factor Signalling Pathways in Developmental
Systems and Pathogenesis 1
2. Growth Factor Families 3
The Membrane-Receptor Binding Family of Growth Factors 3
Cystine-Knot Group of Growth Factors 3
The Intracellular-Receptor Binding Family of Ligands 5
3. Growth Factors in Differentiation and Morphogenesis 7
TGF-ß Family Growth Factors in Differentiation and Morphogenesis 8
TGF-ß in Tumour Growth, Invasion and Metastases 9
The TGF-ß Signalling Cascade 10
The TGF-ß Receptor Group 11
Receptor Types I and II in Signalling by TGF-ß Ligands 11
Receptor Type III Endoglin-Mediated TGF-ß Signalling 11
Receptor Type III Betaglycan in TGF-ß Signalling 12
The Canonical Smad Pathway 12
The Effects of TGF-ß on Cell Proliferation and Apoptosis 13
Cell Proliferation, Invasion and Metastasis
Mediated by Type III Receptors 15
Endoglin as a Chemotherapeutic Target 17
Therapeutic Potential of Betaglycan 17
TGF-ß and Organ-Specific Metastatic Spread 18
Non-Smad (Non-Canonical) Signalling 20
Non-Canonical TGF-ß Signalling in Cancer Invasion
and Angiogenesis 22
MicroRNAs, EMT and TGF-ß Function 23
TGF-ß Operates in Other Signalling Systems of Cell
Adhesion and Motility 27
Interaction between Smad and Non-Smad Signalling 28
Signalling Links between BMP, Oestrogen and ER 29
Functional Synergy and Regulation between Smad and
MAPK Pathways 30
Contents
Nodal Signalling in Development, Differentiation and Pattern Formation 31
Regulation of Nodal Signalling 31
Differential Activation of Contributory Pathways 31
Selective and Differential Activation of Transcription Factors 32
Nodal, miRNA and EMT 34
Requirement of Cofactors in Nodal Regulation 34
Functional Stability of Nodal 35
Bone Morphogenetic Proteins 36
Heterogeneity of BMP Signalling Cascade and Phenotypic
Effects 38
Growth and Differentiation Factors 45
GDFs in Development and Differentiation 45
Co-ordination of GDF Signalling with Other TGF-ß Family Members 46
Synergistic Signalling of GDFs with BMPs 46
GDF and Nodal Signalling in Embryonic Development 50
Collaborative Function of GDFs and Hormones 51
GDF Expression in Cancer 51
Activin and Inhibin Signalling 52
Signalling Antagonism between Activin and Inhibin 53
Vascular Endothelial Growth Factor 55
VEGF Signalling 55
Angiogenic Properties of VEGF Proximal and Distal Splice Variants 56
Synergy of VEGF with Other Angiogenic Signalling Systems 57
Notch Signalling in Angiogenesis 58
Sphingosine 1-Phosphate (SIP) Cross-Talk in VEGF Signalling 58
The Interaction of ADAM Proteins with VEGF Signalling 59
Genetic Polymorphism in VEGF in Disease States 59
Is the Production of SNPs and VEGF Linked? 60
Functional Synergy of SNPs of Angiogenic Agents 60
Neovascularisation and Tumour Progression 61
Targeting VEGF and VEGFR in Cancer Treatment 62
Hepatocyte Growth Factor 65
Molecular Structure of HGF 65
HGF/MET Signalling 65
MET as a Therapeutic Target 69
The Platelet-Derived Growth Factor Family 71
PDGF in Cell Transformation and Cancer 72
Putative Collaborative Participation of PDGF in Angiogenic
Signalling 72
PDGF and Epithelial-Mesenchymal Transition 72
PDGF Signalling in Cell Proliferation and Migration 74
Co-operation with GPCR Pathway in Mitogenic Function 75
Contents vii
Signalling Specificity 75
PDGF Activates ets-1 Transcription Factor 75
Early Growth Response (egr) Zinc Finger Transcription Factors 76
MCP-1 in PDGF Effect 77
Relationship of PDGF Expression to Cancer Invasion and Progression 78
Genetic Changes in PDGFs and PDGFRs 79
7. Nerve Growth Factors 81
NT Signalling 81
Genetic Alterations in NT Receptors 82
Expression of NTs and Their Receptors in Cancer 84
8. Insulin-Like Growth Factors 87
Insulin-Like Growth Factors and Their Receptors 87
Insulin-Like Growth Factor Receptors 87
Insulin Receptor Substrate Proteins 87
IGF Signalling Pathways 88
IGF Signalling Interacts with Other Signalling Systems 90
The Interaction of Insulin and Growth Hormone with IGF Signalling 90
IGF Cross-Talk with Cell Proliferation and Migration Signalling 92
IGF Induces VEGF Expression and Vascularisation 93
Integration of Notch Signalling by IGF 95
IGF and the Morphogenetic Function of Wnt Proteins 96
Leptin Synergy with IGF Function 97
IGF Expression in Cancers 100
Modulation of Migration by IGFs and Their Receptors 102
9. Connective Tissue Growth Factor 105
CTGF in Wound Healing and Fibrosis 105
CTGF Expression Correlates with Cancer Progression and Prognosis 106
Is CTGF Involved in Osteotropic Metastasis? 107
Pro-angiogenic Effect of CTGF 108
Regulation of CTGF by TGF-ß 109
10. Thrombospondins 111
TSPs in Cancer 112
11. Cytokines 115
Tumour Necrosis Factors 115
TNF, Cell Proliferation and Apoptosis 117
TNF, Angiogenesis, Cancer Invasion and Metastasis 117
Targeting TNF-a Function through MicroRNAs 119
Interleukins 119
Interleukins Induce Cell Motility 120
Angiogenic Effects of Interleukins 121
viii Contents
Interferons 122
IFNs in Cancer Progression 123
Cytokines and Myeloid Differentiation 124
Granulocyte-Macrophage (GM-CSF), Granulocyte (G-CSF)
and Macrophage (M-CSF) Colony-Stimulating Factors 125
Cytokines in Cancer Therapy 126
Chemokines 128
IFN-Induced Chemokines in Cancer Invasion 129
Monocyte Chemoattractant Protein (MCP) 131
MCP-1 Expression in Cancers 131
12. Growth Factor and Hedgehog Signalling Pathways Meet
in Developmental Systems 133
The Hedgehog (Hh) Proteins 133
The Hh Signalling Cascade 134
Hh Homologues and Their Role in Morphogenesis 136
Co-operative Signalling by Hh and Growth Factors 138
TGF-ß Family Ligands and Hh Signalling 138
FGF and Hh Signalling 139
13. Epidermal Growth Factors and Their Signalling Systems 141
Growth Factor Signal Transduction 141
Epidermal Growth Factor (EGF) Family Ligands and Receptors 141
EGF Signalling Pathways 144
EGF Signalling through CD44 147
GPCRs in Growth Factor Signalling 149
The Wnt/ß-catenin Pathway in Growth Factor Signalling 150
Hedgehog Signalling in EGFR Function 151
Negative Regulation of EGFR Signalling 152
Preferential Receptor Activation and Transactivation 153
Metastasis Suppressor Genes and Growth Factor Signalling 154
Nm23 Interaction with Growth Factor Function 156
Growth Factor Receptor Expression in Cancer 160
EGF Family Receptors in Cancer Therapy 161
Treatment of Triple-negative Breast Cancer 165
14. The Epidermal Growth Factor (EGF) Family 173
Structure, Function and Expression of Epidermal Growth Factor (EGF)
and EGF Receptor 173
Single Nucleotide Polymorphism of EGF and Its Significance 174
Function of Transforming Growth factor (TGF)-a 176
Neuregulins (Heregulins) 178
Amphiregulin (AREG) 183
Differential Signalling by AREG 183
AREG in Cell Proliferation 184
Contents ix
AREG in Invasion and Metastasis 185
AREG Expression in Human Neoplasms 191
Epiregulin (EREG) 192
EREG Expression in Cancers 193
ß-Cellulin (BTC) 194
BTC Expression in Cancers 195
Heparin-Binding Epidermal Growth Factor-Like Growth Factor 195
HB-EGF Induces Angiogenesis 195
Influence of HB-EGF on Cell Motility and Invasion 196
HB-EGF in Cancer Progression 197
15. The Fibroblast Growth Factor Family 199
FGFs in the Development of the Central Nervous System
and Neuronal Differentiation 201
FGF2 (Basic FGF) 204
FGF2-Mediated Promotion of Intercellular Adhesion 205
FGF2 and Promotion of Neurite Extension 205
FGF2 and Osteogenesis 207
FGFs 1 and 2 Regulate Cell Proliferation 208
FGFs 1 and 2 and the Induction of Angiogenesis 208
16. Intracellular Receptor Binding Growth Factors 211
17. The Androgens and Androgen Receptors in Development,
Differentiation and Neoplasia 213
Androgen Receptor and Androgen-Responsive Elements 213
AR-Activated Signalling Pathways 214
AR Expression in Cancer Progression 216
Functional Integrity of AR and AR-Mediated Signalling 217
Interaction of Androgen and Growth Factor Signalling 217
18. Vitamin D3 in Cell Proliferation, Apoptosis and Differentiation 219
The VD3 Receptor, VDRs and VDR Response Elements 219
VDR Signalling in Cell Proliferation, Apoptosis and Differentiation 220
Modulation of Cell Adhesion and Motility 221
Collaborative Function of VDR and RA Receptors 223
19. Retinoids in Development and Pattern Formation 225
Retinoic Acid Receptors 225
RAR-Mediated Biological Effects 225
20. Oestrogens and Progesterone in Normal Physiology and Neoplasia 229
Receptor Mediation of Oestrogen and Progesterone Function 229
ER/PR in Cell Adhesion, Proliferation and Cross-talk with
Growth Factor Signalling 230
x Contents
ER Signalling and Cell Motility 230
ER and Cell Proliferation 231
ER/PR Cross-talk with Tumour Suppressor and
Promoter Signalling 232
The Trefoil Protein TFF1 234
TFF1, Cell Proliferation and Invasion 234
TFFs in Progression and Prognosis 235
21. Glucocorticoid Signalling in Normal and Aberrant Physiology 237
Glucocorticoid Receptors in Signalling 237
Effects of Glucocorticoids on Cell Function 239
Regulation of Cell Proliferation 239
Modulation of Extracellular Matrix Enzyme Systems 240
Glucocorticoids and Cancer Progression 241
Epilogue 243
References 249
|
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| isbn | 9780123878199 0123878195 |
| language | English |
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| spelling | Sherbet, Gajanan V. 1935- Verfasser (DE-588)118160281 aut Growth factors and their receptors in cell differentiation, cancer and cancer therapy G. V. Sherbet 1. ed. Amsterdam [u.a.] Elsevier 2011 XIX, 347 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Elsevier insights Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Wachstumsfaktor (DE-588)4188802-9 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 gnd rswk-swf Wachstumsfaktor (DE-588)4188802-9 s Zelldifferenzierung (DE-588)4067536-1 s Krebs Medizin (DE-588)4073781-0 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024506903&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sherbet, Gajanan V. 1935- Growth factors and their receptors in cell differentiation, cancer and cancer therapy Krebs Medizin (DE-588)4073781-0 gnd Wachstumsfaktor (DE-588)4188802-9 gnd Zelldifferenzierung (DE-588)4067536-1 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4188802-9 (DE-588)4067536-1 |
| title | Growth factors and their receptors in cell differentiation, cancer and cancer therapy |
| title_auth | Growth factors and their receptors in cell differentiation, cancer and cancer therapy |
| title_exact_search | Growth factors and their receptors in cell differentiation, cancer and cancer therapy |
| title_full | Growth factors and their receptors in cell differentiation, cancer and cancer therapy G. V. Sherbet |
| title_fullStr | Growth factors and their receptors in cell differentiation, cancer and cancer therapy G. V. Sherbet |
| title_full_unstemmed | Growth factors and their receptors in cell differentiation, cancer and cancer therapy G. V. Sherbet |
| title_short | Growth factors and their receptors in cell differentiation, cancer and cancer therapy |
| title_sort | growth factors and their receptors in cell differentiation cancer and cancer therapy |
| topic | Krebs Medizin (DE-588)4073781-0 gnd Wachstumsfaktor (DE-588)4188802-9 gnd Zelldifferenzierung (DE-588)4067536-1 gnd |
| topic_facet | Krebs Medizin Wachstumsfaktor Zelldifferenzierung |
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