Preparative chromatography:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2012
|
| Ausgabe: | 2., completely rev. and upd. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Frühere Aufl. u.d.T.: Preparative chromatography of fine chemicals and pharmaceutical agents |
| Beschreibung: | XXX, 535 S. Ill., graph. Darst. |
| ISBN: | 9783527328987 9783527649280 |
Internformat
MARC
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| 020 | |a 9783527328987 |c print ISBN |9 978-3-527-32898-7 | ||
| 020 | |a 9783527649280 |c oBook ISBN |9 978-3-527-64928-0 | ||
| 035 | |a (OCoLC)756374479 | ||
| 035 | |a (DE-599)BVBBV039614379 | ||
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| 084 | |a CHE 232f |2 stub | ||
| 084 | |a CIT 060f |2 stub | ||
| 245 | 1 | 0 | |a Preparative chromatography |c ed. by Henner Schmidt-Traub ... |
| 250 | |a 2., completely rev. and upd. ed. | ||
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2012 | |
| 300 | |a XXX, 535 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Frühere Aufl. u.d.T.: Preparative chromatography of fine chemicals and pharmaceutical agents | ||
| 650 | 0 | 7 | |a Präparative Chromatographie |0 (DE-588)4435196-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Präparative Chromatographie |0 (DE-588)4435196-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Schmidt-Traub, Henner |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-3-527-64930-3 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, MOBI |z 978-3-527-64929-7 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-64931-0 |
| 856 | 4 | 2 | |m Digitalisierung UB Passau |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024464940&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-024464940 | ||
Datensatz im Suchindex
| _version_ | 1804148458512187392 |
|---|---|
| adam_text | Contents
Preface
XV
About the Editors
XVJÍ
List of Contributors
XIX
List of Abbreviations
XXI
Notations
XXV
1
Introduction
1
Henner Schmidt-Traub and
Reinhard
Ditz
1.1
Development of Chromatography
1
1.2
Focus of the Book
3
1.3
Recommendation to Read this Book
4
References
6
2
Fundamentals and General Terminology
7
Andreas
Seidel-Morgenstern,
Michael
Schulte,
and
Achim Epping
2.1
Principles of Adsorption Chromatography
7
2.1.1
Adsorption Process
9
2.1.2 Chromatographie
Process
10
2.2
Basic Effects and
Chromatographie
Definitions
11
2.2.1
Chromatograms and Parameters
11
2.2.2
Voidage and Porosity
12
2.2.3
Influence of Adsorption Isotherms on Chromatogram Shapes
25
2.3
Fluid Dynamics
18
2.3.1
Extra Column Effects
18
2.3.2
Column Fluid Distribution
29
2.3.3
Packing Nonidealities
19
2.3.4
Sources for
Nonideal
Fluid Distribution
20
2.3.5
Column Pressure Drop
21
2.4
Mass Transfer Phenomena
22
2.4.1
Principles of Mass Transfer
22
2.4.2
Efficiency of
Chromatographie
Separations
24
2 A3
Resolution
27
2.5
Equilibrium Thermodynamics
30
VI
Contents
2.5.1 Definition
of Isotherms
ЗО
2.5.2
Models of Isotherms
32
2.5.2.1
Single-Component Isotherms
32
2.5.2.2
Multicomponent Isotherms Based on the Langmuir Model
34
2.5.2.3
Competitive Isotherms Based on the Ideal Adsorbed Solution
Theory
35
2.5.2.4
Steric Mass Action Isotherms for Ion Exchange Equilibria
38
2.6
Thermodynamic Effects on Mass Separation
40
2.6.1
Mass Load
40
2.6.2
Linear and Nonlinear Isotherms
41
2.6.3
Elution Modes
43
References
45
3
Stationary Phases and
Chromatographie
Systems
47
Michael Schuhe,
Matthias
Jòhnck,
Romas Skudas, Klaus K.
Unger,
Cedrìc
áu Fresne
von Hohenesche,
Wolfgang Wewers, Jules Dingenen,
and Joachim
Kinkel
3.1
Column Packings
47
3.1.1
Survey of Packings and Stationary Phases
47
3.1.2
Generic, Designed, and Customized Adsorbents
48
3.1.2.1
Generic Adsorbents
48
3.1.2.2
Designed Adsorbents
54
3.1.2.3
Customized Adsorbents
62
3.1.3
Reversed Phase Silicas
66
3.1.3.1
Silanisation of the Silica Surface
67
3.1.3.2 Chromatographie
Characterization of Reversed Phase Silicas
69
3.1.4
Cross-Linked Organic Polymers
72
3.1
A.I General Aspects
73
3.1.4.2 Hydrophobie
Polymer Stationary Phases
76
3.1.4.3
Hydrophilic Polymer Stationary Phases
76
3.1.4.4
Ion Exchange (IEX)
77
3.1.4.5
Mixed Mode
85
3.1.5
Chiral Stationary Phases
85
3.1.5.1
Antibiotic CSP
91
3.1.5.2
Synthetic Polymers
91
3.1.5.3
Targeted Selector Design
92
3.1.5.4
Further Developments
93
3.1.6
Properties of Packings and their Relevance to
Chromatographie
Performance
95
3.1.6.1
Chemical and Physical Bulk Properties
95
3.1.6.2
Mass Loadability
101
3.1.6.3
Comparative Rating of Columns
102
3.1.7
Sorbent
Maintenance and Regeneration
103
3.1.7.1
Cleaning in Place
(CIP)
103
3.1.7.2
Conditioning of Silica Surfaces
106
Contents
VII
3.1.7.3 Sanitization in
Place (SIP)
108
3.1.7.4
Column
and Adsorbent Storage
108
3.2
Selection of
Chromatographie
Systems
109
3.2.1
Definition of the Task
114
3.2.2
Mobile Phases for Liquid Chromatography
118
3.2.2.1
Stability
118
3.2.2.2
Safety Concerns
118
3.2.2.3
Operating Conditions
121
3.2.2.4
Aqueous Buffer Systems
123
3.2.3
Adsorbent and Phase Systems
125
3.2.3.1
Choice of Phase System Dependent on Solubility
127
3.2.3.2
Improving Loadability for Poor Solubilities
128
3.2.3.3
Dependency of Solubility on Sample Purity
130
3.2.3.4
Generic Gradients for Fast Separations
131
3.2.4
Criteria for Choosing NP Systems
132
3.2.4.1
Pilot Technique Thin-layer Chromatography
134
3.2.4.2
Retention in NP Systems
134
3.2.4.3
Solvent Strength in Liquid-Solid Chromatography
136
3.2.4.4
Selectivity in NP Systems
138
3.2.4.5
Mobile-Phase Optimization by
TLC
Following the
PRISMA
Model
139
3.2.4.6
Strategy for an Industrial Preparative Chromatography Laboratory
148
3.2.5
Criteria for Choosing RP Systems
153
3.2.5.1
Retention and Selectivity in RP Systems
155
3.2.5.2
Gradient Elution for Small amounts of Product on RP Columns
256
3.2.5.3
Rigorous Optimization for Isocratic Runs
157
3.2.5.4
Rigorous Optimization for Gradient Runs
161
3.2.5.5
Practical Recommendations
164
3.2.6
Criteria for Choosing CSP Systems
167
3.2.6.1
Suitability of Preparative CSP
368
3.2.6.2
Development of Enantioselectivity
169
3.2.6.3
Optimization of Separation Conditions
171
3.2.6.4
Practical Recommendations
172
3.2.7
Downstream Processing of Mabs using Protein A and IEX
274
3.2.8
Size Exclusion (SEC)
279
3.2.9
Overall
Chromatographie
System Optimization
282
3.2.9.1
Conflicts During Optimization of
Chromatographie
Systems
282
3.2.9.2
Stationary Phase Gradients
284
References
189
4
Chromatography Equipment: Engineering and Operation
199
Abdelaziz Toumi, Jules D mgenenjoel
Genokt,
Olivier
Ludemann-Hombourger, Andre
Kiesewetter,
Martin Krahe,
Michele Morelli,
Henner Schmidt-Traub,
Andreas Stein, and
Eric Valéry
4.1
Introduction
299
4.2
Engineering and Operational Challenges
202
VIII Contents
4.3
Chromatography Columns Market
207
4.3.1
Generalities
-
The Suppliers
207
4.3.2
General Design
208
4.3.3
High-and Low-Pressure Columns
210
4.3.3.1
Chemical Compatibility
211
4.3.3.2
Frits Design
211
4.3.3.3
Special Aspects of
Bioseparation 215
4.4
Chromatography Systems Market
217
4.4.1
Generalities
-
The Suppliers
217
4.4.2
General Design Aspects
-
High Performance and Low-Pressure
Systems
217
4.4.3
Material
219
АЛЛ
Batch Low-Pressure Liquid Chromatography (LPLC) Systems
220
4.4.4.1
Inlets
220
4.4.4.2
Valves to Control Flow Direction
220
4.4.4.3
Pumps
221
4.4.4.4
Pump(s) Valves and Gradient Formation
222
4.4.5
Batch High-Pressure Liquid Chromatography (HPLC) Systems
224
4.4.5.1
General Layout
224
4.4.5.2
Inlets and Outlets
224
4.4.5.3
Pumps
226
4.4.5.4
Valves and Pipes
227
4.4.6
Batch SFC Systems
228
4.4.6.1
General Layout
228
4.4.6.2
Inlets
230
4.4.6.3
Pumps, Valves, and Pipes
231
4.4.7
Continuous Systems
-
Simulated Moving Bed
231
4.4.7.1
General Layout
231
4.4.7.2
A Key Choice: The Recycling Strategy
232
4.4.7.3
Pumps, Inlets, and Outlets
233
4.4.7.4
Valves and Piping
233
4.4.8
Auxiliary Systems
233
4.4.8.1
Slurry Preparation Tank
234
4.4.8.2
Slurry Pumps and Packing Stations
234
4.4.8.3
Cranes and Transport Units
235
4.4.8.4
Filter Integrity Test
235
4.5
Process Control
236
4.5.1
Standard Process Control
236
4.5.2
Advanced Process Control
237
4.5.3
Detectors
240
4.6
Packing Methods
243
4.6.1
Column and Packing Methodology Selection
243
4.6.2
Slurry Preparation
244
4.6.3
Column Preparation
246
4.6.4
Flow Packing
246
Contents
IX
4.6.5 Dynamic Axial
Compression
(DAC)
Packing
249
4.6.6
Stall Packing
250
4.6.7
Combined Method (Stall
+
DAC)
250
4.6.8
Vacuum Packing
252
4.6.9
Vibration Packing
253
4.6.10
Column Equilibration
254
4.6.11
Column Testing and Storage
254
4.6.11.1
Test Systems
254
4.6.11.2
Hydrodynamic Properties and Column Efficiency
256
4.6.11.3
Column and Adsorbent Storage
257
4.7
Process Troubleshooting
257
4.7.1
Technical Failures
258
АЛ.
2
Loss of Performance
259
4.7.2.1
Pressure Increase
259
4.7.2.2
Loss of Column Efficiency
262
4.7.2.3
Variation of Elution Profile
263
4.7.2.4
Loss of Purity/Yield
264
4.7.3
Column Stability
265
4.8
Disposable Technology for
Bioseparations
265
4.8.1
Market Trend
265
4.8.2
Prepacked Columns
266
4.8.3
Membrane Chromatography
267
4.8.4
Membrane Technology
269
References
270
5
Process Concepts
273
Malte
Kaspereit,
Michael
Schulte,
Klaus
Wekenborg,
and Wolfgang Wewers
5.1
Discontinuous Processes
273
5.1.1
Isocratic Operation
273
5.1.2
Flip-Flop Chromatography
275
5.1.3
Closed-Loop Recycling Chromatography
276
5.1.4
Steady-State Recycling Chromatography
278
5.1.5
Gradient Chromatography
279
5.1.6 Chromatographie
Batch Reactors
281
5.2
Continuous Processes
283
5.2.1
Column Switching Chromatography
283
5.2.2
Annular Chromatography
283
5.2.3
Multiport Switching Valve Chromatography (ISEP/CSEP)
284
5.2.4
Isocratic Simulated Moving Bed (SMB) Chromatography
286
5.2.5
SMB Chromatography with Variable Process Conditions
290
5.2.5.1
VariCol
290
5.2.5.2
PowerFeed
291
5.2.5.3
Partial-Feed, Partial-Discard, and Fractionation-Feedback
Concepts
292
5.2.5.4
Improved/Intermittent SMB (iSMB)
293
X
Contents
5.2.5.5 ModiCon 294
5.2.5.6
FF-SMB
294
5.2.6
SMB Chromatography with
Variable Solvent
Conditions
294
5.2.6.1 Gradient SMB Chromatography 295
5.2.6.2
Supercritical Fluid SMB
Chromatography 296
5.2.7 Multicomponent Separations 296
5.2.8 Multicolumn Systems
for Bioseparations
298
5.2.8.1
Sequential
Multicolumn Chromatography (SMCC) 298
5.2.8.2 Multicolumn Countercurrent Solvent Gradient
Purification
(MCSGP) 299
5.2.9 Countercurrent Chromatographie
Reactors
301
5.2.9.1 SMB
Reactor
301
5.2.9.2
Processes with Distributed Functionalities
302
5.3
Choice of Process Concepts
304
5.3.1
Scale
305
5.3.2
Range
offe
306
5.3.3
Number of Fractions
306
5.3.4
Example
1:
Lab Scale; Two Fractions
306
5.3.5
Example
2:
Lab Scale; Three or More Fractions
308
5.3.6
Example
3:
Production Scale
-
Wide Range
offe
309
5.3.7
Example
4:
Production Scale; Two Main Fractions
310
5.3.8
Example
5:
Production Scale; Three Fractions
311
5.3.9
Example
6:
Production Scale; Multi-Stage Process
312
References
315
6
Modeling and Model Parameters
321
Andreas
Seidel-Morgenstem, Henner Schmidt-Traub, Mirko
Michel,
Achim Epping,
and Andreas Jupke
6.1
Introduction
321
6.2
Models for Single
Chromatographie
Columns
322
6.2.1
Classes of
Chromatographie
Models
322
6.2.2
Derivation of the Mass Balance Equations
324
6.2.2.1
Mass Balance Equations
325
d.l.l.l Convective Transport
327
6.2.2.3
Axial Dispersion
327
6.2.2.4
Intraparticle Diffusion
327
6.2.2.5
Mass Transfer
328
6.2.2.6
Adsorption Kinetics
329
6.2.2.7
Adsorption Equilibrium
329
6.2.3
Equilibrium ( Ideal ) Model
330
6.2.4
Models with One Band Broadening Effect
334
6.2.4.1
Dispersive Model
334
6.2.4.2
Transport Model
336
6.2.4.3
Reaction Model
337
6.2.5
Lumped Rate Models
338
Contents
XI
6.2.5.1
Transport-Dispersive
Model 338
6.2.5.2
Reaction-Dispersive
Model 339
6.2.6 General Rate Models 340
6.2.7 Initial
and Boundary Conditions of the Column
343
6.2.8
Models of
Chromatographie
Reactors
344
6.2.9
Stage Models
344
6.2.10
Assessment of Different Model Approaches
346
6.2.11
Dimensionless Model Equations
348
6.3
Modeling HPLC Plants
350
6.3.1
Experimental Setup and Simulation Flow Sheet
350
6.3.2
Modeling Extra Column Equipment
351
6.3.2.1
Injection System
351
6.3.2.2
Piping
352
6.3.2.3
Detector
352
6.4
Calculation Methods
353
6.4.1
Analytical Solutions
353
6.4.2
Numerical Solution Methods
353
6.4.2.1
General Solution Procedure
353
6.4.2.2
Discretization
354
6.5
Parameter Determination
357
6.5.1
Parameter Classes for
Chromatographie
Separations
357
6.5.1.1
Design Parameters
357
6.5.1.2
Operating Parameters
358
6.5.1.3
Model Parameters
358
6.5.2
Determination of Model Parameters
359
6.5.3
Evaluation of Chromatograms
361
6.5.3.1
Moment Analysis and
H ETP
Plots
3 62
6.5.3.2
Parameter Estimation
369
6.5.3.3
Peak Fitting Functions
370
6.5.4
Detector Calibration
374
6.5.5
Plant Parameters
375
6.5.6
Determination of Packing Parameters
376
6.5.6.1
Void Fraction and Porosity of the Packing
376
6.5.6.2
Axial Dispersion
377
6.5.6.3
Pressure Drop
378
6.5.7
Isotherms
379
6.5.7.1
Determination of Adsorption Isotherms
379
6.5.7.2
Determination of the Henry Coefficient
382
6.5.7.3
Static Isotherm Determination Methods
382
6.5.7.4
Dynamic Methods
385
6.5.7.5
Frontal Analysis
385
6.5.7.6
Analysis of Disperse Fronts (ECP/FACP)
390
6.5.7.7
Peak Maximum Method
391
6.5.7.8
Minor Disturbance/Perturbation Method
392
6.5.7.9
Curve Fitting of the Chromatogram
394
XII Contents
6.5.7.
.10
6.5.7.
.11
6.5.8
6.5.9
6.6
6.6.1
6.6.2
6.6.2.
,1
6.6.2.
,2
Prediction of Mixture Behavior from Single-Component Data
3 95
Data Analysis and Accuracy
396
Mass Transfer
398
Identification of Isotherms and Mass Transfer Resistance by Neural
Networks
399
Experimental Validation of Column Models
401
Batch Chromatography
401
SMB Chromatography
404
Model Formulation and Parameters
404
Experimental Validation of SMB Models
410
References
418
7
Model-Based Design, Optimization, and Control
425
Henner Schmidt-Traub,
Malte
Kaspereit,
Sebastian Engell, Arthur Susanto,
Achim
Epping, and Andreas Jupke
7.1
Basic Principles and Definitions
425
7.1.1
Performance, Costs, and Optimization
425
7.1.1.1
Performance Criteria
426
7.1.1.2
Economic Criteria
428
7.1.1.3
Objective Functions
429
7.1.2
Degrees of Freedom
430
1 .1.2.1
Optimization Parameters
430
7.1.2.2
Dimensionless Operating and Design Parameters
430
7.1.3
Scaling by Dimensionless Parameters
435
7.1.3.1
Influence of Different
H
ETP Coefficients for Every Component
436
7.1.3.2
Influence of Feed Concentration
437
7.1.3.3
Examples for a Single Batch
Chromatographie
Column
438
7.1.3.4
Examples for SMB Processes
440
7.2
Batch Chromatography
442
7.2.1
Fractionation Mode (Cut Strategy)
442
7.2.2
Design and Optimization of Batch
Chromatographie
Columns
444
7.2.2.1
Design and Optimization Strategy
444
7.2.2.2
Process Performance Depending on Number of Stages
and Loading Factor
447
7.2.2.3
Other Strategies
452
7.3
Recycling Chromatography
453
7.3.1
Design of Steady-State Recycling Chromatography
454
7.3.2
Scale-Up of Closed Loop Recycling Chromatography
457
7.4
Conventional Isocratic SMB Chromatography
461
7.4.1
Optimization of Operating Parameters
462
7 .4.1.1
Process Design Based on TMB Models (Shortcut Methods)
463
7.4.1.2
Process Design Based on Rigorous SMB Models
472
7.4.2
Optimization of Design Parameters
476
Contents
XIII
7.5
Isocratic SMB Chromatography under Variable Operating
Conditions
481
7.6
Gradient SMB Chromatography
490
7.7
Multicolumn Systems for
Bioseparations
495
7.8
Advanced Process Control
497
7.8.1
Online Optimization of Batch Chromatography
498
7.8.2
Advanced Control of SMB Chromatography
501
7.8.2.1
Purity Control for SMB Processes
502
7.8.2.2
Direct Optimizing Control of SMB Processes
503
7.8.3
Advanced Parameter and State Estimation for SMB Processes
509
References
520
Appendix A: Data of Test Systems
519
Index
527
|
| any_adam_object | 1 |
| author2 | Schmidt-Traub, Henner |
| author2_role | edt |
| author2_variant | h s t hst |
| author_facet | Schmidt-Traub, Henner |
| building | Verbundindex |
| bvnumber | BV039614379 |
| classification_rvk | VG 7200 |
| classification_tum | CHE 230f CIT 220f CHE 232f CIT 060f |
| ctrlnum | (OCoLC)756374479 (DE-599)BVBBV039614379 |
| dewey-full | 615.1901 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1901 |
| dewey-search | 615.1901 |
| dewey-sort | 3615.1901 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Chemie Chemie-Ingenieurwesen Medizin |
| edition | 2., completely rev. and upd. ed. |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV039614379 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:07:27Z |
| institution | BVB |
| isbn | 9783527328987 9783527649280 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024464940 |
| oclc_num | 756374479 |
| open_access_boolean | |
| owner | DE-29T DE-91G DE-BY-TUM DE-739 DE-20 DE-11 DE-19 DE-BY-UBM DE-92 |
| owner_facet | DE-29T DE-91G DE-BY-TUM DE-739 DE-20 DE-11 DE-19 DE-BY-UBM DE-92 |
| physical | XXX, 535 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Preparative chromatography ed. by Henner Schmidt-Traub ... 2., completely rev. and upd. ed. Weinheim Wiley-VCH 2012 XXX, 535 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frühere Aufl. u.d.T.: Preparative chromatography of fine chemicals and pharmaceutical agents Präparative Chromatographie (DE-588)4435196-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Präparative Chromatographie (DE-588)4435196-3 s DE-604 Schmidt-Traub, Henner edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-64930-3 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-64929-7 Erscheint auch als Online-Ausgabe, PDF 978-3-527-64931-0 Digitalisierung UB Passau application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024464940&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Preparative chromatography Präparative Chromatographie (DE-588)4435196-3 gnd |
| subject_GND | (DE-588)4435196-3 (DE-588)4143413-4 |
| title | Preparative chromatography |
| title_auth | Preparative chromatography |
| title_exact_search | Preparative chromatography |
| title_full | Preparative chromatography ed. by Henner Schmidt-Traub ... |
| title_fullStr | Preparative chromatography ed. by Henner Schmidt-Traub ... |
| title_full_unstemmed | Preparative chromatography ed. by Henner Schmidt-Traub ... |
| title_short | Preparative chromatography |
| title_sort | preparative chromatography |
| topic | Präparative Chromatographie (DE-588)4435196-3 gnd |
| topic_facet | Präparative Chromatographie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024464940&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schmidttraubhenner preparativechromatography |