The genetics of circadian rhythms:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Academ. Press
2011
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Advances in genetics
74 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 264 S. Ill., graph. Darst. |
| ISBN: | 9780123876904 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804148431659204608 |
|---|---|
| adam_text | Volume 74
The Genetics
of Circadian
Rhythms
Edited by
Stuart Brody
Founder, Center for Chronobiology
Division of Biological Sciences
University of California
San Diego, La Jolla, California, USA
t,t •
r
• • • * / • :
5 ^: C £ , ^ AMSTERDAM • BOSTON • HEIDELBERG • LONDON
NEW YORK • OXFORD • PARIS • SAN DIEGO
SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO
~*i ^il~*j VIKK Academic PK SJ IS an imprint of Elsevier
Contents
Contributors ix
1 Introduction l
Stuart Brody
I Introduction 1
II An Unofficial, Abbreviated/Annotated Version of the History
of the Genetics of Circadian Rhythms 2
III Common Themes 5
IV Some Reflections 7
References 10
2 The Itty-Bitty Time Machine: Genetics of the
Cyanobacterial Circadian Clock 13
Shannon R Mackey, Susan S Golden, and Jayna L Ditty
I Introduction 15
II The Kai-Based Oscillator: Early Studies 17
III KaiC: Breakthroughs into Oscillator Timing and
Clock Synchronization 22
IV Input Pathways: Light-Dependent Cellular Metabolism
Synchronizes the Clock with Local Time 28
V Output Pathways: Multiple Independent Pathways
Merge to Coordinate Cellular and Physiological
Processes 35
VI Conclusions 44
Acknowledgments 46
References 46
3 The Genetics of Circadian Rhythms in Neurospora 55
Patricia L Lakin-Thomas, Deborah Bell-Pedersen, and
Stuart Brody
I Introduction 57
II Early Genetic Analysis 59
vi Contents
III The Genetics and Biochemistry of the FRQ/WCC
Feedback Loop 64
IV Other Clock-Associated Genes 76
V FRQ-Less Rhythms 79
VI Clock-Controlled Genes 89
VII Outlook 94
References 95
4 The Genetics of Plant Clocks 105
C Robertson McClung
I Introduction 106
II Genome-Wide Characterization of Circadian-Regulated
Genes and Processes 107
III Molecular Organization of Plant Circadian Clocks into
Interlocked Transcriptional Feedback Loops 110
IV Conservation of Clock Genes 122
V Circadian Clocks Enhance Fitness 124
VI Concluding Remarks 126
Acknowledgment 126
References 126
5 Molecular Genetic Analysis of Circadian Timekeeping
in Drosophila 141
Paul E Hardin
I Introduction 142
II The Circadian Feedback Loops of Drosophila 144
III Posttranscriptional Regulation of Rhythmic
Transcription 149
IV Light Entrainment of the Drosophila Circadian
Feedback Loops 154
V Summary and Conclusions 161
Acknowledgments 164
References 165
6 Genetics of Circadian Rhythms in Mammalian Model
Organisms 175
Phillip L Lowrey and Joseph S Takahashi
I Introduction 176
II The Beginning of Mammalian Clock Genetics 178
Contents
III Overview of the Mammalian Clock System 183
IV The Mammalian Circadian Molecular Oscillator 186
V Behavioral, Molecular, and Cell/Tissue Effects of Circadian
Clock Gene Mutarions 188
VI Posttranslational Modification of Clock Proteins 194
VII Posttranscriptional Clock Mechanisms 204
VIII Effects of Temperature on the Mammalian Clock 207
IX Unresolved Issues and Future Directions 211
X Conclusion 212
Acknowledgments 213
References 213
The Genetics of the Human Circadian Clock 231
Luoying Zhang, Chris R Jones, Louis J Ptacek, and
Ying-Hui Fu
I Human Circadian Phenotypes 232
II Insights Gained from Familial Advanced Sleep Phase
Syndrome 235
III Insights Gained from Association Studies 242
IV Future Directions 243
References 244
Index 249
|
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| illustrated | Illustrated |
| indexdate | 2024-07-10T00:07:02Z |
| institution | BVB |
| isbn | 9780123876904 |
| language | English |
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| physical | IX, 264 S. Ill., graph. Darst. |
| publishDate | 2011 |
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| publisher | Academ. Press |
| record_format | marc |
| series | Advances in genetics |
| series2 | Advances in genetics |
| spelling | The genetics of circadian rhythms ed. by Stuart Body 1. ed. Amsterdam [u.a.] Academ. Press 2011 IX, 264 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in genetics 74 Tagesrhythmus (DE-588)4078131-8 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Tagesrhythmus (DE-588)4078131-8 s Genetik (DE-588)4071711-2 s DE-604 Brody, Stuart Sonstige oth Advances in genetics 74 (DE-604)BV000897065 74 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024445850&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The genetics of circadian rhythms Advances in genetics Tagesrhythmus (DE-588)4078131-8 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4078131-8 (DE-588)4071711-2 |
| title | The genetics of circadian rhythms |
| title_auth | The genetics of circadian rhythms |
| title_exact_search | The genetics of circadian rhythms |
| title_full | The genetics of circadian rhythms ed. by Stuart Body |
| title_fullStr | The genetics of circadian rhythms ed. by Stuart Body |
| title_full_unstemmed | The genetics of circadian rhythms ed. by Stuart Body |
| title_short | The genetics of circadian rhythms |
| title_sort | the genetics of circadian rhythms |
| topic | Tagesrhythmus (DE-588)4078131-8 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | Tagesrhythmus Genetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024445850&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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