Spray drying of protein precipitates and evaluation of the nano spray dryer B-90:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
München
Verl. Dr. Hut
2011
|
| Edition: | 1. Aufl. |
| Series: | Pharmazeutische Chemie
|
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Item Description: | Erscheint: 07. August 2011 |
| Physical Description: | 125 S. graph. Darst. 210 mm x 148 mm, 221 g |
| ISBN: | 9783843900195 3843900191 |
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Record in the Search Index
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IMAGE 1
TABLE OF CONTENTS
CHAPTER 1
EVALUATING THE CONCEPT OF PRECIPITATION BY VOLATILE SALTS FOR PROTEIN
STABILIZATION DURING SPRAY DRYING
1 INTRODUCTION 2
1.1 SURFACTANTS IN PROTEIN SPRAY DRYING 2
1.2 INTRODUCTION TO AMORPHOUS PROTEIN PRECIPITATION 4
1.3 PROTEIN PRECIPITATION AS FORMULATION TOOL 6
1.4 THE CONCEPT OF PRECIPITATION BY VOLATILE EXCIPIENTS 6
2 MATERIALS AND METHODS 8
2.1 MATERIALS 8
2.2 METHODS 9
2.2.1 PROTEIN PRECIPITATION 9
2.2.2 REDISSOLUTION AND ULTRAFILTRATION OF PRECIPITATES 9
2.2.3 TRANSMISSION FOURIER TRANSFORM INFRARED SPECTROSCOPY (FTIR) 10
2.2.4 HIGH PERFORMANCE SIZE EXCLUSION CHROMATOGRAPHY (HP-SEC) 10
2.2.5 SODIUM DODECYL SULFATE POLYACRYLAMIDE GEL ELECTROPHORESIS
(SDS-PAGE) .11
2.2.6 SPRAY DRYING WITH THE MINI SPRAY DRYER B-290 12
2.2.7 ELEMENTARY ANALYSIS (CHN ANALYSIS) 13
2.2.8 KARL-FISCHER ANALYSIS 13
2.2.9 X-RAY POWDER DIFFRACTION (XRD) 13
2.2.10 SCANNING ELECTRON MICROSCOPY (SEM) 13
2.2.11 NEPHELOMETRY AND OPTICAL DENSITY 14
2.2.12 SUBVISIBLE PARTICLE ANALYSIS BY LIGHT OBSCURATION 14
2.2.13 STATISTICAL ANALYSIS 14
3 FEASIBILITY OF PROTEIN PRECIPITATION BY VOLATILE AMMONIUM SALTS 15
3.1 VOLATILE AMMONIUM SALTS 15
3.2 PRECIPITATION EFFICIENCY 17
3.2.1 PRECIPITATION OF BSA 17
3.2.2 PRECIPITATION OF IGG, 18
3.2.3 PRECIPITATION OF RHLL-11 20
3.3 EFFECT OF PRECIPITATION WITH AMMONIUM CARBAMATE ON PROTEIN STABILITY
21
3.3.1 STABILITY OF IGG, UPON PRECIPITATION WITH AMMONIUM CARBAMATE 21
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1014217075
DIGITALISIERT DURCH
IMAGE 2
3.3.2 STABILITY OFRHLL-11 UPON PRECIPITATION WITH AMMONIUM CARBAMATE AND
SULFATE
22
4 EVALUATION OF VOLATILITY UPON SPRAY DRYING 24
5 SPRAY DRYING OF PROTEIN PRECIPITATES 27
5.1 SPRAY DRYING OF IGG, PRECIPITATES 27
5.2 SPRAY DRYING OF RHLL-11 PRECIPITATES 29
6 SUMMARY AND CONCLUSIONS 35
7 REFERENCES 36
IMAGE 3
CHAPTER 2
EVALUATION OF THE NANO SPRAY DRYER B-90 FOR PHARMACEUTICAL APPLICATIONS
1 INTRODUCTION 42
1.1 CHARACTERISTICS OF THE NANO SPRAY DRYER B-90 42
1.2 EVALUATION PROCEDURE 44
2 MATERIALS AND METHODS 45
2.1 MATERIALS 45
2.2 METHODS 45
2.2.1 SPRAY DRYING WITH THE NANO SPRAY DRYER B-90 45
2.2.2 DROPLET SIZE ANALYSIS 46
2.2.3 CONDUCTIVITY MEASUREMENTS 46
2.2.4 VISCOSITY MEASUREMENTS 46
2.2.5 SURFACE TENSION MEASUREMENTS 47
2.2.6 PARTICLE SIZE ANALYSIS 47
2.2.7 KAH-FISCHERANALYSIS 47
2.2.8 SCANNING ELECTRON MICROSCOPY (SEM) 47
3 RESULTS AND DISCUSSION 48
3.1 DROPLET SIZE ANALYSIS 48
3.2 EVALUATION OF MINIMAL SPRAY DRYING TEMPERATURE 52
3.3 EVALUATION OF PRODUCT DEPOSITION AT THE SPRAY NOZZLE 53
3.4 PREPARATION OF SUBMICRON PARTICLES 57
4 SUMMARY AND CONCLUSIONS 59
5 REFERENCES 60
IMAGE 4
CHAPTER 3
SPRAY DRYING A BCS CLASS II DRUG WITH THE NANO SPRAY DRYER B-90
1 INTRODUCTION 64
1.1 DISPERSION 64
1.2 MICRONIZATION 66
1.3 SOLUBILIZATION 67
1.4 THE SCOPE OF THIS STUDY 68
2 MATERIALS AND METHODS 69
2.1 MATERIALS 69
2.2 METHODS 69
2.2.1 SPRAY DRYING WITH THE NANO SPRAY DRYER B-90 69
2.2.2 SPRAY DRYING WITH THE MINI SPRAY DRYER B-290 70
2.2.3 PARTICLE SIZE ANALYSIS 70
2.2.4 X-RAY POWDER DIFFRACTION (XRD) 71
2.2.5 SCANNING ELECTRON MICROSCOPY (SEM) 71
2.2.6 DISSOLUTION STUDIES 71
2.2.7 CELL CULTURE TECHNIQUE 71
2.2.8 TRANSEPITHELIAL ELECTRICAL RESISTANCE (TEER) MEASUREMENT 72
2.2.9 DRUG TRANSPORT STUDY 72
2.2.10 DRUG PERMEABILITY DETENNINATION 73
2.2.11 STATISTICAL ANALYSIS 74
3 RESULTS AND DISCUSSION 75
3.1 INFLUENCE OF VIBRATING MESH APERTURE SIZE 75
3.2 INFLUENCE OF TOTAL SOLID CONTENT 77
3.3 INFLUENCE OF FORMULATION TECHNIQUE 79
3.4 INFLUENCE OF SURFACTANT ADDITION 81
3.5 INTEGRITY OF CACO-2 MONOLAYERS 85
3.6 ABSOLUTE GRISEOFULVIN PERMEABILITY 86
4 SUMMARY AND CONCLUSIONS 87
5 REFERENCES 88
IMAGE 5
CHAPTER 4
PROTEIN SPRAY DRYING WITH THE NANO SPRAY DRYER B-90 - EVALUATION OF THE
STRESS FACTORS AND THE METHODS OF STABILIZATION
1 INTRODUCTION 92
1.1 STRESS FACTORS DURING SPRAY DRYING 92
1.2 PROTEIN SPRAY DRYING WITH THE NANO SPRAY DRYER B-90 94
2 MATERIALS AND METHODS 98
2.1 MATERIALS 98
2.1.1 EXCIPIENTS 98
2.1.2 PROTEINS 98
2.2 METHODS 99
2.2.1 PREPARATION OF SPRAY SOLUTIONS 99
2.2.2 SPRAY DRYING EXPERIMENTS 99
2.2.3 CIRCULATION EXPERIMENTS 99
2.2.4 TEMPERATURE MEASUREMENTS 99
2.2.5 QUANTIFICATION OF PROTEIN CONTENT 100
2.2.6 LDH ACTIVITY ASSAY 100
2.2.7 SUBVISIBLE PARTICLE ANALYSIS BY LIGHT OBSCURATION 101
2.2.8 TURBIDITY 101
2.2.9 MICROCALORIMETRY 101
2.2.10 HIGH PERFORMANCE SIZE EXCLUSION CHROMATOGRAPHY (HP-SEC) 101
2.2.11 SCANNING ELECTRON MICROSCOPY (SEM) 102
2.2.12 CHEMICAL DOSIMETRY 102
3 RESULTS AND DISCUSSION 103
3.1 STABILITY OF LGG T DURING SPRAY DRYING 103
3.2 STABILITY OF LDH IN SPRAY SOLUTIONS 105
3.3 STABILITY OF LDH DURING CIRCULATION OF SPRAY SOLUTIONS 107
3.4 TEMPERATURE MEASUREMENTS ON THE SPRAY MESH 109
3.5 SPRAY DRYING LDH WITH THE NANO SPRAY DRYER B-90 111
3.6 CAVITATION - CRITICAL FOR PROTEIN SPRAY DRYING WITH THE NANO SPRAY
DRYER B-90?. 114
4 SUMMARY AND CONCLUSIONS 116
5 REFERENCES 117
IMAGE 6
CHAPTER 5
SUMMARY OF THE THESIS 119
APPENDIX
LIST OF ABBREVIATIONS 122
POSTERS AND PUBLICATIONS 124
CURRICULUM VITAE 125 |
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| bvnumber | BV039560785 |
| ctrlnum | (OCoLC)864486320 (DE-599)DNB1014217075 |
| dewey-full | 615.19 |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615.19 |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. Aufl. |
| format | Thesis Book |
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| indexdate | 2024-09-06T00:19:12Z |
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| isbn | 9783843900195 3843900191 |
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| physical | 125 S. graph. Darst. 210 mm x 148 mm, 221 g |
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| publisher | Verl. Dr. Hut |
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| spelling | Schmid, Katja Christine 1981- Verfasser (DE-588)1016129424 aut Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 Katja Christine Schmid 1. Aufl. München Verl. Dr. Hut 2011 125 S. graph. Darst. 210 mm x 148 mm, 221 g txt rdacontent n rdamedia nc rdacarrier Pharmazeutische Chemie Erscheint: 07. August 2011 Zugl.: München, Univ.,, Diss., 2011 Proteine (DE-588)4076388-2 gnd rswk-swf Zerstäubungstrocknung (DE-588)4190759-0 gnd rswk-swf Arzneimittelstabilität (DE-588)4122835-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Proteine (DE-588)4076388-2 s Zerstäubungstrocknung (DE-588)4190759-0 s Arzneimittelstabilität (DE-588)4122835-2 s DE-604 Erscheint auch als Online-Ausgabe Schmid, Katja Spray drying of protein precipitates and Evaluation of the Nano Spray Dryer B-90 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3865756&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024412458&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schmid, Katja Christine 1981- Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 Proteine (DE-588)4076388-2 gnd Zerstäubungstrocknung (DE-588)4190759-0 gnd Arzneimittelstabilität (DE-588)4122835-2 gnd |
| subject_GND | (DE-588)4076388-2 (DE-588)4190759-0 (DE-588)4122835-2 (DE-588)4113937-9 |
| title | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 |
| title_auth | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 |
| title_exact_search | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 |
| title_full | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 Katja Christine Schmid |
| title_fullStr | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 Katja Christine Schmid |
| title_full_unstemmed | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 Katja Christine Schmid |
| title_short | Spray drying of protein precipitates and evaluation of the nano spray dryer B-90 |
| title_sort | spray drying of protein precipitates and evaluation of the nano spray dryer b 90 |
| topic | Proteine (DE-588)4076388-2 gnd Zerstäubungstrocknung (DE-588)4190759-0 gnd Arzneimittelstabilität (DE-588)4122835-2 gnd |
| topic_facet | Proteine Zerstäubungstrocknung Arzneimittelstabilität Hochschulschrift |
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