Clinical research in complementary and integrative medicine: a practical training book
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| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Munich
Elsevier
2011
|
| Edition: | 1. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben. - Zusätzliches Online-Angebot unter www.elsevier.de |
| Physical Description: | XIV, 189 S. graph. Darst. 24 cm |
| ISBN: | 9780702034763 |
Staff View
MARC
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| 245 | 1 | 0 | |a Clinical research in complementary and integrative medicine |b a practical training book |c Claudia M. Witt ; Klaus Linde. In collab. with Adrian White. Pref. by George Lewith and Brian Berman |
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION 1 2.2.4
1.1 WHAT DO WE MEAN BY COMPLEMENTARY MEDICINE IN THIS BOOK? 1 2.3
1.2 THE SCIENCE BEHIND CLINICAL MEDICINE 2 2.3.1
1.2.1 MAJOR AREAS OF RESEARCH 2
1.2.2 TOPICS IN CLINICAL RESEARCH 2 2.3.2
1.2.3 EVIDENCE-BASED MEDICINE 3 2.3.3
1.3 WHY DO WE NEED RESEARCH ON 2.3.4
COMPLEMENTARY THERAPIES? 3 2.4
1.4 IS RESEARCH INTO COMPLEMENTARY THERAPIES SPECIAL? 5 2.4.1
1.4.1 WHY RESEARCH INTO COMPLEMENTARY 2.4.2 THERAPIES IS SOMEWHAT
DIFFERENT? . .. 5 1.4.2 STRATEGIC APPROACHES TO RESEARCH INTO 2.4.3
COMPLEMENTARY MEDICINE 6 2.5
1.4.3 WHY IT IS DIFFICULT TO REALIZE STRATEGIC APPROACHES? 6 3
1.5 AIMS, TARGET AUDIENCE AND STRUCTURE 3.1 OF THIS BOOK 7 3.2
1 THEORY-THINGS YOU SHOULD 3.2.1
KNOW BEFORE EMBARKING ON A 3.2.2 CLINICAL STUDY 9 3.2.3
3.3
2 BASIC STUDY DESIGN 11 3.3.1
2.1 WHEN IS A TREATMENT EFFECTIVE? . .. 11
2.1.1 WHY DO WE NEED CONTROL OR 3.3.2
COMPARISON GROUPS? 11 3.3.3
2.1.2 TYPES OF CONTROLS AND COMPARISONS 12 3.3.4
2.1.3 SPECIFIC AND NON-SPECIFIC EFFECTS . .. 14 3.3.5 2.2 BIAS - THREATS
TO INTERNAL VALIDITY 15 3.4
2.2.1 PROGNOSTIC AND BASELINE DIFFERENCES BETWEEN GROUPS - WHY
RANDOMIZATION 3.4.1 IS SO DESIRABLE 15
2.2.2 DIFFERENCES BETWEEN GROUPS AFTER 3.4.2
TREATMENT HAS STARTED - WHY BLINDING IS SO DESIRABLE 17 3.4.3
2.2.3 ATTRITION 17 3.4.4
BIAS DURING ANALYSIS AND REPORTING 18
CLINICAL STUDIES AND THE REAL WORLD - EXTERNAL VALIDITY 18
THE NEED FOR BALANCING INTERNAL AND EXTERNAL VALIDITY 18
SELECTION OF STUDY PARTICIPANTS 20 SELECTION OF STUDY INTERVENTIONS 21
SELECTION OF OUTCOME MEASURES . . .. 22 WHAT STUDY DESIGN FOR WHAT
PURPOSE? 22
STUDIES WITHOUT A CONTROL GROUP 22 STUDIES WITH A NON-RANDOMIZED
COMPARISON GROUP 25
RANDOMIZED TRIALS 27
ESTABLISHING AN EVIDENCE PICTURE .. 31
BASIC STATISTICS 33
WHY STATISTICS? 33
TYPES OF VARIABLES AND THEIR DISTRIBUTION 33
CATEGORICAL VARIABLES 33
CONTINUOUS VARIABLES 34
CATEGORICAL OR CONTINUOUS? 34
SUMMARIZING YOUR DATA 34
CALCULATING THE MEAN AND THE MEDIAN 35
THE DISTRIBUTION OF YOUR DATA 35
MEASURING VARIATION WITHIN YOUR STUDY POPULATION 36
MEASURING SAMPLING VARIATION 37 STANDARD DEVIATION, STANDARD ERROR AND
CONFIDENCE INTERVAL 38
COMPARING TWO GROUPS OR TWO TIME POINTS FOR ONE VARIABLE 38
CALCULATING SUMMARY MEASURES FOR DICHOTOMOUS VARIABLES 38
CALCULATING SUMMARY MEASURES FOR CONTINUOUS VARIABLES 39
TESTING A HYPOTHESIS 40
RELEVANCE OF THE P-VALUE 41
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1014406897
DIGITALISIERT DURCH
IMAGE 2
XII
CONTENTS
3.4.5 STATISTICAL TESTS FOR COMPARING 4.4.2
MEANS 42 4.4.3
3.4.6 STATISTICAL TESTS FOR COMPARING 4.5
PROPORTIONS 42
3.4.7 CONFIDENCE INTERVALS 42 4.5.1
3.4.8 TYPE I AND TYPE II ERRORS 43
3.4.9 HOW TO DEAL WITH MULTIPLE TESTING .. 43 4.5.2
3.5 COMPARING MORE THAN TWO GROUPS 4.5.3
FOR ONE VARIABLE 44
3.5.1 STATISTICAL MODELS AND TESTS FOR 4.5.4
COMPARING MORE THAN TWO GROUPS FOR 4.6
ONE VARIABLE 44 4.6.1
3.6 COMPARING TWO OR MORE GROUPS FOR 4.6.2
MORE THAN ONE VARIABLE 45 4.6.3
3.6.1 CORRECTING FOR BASELINE DIFFERENCES .. 45 4.7 3.6.2 LOGISTIC
REGRESSION AND STATISTICAL 4.7.1
MODELLING 45
3.7 ANALYSIS POPULATIONS 46 4.7.2
3.8 DEALING WITH MISSING VALUES 46 4.7.3
3.9 INTERVAL HYPOTHESES: EQUIVALENCE/ 4.8
NON-INFERIORITY AND SUPERIORITY . . .. 47 4.8.1 4.8.2
II PRACTICE - PLANNING, MANAGING, ANALYZING AND PUBLISHING 4.8.3
A CLINICAL STUDY 49 4.9
4.9.1
4 PLANNING 51
4.1 FORMULATING THE RESEARCH 4.9.2
QUESTION 51 4.9.3
4.1.1 WHY A CLEAR RESEARCH QUESTION 4.10
IS SO CRUCIAL 51 4.10.1
4.1.2 PRACTICAL STEPS 51
4.1.3 CASE STUDIES 54 4.10.2
4.2 STUDY PROTOCOL 56
4.2.1 WHAT IS A STUDY PROTOCOL? 56 4.10.3
4.2.2 DEVELOP YOUR STUDY PROTOCOL - STEP BY STEP 56 5
4.3 INTERVENTIONS AND CONTROLS 59
4.3.1 THEORETICAL BACKGROUND 59 5.1
4.3.2 DEFINE YOUR CONTROL AND 5.1.1
INTERVENTIONS 62 5.1.2
4.3.3 CASE STUDIES 64 5.2
4.4 RANDOMIZATION 65 5.3
4.4.1 INDIVIDUAL AND DUSTER 5.3.1
RANDOMIZATION 65 5.3.2
PRACTICAL STEPS 66
CASE STUDIES 70
WHAT TO DO IF YOU DO NOT RANDOMIZE 71
TAKING BASELINE DIFFERENCES INTO ACCOUNT 72
MATCHING - PRACTICAL STEPS 72
ADJUSTING ANALYSES FOR IMBALANCES - PRACTICAL STEPS 73
CASE STUDY 74
BLINDING 74
SHOULD YOU GO FOR BLINDING? 74
PRACTICAL STEPS 76
CASE STUDIES 79
STUDY PARTICIPANTS 81
WHO SHOULD BE INCLUDED IN YOUR STUDY? 81
PRACTICAL STEPS 81
CASE STUDIES 83
OUTCOME MEASUREMENT 85
THEORETICAL BACKGROUND 85
DEFINE YOUR OUTCOME MEASURES AND PREPARE YOUR CRF 89
CASE STUDIES ON OUTCOMES 91
SAMPLE SIZE CALCULATION 93
WHAT DOES SAMPLE SIZE CALCULATION MEAN? 93
PRACTICAL STEPS 94
CASE STUDIES 100
ETHICS AND REGULATORY ASPECTS . . .. 102 THEORETICAL BACKGROUND ON
ETHICS 102
GETTING APPROVAL FROM THE IRB/ETHICS COMMITTEE 103
REGULATORY ASPECTS 104
STUDY AND DATA MANAGEMENT 105
PROJECT MANAGEMENT 105
PHASES OF PROJECT MANAGEMENT 1 05 TAKING NOTES 105
GUIDELINES FOR CLINICAL TRIALS 106 STUDY MANAGEMENT 107
THEORETICAL BACKGROUND 108
MANAGE YOUR STUDY 109
IMAGE 3
CONTENTS
XIII
5.4 DATA MANAGEMENT 113 7.4.1
5.4.1 THEORETICAL BACKGROUND 113 7.4.2
5.4.2 MANAGE YOUR DATA 116 7.4.3
5.5 CASE STUDIES 121 7.4.4
7.4.5
6 DATA ANALYSIS 123 7.5
6.1 ANALYSING YOUR OWN DATA STEP BY 7.5.1
STEP 123 7.5.2
6.1.1 STEP 1 : DEFINE THE ANALYSIS POPULATIONS 7.5.3 AND THE HANDLING OF
MISSING VALUES .. 123 6.1.2 STEP 2: IDENTIFY THE DIFFERENT TYPES OF III
VARIABLE 124
6.1.3 STEP 3: CLARIFY WHAT YOU CAN CALCULATE FROM YOUR DATA 1 24 8
6.1.4 STEP 4: CHOOSE SUITABLE STATISTICAL 8.1
METHODS 125
6.1.5 STEP 5: PERFORM THE STATISTICAL 8.2
ANALYSIS 126 8.2.1
6.1.6 STEP 6: DECIDE HOW YOU WILL PRESENT 8.2.2
YOUR RESULTS 127 8.2.3
6.1.7 STEP 7: INTERPRET YOUR RESULTS AND 8.3
DRAW YOUR CONCLUSIONS 127
6.2 CASE STUDIES 127 8.3.1
8.3.2
7 PUBLICATION 133 8.3.3
7.1 GENERAL ISSUES 133 8.4
7.1.1 WHY IS PUBLICATION SO CRUCIAL? 133 8.4.1
7.1.2 BASIC THINGS TO KEEP IN MIND 133 8.4.2
7.2 EARLY PREPARATORY WORK 134 8.5
7.2.1 DEFINE YOUR AIMS 134
7.2.2 DECIDING ON AUTHORSHIP 134 8.6
7.2.3 SELECTING A JOURNAL 135
7.2.4 CHECKING INSTRUCTIONS FOR AUTHORS .. 137 7.2.5 CHECKING GENERAL
GUIDELINES FOR 9
REPORTING 137 9.1
7.3 WRITING THE MANUSCRIPT 137 9.1.1
7.3.1 RESULTS SECTION 138 9.1.2
7.3.2 METHODS SECTION 138 9.2
7.3.3 INTRODUCTION 139 9.2.1
7.3.4 DISCUSSION 139 9.2.2
7.3.5 ABSTRACT 140 9.2.3
7.3.6 REFERENCES 140 9.2.4
7.3.7 ADDITIONAL STATEMENTS 140 9.2.5
7.3.8 INTERNAL REVISION 141 9.3
7.4 GETTING YOUR MANUSCRIPT ACCEPTED .. 141 9.4
PREPARING THE SUBMISSION 141
SUBMITTING THE MANUSCRIPT 142
WHAT HAPPENS AT THE JOURNAL? 142 REVISION 143
AFTER REJECTION 143
AFTER ACCEPTANCE 144
PROOFREADING 1 44
FINALLY: PUBLICATION 144
DEALING WITH MASS MEDIA 144
PUTTING A CLINICAL STUDY
INTO CONTEXT 145
QUALITATIVE RESEARCH 147
RESEARCH QUESTION AND EXAMPLES 147
QUALITATIVE APPROACHES 148
ETHNOGRAPHY 148
FIELD RESEARCH 148
CASE STUDIES 149
QUALITATIVE METHODS AND TYPES OF DATA 149
INTERVIEWS 149
OBSERVATION 149
WRITTEN DOCUMENTS OR PICTURES 150
QUALITATIVE DATA ANALYSIS 150
CONTENT ANALYSIS 1 50
GROUNDED THEORY 150
QUALITY ASSURANCE IN QUALITATIVE RESEARCH 151
COMBINING QUALITATIVE AND QUANTITATIVE RESEARCH METHODS . .. 151
ECONOMIC STUDIES 153
PRINCIPLES OF ECONOMIC ANALYSIS . .. 153 COSTING 153
MEASURING THE BENEFIT 1 54
TYPES OF ECONOMIC EVALUATIONS . .. 1 56
COST OF DISEASE ANALYSIS 1 56
COST-BENEFIT ANALYSIS 157
COST-EFFECTIVENESS-ANALYSIS 1 57 COST-UTILITY ANALYSIS 1 57
COST-MINIMIZATION ANALYSIS 158
EXAMPLES OF ECONOMIC ANALYSIS . .. 158 CRITICAL APPRAISAL 159
IMAGE 4
XIV
CONTENTS
10 SINGLE-CASE RESEARCH 163 10.6
10.1 WHY CASE REPORTS ARE NOT
SCIENTIFIC 163
10.2 WHY SINGLE-CASE RESEARCH 10.6.1
IS IMPORTANT? 163 10.6.2
10.3 ASSESSING CAUSALITY IN 10.6.3
SINGLE CASES 164
10.4 EXPERIMENTAL SINGLE-CASE 10.6.4
STUDIES 164
10.4.1 GENERAL ASPECTS 164
10.4.2 PROGRESSIVE APPROACHES 165 11
10.4.3 REPETITIVE APPROACHES 167
10.5 OBSERVATIONAL SINGLE CASE 11.1
STUDIES 168 11.2
10.5.1 RETROSPECTIVE CASE STUDIES 168 11.3
10.5.2 PROSPECTIVE CASE STUDIES 168
10.5.3 SEMI-PROSPECTIVE CASE
STUDIES 169
CROSS-ROADS BETWEEN RESEARCH ON SINGLE CASES AND GROUPS OF PATIENTS 169
BEST CASE SERIES 169
MULTIPLE BASELINE STUDIES 170
SINGLE-CASE STUDIES EMBEDDED IN STUDIES OF GROUPS OF PATIENTS 1 70
META-ANALYSIS OF SINGLE CASE STUDIES 170
A BRIEF LOOK AT OTHER STUDY
DESIGNS 173
CROSS-SECTIONAL STUDIES/SURVEYS . .. 173 DIAGNOSTIC STUDIES 175
ETIOLOGICAL AND PROGNOSTIC STUDIES 177
APPENDIX 181
INDEX 187
|
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| id | DE-604.BV039550368 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:06:03Z |
| institution | BVB |
| isbn | 9780702034763 |
| language | English |
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| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-578 |
| physical | XIV, 189 S. graph. Darst. 24 cm |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Elsevier |
| record_format | marc |
| spelling | Witt, Claudia M. Verfasser aut Clinical research in complementary and integrative medicine a practical training book Claudia M. Witt ; Klaus Linde. In collab. with Adrian White. Pref. by George Lewith and Brian Berman 1. ed. Munich Elsevier 2011 XIV, 189 S. graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben. - Zusätzliches Online-Angebot unter www.elsevier.de Alternative Medizin (DE-588)4112639-7 gnd rswk-swf Forschung (DE-588)4017894-8 gnd rswk-swf Alternative Medizin (DE-588)4112639-7 s Forschung (DE-588)4017894-8 s DE-604 Linde, Klaus Verfasser aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024402256&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Witt, Claudia M. Linde, Klaus Clinical research in complementary and integrative medicine a practical training book Alternative Medizin (DE-588)4112639-7 gnd Forschung (DE-588)4017894-8 gnd |
| subject_GND | (DE-588)4112639-7 (DE-588)4017894-8 |
| title | Clinical research in complementary and integrative medicine a practical training book |
| title_auth | Clinical research in complementary and integrative medicine a practical training book |
| title_exact_search | Clinical research in complementary and integrative medicine a practical training book |
| title_full | Clinical research in complementary and integrative medicine a practical training book Claudia M. Witt ; Klaus Linde. In collab. with Adrian White. Pref. by George Lewith and Brian Berman |
| title_fullStr | Clinical research in complementary and integrative medicine a practical training book Claudia M. Witt ; Klaus Linde. In collab. with Adrian White. Pref. by George Lewith and Brian Berman |
| title_full_unstemmed | Clinical research in complementary and integrative medicine a practical training book Claudia M. Witt ; Klaus Linde. In collab. with Adrian White. Pref. by George Lewith and Brian Berman |
| title_short | Clinical research in complementary and integrative medicine |
| title_sort | clinical research in complementary and integrative medicine a practical training book |
| title_sub | a practical training book |
| topic | Alternative Medizin (DE-588)4112639-7 gnd Forschung (DE-588)4017894-8 gnd |
| topic_facet | Alternative Medizin Forschung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024402256&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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