DNA topoisomerases and cancer:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Humana Press
2012
|
| Series: | Cancer Drug Discovery and Development
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | XI, 443 S. Ill., graph. Darst. |
| ISBN: | 1461403227 9781461403227 9781461429630 |
Staff View
MARC
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| 245 | 1 | 0 | |a DNA topoisomerases and cancer |c Yves Pommier, ed. |
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Record in the Search Index
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| adam_text | Contents
1
Introduction
and Historical Perspective
.............................................. 1
Patrick Forterre
2
Human
DNA Topoisomerase
I:
Structure, Enzymology and Biology
..................................................... 53
James J. Champoux
3
Mitochondrial Topoisomerases
............................................................. 71
Ilaria
Dalla
Rosa,
Yves Pommier, and Hongliang
Zhang
4
Structure
and Mechanism of
Eukaryotic Type HA
Topoisomerases
....................................................................................... 87
James M. Berger and
Neil Osheroff
5
Essential Functions of
Topoisomerase
Ша
in the Nucleus
and Mitochondria
................................................................................... 103
Stefanie Hartman
Chen, Jianhong Wu, and Tao-shih Hsieh
6 DNA Topoisomerase
I and Illegitimate Recombination
..................... 119
Céline
Auzarmeau and Philippe Pourquier
7
Topoisomerase-Induced
DNA
Damage
................................................ 145
Yves Pommier
and Neil Osheroff
8
Topoisomerases and Carcinogenesis:
Topoisomerase
Ша
and
BLM
.............................................................. 155
Mounira
Amor-Guéret
and
Jean-François Riou
9
Topoisomerases Inhibitors: A Paradigm
for
Interfacial
Inhibition
....................................................................... 175
Christophe Marchand
and
Yves Pommier
10
Topoisomerase I Inhibitors: Cbemkai Biology
................................... 185
Beverly A. Teicher
vä
viii Contents
11
Topoisomerase
II
Inhibitors:
Chemical
Biology
................................. 211
Anna
Rogojina,
Stefan Gajewski,
Karím Bahmed,
Neil Osheroff, and John
L.
Nitiss
12
Topoisomerase I Inhibitors: Current Use and Prospects
................... 245
Yan Makeyev, Franco Muggia,
Aran Rajan,
Giuseppe Giaccone, Takahisa Furuta, and Philippe Rougier
13
Topoisomerase
Π
Inhibitors: Current Use and Prospects
.................. 279
Olivier Mir, William Dahut,
François
Goldwasser,
and Christopher Heery
14
Transcriptional Stress by Camptothecin: Mechanisms
and Implications for the Drug
Antitumor
Activity
............................. 309
Giovanni Capranico, Laura Baranello,
Davide Bertozzi,
and Jessica
Mannello
15
Mechanisms Regulating Cellular Responses
to
DNA
Topoisomerase I-Targeted Agents
.......................................... 325
Piero Benedetti
and Mary-Ann Bjornsti
16
Tyrosyl-DNA-Phosphodiesterase
.......................................................... 335
Thomas S. Dexheimer, Shar-yin
N.
Huang,
Benu Brata
Das,
and
Yves Pommier
17
Ubiquitin and Ubiquitin-Like Proteins in Repair
of
Topoisomerase-Mediated DNA
Damage
.......................................... 355
Shyamal D. Desai
18
Repair of Topoisomerase
U-Mediated DNA
Damage:
Fixing
DNA
Damage Arising from a Protein Covalently
Trapped on
DNA.................................................................................... 381
John L. Nitiss,
Eroica
Soans, Jeffrey Berk,
Aman
Seih,
Margarita Mishina, and
Karin
С.
Nitiss
19
Topoisomerases and Apoptosis
............................................................. 409
Olivier Sordet and
Stéphanie
Solier
Index
................................................................................................................ 437
Cancer
Drug Discovery and Development
Beverly A. Teicher, Series editor
Yves Pommier
Editor
DNA
Topoisomerases and Cancer
DNA
topoisomerases are present in all living organisms and are essential to maintaining
the helical structure of
DNA.
They are highly relevant for cancer because a number of
anti-cancer drugs selectively target two of the human enzymes,
DNA
topoisomerases
I and II. Those drugs convert topoisomerases into cellular poisons by trapping the
enzymes as they cleave
DNA.
The book starts out with a detailed outline of the phyllogeny
of the different topoisomerases, continues with recent studies on the crystal structures
of the human topoisomerases, and their biochemistry. The following section reviews
the chemical biology of the topoisomerase inhibitors used in cancer chemotherapy and
the implication of topoisomerases in generating recombinations and
DNA
damage. The
third section summarizes the current use of the various topoisomerase inhibitors in
cancer chemotherapy. And finally, the last section includes several chapters describiag
the
DNA
repair pathways for topoisomerase-induced
DNA
damage. This book is inte¬
nded for students and faculty but also for health care professionals who wish to
ћате
a self-contained and up-to-date information on topoisomerases. Chapters have been
written by leaders and world reknowned experts in the topoisomerase 6eld.
|
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| id | DE-604.BV039166385 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:00:27Z |
| institution | BVB |
| isbn | 1461403227 9781461403227 9781461429630 |
| language | English |
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| physical | XI, 443 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Humana Press |
| record_format | marc |
| series2 | Cancer Drug Discovery and Development |
| spelling | DNA topoisomerases and cancer Yves Pommier, ed. New York [u.a.] Humana Press 2012 XI, 443 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer Drug Discovery and Development DNS-Topoisomerasen (DE-588)4333298-5 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s DNS-Topoisomerasen (DE-588)4333298-5 s DE-604 Pommier, Yves Sonstige oth Erscheint auch als Online-Ausgabe 978-1-4614-0323-4 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024183732&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024183732&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | DNA topoisomerases and cancer DNS-Topoisomerasen (DE-588)4333298-5 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4333298-5 (DE-588)4073781-0 |
| title | DNA topoisomerases and cancer |
| title_auth | DNA topoisomerases and cancer |
| title_exact_search | DNA topoisomerases and cancer |
| title_full | DNA topoisomerases and cancer Yves Pommier, ed. |
| title_fullStr | DNA topoisomerases and cancer Yves Pommier, ed. |
| title_full_unstemmed | DNA topoisomerases and cancer Yves Pommier, ed. |
| title_short | DNA topoisomerases and cancer |
| title_sort | dna topoisomerases and cancer |
| topic | DNS-Topoisomerasen (DE-588)4333298-5 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | DNS-Topoisomerasen Krebs Medizin |
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