Handbook of biodegradable polymers: synthesis, characterization and applications
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Wiley-VCH
2011
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| ISBN: | 9783527324415 3527324410 |
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| 245 | 1 | 0 | |a Handbook of biodegradable polymers |b synthesis, characterization and applications |c ed. by Andreas Lendlein ... |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2011 | |
| 300 | |a XX, 405 S. |b Ill., graph. Darst. | ||
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IMAGE 1
CONTENTS
PREFACE XV LIST OF CONTRIBUTORS XVII
1 POLYESTERS 1
ADAM L SISSON, MICHAEL SCHROETER, AND ANDREAS LENDLEIN 1.1 HISTORICAL
BACKGROUND 1
1.1.1 BIOMEDICAL APPLICATIONS 1 1.1.2 POLY(HYDROXYCARBOXYLIC ACIDS) 2
1.2 PREPARATIVE METHODS 3
1.2.1 POLY(HYDROXYCARBOXYLIC ACID) SYNTHESES 3 1.2.2 METAL-FREE
SYNTHETIC PROCESSES 6 1.2.3 POLYANHYDRIDES 6 1.3 PHYSICAL PROPERTIES 7
1.3.1 CRYSTALLINITY AND THERMAL TRANSITION TEMPERATURES 7 1.3.2
IMPROVING ELASTICITY BY PREPARING MULTIBLOCK COPOLYMERS 9 1.3.3
COVALENTLY CROSSLINKED POLYESTERS 11
1.3.4 NETWORKS WITH SHAPE-MEMORY CAPABILITY 11 1.4 DEGRADATION
MECHANISMS 12 1.4.1 DETERMINING EROSION KINETICS 12
1.4.2 FACTORS AFFECTING EROSION KINETICS 13 1.5 BEYOND CLASSICAL
POLY(HYDROXYCARBOXYLIC ACIDS) 14 1.5.1 ALTERNATE SYSTEMS 14
1.5.2 COMPLEX ARCHITECTURES 35 1.5.3 NANOFABRICATION 26 REFERENCES 17
2 BIOTECHNOLOGICALLY PRODUCED BIODEGRADABLE POLYESTERS 23 JACIANE LUTZ
LENCZAK AND CLAUCIA MARIA FALCAO DE ARAGAO 2.1 INTRODUCTION 23
2.2 HISTORY 24
2.3 POLYHYDROXYALKANOATES - GRANULES MORPHOLOGY 26 2.4 BIOSYNTHESIS AND
BIODEGRADABILITY OF POLY(3-HYDROXYBURYRATE) AND OTHER
POLYHYDROXYALKANOATES 29
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1009639862
DIGITALISIERT DURCH
IMAGE 2
VI CONTENTS
2.4.1 POLYHYDROXYALKANOATES BIOSYNTHESIS ON MICROORGANISMS 29
2.4.2 PLANTS AS POLYHYDROXYALKANOATES PRODUCERS 32 2.4.3 MICROBIAL
DEGRADATION OF POLYHYDROXYALKANOATES 33 2.5 EXTRACTION AND RECOVERY 34
2.6 PHYSICAL, MECHANICAL, AND THERMAL PROPERTIES OF
POLYHYDROXYALKANOATES 36 2.7 FUTURE DIRECTIONS 37
REFERENCES 38
3 POLYANHYDRIDES 45
AVI DOMB,JAY PRAKASH JAIN, AND NEERAJ KUMAR 3.1 INTRODUCTION 45
3.2 TYPES OF POLYANHYDRIDE 46
3.2.1 AROMATIC POLYANHYDRIDES 46 3.2.2 ALIPHATIC-AROMATIC POLYANHYDRIDES
49 3.2.3 POLY(ESTER-ANHYDRIDES) AND POLY(ETHER-ANHYDRIDES) 49 3.2.4
FATTY ACID-BASED POLYANHYDRIDES 49
3.2.5 RA-BASED POLYANHYDRIDES 49 3.2.6 AMINO ACID-BASED POLYANHYDRIDES
52 3.2.7 PHOTOPOLYMERIZABLE POLYANHYDRIDES 52 3.2.8 SALICYLATE-BASED
POLYANHYDRIDES 53 3.2.9 SUCCINIC ACID-BASED POLYANHYDRIDES 54 3.2.10
BLENDS 55
3.3 SYNTHESIS 55
3.4 PROPERTIES 58
3.5 IN VITRO DEGRADATION AND EROSION OF POLYANHYDRIDES 63 3.6 IN VIVO
DEGRADATION AND ELIMINATION OF POLYANHYDRIDES 64 3.7 TOXICOLOGICAL
ASPECTS OF POLYANHYDRIDES 65 3.8 FABRICATION OF DELIVERY SYSTEMS 67 3.9
PRODUCTION AND WORLD MARKET 68
3.10 BIOMEDICAL APPLICATIONS 68 REFERENCES 71
4 POLY(ORTHO ESTERS) 77
JORGE HELLER
4.1 INTRODUCTION 77
4.2 POE II 79
4.2.1 POLYMER SYNTHESIS 79 4.2.1.1 REARRANGEMENT PROCEDURE USING AN
RU(PPH 3 ) 3 CL 2 NA 2 CO 3 CATALYST 80
4.2.1.2 ALTERNATE DIKETENE ACETALS 80 4.2.1.3 TYPICAL POLYMER SYNTHESIS
PROCEDURE 80 4.2.2 DRUG DELIVERY 81
4.2.2.1 DEVELOPMENT OF IVERMECTIN CONTAINING STRANDS TO PREVENT
HEARTWORM INFESTATION IN DOGS 82 4.2.2.2 EXPERIMENTAL PROCEDURE 82
IMAGE 3
CONTENTS VII
4.2.2.3 RESULTS 82
4.3 POE IV 82
4.3.1 POLYMER SYNTHESIS 82 4.3.1.1 TYPICAL POLYMER SYNTHESIS PROCEDURE
82 4.3.1.2 LATENT ACID 83 4.3.1.3 EXPERIMENTAL PROCEDURE 83 4.3.2
MECHANICAL PROPERTIES 83 4.4 SOLID POLYMERS 86
4.4.1 FABRICATION 86
4.4.2 POLYMER STORAGE STABILITY 87 4.4.3 POLYMER STERILIZATION 87 4.4.4
POLYMER HYDROLYSIS 88 4.4.5 DRUG DELIVERY 91 4.4.5.1 RELEASE OF BOVINE
SERUM ALBUMIN FROM EXTRUDED STRANDS 91 4.4.5.2 EXPERIMENTAL PROCEDURE 93
4.4.6 DELIVERY OF DNA PLASMID 93 4.4.6.1 DNA PLASMID STABILITY 94
4.4.6.2 MICROENCAPSULATION PROCEDURE 94
4.4.7 DELIVERY OF 5-FLUOROURACIL 95 4.5 GEL-LIKE MATERIALS 96
4.5.1 POLYMER MOLECULAR WEIGHT CONTROL 96 4.5.2 POLYMER STABILITY 98
4.5.3 DRUG DELIVERY 99 4.5.3.1 DEVELOPMENT OF APF 112 MEPIVACAINE
DELIVERY SYSTEM 99 4.5.3.2 FORMULATION USED 99 4.5.4 PRECLINICAL
TOXICOLOGY 200 4.5.4.1 POLYMER HYDROLYSATE 200 4.5.4.2 WOUND
INSTILLATION 200 4.5.5 PHASE II CLINICAL TRIAL 200 4.5.6 DEVELOPMENT OF
APF 530 GRANISETRON DELIVERY SYSTEM 200 4.5.6.1 PRECLINICAL TOXICOLOGY
200 4.5.6.2 RAT STUDY 101
4.5.6.3 DOG STUDY 202 4.5.6.4 PHASE II AND PHASE III CLINICAL TRIALS 202
4.6 POLYMERS BASED ON AN ALTERNATE DIKETENE ACETAL 202
4.7 CONCLUSIONS 204
REFERENCES 204
5 BIODEGRADABLE POLYMERS COMPOSED OF NATURALLY OCCURRING A-AMINO ACIDS
207 RAMAZ KATSARAVA AND ZAZA GOMURASHVILI 5.1 INTRODUCTION 207
5.2 AMINO ACID-BASED BIODEGRADABLE POLYMERS (AABBPS) 209 5.2.1 MONOMERS
FOR SYNTHESIZING AABBPS 209 5.2.1.1 KEY BIS-NUCLEOPHILIC MONOMERS 209
5.2.1.2 BIS-ELECTROPHILES 222
IMAGE 4
VIII I CONTENTS
5.2.2 AABBPS'SYNTHESIS METHODS 222
5.2.3 AABBPS: SYNTHESIS, STRUCTURE, AND TRANSFORMATIONS 225 5.2.3.1
POLY(ESTER AMIDE)S 225 5.2.3.2 POLY(ESTER URETHANE)S 229 5.2.3.3
POLY(ESTER UREA)S 229 5.2.3.4 TRANSFORMATION OF AABBPS 229 5.2.4
PROPERTIES OF AABBPS 222 5.2.4.1 MWS, THERMAL, MECHANICAL PROPERTIES,
AND SOLUBILITY 222 5.2.4.2 BIODEGRADATION OF AABBPS 222 5.2.4.3
BIOCOMPATIBILITY OF AABBPS 223 5.2.5 SOME APPLICATIONS OF AABBPS 224
5.2.6 AABBPS VERSUS BIODEGRADABLE POLYESTERS 225 5.3 CONCLUSION AND
PERSPECTIVES 226
REFERENCES 227
6 BIODEGRADABLE POLYURETHANES AND POLY(ESTER AMIDE)S 233 ALFONSO
RODRIGUEZ-GALAN, LOURDES FRANCO, ANDJORDI PUIGGALL ABBREVIATIONS 233
6.1 CHEMISTRY AND PROPERTIES OF BIODEGRADABLE POLYURETHANES 234 6.2
BIODEGRADATION MECHANISMS OF POLYURETHANES 240 6.3 APPLICATIONS OF
BIODEGRADABLE POLYURETHANES 242 6.3.1 SCAFFOLDS 242
6.3.1.1 CARDIOVASCULAR APPLICATIONS 243 6.3.1.2 MUSCULOSKELETAL
APPLICATIONS 243 6.3.1.3 NEUROLOGICAL APPLICATIONS 144 6.3.2 DRUG
DELIVERY SYSTEMS 244
6.3.3 OTHER BIOMEDICAL APPLICATIONS 245 6.4 NEW POLYMERIZATION TRENDS TO
OBTAIN DEGRADABLE POLYURETHANES 145 6.4.1 POLYURETHANES OBTAINED WITHOUT
USING DIISOCYNATES 245
6.4.2 ENZYMATIC SYNTHESIS OF POLYURETHANES 246 6.4.3 POLYURETHANES FROM
VEGETABLE OILS 247 6.4.4 POLYURETHANES FROM SUGARS 247 6.5 ALIPHATIC
POLY(ESTER AMIDE)S: A FAMILY OF BIODEGRADABLE
THERMOPLASTICS WITH INTEREST AS NEW BIOMATERIALS 249 ACKNOWLEDGMENTS 252
REFERENCES 252
7 CARBOHYDRATES 255
GERALD DRAEGER, ANDREAS KRAUSE, LENA MOELLER, AND SEVERIAN DUMITRIU 7.1
INTRODUCTION 255
7.2 ALGINATE 256
7.3 CARRAGEENAN 160
7.4 CELLULOSE AND ITS DERIVATIVES 262
7.5 MICROBIAL CELLULOSE 264
7.6 CHITIN AND CHITOSAN 265
IMAGE 5
CONTENTS IX
7.7
7.8 7.9 7.10 7.11 7.12 7.13 7.14
DEXTRAN 269 GELLAN 272 GUAR GUM 274 HYALURONIC ACID (HYALURONAN)
PULLULAN 280 SDEROGLUCAN 282 XANTHAN 284
SUMMARY 286 ACKNOWLEDGMENTS 287 IN MEMORIAM 287 REFERENCES 287
276
8 BIODEGRADABLE SHAPE-MEMORY POLYMERS 295 MARC BEHL, JOERG ZOTZMANN,
MICHAEL SCHROETER, AND ANDREAS LENDLEIN 8.1 INTRODUCTION 295
8.2 GENERAL CONCEPT OF SMPS 297 8.3 CLASSES OF DEGRADABLE SMPS 202 8.3.1
COVALENT NETWORKS WITH CRYSTALLIZABLE SWITCHING DOMAINS, T AANS =T M 202
8.3.2 COVALENT NETWORKS WITH AMORPHOUS SWITCHING DOMAINS, T UELNS =T S
204
8.3.3 PHYSICAL NETWORKS WITH CRYSTALLIZABLE SWITCHING DOMAINS, T T A N S
= R M 205
8.3.4 PHYSICAL NETWORKS WITH AMORPHOUS SWITCHING DOMAINS, T TANS = T G
208
8.4 APPLICATIONS OF BIODEGRADABLE SMPS 209 8.4.1 SURGERY AND MEDICAL
DEVICES 209 8.4.2 DRUG RELEASE SYSTEMS 220 REFERENCES 222
9 BIODEGRADABLE ELASTIC HYDROGELS FOR TISSUE EXPANDER APPLICATION 227
THANH HUYEN TRAN, JOHN GARNER, YOURONG FU, KINAM PARK, AND KANG MOO HUH
9.1 INTRODUCTION 227
9.1.1 HYDROGELS 227
9.1.2 ELASTIC HYDROGELS 227 9.1.3 HISTORY OF ELASTIC HYDROGELS AS
BIOMATERIALS 228 9.1.4 ELASTICITY OF HYDROGEL FOR TISSUE APPLICATION 229
9.2 SYNTHESIS OF ELASTIC HYDROGELS 220
9.2.1 CHEMICAL ELASTIC HYDROGELS 220 9.2.1.1 POLYMERIZATION OF
WATER-SOLUBLE MONOMERS IN THE PRESENCE OF CROSSLINKING AGENTS 220
9.2.1.2 CROSSLINKING OF WATER-SOLUBLE POLYMERS 221
9.2.2 PHYSICAL ELASTIC HYDROGELS 222 9.2.2.1 FORMATION OF PHYSICAL
ELASTIC HYDROGELS VIA HYDROGEN BONDING 222
IMAGE 6
X I CONTENTS
9.2.2.2 FORMATION OF PHYSICAL ELASTIC HYDROGELS VIA
HYDROPHOBIE INTERACTION 224 9.3 PHYSICAL PROPERTIES OF ELASTIC HYDROGELS
225 9.3.1 MECHANICAL PROPERTY 225 9.3.2 SWELLING PROPERTY 227 9.3.3
DEGRADATION OF BIODEGRADABLE ELASTIC HYDROGELS 229 9.4 APPLICATIONS OF
ELASTIC HYDROGELS 229 9.4.1 TISSUE ENGINEERING APPLICATION 229 9.4.2
APPLICATION OF ELASTIC SHAPE-MEMORY HYDROGELS AS BIODEGRADABLE
SUTURES 230
9.5 ELASTIC HYDROGELS FOR TISSUE EXPANDER APPLICATIONS 232 9.6
CONCLUSION 233
REFERENCES 234
10 BIODEGRADABLE DENDRIMERS AND DENDRITIC POLYMERS 237 JAYANT KHANDARE
AND SANJAY KUMAR 10.1 INTRODUCTION 237 10.2 CHALLENGES FOR DESIGNING
BIODEGRADABLE DENDRIMERS 240 10.2.1 IS BIODEGRADATION A CRITICAL MEASURE
OF BIOCOMPATIBILITY? 243 10.3 DESIGN OF SELF-IMMOLATIVE BIODEGRADABLE
DENDRIMERS 245 10.3.1 CLEVABLE SHELLS-MULTIVALENT PEGYLATED DENDRIMER
FOR
PROLONGED CIRCULATION 246 10.3.1.1 POLYLYSINE-CORE BIODEGRADABLE
DENDRIMER PRODRUG 250 10.4 BIOLOGICAL IMPLICATIONS OF BIODEGRADABLE
DENDRIMERS 256 10.5 FUTURE PERSPECTIVES OF BIODEGRADABLE DENDRIMERS 259
10.6 CONCLUDING REMARKS 259 REFERENCES 260
11 ANALYTICAL METHODS FOR MONITORING BIODEGRADATION PROCESSES OF
ENVIRONMENTALLY DEGRADABLE POLYMERS 263 MAARTEN VAN DER ZEE 11.1
INTRODUCTION 263 11.2 SOME BACKGROUND 263 11.3 DEFINING BIODEGRADABILITY
265
11.4 MECHANISMS OF POLYMER DEGRADATION 266 11.4.1 NONBIOLOGICAL
DEGRADATION OF POLYMERS 266 11.4.2 BIOLOGICAL DEGRADATION OF POLYMERS
267 11.5 MEASURING BIODEGRADATION OF POLYMERS 267
11.5.1 ENZYME ASSAYS 269 11.5.1.1 PRINCIPLE 269 11.5.1.2 APPLICATIONS
269 11.5.1.3 DRAWBACKS 270 11.5.2 PLATE TESTS 270
11.5.2.1 PRINCIPLE 270 11.5.2.2 APPLICATIONS 270 11.5.2.3 DRAWBACKS 270
IMAGE 7
CONTENTS XI
11.5.3 RESPIRATION TESTS 272
11.5.3.1 PRINCIPLE 272 11.5.3.2 APPLICATIONS 272 11.5.3.3 SUITABILITY
272 11.5.4 GAS (CO 2 OR CH 4 ) EVOLUTION TESTS 272
11.5.4.1 PRINCIPLE 272 11.5.4.2 APPLICATIONS 272 11.5.4.3 SUITABILITY
273 11.5.5 RADIOACTIVELY LABELED POLYMERS 273 11.5.5.1 PRINCIPLE AND
APPLICATIONS 273 11.5.5.2 DRAWBACKS 273 11.5.6 LABORATORY-S CALE
SIMULATED ACCELERATING ENVIRONMENTS 274 11.5.6.1 PRINCIPLE 274 11.5.6.2
APPLICATIONS 274 11.5.6.3 DRAWBACKS 275 11.5.7 NATURAL ENVIRONMENTS,
FIELD TRIALS 275
11.6 CONCLUSIONS 275
REFERENCES 276
12 MODELING AND SIMULATION OF MICROBIAL DEPOLYMERIZATION PROCESSES OF
XENOBIOTIC POLYMERS 283 MASAJI WATANABE AND FUSAKO KAWAI 12.1
INTRODUCTION 283
12.2 ANALYSIS OF EXOGENOUS DEPOLYMERIZATION 284 12.2.1 MODELING OF
EXOGENOUS DEPOLYMERIZATION 284 12.2.2 BIODEGRADATION OF PEG 287 12.3
MATERIALS AND METHODS 287 12.3.1 CHEMICALS 287 12.3.2 MICROORGANISMS AND
CULTIVATION 287 12.3.3 HPLC ANALYSIS 288 12.3.4 NUMERICAL STUDY OF
EXOGENOUS DEPOLYMERIZATION 288 12.3.5 TIME FACTOR OF DEGRADATION RATE
291 12.3.6 SIMULATION WITH TIME-DEPENDENT DEGRADATION RATE 293 12.4
ANALYSIS OF ENDOGENOUS DEPOLYMERIZATION 295 12.4.1 MODELING OF
ENDOGENOUS DEPOLYMERIZATION 295 12.4.2 ANALYSIS OF ENZYMATIC PLA
DEPOLYMERIZATION 300 12.4.3 SIMULATION OF AN ENDOGENOUS DEPOLYMERIZATION
PROCESS OF PLA 302 12.5 DISCUSSION 306
ACKNOWLEDGMENTS 307 REFERENCES 307
13 REGENERATIVE MEDICINE: RECONSTRUCTION OF TRACHEAL AND PHARYNGEAL
MUCOSAL DEFECTS IN HEAD AND NECK SURGERY 309 DOROTHEE RICKERT, BERNHARD
HIEBT, ROSEMARIE FUHRMANN, FRIEDRICH JUNG, ANDREAS LENDLEIN, AND
RALF-PETER FRANKE
IMAGE 8
XII CONTENTS
13.1 INTRODUCTION 309
13.1.1 HISTORY OF IMPLANT MATERIALS 309 13.1.2 REGENERATIVE MEDICINE 309
13.1.3 FUNCTIONALIZED IMPLANT MATERIALS 310 13.1.4 STERILIZATION OF
POLYMER-BASED DEGRADABLE
IMPLANT MATERIALS 320 13.2 REGENERATIVE MEDICINE FOR THE RECONSTRUCTION
OF THE UPPER AERODIGESTIVE TRACT 322 13.2.1 APPLICATIONS OF DIFFERENT
IMPLANT MATERIALS IN
TRACHEAL SURGERY 322 13.2.2 NEW METHODS AND APPROACHES FOR TRACHEAL
RECONSTRUCTION 323 13.2.2.1 EPITHELIALIZATION OF TRACHEAL SCAFFOLDS 327
13.2.2.2 VASCULAR SUPPLY OF TRACHEAL CONSTRUCTS 329 13.2.3 REGENERATIVE
MEDICINE FOR RECONSTRUCTION OF
PHARYNGEAL DEFECTS 320 13.3 METHODS AND NOVEL THERAPEUTICAL OPTIONS IN
HEAD AND NECK SURGERY 322 13.3.1 PRIMARY CELL CULTURES OF THE UPPER
AERODIGESTIVE TRACT 322 13.3.2 ASSESSMENT AND REGULATION OF MATRIX
METALLOPROTEASES AND WOUND
HEALING 321
13.3.3 INFLUENCE OF IMPLANT TOPOGRAPHY 322 13.3.4 APPLICATION OF NEW
IMPLANT MATERIALS IN ANIMAL MODELS 324 13.4 VASCULARIZATION OF
TISSUE-ENGINEERED CONSTRUCTS 328 13.5 APPLICATION OF STEM CELLS IN
REGENERATIVE MEDICINE 329 13.6 CONCLUSION 332
REFERENCES 332
14 BIODEGRADABLE POLYMERS AS SCAFFOLDS FOR TISSUE ENGINEERING 342
YOSHITO IKADA ABBREVIATIONS 342 14.1 INTRODUCTION 342 14.2 SHORT
OVERVIEW OF REGENERATIVE BIOLOGY 342
14.2.1 LIMB REGENERATION OF URODELES 342 14.2.2 WOUND REPAIR AND
MORPHOGENESIS IN THE EMBRYO 343 14.2.3 REGENERATION IN HUMAN FINGERTIPS
344 14.2.4 THE DEVELOPMENT OF BONES: OSTEOGENESIS 345 14.2.5
REGENERATION IN LIVER: COMPENSATORY REGENERATION 347 14.3 MINIMUM
REQUIREMENTS FOR TISSUE ENGINEERING 348 14.3.1 CELLS AND GROWTH FACTORS
348 14.3.2 FAVORABLE ENVIRONMENTS FOR TISSUE REGENERATION 349 14.3.3
NEED FOR SCAFFOLDS 350 14 A STRUCTURE OF SCAFFOLDS 352 14A.I SURFACE
STRUCTURE 352 14.4.2 POROUS STRUCTURE 353
IMAGE 9
CONTENTS XIII
14.4.3 ARCHITECTURE OF SCAFFOLD 353
14.4.4 BARRIER AND GUIDANCE STRUCTURE 354 14.5 BIODEGRADABLE POLYMERS
FOR TISSUE ENGINEERING 354 14.5.1 SYNTHETIC POLYMERS 355
14.5.2 BIOPOLYMERS 356 14.5.3 CALCIUM PHOSPHATES 357 14.6 SOME EXAMPLES
FOR CLINICAL APPLICATION OF SCAFFOLD 357 14.6.1 SKIN 357
14.6.2 ARTICULAR CARTILAGE 357 14.6.3 MANDIBLE 358 14.6.4 VASCULAR
TISSUE 359 14.7 CONCLUSIONS 362
REFERENCES 362
15 DRUG DELIVERY SYSTEMS 363 KEVIN M. SHAKESHEFF 15.1 INTRODUCTION 363
15.2 THE CLINICAL NEED FOR DRUG DELIVERY SYSTEMS 364 15.3
POLY(OC-HYDROXYL ACIDS) 365 15.3.1 CONTROLLING DEGRADATION RATE 366 15.4
POLYANHYDRIDES 368
15.5 MANUFACTURING ROUTES 370 15.6 EXAMPLES OF BIODEGRADABLE POLYMER
DRUG DELIVERY SYSTEMS UNDER DEVELOPMENT 372 15.6.1 POLYKETALS 371
15.6.2 SYNTHETIC FIBRIN 372 15.6.3 NANOPARTIDES 372 15.6.4
MICROFABRICATED DEVICES 373 15.6.5 POLYMER-DRUG CONJUGATES 373 15.6.6
RESPONSIVE POLYMERS FOR INJECTABLE DELIVERY 375 15.6.7 PEPTIDE-BASED
DRUG DELIVERY SYSTEMS 375 15.7 CONCLUDING REMARKS 376
REFERENCES 376
16 OXO-BIODEGRADABLE POLYMERS: PRESENT STATUS AND FUTURE PERSPECTIVES
379 EMO CHIELLINI, ANDREA CORTI, SALVATORE D'ANTONE, AND DAVID MCKEEN
WILES 16.1 INTRODUCTION 379
16.2 CONTROLLED-LIFETIME PLASTICS 380 16.3 THE ABIOTIC OXIDATION OF
POLYOLEFINS 382 16.3.1 MECHANISMS 383 16.3.2 OXIDATION PRODUCTS 384
16.3.3 PRODEGRADANT EFFECTS 386
16.4 ENHANCED OXO-BIODEGRADATION OF POLYOLEFINS 387 16.4.1
BIODEGRADATION OF POLYOLEFIN OXIDATION PRODUCTS 390
IMAGE 10
XIV CONTENTS
16.4.2 STANDARD TESTS 391
16.4.3 BIOMETRIE MEASUREMENTS 393 16.5 PROCESSABILITY AND RECOVERY OF
OXO-BIODEGRADABLE POLYOLEFINS 395 16.6 CONCLUDING REMARKS 396 REFERENCES
397
INDEX 399 |
| any_adam_object | 1 |
| author2 | Lendlein, Andreas |
| author2_role | edt |
| author2_variant | a l al |
| author_facet | Lendlein, Andreas |
| building | Verbundindex |
| bvnumber | BV039132464 |
| classification_rvk | UV 9450 VN 5900 WD 5000 ZM 5300 |
| classification_tum | CHE 762f |
| ctrlnum | (OCoLC)707201108 (DE-599)DNB1009639862 |
| dewey-full | 620.192323 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 620 - Engineering and allied operations |
| dewey-raw | 620.192323 |
| dewey-search | 620.192323 |
| dewey-sort | 3620.192323 |
| dewey-tens | 620 - Engineering and allied operations |
| discipline | Chemie / Pharmazie Maschinenbau / Maschinenwesen Physik Biologie Chemie Werkstoffwissenschaften / Fertigungstechnik |
| format | Book |
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| id | DE-604.BV039132464 |
| illustrated | Illustrated |
| indexdate | 2024-09-06T00:19:01Z |
| institution | BVB |
| isbn | 9783527324415 3527324410 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024150752 |
| oclc_num | 707201108 |
| open_access_boolean | |
| owner | DE-11 DE-83 DE-92 DE-703 DE-634 DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-M49 DE-BY-TUM DE-29T |
| owner_facet | DE-11 DE-83 DE-92 DE-703 DE-634 DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-M49 DE-BY-TUM DE-29T |
| physical | XX, 405 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Handbook of biodegradable polymers synthesis, characterization and applications ed. by Andreas Lendlein ... Weinheim Wiley-VCH 2011 XX, 405 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologisch abbaubarer Kunststoff (DE-588)4634464-0 gnd rswk-swf Biologisch abbaubarer Kunststoff (DE-588)4634464-0 s DE-604 Lendlein, Andreas edt X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3655690&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024150752&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of biodegradable polymers synthesis, characterization and applications Biologisch abbaubarer Kunststoff (DE-588)4634464-0 gnd |
| subject_GND | (DE-588)4634464-0 |
| title | Handbook of biodegradable polymers synthesis, characterization and applications |
| title_auth | Handbook of biodegradable polymers synthesis, characterization and applications |
| title_exact_search | Handbook of biodegradable polymers synthesis, characterization and applications |
| title_full | Handbook of biodegradable polymers synthesis, characterization and applications ed. by Andreas Lendlein ... |
| title_fullStr | Handbook of biodegradable polymers synthesis, characterization and applications ed. by Andreas Lendlein ... |
| title_full_unstemmed | Handbook of biodegradable polymers synthesis, characterization and applications ed. by Andreas Lendlein ... |
| title_short | Handbook of biodegradable polymers |
| title_sort | handbook of biodegradable polymers synthesis characterization and applications |
| title_sub | synthesis, characterization and applications |
| topic | Biologisch abbaubarer Kunststoff (DE-588)4634464-0 gnd |
| topic_facet | Biologisch abbaubarer Kunststoff |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3655690&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024150752&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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