Cysteine proteases of pathogenic organisms:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Springer [u.a.]
2011
|
| Series: | Advances in experimental medicine and biology
712 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIX, 226 S. Ill. |
| ISBN: | 9781441984135 1441984135 |
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MARC
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| 245 | 1 | 0 | |a Cysteine proteases of pathogenic organisms |c [participants: Linda S. Brinen ...]Ed. by Mark W. Robinson ... |
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| 650 | 2 | |a Cysteine Proteases |a chemistry | |
| 650 | 2 | |a Cysteine Proteases |a immunology | |
| 650 | 2 | |a Bacteria |a enzymology | |
| 650 | 2 | |a Eukaryota |a enzymology | |
| 650 | 2 | |a Viruses |a enzymology | |
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Record in the Search Index
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|---|---|
| adam_text | Titel: Cysteine proteases of pathogenic organisms
Autor: Robinson, Mark W.
Jahr: 2011
1. PAPAIN-LIKE PROTEASES OF STAPHYLOCOCCUS AUREUS.....................1
Tomasz Kantyka, Lindsey N. Shaw and Jan Potempa
Abstract.........................................................................................................................................1
Introduction..................................................................................................................................2
The Pathogenic Potential of S. aureus........................................................................................2
The Proteolytic Enzymes of S. aureus........................................................................................4
Genetic Organisation of the Staphylococcal Proteolytic Enzymes..........................................4
Expression and Activation of S. aureus Extracellular Proteases.............................................5
Staphopain Activity and Its Relevance to Virulence.................................................................7
Staphostatins are Effective Regulators of Staphopain Activity...............................................8
Conclusion..................................................................................................................................12
2. THE LYSINE-SPECIFIC G1NGIPAIN OF PORPHYROMONAS
GINGIVALIS: IMPORTANCE TO PATHOGENICITY
AND POTENTIAL STRATEGIES FOR INHIBITION.............................15
Tang Yongqing, Jan Potempa, Robert N. Pike and Lakshmi C. Wijeyewickrema
Abstract.......................................................................................................................................15
Introduction: Periodontal Disease-Significance and Aetiology...........................................15
Gingipains...................................................................................................................................17
The Biological Functions of Kgp..............................................................................................17
The Structural Chemistry of Kgp............................................................................................18
The Catalytic Mechanism of Kgp.............................................................................................22
Previously Developed Kgp Inhibitors......................................................................................24
Conclusion..................................................................................................................................25
3. FALCIPAINS AND OTHER CYSTEINE PROTEASES
OF MALARIA PARASITES..........................................................................30
Philip J. Rosenthal
Abstract.......................................................................................................................................30
Introduction................................................................................................................................31
xvi CONTENTS
Cysteine Protease Nomenclature..............................................................................................31
Functions of Plasmodium Cysteine Proteases Determined from Inhibitor Studies.............31
Falcipain Cysteine Proteases.....................................................................................................37
Other Clan CA Cysteine Proteases of Malaria Parasites.......................................................41
Potential for Cysteine Protease Inhibitors as Antimalarial Drugs........................................43
Conclusion..................................................................................................................................44
4. CATHEPSIN PROTEASES IN TOXOPLASMA GONDII..................................49
Zhicheng Dou and Vern B. Carruthers
Abstract.......................................................................................................................................49
Introduction................................................................................................................................49
General Roles of Cathepsins in Biological Systems................................................................50
Properties of Toxoplasma gondii and its Cathepsins...............................................................50
Phylogenetic Relationships........................................................................................................55
Localization, Physiological Functions and Regulation...........................................................55
Therapeutic Potential................................................................................................................58
Conclusion and Future Perspectives........................................................................................58
5. ENTAMOEBA HISTOLYTICA CATHEPSIN-LIKE ENZYMES:
INTERACTIONS WITH THE HOST GUT................................................62
Vanessa Kissoon-Singh, Leanne Mortimer and Kris Chadee
Abstract.......................................................................................................................................62
Introduction................................................................................................................................62
E. histolytica Cysteine Proteases...............................................................................................64
Host Defence and Amoeba Cysteine Proteases........................................................................68
Cysteine Proteases as Targets for Disease Intervention.........................................................78
Conclusion..................................................................................................................................78
6. CYSTEINE PEPTIDASES OF KINETOPLASTID PARASITES.....................84
Conor R. Caffrey, Ana-Paula Lima and Dietmar Steverding
Abstract.......................................................................................................................................84
Introduction................................................................................................................................84
History of Kinetoplastid CP Discovery....................................................................................85
Nomenclature.............................................................................................................................89
Genomic Organization and Control of Gene Expression.......................................................89
Peptidase Trafficking, Processing and Biochemistry..............................................................90
Vaccines and Diagnosis..............................................................................................................91
Drug Targets...............................................................................................................................92
Virulence Factors and Immunomodulators............................................................................93
Conclusion..................................................................................................................................94
CONTENTS xvii
7. CRUZAIN: THE PATH FROM TARGET VALIDATION
TO THE CLINIC..........................................................................................100
Mohammed Sajid, Stephanie A. Robertson, Linda S. Brinen and James H. McKerrow
Abstract.....................................................................................................................................100
Introduction..............................................................................................................................100
Current Treatments for Chagas Disease...............................................................................101
Cruzain......................................................................................................................................101
Biochemistry of Cruzain..........................................................................................................103
Biological Roles of Cruzain.....................................................................................................105
Chemical Inhibition of Cruzain-First Studies and Biological Data..................................105
The Structural Basis of Cruzain Inhibition...........................................................................106
K777: The Path to the Clinic...................................................................................................109
Conclusion.................................................................................................................................Ill
8. THE PHYLOGENY, STRUCTURE AND FUNCTION OF TREMATODE
CYSTEINE PROTEASES, WITH PARTICULAR EMPHASIS
ON THE FASCIOLA HEPÁTICA CATHEPSIN L FAMILY....................116
Colin Stack, John P. Dalton and Mark W. Robinson
Abstract.....................................................................................................................................116
Introduction..............................................................................................................................117
Trematode Cysteine Proteases................................................................................................117
Evolutionary Relationships of Trematode Cysteine Proteases............................................118
Fasciola as an Example of a Large Cysteine Protease Gene Family...................................119
Variation in the S2 Subsite of the Active Site and its Influence
on Enzyme Specificity......................................................................................................121
Atomic Structure and Substrate Specificity..........................................................................123
The Role of the Prosegment in Regulating the Function of Trematode Cathepsins..........124
Trans-Activation of Trematode Cathepsins by Asparaginyl Endopeptidase?....................126
Biological Roles of Trematode Cathepsin Proteases.............................................................127
Localisation Patterns and Secretion of Trematode Cathepsins...........................................130
The Role of Ph in Regulating Cathepsin Function in Trematodes......................................131
Conclusion................................................................................................................................131
9. CATHEPSINS Bl AND B2 OF TRICHOBILHARZIA SPP., BIRD
SCHISTOSOMES CAUSING CERCARIAL DERMATITIS..................136
Martin Kasny, Libor Mikes, Katefina Dolecková, Vladimir Hampl, Jan Dvorak,
Marian Novotny and Petr Horák
Abstract.....................................................................................................................................136
Introduction..............................................................................................................................136
Peptidases of Trichobilharzia...................................................................................................138
Conclusion................................................................................................................................150
xviii CONTENTS
10. PROTEASES IN BLOOD-FEEDING NEMATODES
AND THEIR POTENTIAL AS VACCINE CANDIDATES......................155
David Knox
Abstract.....................................................................................................................................155
Introduction..............................................................................................................................155
Haemonchus Contortus...........................................................................................................157
Hookworms-Necator americanus and Ancylostoma spp.....................................................166
Conclusion-----------------.----------.------.-...-----..............................................................171
11. CYSTEINE PROTEASES FROM BLOODFEEDING ARTHROPOD
ECTOPARASITES.......................................................................................177
Daniel Sojka, Ivo M.B. Francischetti, Eric Calvo and Michalis Kotsyfakis
Abstract.....................................................................................................................................177
Introduction..............................................................................................................................177
Cysteine Proteases of Ticks.....................................................................................................178
Cysteine Proteases in Mosquitoes...........................................................................................182
Cysteine Proteases in Other Bloodfeeding Arthropods........................................................185
Conclusion................................................................................................................................187
12. HOW PATHOGEN-DERIVED CYSTEINE PROTEASES
MODULATE HOST IMMUNE RESPONSES..........................................192
Sheila Donnelly, John P. Dalton and Mark W. Robinson
Abstract.....................................................................................................................................192
Introduction..............................................................................................................................192
Adaptive Immune Responses..................................................................................................195
Innate Immune Responses......................................................................................................196
Degradation of Soluble Mediators of Immune Response.....................................................200
Conclusion................................................................................................................................203
13. CYSTATINS OF PARASITIC ORGANISMS.................................................208
Christian Klotz, Thomas Ziegler, Emilia Danitowicz-Luebert
and Susanne Hartmann
Abstract.....................................................................................................................................208
Introduction: Cystatin Superfamily-Classification and Structural Characteristics..........208
Parasite Cystatins.....................................................................................................................209
Biological Function of Parasite Cystatins..............................................................................214
Interference with Antigen Processing and Presentation.......................................................216
Modulation of Cytokine Responses and Nitric Oxide Production......................................217
Anticipated Developments.......................................................................................................218
Conclusion................................................................................................................................219
INDEX.......................................................................................................................................223
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| indexdate | 2024-07-09T23:24:44Z |
| institution | BVB |
| isbn | 9781441984135 1441984135 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022616583 |
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| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XIX, 226 S. Ill. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Cysteine proteases of pathogenic organisms [participants: Linda S. Brinen ...]Ed. by Mark W. Robinson ... New York [u.a.] Springer [u.a.] 2011 XIX, 226 S. Ill. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 712 Cysteine Proteases chemistry Cysteine Proteases immunology Bacteria enzymology Eukaryota enzymology Viruses enzymology Robinson, Mark W. 1977- Sonstige (DE-588)1011935945 oth Brinen, Linda S. Sonstige oth Advances in experimental medicine and biology 712 (DE-604)BV000003102 712 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022616583&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cysteine proteases of pathogenic organisms Advances in experimental medicine and biology Cysteine Proteases chemistry Cysteine Proteases immunology Bacteria enzymology Eukaryota enzymology Viruses enzymology |
| title | Cysteine proteases of pathogenic organisms |
| title_auth | Cysteine proteases of pathogenic organisms |
| title_exact_search | Cysteine proteases of pathogenic organisms |
| title_full | Cysteine proteases of pathogenic organisms [participants: Linda S. Brinen ...]Ed. by Mark W. Robinson ... |
| title_fullStr | Cysteine proteases of pathogenic organisms [participants: Linda S. Brinen ...]Ed. by Mark W. Robinson ... |
| title_full_unstemmed | Cysteine proteases of pathogenic organisms [participants: Linda S. Brinen ...]Ed. by Mark W. Robinson ... |
| title_short | Cysteine proteases of pathogenic organisms |
| title_sort | cysteine proteases of pathogenic organisms |
| topic | Cysteine Proteases chemistry Cysteine Proteases immunology Bacteria enzymology Eukaryota enzymology Viruses enzymology |
| topic_facet | Cysteine Proteases chemistry Cysteine Proteases immunology Bacteria enzymology Eukaryota enzymology Viruses enzymology |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022616583&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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