Malignant mesothelioma:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Berlin [u.a.]
Springer
2011
|
Schriftenreihe: | Recent results in cancer research
189 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XI, 193 S. Ill., graph. Darst. |
ISBN: | 9783642108617 |
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Datensatz im Suchindex
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adam_text | IMAGE 1
1 MINERALOGY OF ASBESTOS 1
THOMAS A. SPORN
1.1 INTRODUCTION AND HISTORICAL BACKGROUND 1
1.2 GEOLOGIC AND MINERALOGIE FEATURES 2
1.3 DISTRIBUTION AND PHYSICOCHEMICAL PROPERTIES OF CHRYSOTILE 4 1.4
DISTRIBUTION AND PHYSICOCHEMICAL PROPERTIES OF THE AMPHIBOLE SPECIES 7
1.5 IDENTIFICATION AND CHARACTERIZATION OF ASBESTOS 9
REFERENCES 10
2 EPIDEMIOLOGY OF MESOTHELIOMA AND HISTORICAL BACKGROUND 13 J.E.
CRAIGHEAD
REFERENCES 23
3 IMAGING OF MESOTHELIOMA 27
RITU R. GILL
3.1 INTRODUCTION 27
3.2 PATTERNS OF PRESENTATION AND IMAGING FEATURES 28
3.3 PREOPERATIVE EVALUATION OF MPM 29
3.4 POSTOPERATIVE EVALUATION 36
3.5 UNRESECTABLE DISEASE 36
3.6 FUTURE DIRECTIONS 38
3.7 SUMMARY 41
REFERENCES 41
4 BIOPSY TECHNIQUES FOR THE DIAGNOSIS OF MESOTHELIOMA 45
J. WALTERS AND NICK A. MASKELL
4.1 INTRODUCTION 45
4.2 CLINICAL PRESENTATION 46
VII
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1000034240
DIGITALISIERT DURCH
IMAGE 2
VIII CONTENTS
4.3 INVESTIGATION OF PLEURAL EFFUSION 46
4.3.1 CYTOLOGY 46
4.4 INVESTIGATION OF PLEURAL THICKENING WITH NO EFFUSION 47
4.5 PERCUTANEOUS PLEURAL BIOPSY TECHNIQUES 47
4.5.1 ABRAMS NEEDLE 47
4.5.2 RADIOLOGICALLY GUIDED PERCUTANEOUS PLEURAL BIOPSY 48
4.5.3 POSITRON EMISSION TOMOGRAPHY (PET) CT 49
4.6 THORACOSCOPY 49
4.6.1 LOCAL ANAESTHETIC THORACOSCOPY 50
4.6.2 VIDEO-ASSISTED THORACOSCOPIC SURGERY 51
4.7 OPEN BIOPSY 52
4.8 PROPHYLACTIC RADIOTHERAPY 52
REFERENCES 53
PATHOHISTOLOGICAL DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS 57
IRIS TISCHOFF, MATTHIAS NEID, VOLKER NEUMANN, AND ANDREA TANNAPFEL
5.1 INTRODUCTION 58
5.2 MALIGNANT MESOTHELIOMA OF THE PLEURA 58
5.2.1 MORPHOLOGY 58
5.3 DIFFERENTIAL DIAGNOSIS OF MALIGNANT MESOTHELIOMA AND PLEURAL
METASTASES 61
5.3.1 MORPHOLOGICAL DIFFERENCES 61
5.3.2 IMMUNOHISTOCHEMISTRY 62
5.4 REACTIVE VERSUS NEOPLASTIC MESOTHELIAL PROLIFERATION 65
5.5 PRIMARY PLEURAL TUMOURS OTHER THAN MALIGNANT MESOTHELIOMA 66 5.5.1
PERITONEAL MESOTHELIOMA 67
5.5.2 MALIGNANT MESOTHELIOMA OF TUNICA VAGINALIS TESTIS 69
5.5.3 WELL-DIFFERENTIATED PAPILLARY MESOTHELIOMA 69
5.5.4 PROGNOSIS AND PREDICTIVE FACTORS 70
5.5.5 DIFFERENTIAL DIAGNOSIS 71
5.5.6 BENIGN LESIONS 71
5.5.7 MALIGNANT LESIONS 72
5.5.8 IMMUNOHISTOCHEMISTRY 73
5.6 PRIMARY PERITONEAL CARCINOMA/METASTASES OF SEROUS OVARIAN CANCER
VERSUS MALIGNANT PERITONEAL MESOTHELIOMA 74 REFERENCES 75
MESOTHELIOMA AND ANALYSIS OF TISSUE FIBER CONTENT 79
VOLKER NEUMANN, STEFAN LOESEKE, AND ANDREA TANNAPFEL
6.1 INTRODUCTION 80
6.2 TECHNIQUES FOR ANALYSIS OF PULMONARY MINERAL-FIBER CONTENT 82 6.2.1
LUNG TISSUE DIGESTS 82
6.3 METHODS FOR MINERAL FIBER ANALYSIS 83
6.3.1 LIGHT MICROSCOPY (LM) 83
IMAGE 3
CONTENTS
6.3.2 ELECTRON MICROSCOPY 83
6.3.3 COMPARABILITY OF RESULTS GENERATED BY LIGHT OR ELECTRON MICROSCOPY
84
6.3.4 REFERENCE POPULATION AND BACKGROUND LUNG ASBESTOS BURDEN 84 6.3.5
ASBESTOS BODIES AND FIBER COUNTING 84
6.4 ASBESTOS LUNG TISSUE CONTENT IN PATIENTS WITH MESOTHELIOMA 85 6.4.1
LIGHT MICROSCOPY 85
6.4.2 ELECTRON MICROSCOPY 86
6.4.3 ASBESTOS CONTENT AND FIBER DIMENSIONS IN PLEURAL SAMPLES 86 6.5
DISCUSSION 87
6.5.1 ASBESTOS BODIES AND FIBER BURDEN OF THE LUNG 87
6.5.2 LATENCY PERIOD AND MEAN AGE AT DIAGNOSIS OF MESOTHELIOMA 88 6.5.3
CLEARANCE AND BIOPERSISTENCE OF ASBESTOS FIBERS 88
6.5.4 CARCINOGENIC POTENCY OF ASBESTOS FIBERS 89
6.5.5 PERITONEAL MESOTHELIOMA 89
6.5.6 ASBESTOS-ASSOCIATED MESOTHELIOMA AND OTHER POSSIBLE CAUSES OF
MALIGNANT MESOTHELIOMA 89 6.5.7 THRESHOLD OR CUT-OFF LEVEL 90
6.6 CONCLUSION 90
REFERENCES 90
7 SURGICAL THERAPY OF MESOTHELIOMA 97
DAVID RICE
7.1 INTRODUCTION 97
7.2 NATURAL HISTORY 98
7.3 DIAGNOSIS 98
7.3.1 VIDEO-ASSISTED THORACOSCOPY 98
7.4 STAGING 100
7.4.1 LAPAROSCOPY 100
7.4.2 MEDIASTINOSCOPY 101
7.4.3 THORACOSCOPY 102
7.4.4 ENDOSCOPIE STAGING 102
7.5 PALLIATIVE SURGERY 103
7.5.1 PLEURAL DRAINAGE 103
7.5.2 PLEURECTOMY 103
7.6 CYTOREDUCTIVE SURGERY 105
7.6.1 EXTRAPLEURAL PNEUMONECTOMY (EPP) 105
7.6.2 PLEURECTOMY/DECORTICATION (P/D) 113
7.6.3 INTRAPLEURAL THERAPIES 115
7.6.4 EXTRAPLEURAL PNEUMONECTOMY VERSUS PLEURECTOMY/DECORTICATION 119
7.6.5 DOES CYTOREDUCTIVE SURGERY IMPROVE SURVIVAL? 120
7.7 SUMMARY 121
REFERENCES 121
IMAGE 4
CONTENTS
8 CHEMOTHERAPY AND RADIOTHERAPY FOR MESOTHELIOMA 127
XAVIER DHALLUIN AND ARNAUD SCHERPEREEL
8.1 INTRODUCTION 127
8.2 RADIOTHERAPY 128
8.2.1 RADICAL RADIOTHERAPY 128
8.2.2 PROPHYLACTIC RADIOTHERAPY 132
8.3 SYSTEMIC THERAPIES FOR MALIGNANT PLEURAL MESOTHELIOMA 133 8.3.1
SYSTEMIC CHEMOTHERAPY 133
8.3.2 TARGETED THERAPIES 138
8.3.3 IMMUNOMODULATORS, GENE THERAPY AND CELL THERAPY 141
8.4 CONCLUSION 142
REFERENCES 142
9 GENETICS AND MOLECULAR BIOLOGY OF MESOTHELIOMA 149
DEAN A. FENNELL
9.1 APOPTOSIS AS A TUMOR SUPPRESSOR MECHANISM 149
9.2 KEY ALTERATIONS IN THE CORE APOPTOSIS SIGNALING IN MESOTHELIOMA ..
149 9.2.1 REGULATION OF THE INTRINSIC (MITOCHONDRIAL) APOPTOSIS PATHWAY
IN MESOTHELIOMA 149
9.2.2 EXTRINSIC APOPTOSIS PATHWAY REGULATION IN MESOTHELIOMA 152 9.2.3
INHIBITORS OF APOPTOSIS IN MESOTHELIOMA 152
9.3 TUMOR SUPPRESSOR LOSS IN MESOTHELIOMA 152
9.3.1 LOSS OF NF2 IS FREQUENT IN MESOTHELIOMA 152
9.3.2 NF2 ENCODES THE TUMOR SUPPRESSOR MERLIN 153
9.3.3 PLZF IS A NOVEL TUMOR SUPPRESSOR IN MESOTHELIOMA 154
9.4 THERAPEUTIC INHIBITION OF SURVIVAL PATHWAYS 154
9.4.1 PI3K/AKT/MTOR AXIS IN MESOTHELIOMA 154
9.4.2 HGF/CMET PATHWAY IS ACTIVATED IN MESOTHELIOMA 154
9.4.3 WNT PATHWAY ACTIVATION IN MESOTHELIOMA 155
9.4.4 ESTROGEN RECEPTOR BETA 156
9.5 THERAPEUTIC REACTIVATION OF TUMOR SUPPRESSORS 156
9.5.1 EPIGENOMIC DYSREGULATION IN MESOTHELIOMA 156
9.5.2 TARGETING THE MESOTHELIOMA EPIGENOME VIA INHIBITION OF HISTONE
DEACETYLASES 157
9.5.3 TARGETING THE UBIQUITIN PROTEASOME PATHWAY 158
9.6 SYNTHETIC LETHAL STRATEGIES 158
9.7 SUMMARY 159
REFERENCES 159
IMAGE 5
CONTENTS
10 EARLY STAGES OF MESOTHELIOMA, SCREENING AND BIOMARKERS 169
SONJA KLEBE AND DOUGLAS W. HENDERSON
10.1 EARLY-STAGE MALIGNANT MESOTHELIOMA, INCLUDING THE CONCEPT OF
MESOTHELIOMA IN SITU AND THE DISTINCTION FROM REACTIVE MESOTHELIAL
HYPERPLASIA 169
10.2 BIOMARKERS FOR EARLY-STAGE EPITHELIOID MALIGNANT MESOTHELIOMA
VERSUS REACTIVE MESOTHELIAL HYPERPLASIA 174 10.2.1 EPITHELIAL MEMBRANE
ANTIGEN (EMA) 174
10.2.2 GLUT-1 175
10.2.3 BCL-2 176
10.2.4 P53 176
10.2.5 X-LINKED INHIBITOR OF APOPTOSIS PROTEINS (XIAP) 177
10.2.6 P-GLYCOPROTEIN (P-170) 177
10.2.7 NEURAL CELL ADHESION MOLECULES (NCAMS): CD56 177
10.3 SCREENING FOR MALIGNANT MESOTHELIOMA AND PROGNOSTIC BIOMARKERS:
SERUM LEVELS OF SOLUBLE MESOTHELIN-RELATED PROTEINS (SMRPS), OSTEOPONTIN
(OPN), MEGAKARYOCYTE POTENTIATING FACTOR (MKPF) AND CA125 178
10.3.1 INTRODUCTORY REMARKS ON SCREENING FOR MALIGNANT MESOTHELIOMA 178
10.3.2 RADIOLOGICAL SCREENING FOR MM 179
10.3.3 SOLUBLE MESOTHELIN-RELATED PROTEINS (SMRPS) 179
10.3.4 SERUM OSTEOPONTIN (OPN) LEVELS 181
10.3.5 MEGAKARYOCYTE POTENTIATING FACTOR (MKPF) 182
10.3.6 CA125 182
10.3.7 SUMMARY 182
10.4 AQUAPORINS AND MALIGNANT MESOTHELIOMA 183
REFERENCES 185
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physical | XI, 193 S. Ill., graph. Darst. |
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spelling | Malignant mesothelioma Andrea Tannapfel (ed.) Berlin [u.a.] Springer 2011 XI, 193 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 189 Mesotheliom (DE-588)4210059-8 gnd rswk-swf Pleuramesotheliom (DE-588)4221580-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Pleuramesotheliom (DE-588)4221580-8 s DE-604 Mesotheliom (DE-588)4210059-8 s 1\p DE-604 Tannapfel, Andrea 1966- Sonstige (DE-588)122478460 oth Erscheint auch als Online-Ausgabe 978-3-642-10862-4 Recent results in cancer research 189 (DE-604)BV000000043 189 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022549995&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
spellingShingle | Malignant mesothelioma Recent results in cancer research Mesotheliom (DE-588)4210059-8 gnd Pleuramesotheliom (DE-588)4221580-8 gnd |
subject_GND | (DE-588)4210059-8 (DE-588)4221580-8 (DE-588)4143413-4 |
title | Malignant mesothelioma |
title_auth | Malignant mesothelioma |
title_exact_search | Malignant mesothelioma |
title_full | Malignant mesothelioma Andrea Tannapfel (ed.) |
title_fullStr | Malignant mesothelioma Andrea Tannapfel (ed.) |
title_full_unstemmed | Malignant mesothelioma Andrea Tannapfel (ed.) |
title_short | Malignant mesothelioma |
title_sort | malignant mesothelioma |
topic | Mesotheliom (DE-588)4210059-8 gnd Pleuramesotheliom (DE-588)4221580-8 gnd |
topic_facet | Mesotheliom Pleuramesotheliom Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022549995&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV000000043 |
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