Myopathies:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Philadelphia, Pa.
Saunders
2011
|
| Series: | Rheumatic disease clinics of North America
37,2 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | X S., S. 144 - 322 Ill., graph. Darst. |
| ISBN: | 9781455705030 |
Staff View
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV037384310 | ||
| 003 | DE-604 | ||
| 005 | 20120917 | ||
| 007 | t | ||
| 008 | 110506s2011 ad|| |||| 00||| eng d | ||
| 020 | |a 9781455705030 |9 978-1-4557-0503-0 | ||
| 035 | |a (OCoLC)730014669 | ||
| 035 | |a (DE-599)BVBBV037384310 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 084 | |a YC 8700 |0 (DE-625)153265: |2 rvk | ||
| 084 | |a YG 6200 |0 (DE-625)153508:12905 |2 rvk | ||
| 245 | 1 | 0 | |a Myopathies |c guest ed.: Robert L. Wortmann |
| 264 | 1 | |a Philadelphia, Pa. |b Saunders |c 2011 | |
| 300 | |a X S., S. 144 - 322 |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Rheumatic disease clinics of North America |v 37,2 | |
| 650 | 0 | 7 | |a Muskelkrankheit |0 (DE-588)4075131-4 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Muskelkrankheit |0 (DE-588)4075131-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Wortmann, Robert L. |e Sonstige |0 (DE-588)1011577836 |4 oth | |
| 830 | 0 | |a Rheumatic disease clinics of North America |v 37,2 |w (DE-604)BV000625464 |9 37,2 | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022537375&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-022537375 | ||
Record in the Search Index
| _version_ | 1804145670942097408 |
|---|---|
| adam_text | Myopathies
Contents
Preface:
Myopathies
Robert
L.
Wortmann
Polymyositis, Dermatomyositis, and Autoimmune Necrotizing Myopathy:
Clinical
Features 143
Sabina Khan
and Lisa Christopher-Stine
Idiopathic
inflammatory
myopathies
are a heterogeneous group of autoim¬
mune disorders predominantly affecting skeletal muscles, resulting in
muscle inflammation and weakness. The
3
most common inflammatory
myopathies
are polymyositis (PM), dermatomyositis (DM), and inclusion
body myositis. This review details the clinical findings noted in PM, DM,
and the emerging entity of autoimmune necrotizing myopathy.
Polymyositis and Dermatomyositis: Pathophysiology
159
Kanneboyina Nagaraju and
Ingrid
E.
Lundberg
Recent advances have increased the understanding of the pathogenesis
of polymyositis and dermatomyositis. Clearly, the pathogenesis is com¬
plex, and adaptive (eg, autoimmune) and innate and
nonimmune
pathways
play a role in the disease mechanisms, but the relative contribution may
vary between patients and in different phases of the disease. Phenotyping
patients using autoantibody profiling has resulted in information on molec¬
ular pathways that may be relevant in certain subsets of patients with poly¬
myositis or dermatomyositis, but combining the autoantibody profiles with
molecular signatures of innate and nonirhmune mechanisms would
enhance our ability to classify, diagnose, and treat these disorders more
effectively.
Inclusion Body Myositis: Diagnosis, Pathogenesis, and Treatment Options
173
Guillermo
E.
Solorzano and Lawrence H. Phillips II
Inclusion body myositis (IBM) is the most common acquired myopathy in
people older than
50
years. IBM typically presents with distal upper
extremity weakness accompanied by proximal lower extremity muscle
weakness. Associated clinical findings include asymmetric weakness,
foot drop, and dysphagia. The pathogenesis of IBM is not clear. In this
article the authors briefly discuss postulated pathogenic mechanisms.
Although no proven pharmacotherapy exists, some promising candidates
are discussed.
Paraneoplastic Muscle Disease
185
Alan
N.
Baer
In paraneoplastic muscle disease, the malignancy may remotely affect
neuromuscular transmission or incite muscle inflammation or necrosis. In
several of these diseases, an autoimmune basis for the muscle disease
Contents
has been established and has become a defining feature. These paraneo-
plastic muscle diseases may be the first manifestation of a malignancy,
and their diagnosis thus demands a vigilant search for an underlying
tumor. This article is focused on inflammatory and necrotizing
myopathies
and disorders of neuromuscular transmission that may arise in the setting
of malignancy and are considered paraneoplastic phenomena.
Metabolic
Myopathies:
Clinical Features and Diagnostic Approach
201
Edward C. Smith, Areeg El-Gharbawy, and Dwight D. Koeberl
The rheumatologist is frequently called on to evaluate patients with com¬
plaints of myalgia, muscle cramps, and fatigue. The evaluation of these
patients presents a diagnostic challenge given the nonspecific and inter¬
mittent nature of their complaints, often leading to inappropriate diagnos¬
tic testing. When these symptoms are associated with physical exertion,
a metabolic myopathy should be suspected Although inflammatory
myop¬
athies
may present with similar features, such a pattern should prompt
a thorough evaluation for an underlying metabolic myopathy. This review
discusses the most common causes of metabolic
myopathies
and reviews
the current diagnostic options available to the clinician.
Drugs Causing Muscle Disease
219
Adam
Mor,
Robert
L
Wortmann,
Hal
J.
Mitnick,
and Michael
H. Pillinger
Many drugs can cause
myopathies,
and such
myopathies
may range
widely from asymptomatic elevations in the serum
creatine
phosphokinase
levels to severe myalgias, cramps, exercise intolerance, muscle weak¬
ness, and even rhabdomyolysis. In this article, some of the commonly
used drugs that may induce
myopathies, as
well as the clinical pheno-
types, diagnosis, and management of these syndromes are reviewed.
Muscular Dystrophies and Neurologic Diseases that Present as Myopathy
233
Dianna Quan
Chronic muscle weakness is a common complaint among patients seen in
rheumatology and neuromuscular specialty clinics. This article focuses on
adult-onset muscular dystrophies, select hereditary
myopathies,
and other
neuromuscular conditions that must be distinguished from acquired
causes of inflammatory muscle disease such as polymyositis. A few orga¬
nizing principles help to focus the evaluation and narrow the differential
diagnosis.
Imaging of Skeletal Muscle
245
Douglas W. Goodwin
Various diagnostic imaging techniques such as sonography, computed to¬
mography, scintigraphy, radiography, and magnetic resonance imaging
(MRI)
have made possible the noninvasive evaluation of skeletal muscle in¬
jury and disease. Although these different modalities have roles to play,
MRI
is especially sensitive in the diagnosis of muscle disorders and injury
and has proved to be useful in determining the extent of disease, in direct¬
ing interventions, and in monitoring the response to therapies. This article
Contents
describes how magnetic resonance images are formed and how the signal
intensities in T1
-
and T2-weighted images may be used for diagnosis of the
above-mentioned conditions and injuries.
A Primer on Electrophysiologic Studies in Myopathy
253
Matthew
С
Lynch and Jeffrey A. Cohen
Electromyography and nerve conduction studies are the primary electro-
diagnostic studies employed in the evaluation of patients with weakness
and suspected myopathy. This article discusses the physiologic principles
that serve as a framework for understanding the purpose, limitations, and
interpretation of these tests. In the process the authors also review the
differential diagnosis of myopathy.
Molecular Diagnosis of
Myopathies
269
Andrew Gomez-Vargas and Steven K. Baker
Neuromuscular diseases (NMD) constitute a group of phenotypically and
genetically heterogeneous disorders, characterized by (progressive)
weakness and atrophy of proximal and/or distal muscles. The objective
of molecular testing is to confirm the pathogenicity of a relevant sequence
variation by correlating an individual s phenotype with what is expected in
a given condition. Within the last two decades the application of molecular
genetic strategies has led to a delineation of subgroups of clinically indis¬
tinguishable NMDs and has disclosed marked disease overlap. The
expanding number of molecular defined NMDs requires new strategies
to classify overlapping and clinical indistinguishable phenotypes.
Essential Muscle Pathology for the Rheumatologist
289
Brent T. Harris and Carrie A. Mohila
This review introduces/refreshes some basic histopathologic methods and
findings of skeletal muscle biopsies with emphasis on those diseases
commonly encountered in a rheumatologist s practice. The
3
general
areas of myopathology discussed are metabolic
myopathies,
toxic
myop¬
athies,
and inflammatory
myopathies.
The authors, neuropathologists,
hope to provide in this article what they think are some commonalities
and disease-specific methods in their pathologic workup, as well as a prac¬
tical approach to the collaboration that pathologists undertake with their
rheumatology colleagues to come to a working diagnosis.
Index
309
|
| any_adam_object | 1 |
| author_GND | (DE-588)1011577836 |
| building | Verbundindex |
| bvnumber | BV037384310 |
| classification_rvk | YC 8700 YG 6200 |
| ctrlnum | (OCoLC)730014669 (DE-599)BVBBV037384310 |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01396nam a2200349 cb4500</leader><controlfield tag="001">BV037384310</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20120917 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">110506s2011 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781455705030</subfield><subfield code="9">978-1-4557-0503-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)730014669</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV037384310</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YC 8700</subfield><subfield code="0">(DE-625)153265:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YG 6200</subfield><subfield code="0">(DE-625)153508:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Myopathies</subfield><subfield code="c">guest ed.: Robert L. Wortmann</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Philadelphia, Pa.</subfield><subfield code="b">Saunders</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">X S., S. 144 - 322</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Rheumatic disease clinics of North America</subfield><subfield code="v">37,2</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Muskelkrankheit</subfield><subfield code="0">(DE-588)4075131-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Muskelkrankheit</subfield><subfield code="0">(DE-588)4075131-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wortmann, Robert L.</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)1011577836</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Rheumatic disease clinics of North America</subfield><subfield code="v">37,2</subfield><subfield code="w">(DE-604)BV000625464</subfield><subfield code="9">37,2</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022537375&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-022537375</subfield></datafield></record></collection> |
| id | DE-604.BV037384310 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:23:09Z |
| institution | BVB |
| isbn | 9781455705030 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022537375 |
| oclc_num | 730014669 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | X S., S. 144 - 322 Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Saunders |
| record_format | marc |
| series | Rheumatic disease clinics of North America |
| series2 | Rheumatic disease clinics of North America |
| spelling | Myopathies guest ed.: Robert L. Wortmann Philadelphia, Pa. Saunders 2011 X S., S. 144 - 322 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Rheumatic disease clinics of North America 37,2 Muskelkrankheit (DE-588)4075131-4 gnd rswk-swf Muskelkrankheit (DE-588)4075131-4 s DE-604 Wortmann, Robert L. Sonstige (DE-588)1011577836 oth Rheumatic disease clinics of North America 37,2 (DE-604)BV000625464 37,2 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022537375&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Myopathies Rheumatic disease clinics of North America Muskelkrankheit (DE-588)4075131-4 gnd |
| subject_GND | (DE-588)4075131-4 |
| title | Myopathies |
| title_auth | Myopathies |
| title_exact_search | Myopathies |
| title_full | Myopathies guest ed.: Robert L. Wortmann |
| title_fullStr | Myopathies guest ed.: Robert L. Wortmann |
| title_full_unstemmed | Myopathies guest ed.: Robert L. Wortmann |
| title_short | Myopathies |
| title_sort | myopathies |
| topic | Muskelkrankheit (DE-588)4075131-4 gnd |
| topic_facet | Muskelkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022537375&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000625464 |
| work_keys_str_mv | AT wortmannrobertl myopathies |