Holdings: Transfusion therapy

Transfusion therapy: clinical principles and practice

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Bibliographic Details
Format:	Book
Language:	English
Published:	Bethesda, Md. AABB Press 2011
Edition:	3. ed.
Subjects:	Blood > Transfusion Blood products > Therapeutic use Anemia > Treatment Blood Transfusion Bluttransfusion Einführung
Online Access:	Inhaltsverzeichnis
Item Description:	Includes bibliographical references and index
Physical Description:	XXIII, 931 S. Ill., graph. Darst.
ISBN:	9781563953071 9783805596961

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adam_text	Table of Contents Preface ...................................................................xxi About the Editor ........................................................xxiii Use of Blood Components in Clinical Practice 1. The Use of Blood Components Prior to Invasive Bedside Procedures: A Critical Appraisal ..................................................1 Jamnie L. Callum, MD, FRCPţC), and Walter H. Dzik, MD Prophylactic Use of Blood Components Before Invasive Procedures ..............2 Assumptions that Underlie the Prophylactic Use of Blood Components .............3 Specific Bedside Procedures ...............................................10 References .............................................................29 2. Red Cell Transfusion Therapy in Anemia .................................37 Jay E. Menitove, MD Oxygen Transport Physiology .............................................38 Physiologic Compensatory Factors Affecting Oxygen Delivery ...................39 Critical Hemoglobin Concentration .........................................41 Clinical and Experimental Observations in Anemia ............................42 Confounding Factors .....................................................47 Conclusion .............................................................49 References .............................................................50 3. Transfusion Therapy in Autoimmune Hemolytic Anemia ...................55 Anne E Eder, MD, PhD Warm Autoimmune Hemolytic Anemia .....................................57 Cold Autoantibodies and Cold Agglutinin Syndrome ...........................69 Autoimmune Hemolytic Anemia with Both Warm and Cold Autoantibodies .......76 Transfusion Therapy: Clinical Principles and Practice Paroxysmal Cold Hemoglobinuria ..........................................76 Drug-Induced Immune Hemolytic Anemia ...................................79 Summary ..............................................................82 References .............................................................83 4. Transfusion Therapy in Congenital Hemolytic Anemias ....................87 Bruce I. Sharon, MD Hemoglobinopaťhies and Thalassemias ......................................87 Disorders of Red Cell Enzymes .......................................... 118 Disorders of Red Cell Membranes ........................................ 119 Conclusion ........................................................... 119 References ........................................................... 120 5. Treatment of Acquired Disorders of Hemostasis .........................127 Thomas L. Ortel, MD, PhD; Evelyn Lockhart, MD; and John E. Humphries, MD Blood Components and Products ......................................... 128 Hemostatic Agents ..................................................... 134 Acquired Coagulation Disorders .......................................... 137 Acquired Coagulation Inhibitors ..........................................151 Conclusion ........................................................... 155 References ........................................................... 155 6. Treatment of Congenital Coagulopathies ...............................167 Roshni Kulkami, MD; Meera Chitlur, MD; and Jeanne M. Lusher, MD Treatment of Hemophilia A and Hemophilia В .............................169 von Willebrand Disease ................................................ 187 Other Hereditary Disorders of Blood Coagulation ........................... 195 References ...........................................................203 7. Intrauterine, Neonatal, and Pediatric Transfusion Therapy ...............209 Edward C.C. Wong, MD, and Wendy Paul, MD Fetuses as Transfusion Recipients ........................................209 Neonates as Transfusion Recipients .......................................225 Transfusion Beyond the Neonatal Period ..................................239 Summary ............................................................251 References ...........................................................251 8. Transfusion Therapy in Surgery .......................................265 Richard К Spence, MD, MHA, FACS Recent Trends ........................................................265 Red Biood Cells in Surgery ..............................................266 Xli Table of Contents Transfusion in Trauma ..................................................276 Risks of Transfusion ....................................................279 Avoidance of Transfusion ................................................283 Platelets, Fresh Frozen Plasma, and Cryoprecipitate in Surgery .................290 Conclusion ............................................................291 References ............................................................292 9. Massive Transfusion and Transfusion Therapy in Trauma ................305 John R. Hess, MD, MPH, FACP, FAAAS; Pär I. Johansson, MD, МРА; and John B. Holcomb, MD, FACS Approach to Severely Injured Patients .....................................306 The Acute Coagulopathy of Trauma and Shock ..............................308 Military Surgical Experience ..............................................312 Other Experience and Studies ............................................313 Who Needs Damage- or Hemorrhage-Control Resuscitation? ...................314 The Lack of Level I Evidence ............................................315 The Need for Better Hemorrhage-Control Products ...........................316 Massive Transfusion Protocols ............................................317 Conclusions ...........................................................318 References ............................................................318 10. Transfusion Therapy in Critical Care ....................................323 Thinesh Dahanayake, MD; Patricia Janet Sime, MD, FRCP; Richard Phipps, PhD; and Neil Blumberg, MD Causes of Anemia in the ICU .............................................324 RBC Transfusion in the ICU ..............................................324 Risks of Transfusion ....................................................328 Emergency Transfusions ...............................-----..............330 Decreasing the Need for Transfusion ......................................331 Platelet Transfusion .....................................................332 FFP Transfusions .......................................................334 Conclusion ............................................................335 References ............................................................335 11. Transfusion Practice in Solid Organ Transplantation .....................339 Glenn Ramsey, MD, and Paul D. Mintz, MD Best-Accepted Practices .................................................340 Transfusion Support ....................................................342 Areas of Interest ...........................................·...........344 Immunohematologic Considerations .......................................345 Allograft Donor Infectious Disease Testing ..................................348 References ............................................................350 Transfusion Therapy: Clinical Principles and Practice 12. Transfusion Therapy in Therapeutic Apheresis ..........................355 Gay Wehrli, MD, MSEd Overview of Therapeutic Apheresis .......................................363 Therapeutic Apheresis Modalities ........................................364 Replacement Fluids for Therapeutic Apheresis ..............................377 Patient Evaluation .....................................................380 Patient Preparation ....................................................382 Procedure Complications ................................................384 Conclusion ...........................................................387 References ...........................................................387 Appendix 12-1. Table of Predicted Normal Blood Volumes in Men ...........392 Appendix 12-2. Table of Predicted Normal Blood Volumes in Women ........393 Appendix 12-3. Example of a Therapeutic Apheresis Service Consultation Form . 394 Blood Components and Derivatives 13. Platelet Transfusion Therapy ..........................................397 Deborah Sesok-Pizzini, MD, MBA, and Jay H. Herman, MD Platelet Products ......................................................398 Platelet Refractoriness: Etiology, Prevention, and Management ................404 Indications for Platelet Transfusion .......................................406 Transfusion Threshold and Prophylactic Transfusion ........................412 Assessment and Dose ..................................................413 Selected Adverse Events: Bacterial Contamination, Pathogen Reduction, and Alloimmunization ..................................................421 Platelet Additive Solutions ..............................................422 Red Blood Cell Transfusion for Thrombocytopenic and Thrombocytopamic Bleeding ..........................................................424 Conclusion ...........................................................425 References ...........................................................426 14. Granulocyte (Neutrophil) Transfusion Therapy ..........................433 Ronald G. Strauss, MD Therapeutic Granulocyte (Neutrophil) Transfusions ..........................434 Prophylactic Granulocyte (Neutrophil) Transfusions ..........................441 Methods for PMN Collection and Transfusion ...............................443 References ...........................................................445 15. Immune Globulin Therapy ............................................449 E. Richard Stiehm, MD Animal Sera and Antitoxins.............................................449 Table of Contents Human Immunoglobulins ................................................453 Intramuscular Immune Globulin ..........................................454 Intravenous Immunoglobulin .............................................455 Subcutaneous Immunoglobulin ...........................................462 Advantages and Disadvantages of IGSC ....................................463 Effectiveness of IGIV or IGSC in Primary Antibody Deficiencies ...............463 IGIV or IGSC in Combined Immunodeficiencies .............................463 IGIV in Secondary Antibody Deficiencies ...................................463 Immunoglobulin Therapy in Infection ......................................466 IGIV in Inflammatory and Autoimmune Disorders ...........................471 Monoclonal Antibodies ..................................................477 Special Immunoglobulins for Noninfectious Use ..............................481 Immunoglobulin Use by Unusual Routes ...................................481 Future Directions .......................................................482 References ............................................................482 16. Rh Immune Globulin ..................................................493 Paul D. Mintz, MD Overview of RhIG Use .................................................494 Testing and Treatment of Women Who Are Pregnant or Have Been Pregnant Recently ...................................................495 Antenatal Fetal D Genoryping ............................................497 Testing the Father ......................................................499 Dose of RhIG ..........................................................499 Failure of Prophylaxis ...................................................500 Risks of RhIG Administration .............................................501 Special Circumstances ...................................................502 Prevention of D Alloimmunization after Transfusion of D-Positive Red Cells ..........................................................504 Conclusion ............................................................508 References ............................................................508 17. Clinical Uses of Fibrin Sealant ..........................................511 William D. Spotnitz, MD, MBA Abdominal Surgery .....................................................513 Cardiovascular Surgery ..................................................516 Dental Surgery .........................................................518 Head and Neck Surgery .................................................518 Neurosurgery ..........................................................519 Obstetric and Gynecologic Surgery ........................................521 Oncology Surgery (Breast and Inguinal Dissection Procedures) .................521 Ophthalmologic Surgery .................................................522 Orthopedic Surgery .....................................................523 Transfusion Therapy: Clinical Principles and ftactice Plastic Surgery ........................................................524 Thoracic Surgery ......................................................525 Urologie Surgery ......................................................526 Vascular Surgery ......................................................527 Conclusion ...........................................................527 References ...........................................................527 18. Transfusion Therapy in Hematopoietic Progenitor and Stem Cell Transplantation ...................................................539 Richard С Friedberg, MD, PhD, FCAP, and Chester Andrzejeivskijr, PhD, MD,FCAP Provision of Blood Components ..........................................540 Modifications to Blood Components .......................................548 Hematopoietic Progenitor Cell Products ...................................552 Conclusion ...........................................................552 References ...........................................................553 19. Lymphocytes as Transfusion Immunotherapy ...........................559 Hanh M. Khuu, MD, and Harvey G. Klein, MD Introduction ..........................................................560 Lymphocytes, Minimally Manipulated .....................................562 Lymphocytes, More than Minimally Manipulated ............................567 Regulatory Considerations ..............................................571 References ...........................................................572 20. The Role of Hematopoietic Growth Factors in Transfusion Medicine ......583 Carolyn F. Whitsett,MD Erythropoiesis Stimulating Agents ........................................ 584 Myeloid Growth Factors ................................................ 604 Clinical Indications ..................................................... 606 Thrombopoiesis Stimulating Agents ....................................... 611 Conclusion ........................................................... 615 References ........................................................... 615 Appendix 20-1. NCCN Guidelines on Myeloid Growth Factors ................ 626 21. Alloimmunization to Red Cell Antigens and Management of Alloimmunized Patients ............................................631 James C. Zimring, MD, PhD, and Steven L. Spitalnik, MD Induction of Alloantibodies by Red Cell Transfusion .........................632 Management of Alloimmunized Patients ...................................637 Summary ............................................................640 References ...........................................................640 XVI Table of Contents Preventing and Managing Adverse Events 22. Transfusion-Associated Graft-vs-Host Disease ............................643 Jed B. Gorlin, MD, and Paul D. Mintz, MD History ...............................................................643 Clinical Manifestations ...................................................644 Irradiation ............................................................645 General Indications for Irradiation .........................................649 Which Components May Cause TA-GVHD? ................................649 Indications for Irradiating Cellular Blood Components ........................649 Alternatives to Irradiation ................................................656 Conclusion ............................................................657 References ............................................................657 23. Leukocyte-Reduced and Cytomegalovirus-Reduced-Risk Blood Components .................................................665 Pamela Clark, MDJD, and John P. Miller, MD, PhD Leukocyte Reduction: Definition, Mechanisms, Timing, and Potential Adverse Effects .............................................................665 Febrile Nonhemolytic Transfiision Reactions ................................667 Prevention of Alloimmunization and Platelet Refractoriness ....................669 Use of Cytomegalovirus-Reduced-Risk Blood Components ....................673 Transfusion-Related Immune Modulation ...................................680 Practical Considerations .................................................686 Summary .............................................................687 References ............................................................687 24. Alternatives to Allogeneic Transfusion in Patients with Surgical Anemia. .. .699 Lawrence T. Goodnough, MD Perioperative Autologous Blood Donation and Transfusion ....................699 Pharmacologie Interventions to Reduce AUogeneic Blood Transfusion ...........707 Conclusion ............................................................714 References ............................................................715 25. Pathogen Reduction Techniques ........................................721 Joseph P. R Pelletier, MD, and Christopher A. Tormey, MD Overview .............................................................721 Solvent/Detergent Treatment .............................................724 Methylene Blue ........................................................728 Amotosalen ...........................................................731 FRALE ...............................................................736 PENI 10..............................................................737 XVII Transfusion Therapy: Clinical Principles and Practice Riboflavin ............................................................741 Clinical Trials of Pathogen-Reduced Blood Components ......................744 Transfusion-Associated Graft-vs-Host Disease ...............................749 Conclusion ...........................................................750 References ...........................................................750 26. Management of Transfusion Reactions .................................757 Robertson D. Davenport, MD Febrile Nonhemolytic Reactions ..........................................757 Allergic Reactions .....................................................762 Severe Allergic (Anaphylactic) Reactions ...................................763 Acute Hemolytic Reactions ..............................................764 Delayed Hemolytic Reactions ............................................767 Bacterial Contamination of Blood Components .............................769 Transfusion-Related Acute Lung Injury ....................................770 Posttransfusion Purpura................................................ 772 Graft-vs-Host Disease ...................................................773 Hypotensive Reactions .................................................773 Nonimmune Hemolysis .................................................774 Transfusion-Associated Circulatory Overload ...............................775 Transfusion-Related Hypothermia ........................................776 Transfusion-Related Hyperkalemia .......................................777 Transfusion-Related Acid-Base Abnormalities ..............................777 Acute Pain Transfusion Reaction .........................................778 References ...........................................................778 Quality in Transfusion Practice 27. Administration of Blood Componente ..................................785 Joanne L. Becker, MD Preadministration Issues ................................................785 Blood Administration ..................................................787 Current Practices ......................................................792 Conclusion ...........................................................794 References ...........................................................794 28. Hemovigilance: An Approach to Risk Management in Transfusion Medicine .........................................................797 Cees Th. Smit Sibinga, MD, PhD, FRCPEdin, FRCPath, and Michael E Murphy, MD, FRCP, FRCPath Overview of Hemovigilance .............................................798 Public Health Objectives ................................................798 Table of Contents Transfusion Chain ......................................................799 Transfusion Reactions ...................................................800 Transfusion Quality System ..............................................802 Classification of Adverse Events to Transfusion ..............................802 Organizational Structure and Levels of Reporting ............................803 Use of Data by the French and UK Hemovigilance Systems to Reduce Adverse Events Associated with Transfusion .............................804 Contribution of Hemovigilance to Public Health .............................808 Implementation ........................................................809 Most Commonly Encountered Difficulties ...................................810 Conclusion ............................................................810 References ............................................................810 29. Quality Assessment and Improvement of Blood Transfusion Practices ......813 Paul D. Mintz, MD History ...............................................................815 Errors in Transfusion Practice ............................................815 Accreditation and Regulatory Requirements ................................817 The Transfusion Committee ..............................................818 Conclusion ............................................................832 References ............................................................832 30. Overview of Medical-Legal Issues in Transfusion Medicine in the United States ................................................837 Hon. Edward D. Bronfin and Pamela Clark, MD,JD Applicable Legal Principles ...............................................837 Strict Products Liability/Breach of Warranties and Blood Shield Laws ...........838 Summary .............................................................850 References ............................................................851 Appendix 30-1. Blood Shield Laws as of May 2010..........................853 Summation 31. To Transfuse or Not to Transfuse: An Assessment of Risks and Benefits -----855 Manan Petrides, MD, and James P. AuBuchon, MD Noninfectious Risks of Transfusion ........................................855 Infectious Risks of Transfusion ............................................863 Indications for Transfusion ...............................................875 Conclusions ........................................·..................888 References ............................................................889 Index ....................................................................901
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spelling	Transfusion therapy clinical principles and practice ed.: Paul D. Mintz 3. ed. Bethesda, Md. AABB Press 2011 XXIII, 931 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Blood Transfusion Blood products Therapeutic use Anemia Treatment Bluttransfusion (DE-588)4007293-9 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Bluttransfusion (DE-588)4007293-9 s b DE-604 Mintz, Paul D. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022495640&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Transfusion therapy clinical principles and practice Blood Transfusion Blood products Therapeutic use Anemia Treatment Bluttransfusion (DE-588)4007293-9 gnd
subject_GND	(DE-588)4007293-9 (DE-588)4151278-9
title	Transfusion therapy clinical principles and practice
title_auth	Transfusion therapy clinical principles and practice
title_exact_search	Transfusion therapy clinical principles and practice
title_full	Transfusion therapy clinical principles and practice ed.: Paul D. Mintz
title_fullStr	Transfusion therapy clinical principles and practice ed.: Paul D. Mintz
title_full_unstemmed	Transfusion therapy clinical principles and practice ed.: Paul D. Mintz
title_short	Transfusion therapy
title_sort	transfusion therapy clinical principles and practice
title_sub	clinical principles and practice
topic	Blood Transfusion Blood products Therapeutic use Anemia Treatment Bluttransfusion (DE-588)4007293-9 gnd
topic_facet	Blood Transfusion Blood products Therapeutic use Anemia Treatment Bluttransfusion Einführung
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