Activins and inhibins:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier
2011
|
| Edition: | 1. ed. |
| Series: | Vitamins and hormones
85 |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Einzelaufn. für Zeitschr.-H. |
| Physical Description: | XVIII, 349 S. Ill., graph. Darst. |
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MARC
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| 245 | 1 | 0 | |a Activins and inhibins |c ed.-in-chief: Gerald Litwack |
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| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2011 | |
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| 490 | 0 | |a Vitamins and hormones |v 85 | |
| 500 | |a Einzelaufn. für Zeitschr.-H. | ||
| 700 | 1 | |a Litwack, Gerald |e Sonstige |4 oth | |
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Record in the Search Index
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| adam_text | Titel: Activins and inhibins
Autor: Litwack, Gerald
Jahr: 2011
Contributors xiii
Preface xvii
1. Activin Receptor-Like Kinase and the Insulin Gene i
Rie Watanabe
I. Introduction 2
II. TGF-ß Family Receptors: ALK 3
III. Activin Isoforms A, B, and AB 5
IV. Nodal 9
V. Insulin Gene Regulation 9
VI. Conclusion 15
Acknowledgments 16
References 16
2. Crystal Structure of Activin Receptor Type IIB Kinase Domain 29
Seungil Han
I. Introduction 30
II. Type I Receptor Kinase Domain Structures 31
III. 3D Structure of ActRIIB 32
IV. Conclusion 36
References 36
3. Activin/Nodal Signaling and Pluripotency 39
Zhenzhi Chng, Ludovic Valuer, and Roger Pedersen
I. Introduction 40
II. Conclusion 51
References 52
4. Intracrine Signaling Mechanisms of Activin A and TGF-ß 59
Olav A. Gressner
I. Common TGF-ß and Activin A Signaling and Target Genes:
Focusing on CTGF/CCN2 60
viii Contents
II. The Early Response to Cellular Stress: Intracellular
Activation of TGF-ß 61
III. Continuous Low-Level Activation of Activin A/TGF-ß Target Genes 63
IV. Intracrine Signaling: General Aspects 65
V. Intracrine Signaling of TGF-ß: The Stimulatory Pathway 66
VI. Intracrine Signaling of TGF-ß: The Inhibitory Pathway 70
VII. Intracrine Activin A Signaling 72
VIII. Conclusion 73
References 74
5. Negative Regulation of Activin Signal Transduction 79
Sun-Cheol Choi and Jin-Kwan Han
I. Introduction 80
II. Extracellular Antagonists 82
III. Negative Regulation of Activin Receptor Function 85
IV. Inhibitory Smads 89
V. Interfering with Smad Function 90
VI. Negative Regulation of Gene Transcription 94
VII. Conclusions 97
Acknowledgments 98
References 98
6. Antagonism of Activin by Activin Chimeras 105
Uwe Muenster, Radhika Korupolu, Ratindra Rastogi, Jessica Read,
and Wolfgang H. Fischer
I. Introduction 106
II. The Activin/BMP Receptor System 107
III. Design of Chimeras 115
IV. Assessment of Binding and Biological Properties of Chimeras 116
V. Summary, Conclusions, and Future Directions 121
Acknowledgments 123
References 123
7. Activins and Cell Migration 129
Hong-Yo Kang and Chih-Rong Shyr
I. Introduction 130
II. Molecular Mechanism of Activin Signaling Regulated Cell Migration 132
III. The Role of Activins in the Regulation of Tumor
Cell Migration and Metastasis 134
IV. The Role of Activins in the Modulation of Immune Cell Migration 139
V. Conclusion and Future Prospective 142
Acknowledgments 143
References 144
Contents ix
8. The Synthesis and Secretion of Inhibins 149
Kelly L. Walton, Yogeshwar Makanji, David M. Robertson,
and Craig A. Harrison
I. Introduction 150
II. Inhibin Expression and Regulation 151
III. Expression Profile of Inhibin in Human Tissues 155
IV. Inhibin Assembly 159
V. Circulating Inhibin Forms 164
VI. Concluding Remarks 170
References 171
9. Multifunctional Roles of Activins in the Brain 185
Hiroshi Ageta and Kunihiro Tsuchida
I. Introduction 186
II. Expression Pattern of Activin and Activin Receptor in the Brain 187
III. Activin Receptor and its Regulatory Proteins 188
IV. Functions of Activins in the CNS 189
V. Conclusion and Perspectives 200
Acknowledgments 201
References 201
10. The Role of Activin/Nodal and Wnt Signaling in
Endoderm Formation 207
Catherine Payne, Jason King, and David Hay
I. Introduction 208
II. TGFß Signaling 209
III. WNT/ß-Catenin Signaling 210
IV. Applied Biology 212
V. Conclusions 214
Acknowledgments 214
References 214
11. Activin in Glucose Metabolism 217
Osamu Hashimoto and Masayuki Fuñaba
I. Introduction 218
II. Activin Activity in Insulin-Producing and Insulin-Sensitive Tissues 219
III. Activin in Adipose Tissue Inflammation 225
IV. Conclusions and Future Directions 226
Acknowledgments 228
References 228
x Contents
12. Activin in Humoral Immune Responses 235
Kenji Ogawa and Masayuki Fuñaba
I. Introduction 236
II. Activin A in Th2 Cells 237
III. Activin A in B Cells 239
IV. Activin A in Macrophages 240
V. Activin A in Mast Cells 242
VI. Conclusions and Future Directions 246
References 248
13. The Regulation and Functions of Activin and
Follistatin in Inflammation and Immunity 255
Mark P. Hedger, Wendy R. Winnall, David J. Phillips,
and David M. de Kretser
I. Introduction 256
II. Molecular Biology of Activin 258
III. Production and Regulation of Activin and Follistatin 264
IV. Activin Actions 270
V. Conclusions 280
References 281
14. Feedback Regulation by Inhibins A and B of the
Pituitary Secretion of Follicle-Stimulating Hormone 299
Yogeshwar Makanji, Craig A. Harrison,
and David M. Robertson
I. Introduction 300
II. Structure, Mechanism of Action, and Function of
Inhibins and Activins 301
III. Inhibins A and B Mediated FSH Suppression in
Males and Females 305
IV. Understanding the Increased Potency of Inhibin B
In Vivo and In Vitro 312
Acknowledgments 317
References 317
15. Activin A in Nonalcoholic Fatty Liver Disease 323
Arne Yndestad, John Willy Haukeland, Tuva B. Dahl, Bente Halvorsen,
and Pal Aukrust
I. Introduction 324
II. Nonalcoholic Fatty Liver Disease 325
III. Activin A in Liver Biology and Pathology 329
Contents xi
IV. Activin A in NAFLD 331
V. Conclusion and Future Perspectives 337
References 338
Index 343
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| id | DE-604.BV037298665 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:55:35Z |
| institution | BVB |
| language | English |
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| physical | XVIII, 349 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Elsevier |
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| series2 | Vitamins and hormones |
| spelling | Activins and inhibins ed.-in-chief: Gerald Litwack 1. ed. Amsterdam [u.a.] Elsevier 2011 XVIII, 349 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 85 Einzelaufn. für Zeitschr.-H. Litwack, Gerald Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021211115&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Activins and inhibins |
| title | Activins and inhibins |
| title_auth | Activins and inhibins |
| title_exact_search | Activins and inhibins |
| title_full | Activins and inhibins ed.-in-chief: Gerald Litwack |
| title_fullStr | Activins and inhibins ed.-in-chief: Gerald Litwack |
| title_full_unstemmed | Activins and inhibins ed.-in-chief: Gerald Litwack |
| title_short | Activins and inhibins |
| title_sort | activins and inhibins |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021211115&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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