Macromolecular crystallization and crystal perfection:
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford
Oxford Univ. Press
2010
|
| Edition: | 1. publ. |
| Series: | IUCr monographs on crystallography
24 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | X, 221 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9780199213252 0199213259 |
Staff View
MARC
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| 100 | 1 | |a Chayen, Naomi E. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Macromolecular crystallization and crystal perfection |c Naomi E. Chayen ; John R. Helliwell ; Edward H. Snell |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford |b Oxford Univ. Press |c 2010 | |
| 300 | |a X, 221 S. |b Ill., graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
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Record in the Search Index
| _version_ | 1804143935353782272 |
|---|---|
| adam_text | IMAGE 1
PREFACE
P. IX
ACKNOWLEDGEMENTS
P. XI
INTRODUCTION AND OVERVIEW
INTRODUCTION P. 3 CRYSTAL GROWTH P. 4 DIFFRACTION TECHNIQUES P. 6 X-RAYS
P. 6 NEUTRONS P. 7 CRYSTAL VOLUME AND QUALITY P. 9 SHORT-RANGE ORDER
(INTERMOLECULAR) P. 10 LONG-RANGE ORDER (DOMAIN STRUCTURE) P. 14 THE
COMBINATION OF SHORT- AND LONG-RANGE ORDER P. 16 CHAPTER SUMMARY P. 17
CRYSTALLIZATION CRYSTALLIZATION THEORY P. 21 CHAPTER SUMMARY P. 23
PRACTICAL METHODS OF CRYSTALLIZATION P. 24 BATCH P. 24 VAPOUR DIFFUSION
P. 25 DIALYSIS P. 26 FREE INTERFACE DIFFUSION P. 26 CONVERTING BETWEEN
METHODS P. 27 CHAPTER SUMMARY P. 28 SCREENING P. 29 SCREENS: PROBLEMS
AND NEW DEVELOPMENTS P. 29 AUTOMATION-AND MINIATURIZATION OF SCREENING
PROCEDURES P. 29 THE EFFECT OF HIGH-THROUGHPUT: CRYSTALLIZATION ROBOTICS
P. 34 ANALYSIS OF LARGE QUANTITIES OF CRYSTALLIZATION DATA P. 34
EXPERIMENT VOLUME CONSIDERATIONS P. 37 IMAGING AND MONITORING OF
CRYSTALLIZATION TRIALS P. 37 CHAPTER SUMMARY P. 37 OPTIMIZATION P. 38
PRACTICAL USES OF THE CRYSTALLIZATION PHASE DIAGRAM P. 38 METHODS FOR
SEPARATING NUCLEATION AND GROWTH P. 40 SEEDING P. 41 DILUTION TECHNIQUES
P. 42 THE APPLICATION O FLIGHT-SCATTERING TECHNIQUES P. 44 STATIC LIGHT
SCATTERING P. 44 DYNAMIC LIGHT SCATTERING P. 44 CHAPTER SUMMARY P. 47
STRATEGIES TO APPLY WHEN HIGH-QUALITY CRYSTALS CANNOT BE OBTAINED P. 48
IMAGE 2
INTRODUCTION
P. 48
NON-COVALENT MODIFICATION OF THE SAMPLE
P. 48
COVALENT MODIFICATION OF THE SAMPLE
P. 49
REDUCTIVE METHYLATION
P. 49
GENERAL CHEMICAL MODIFICATION
P. 50
MUTAGENESIS, DOMAIN REFINEMENT AND HOMOLOGUES
P. 50
SURFACE-ENTROPY REDUCTION
P. 50
PROTEOLYSIS
P. 51
ORTHOLOGUES AND HOMOLOGUES
P. 51
ANTIBODY FRAGMENTS
P. 52
CHAPTER SUMMARY
P. 52
MEMBRANE PROTEINS
P. 53
INTRODUCTION
P. 53
CRYSTALLIZATION
P. 53
SCREENING WITH DETERGENTS
P. 55
LIPIDIC CUBIC-PHASE CRYSTALLIZATION
P. 55
ANTIBODY FRAGMENT APPROACHES
P. 56
CHARACTERIZATION USING NEUTRON-ENHANCED CONTRAST
P. 56
CHAPTER SUMMARY
P. 56
ALTERNATIVE APPROACHES
P. 58
GEL GROWTH
P. 58
MICROGRAVITY
P. 59
INTERFEROMETRY
P. 59
DEPLETION ZONE
P. 60
MICROFLUIDICS
P. 61
MAGNETIC AND ELECTRIC FIELDS
P. 62
CHAPTER SUMMARY
P. 64
DIFFRACTION
EXPERIMENTAL ASPECTS P. 67 THE DIFFRACTION PATTERN P. 67 STRUCTURAL
DETAIL P. 70 DETERMINING STRUCTURE WHEN THE RESOLUTION IS NOT IDEAL P.
72 HOW ACCURATE IS THE STRUCTURE? P. 73 CHAPTER SUMMARY P. 76 ANALYSIS
OF THE MOLECULAR SHORT-RANGE ORDER P. 78 STRUCTURAL DATA P. 78 THERMAL
MOTION AND DIFFUSE SCATTERING P. 79 DIFFUSE SCATTERING AS A SOURCE OF
MEASUREMENT ERROR IN THE BRAGG INTENSITIES P. 81 CHAPTER SUMMARY P. 82
ANALYSIS OF LONG-RANGE ORDER P. 83 REFLECTION PROFILING P. 83
IMAGE 3
TOPOGRAPHY
P. 88
PHOTOGRAPHY-BASED TOPOGRAPHY
P. 89
DIGITAL-BASED TOPOGRAPHY
P. 90
RECIPROCAL-SPACE MAPPING
P. 91
COMBINATIONAL ANALYSIS AND CHAPTER SUMMARY
P. 94
MACROMOLECULAR CRYSTALS AND TWINNING
P. 96
HISTORICAL EXAMPLES
P. 97
TYPES OF TWINNING
P. 98
THE TWIN FRACTION AND TESTING FOR TWINNED DATA
P. 102
USING TWINNED DATA
P. 104
OVERCOMING TWINNING IN CRYSTALS
P. 105
HOW PREVALENT IS TWINNING?
P. 109
CHAPTER SUMMARY
P. 110
OTHER MACROMOLECULAR CRYSTAL DIFFRACTION DISORDERS
P. 112
INTRODUCTION
P. 112
CASE STUDIES
P. 112
CHAPTER SUMMARY
P. 118
DEGRADATION AND IMPROVEMENT OF CRYSTAL PERFECTION
P. 119
AGEING
P. 119
RADIATION DAMAGE
P. 119
CRYO-COOLING
P. 124
DEHYDRATION AND HUMIDITY CONTROL
P. 127
CHAPTER SUMMARY
P. 131
UNUSUAL DIFFRACTION GEOMETRIES
P. 132
CHAPTER SUMMARY
P. 136
MAKING THE MOST OF DIFFICULT CRYSTALS - BEAMLINE AND DETECTOR
OPTIMIZATION P. 137
INTRODUCTION
P. 137
GEOMETRY AND END-STATION INSTRUMENTATION
P. 137
SIGNAL AND NOISE CONSIDERATIONS
P. 138
VERY SMALL CRYSTAL VOLUME MICROCRYSTALS
P. 143
PHASING AND THE AVAILABLE INSTRUMENTATION
P. 147
ROBOTICS, TELEPRESENCE AND REMOTE ACCESS
P. 148
MORE SPECIALIZED APPLICATIONS
P. 149
CHAPTER SUMMARY
P. 150
PROTEIN POWDERS-MAKING THE MOST OF TINY CRYSTALLITES IN BULK
P. 151
INTRODUCTION
P. 151
QUANTITATIVE PROTEIN POWDER ANALYSES HAVE OPENED UP IN RECENT YEARS P.
152
STRUCTURE DETERMINATION OF UNKNOWN PROTEINS?
P. 154
CHARACTERIZATION OF PROTEIN CRYSTAL POLYMORPHISM
P. 155
CHAPTER SUMMARY
P. 156
COMPLEMENTARY TECHNIQUES
P. 158
IMAGE 4
CHAPTER SUMMARY
P. 159
THE FUTURE
THE X-RAY LASER AND THE SINGLE MOLECULE - NO CRYSTAL NEEDED? P. 163
OVERALL SUMMARY AND FUTURE THOUGHTS P. 168 GLOSSARY OF ABBREVIATIONS,
TERMS AND SYMBOLS P. 170 ABBREVIATIONS P. 170 GENERAL P. 170 SYNCHROTRON
SOURCES P. 171 NEUTRON SOURCES P. 171 TERMS P. 171 CRYSTALLIZATION P.
171 X-RAY ANALYSIS P. 172 SYMBOLS P. 173 CRYSTALLIZATION AND
CRYSTAL-GROWTH-MONITORING SYMBOLS P. 173 DIFFRACTION SYMBOLS P. 174
REFERENCES P. 175 INDEX P. 219 TABLE OF CONTENTS PROVIDED BY BLACKWELL S
BOOK SERVICES AND R.R. BOWKER. USED WITH PERMISSION.
|
| any_adam_object | 1 |
| author | Chayen, Naomi E. Helliwell, John R. Snell, Edward H. |
| author_facet | Chayen, Naomi E. Helliwell, John R. Snell, Edward H. |
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| id | DE-604.BV037297730 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:55:34Z |
| institution | BVB |
| isbn | 9780199213252 0199213259 |
| language | English |
| lccn | 2010279200 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021210202 |
| oclc_num | 699670510 |
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| owner | DE-19 DE-BY-UBM DE-703 DE-355 DE-BY-UBR |
| owner_facet | DE-19 DE-BY-UBM DE-703 DE-355 DE-BY-UBR |
| physical | X, 221 S. Ill., graph. Darst. 24 cm |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| series | IUCr monographs on crystallography |
| series2 | IUCr monographs on crystallography |
| spelling | Chayen, Naomi E. Verfasser aut Macromolecular crystallization and crystal perfection Naomi E. Chayen ; John R. Helliwell ; Edward H. Snell 1. publ. Oxford Oxford Univ. Press 2010 X, 221 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier IUCr monographs on crystallography 24 Kristallisation (DE-588)4033215-9 gnd rswk-swf Makromolekül (DE-588)4037172-4 gnd rswk-swf Makromolekül (DE-588)4037172-4 s Kristallisation (DE-588)4033215-9 s DE-604 Helliwell, John R. Verfasser aut Snell, Edward H. Verfasser aut IUCr monographs on crystallography 24 (DE-604)BV005455767 24 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021210202&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chayen, Naomi E. Helliwell, John R. Snell, Edward H. Macromolecular crystallization and crystal perfection IUCr monographs on crystallography Kristallisation (DE-588)4033215-9 gnd Makromolekül (DE-588)4037172-4 gnd |
| subject_GND | (DE-588)4033215-9 (DE-588)4037172-4 |
| title | Macromolecular crystallization and crystal perfection |
| title_auth | Macromolecular crystallization and crystal perfection |
| title_exact_search | Macromolecular crystallization and crystal perfection |
| title_full | Macromolecular crystallization and crystal perfection Naomi E. Chayen ; John R. Helliwell ; Edward H. Snell |
| title_fullStr | Macromolecular crystallization and crystal perfection Naomi E. Chayen ; John R. Helliwell ; Edward H. Snell |
| title_full_unstemmed | Macromolecular crystallization and crystal perfection Naomi E. Chayen ; John R. Helliwell ; Edward H. Snell |
| title_short | Macromolecular crystallization and crystal perfection |
| title_sort | macromolecular crystallization and crystal perfection |
| topic | Kristallisation (DE-588)4033215-9 gnd Makromolekül (DE-588)4037172-4 gnd |
| topic_facet | Kristallisation Makromolekül |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021210202&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV005455767 |
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