Replication of bulky DNA adducts: = Replikation von sterisch anspruchsvollen DNA Addukten
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
München
Verl. Dr. Hut
2010
|
| Ausgabe: | 1. Aufl. |
| Schriftenreihe: | Organische Chemie
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:19-125267 Inhaltsverzeichnis |
| Beschreibung: | XX, 169 S. Ill., graph. Darst. |
| ISBN: | 9783868537444 |
Internformat
MARC
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| 100 | 1 | |a Schorr, Stephanie |d 1982- |e Verfasser |0 (DE-588)143465287 |4 aut | |
| 245 | 1 | 0 | |a Replication of bulky DNA adducts |b = Replikation von sterisch anspruchsvollen DNA Addukten |c Stephanie Schorr |
| 246 | 1 | 1 | |a Replikation von sterisch anspruchsvollen DNA Addukten |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |a München |b Verl. Dr. Hut |c 2010 | |
| 300 | |a XX, 169 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Organische Chemie | |
| 502 | |a Zugl.: München, Univ., Diss., 2010 | ||
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Datensatz im Suchindex
| _version_ | 1804143815993327616 |
|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
1 SUMMARY_ IX
2 ZUSAMMENFASSUNG XV
3 INTRODUCTION 1
3.1 CHEMICALLY INDUCED DNA DAMAGE 1
3.2 FORMATION OF BULKY DNA ADDUCTS 3
3.2.1 FORMATION OF DNA ADDUCTS BY AROMATIC AMINES 3
3.2.2 FORMATION OF OTHER BULKY ADDUCTS 6
3.3 THE BULKY C8-DG ADDUCTS ARE MUTAGENIC 7
3.4 EUKARYOTIC LOW FIDELITY DNA POLYMERASES 9
3.4.1 POFYMERASE SWITCH 10
3.4.2 POLRI 11
3.4.3 POIK 12
3.4.4 POL I 13
3.4.5 POLC H
3.4.6 REVL 14
3.5 CRYSTALLOGRAPHIC SNAPSHOTS OF BULKY DNA ADDUCT BLOCKAGE AND BYPASS
15
3.6 REPAIR OF BULKY DNA ADDUCTS 18
4 AIMS OF THE PROJECT 21
5 SYNTHESIS OF C8-DEOXYGUANOSINE ADDUCTS 23
6 INCORPORATION OF C8- DG ADDUCTS INTO OLIGONUCLEOTHJES 31
6.1 SOLID PHASE DNA SYNTHESIS 31
6.2 PURIFICATION AND CHARACTERIZATION OF THE VARIOUS C8-DG ADDUCT
CONTAINING
OLIGONUCLEOTIDES 32
6.2.1 HPLCPURIFICATION AND CHARACTERIZATION VIA MALD1-T0F MASS
SPECTROMETRY 32
6.2.2 ENZYMATIC DIGESTION ANALYSIS 35
6.2.3 MELTING POINT ANALYSIS 40
7 BYPASS OF BULKY DNA ADDUCTS BY Y-FAMILY DNA POLYMERASES 43
7. 1 TRANSLESION SYNTHESIS OF BULKY DNA ADDUCTS BY POL T] 43
7.1.1 PURIFICATION OF YEAST PO! N 43
7.1.2 MECHANISM OF REPLICATION BLOCKING AND BYPASS OF POL R BY AAF-DG
ADDUCTS 44
7.1.3 CRYSTALLIZATION EXPERIMENTS WITH OTHER BULKY ADDUCTS 57
7.1.4 MECHANISM OFACETYLAMINOFLUORENE-DG INDUCEDFRAMESHIFTING 59
7.2 BYPASS OF BULKY DNA ADDUCTS BY POL K 67
7.2.1 CLONING, EXPRESSION AND PURIFICATION OF HUMAN POL K 67
7.2.2 PRIMER EXTENSION STUDIES WITH POL K 68
7.2.3 PRELIMINARY CRYSTALLIZATION SCREENS WITH C8-DG CONTAINING
OLIGONUCLOTIDES AND THE LOW FIDELITY
POFYMERASE K 72
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1009330276
DIGITALISIERT DURCH
IMAGE 2
8 CO-CRYSTALLIZATION OF AAF-DG CONTAINING OLIGONUCLEOTIDES WITH THE
NER PROTEINS RAD14 FROM YEAST AND ITS HUMAN HOMOLOGUE XPA 73
8.1 PURIFICATION OF RAD14 AND XPA 73
8.2 CRYSTALLIZATION OF RAD14/XPA IN COMPLEX WITH AN AAF-DG CONTAINING
DNA DUPLEX 74
8.3 PHASE DETERMINATION FOR STRUCTURE SOLUTION OF THE RAD 14 CRYSTALS 76
8.4 DISCUSSION 78
9 CONCLUSION AND OUTLOOK 79
10 EXPERIMENTAL 83
10.1 GENERAL CHEMICAL MATERIALS AN METHODS 83
10.2 OUGONUCLEOTIDE SYNTHESIS AND CHARACTERIZATION 85
10.2.1 AUTOMATED DNA SYNTHESIS 85
86
88
88
89
89
90
90
92
93
93
94
94
95
95
95
95
96
98
99
99
99
100
100
104
104
105
105
108
VI
10.2.2 10.2.3
10.2.4
10.2.5
10.2.6
PURIFICATION OF BULKY ADDUCT CONTAINING OLISONUCLEOTIDES
PREPARATION OFAF-DG CONTAININZ OLIGONUCLEOTIDES
DNA QUANTIFICATION
MELTING POINT MEASUREMENTS
ENZYMATIC DNA DIGESTION
10.3 BIOCHEMICAL MATERIALS
10.3.1
10.3.2
10.3.3
10.3.4
10.3.5
10.3.6
10.3.7
BUFFERS
EQUIPMENT
BACTERIAL STRAINS
MEDIA
SOLUTIONS
ANTIBIOTICS ANDLNDUCERS
ENZYMES
10.4 BIOCHEMICAL METHODS
10.4.1
10.4.2
10.4.3
10.4.4
10.4.5
10.4.6
10.4.7
10.4.8
10.4.9
AGAROSE GEL ELECTROPHORESIS
POFYACRYLAMIDE GEL ELECTROPHORESIS
POFYMERASE CHAIN REACTION (PCR)
ASSEMBLY OF THE EXPRESSION VECTORS FOR POL K
TRANSFORMATION OFE. COLI
E. COLI CULTURES
ISOLATION OFPLASMIDDNA
INDUCTION OF THE PROTEIN EXPRESSION
PROTEIN PURIFICATION
10.4.10 PROTEIN QUANTIFICATION
10.4.11 PRIMER EXTENSION STUDIES
10.4.12 MASS SPECTROMETRY ANALYSIS OF THE PRIMER EXTENSION EXPERIMENTS
10.5 PROTEIN CRYSTALLIZATION
10.6 COLLECTION AND PROCESSING OF X-RAY DIFFRACTION DATA, PHASE
DETERMINATION AND
STRUCTURE REFINEMENT
IMAGE 3
10.7 SYNTHESIS OF BULKY DNA ADDUCTS 111
10.7.1 8-BROMO-2 -DESOXYGUANOSINE 111
10.7.2 8-BROMO-3 R5 -O-BIS(TERT-BUTYLDIMETHYLSILYL)-2 -DEOXYGUANOSINE
111
10.7.3 CF -BENZYL-8-BROMO-3 5
T-0-BIS(TERT-BUTYLDIMETHYLSILYL)-2 -DEOXY_UANOSINE 113
10.7.4 O
6-BENZYL-8-BROMO-3 ,5 -O-BIS(TERT-BUTYLDIMETHYISIIYL)-N2-DIMETHOXYTRITYL-2 -DEOXYGUANOSINE
114
10.7.5 COUPLING OF THE PROTECTED DEOXYGUANOSINE WITH THE AROMATIC UNIT
115
10.7.6 N-ACETYLATION AT C8-POSITION OF THE AROMATIC AMINE DG ADDUCTS 120
10.7.7 PROTECTION OF THE ^-POSITION OF THE AROMATIC AMINE DG ADDUCTS 125
10.7.8 DEPROTECTION OF THE HYDROXYL GROUPS OF THE AROMATIC AMINE DG
ADDUCTS 130
10.7.9 DEPROTECTION OF THE (F-POSITION OF THE AROMATIC AMINE DG ADDUCTS
135
10.7.10 5 -DMT PROTECTION OFTHE BULKY DG ADDUCTS 140
10.7.11 SYNTHESIS OF THE PHOSPHORAMIDITES 145
10.7.12 (4-ISOPROPYL)-PHENOXY ACETYL CHLORIDE 150
10.7.13 PHENOXYACETIC ANHYDRIDE 150
11 APPENDIX 151
11.1 CRYSTAL STRUCTURE DATA 151
11.2 M A L D I - T OF MASS SPECTROMETRY ANALYSIS OF THE PRIMER EXTENSION
PRODUCTS WITH A A F - DG
CONTAINING OLIGONUCLEOTIDES 1 53
11.3 COMPOSITION OF THE LEMASIER MEDIUM 11641 153
11.4 LIST OF ABBREVIATIONS 155
12 REFERENCES 157
VII
|
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| dewey-tens | 570 - Biology |
| discipline | Chemie / Pharmazie Biologie |
| edition | 1. Aufl. |
| format | Thesis Book |
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| spelling | Schorr, Stephanie 1982- Verfasser (DE-588)143465287 aut Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten Stephanie Schorr Replikation von sterisch anspruchsvollen DNA Addukten 1. Aufl. München Verl. Dr. Hut 2010 XX, 169 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Organische Chemie Zugl.: München, Univ., Diss., 2010 Replikation (DE-588)4153174-7 gnd rswk-swf DNS-Schädigung (DE-588)4150350-8 gnd rswk-swf Arylamine (DE-588)4231350-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Arylamine (DE-588)4231350-8 s DNS-Schädigung (DE-588)4150350-8 s Replikation (DE-588)4153174-7 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-125267 http://edoc.ub.uni-muenchen.de/12526/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-125267 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021128594&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schorr, Stephanie 1982- Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten Replikation (DE-588)4153174-7 gnd DNS-Schädigung (DE-588)4150350-8 gnd Arylamine (DE-588)4231350-8 gnd |
| subject_GND | (DE-588)4153174-7 (DE-588)4150350-8 (DE-588)4231350-8 (DE-588)4113937-9 |
| title | Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten |
| title_alt | Replikation von sterisch anspruchsvollen DNA Addukten |
| title_auth | Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten |
| title_exact_search | Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten |
| title_full | Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten Stephanie Schorr |
| title_fullStr | Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten Stephanie Schorr |
| title_full_unstemmed | Replication of bulky DNA adducts = Replikation von sterisch anspruchsvollen DNA Addukten Stephanie Schorr |
| title_short | Replication of bulky DNA adducts |
| title_sort | replication of bulky dna adducts replikation von sterisch anspruchsvollen dna addukten |
| title_sub | = Replikation von sterisch anspruchsvollen DNA Addukten |
| topic | Replikation (DE-588)4153174-7 gnd DNS-Schädigung (DE-588)4150350-8 gnd Arylamine (DE-588)4231350-8 gnd |
| topic_facet | Replikation DNS-Schädigung Arylamine Hochschulschrift |
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