Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
2010
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 62 S. Ill., graph. Darst. 21 cm |
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MARC
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| 245 | 1 | 0 | |a Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen |c vorgelegt von Hans-Bernhard K. Alter |
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Record in the Search Index
| _version_ | 1804143806510006272 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
VERZEICHNIS
DER
VERWENDETEN
ABKUERZUNGEN
..........................................................
8
1
EINLEITUNG
...................................................................................................................
9
1.1
DIE
ENDOTHELIALE
NO-SYNTHASE
...............................................................................
9
1.1.1
MODULATION
DER
KARDIALEN
FUNKTION
DURCH
NO
.................................................
11
1.1.2
REGULATION
DER
ENOS-AKTIVITAET
AM
MYOKARD
....................................................
12
1.2
DAS
SS-ADRENERGE
SYSTEM
.........................................................................................
15
1.3
GENETISCH
VERAENDERTE
MAEUSE
..................................................................................
18
1.3.1
SS-ADRENOZEPTOR
KNOCKOUTMODELLE
......................................................................
18
1.4
FRAGESTELLUNG
DER
ARBEIT
..........................................................................................
21
2
MATERIAL
UND
METHODIK
............................................................................................
22
2.1
MATERIAL
......................................................................................................................
22
2.1.1
HERZMUSKELGEWEBE
............................................................................................22
2.1.2
REAGENTIEN
UND
ANTIKOERPER
................................................................................
23
2.2
METHODEN
...................................................................................................................
25
2.2.1
HERZ
UND
KOERPERGEWICHTSMESSUNGEN
..............................................................
25
2.2.2
IMMUNHISTOCHEMIE
..............................................................................................
25
2.2.2.1
GEWEBEFIXATION
...............................................................................................
25
2.2.2.2
IMMUNHISTOCHEMIE
..........................................................................................
25
2.2.2.3
TV-DENSITOMETRIE
............................................................................................
26
2.3
STATISTISCHE
ANALYSE
..................................................................................................
27
3
ERGEBNISSE
................................................................................................................
28
3.1
HERZMORPHOMETRIE
.....................................................................................................
28
3.2
ENOS-TRANSLOKATION
..................................................................................................
30
3.3
ENOS-PHOSPHORYLIERUNG
AN
SERIN
1177
UND
THREONIN
495
....................................
32
3.4
SERIN
11
6-PHOSPHORYLIERUNG
DER
ENOS
...................................................................35
3.5
OXIDATIVER
UND
NITROSATIVER
STRESS
.............................................................................
37
4
DISKUSSION
...............................................................................................................
40
4.1
HERZMORPHOMETRIE
....................................................................................................
42
4.2
PROTEINEXPRESSION
UND
PROTEINREGULIERUNG
..............................................................
43
4.3
ENOS-PHOSPHORYLIERUNG
AN
SERIN
1177
..................................................................
44
4.4
ENOS-PHOSPHORYLIERUNG
AN
THREONIN
495
..............................................................
45
4.5
ENOS-PHOSPHORYLIERUNG
AN
SERIN
116
.....................................................................
46
4.6
OXIDATIVER
STRESS
........................................................................................................
47
5
SCHLUSSFOLGERUNG
....................................................................................................
49
6
ZUSAMMENFASSUNG
..................................................................................................
51
7
LITERATURVERZEICHNIS
................................................................................................
53
8
LEBENSLAUF
................................................................................................................
61
|
| any_adam_object | 1 |
| author | Alter, Hans-Bernhard K. 1971- |
| author_GND | (DE-588)143067249 |
| author_facet | Alter, Hans-Bernhard K. 1971- |
| author_role | aut |
| author_sort | Alter, Hans-Bernhard K. 1971- |
| author_variant | h b k a hbk hbka |
| building | Verbundindex |
| bvnumber | BV037212827 |
| ctrlnum | (OCoLC)697839967 (DE-599)DNB1009061097 |
| discipline | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV037212827 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:53:31Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021126852 |
| oclc_num | 697839967 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 62 S. Ill., graph. Darst. 21 cm |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| record_format | marc |
| spelling | Alter, Hans-Bernhard K. 1971- Verfasser (DE-588)143067249 aut Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen vorgelegt von Hans-Bernhard K. Alter 2010 62 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Köln, Univ., Diss., 2010 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021126852&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Alter, Hans-Bernhard K. 1971- Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen |
| subject_GND | (DE-588)4113937-9 |
| title | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen |
| title_auth | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen |
| title_exact_search | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen |
| title_full | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen vorgelegt von Hans-Bernhard K. Alter |
| title_fullStr | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen vorgelegt von Hans-Bernhard K. Alter |
| title_full_unstemmed | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen vorgelegt von Hans-Bernhard K. Alter |
| title_short | Geschlechtsdifferenzierung der endothelialen NO-Synthase bei transgenen Mäusen |
| title_sort | geschlechtsdifferenzierung der endothelialen no synthase bei transgenen mausen |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021126852&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT alterhansbernhardk geschlechtsdifferenzierungderendothelialennosynthasebeitransgenenmausen |