Oxidative folding of peptides and proteins:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2008
|
| Schriftenreihe: | RSC Biomolecular sciences
v. 16 |
| Schlagworte: | |
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| Beschreibung: | With contributions from experts in the field, this book provides a comprehensive overview of the oxidative folding of cysteine-rich peptides, The formation of disulfide bonds is probably the most influential modification of peptides and proteins. An elaborate set of cellular machinery exists to catalyze and guide this process. In recent years, significant developments have been made in both our understanding of the in vivo situation and the in vitro manipulation of disulfide bonds. This is the first monograph to provide a comprehensive overview of this exciting and rapidly developing area. It offers in-depth insights into the mechanisms of in vivo and in vitro oxidative folding of proteins as well as mono- and multiple-stranded peptides. Procedures applied for laboratory and industrial purposes are also discussed by top experts in the field. The book describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins in prokaryotes and eukaryotes. It then goes on to discuss the mimicking of these enzymes for successful in vitro folding of proteins (including synthetic replicates) and to deal with important issues concerning cysteine-rich peptides. The ability of natural bioactive peptides to fold correctly, and in high yields, to form defined structural motifs using cysteine sequence patterns is still puzzling. With this in mind, synthetic procedures for establishing native cysteine frameworks are discussed using selected examples, such as the potential of selenocysteines. The biotechnological and pharmaceutical relevance of proteins, peptides, their variants and synthetic replicates is continuously increasing. Consequently, this book is invaluable for peptide and protein chemists involved in related research and production |
| Beschreibung: | 1 Online-Ressource (448 p.) 57 b&w, 51 b&w halftones, line drawings |
| ISBN: | 1847559263 9781847559265 |
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| id | DE-604.BV037195503 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:43:57Z |
| institution | BVB |
| isbn | 1847559263 9781847559265 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021109865 |
| oclc_num | 873741908 |
| open_access_boolean | |
| owner | DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-Aug4 DE-1046 DE-1047 DE-1102 DE-1050 DE-859 DE-M347 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-210 DE-2070s DE-634 DE-526 DE-860 DE-70 DE-B768 |
| owner_facet | DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-Aug4 DE-1046 DE-1047 DE-1102 DE-1050 DE-859 DE-M347 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-210 DE-2070s DE-634 DE-526 DE-860 DE-70 DE-B768 |
| physical | 1 Online-Ressource (448 p.) 57 b&w, 51 b&w halftones, line drawings |
| psigel | ZDB-1-RSE |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Royal Society of Chemistry |
| record_format | marc |
| series2 | RSC Biomolecular sciences |
| spellingShingle | Oxidative folding of peptides and proteins Protein folding Biologische Oxidation (DE-588)4126898-2 gnd Proteinfaltung (DE-588)4324567-5 gnd |
| subject_GND | (DE-588)4126898-2 (DE-588)4324567-5 |
| title | Oxidative folding of peptides and proteins |
| title_auth | Oxidative folding of peptides and proteins |
| title_exact_search | Oxidative folding of peptides and proteins |
| title_full | Oxidative folding of peptides and proteins Edited by Luis Moroder, Johannes Buchner ; Contributions by Grzegorz Bulaj [et al.] |
| title_fullStr | Oxidative folding of peptides and proteins Edited by Luis Moroder, Johannes Buchner ; Contributions by Grzegorz Bulaj [et al.] |
| title_full_unstemmed | Oxidative folding of peptides and proteins Edited by Luis Moroder, Johannes Buchner ; Contributions by Grzegorz Bulaj [et al.] |
| title_short | Oxidative folding of peptides and proteins |
| title_sort | oxidative folding of peptides and proteins |
| topic | Protein folding Biologische Oxidation (DE-588)4126898-2 gnd Proteinfaltung (DE-588)4324567-5 gnd |
| topic_facet | Protein folding Biologische Oxidation Proteinfaltung |
| url | http://www.rsc.org/publishing/ebooks/2008/9780854041480.asp |
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