Dynamics of the IL-2 cytokine network and T-cell proliferation:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Berlin
Logos-Verl.
2010
|
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | 111 S. Ill., graph. Darst. |
| ISBN: | 9783832526931 |
Staff View
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Record in the Search Index
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IMAGE 1
CONTENTS
1 INTRODUCTION 7
1.1 IL-2 SIGNALING IN T HELPER LYMPHOCYTES 8
1.2 ACTIVATION OF REGULATORY T CELLS 11
1.3 ROLE OF INTERLEUKIN 2 IN IMMUNITY AND TOLERANCE 13
1.4 SPACE AS A PARAMETER IN TH/TREG CELL INTERACTION 16
1.5 OBJECTIVES OF THIS STUDY 17
2 MATHEMATICAL MODEL 21
2.1 MODEL EQUATIONS 21
2.2 QUASI-STEADY-STATE APPROXIMATION 25
2.3 MODEL VARIANTS 26
2.4 MODEL PARAMETERS 27
3 THE IL-2/IL-2R GENE-EXPRESSION NETWORK 31
3.1 NETWORK DYNAMICS 31
3.2 POSITIVE FEEDBACK REGULATION OF THE IL-2R 34
3.3 ANALYSIS OF A SIMPLIFIED MODEL 37
3.4 PARAMETER DEPENDENCE OF BISTABILITY 39
3.5 ALL-OR-NOTHING ACTIVATION OF TH CELLS 41
3.6 PARACRINE IL-2 SIGNALING 44
3.7 DISCUSSION 47
5
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1008402052
DIGITALISIERT DURCH
IMAGE 2
6 CONTENTS
4 TH AND TREG CELL INTERACTION 51
4.1 PARACRINE IL-2 UPTAKE BY TREG CELLS SHIFTS THE TH-RESPONSE THRESHOLD
51
4.2 COMPETITIVE IL-2 UPTAKE OF TREG CELLS ADAPTS TO IL-2 SUPPLY . 53
4.3 DISTANCE DEPENDENCE OF PARACRINE IL-2 UPTAKE 57
4.4 REGULATION OF TH CELL ACTIVATION 61
4.5 DISCUSSION 63
5 OUTLOOK 67
6 MATERIALS AND METHODS 77
A APPROXIMATION OF THE RELAXATION TIME 81
B CALCULATING IL-2 CONCENTRATIONS 83
B.I MATHEMATICAL MODEL OF THE IL-2/IL-2 RECEPTOR DYNAMICS OF A
SINGLE TH CELL 83
B.2 TH CELL INTERACTION 84
B.3 2:1 (TH/TREG) CELL MODEL 85
C IL-2 AND IL-2R EXPRESSION 89
D CRITICAL DISTANCE FOR COMPETITION 93
E ANALYSIS OF TH CELL PROLIFERATION 95
E.I THE SMITH-MARTIN MODEL 95 |
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| spelling | Busse, Dorothea 1975- Verfasser (DE-588)143166158 aut Dynamics of the IL-2 cytokine network and T-cell proliferation von Dorothea Busse Berlin Logos-Verl. 2010 111 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: Berlin, Humboldt-Univ., Diss., 2009 Interleukin 2 (DE-588)4162018-5 gnd rswk-swf T-Lymphozyt (DE-588)4127387-4 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content T-Lymphozyt (DE-588)4127387-4 s Interleukin 2 (DE-588)4162018-5 s Signaltransduktion (DE-588)4318717-1 s DE-604 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3595986&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020872280&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Busse, Dorothea 1975- Dynamics of the IL-2 cytokine network and T-cell proliferation Interleukin 2 (DE-588)4162018-5 gnd T-Lymphozyt (DE-588)4127387-4 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4162018-5 (DE-588)4127387-4 (DE-588)4318717-1 (DE-588)4113937-9 |
| title | Dynamics of the IL-2 cytokine network and T-cell proliferation |
| title_auth | Dynamics of the IL-2 cytokine network and T-cell proliferation |
| title_exact_search | Dynamics of the IL-2 cytokine network and T-cell proliferation |
| title_full | Dynamics of the IL-2 cytokine network and T-cell proliferation von Dorothea Busse |
| title_fullStr | Dynamics of the IL-2 cytokine network and T-cell proliferation von Dorothea Busse |
| title_full_unstemmed | Dynamics of the IL-2 cytokine network and T-cell proliferation von Dorothea Busse |
| title_short | Dynamics of the IL-2 cytokine network and T-cell proliferation |
| title_sort | dynamics of the il 2 cytokine network and t cell proliferation |
| topic | Interleukin 2 (DE-588)4162018-5 gnd T-Lymphozyt (DE-588)4127387-4 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Interleukin 2 T-Lymphozyt Signaltransduktion Hochschulschrift |
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