Verfügbarkeit: Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation: a handbook for clinicians

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Format:	Buch
Sprache:	English
Veröffentlicht:	[Basel] [Karger] [2010] Bethesda, Md. AABB Press
Schlagworte:	Periphere Stammzellentransplantation
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	©2009
Beschreibung:	XXVII, 729 S. Ill., graph. Darst.
ISBN:	9783805595766 380559576X 9781563952975

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245	1	0	\|a Hematopoietic stem cell transplantation \|b a handbook for clinicians \|c ed.: John R. Wingard ...
264		1	\|a [Basel] \|b [Karger] \|c [2010]
264		1	\|a Bethesda, Md. \|b AABB Press
300			\|a XXVII, 729 S. \|b Ill., graph. Darst.
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Datensatz im Suchindex

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adam_text	Table of Contents Preface . .xxv 1. Overview of Hematopoietic Stem Cell Transplantation .......1 John R. Wingard, MD I. Historical Perspective .................................1 II. A Primer of the Transplant Procedure ...................3 III. General Aspects About Different Types of HSCT ..........5 IV. What This Book Is About ..............................7 2. Common Uses of Hematopoietic Stem Cell Transplantation .......................................9 Joseph H. Antin, MD I. Introduction .........................................9 II. Marrow Failure ......................................9 III. Hematologic Malignancies ............................14 IV. References/Suggested Readings ........................25 3. Patient Evaluation Before Transplantation (Adult) .........27 Mehdi Hamadani, MD, and Steven M, Devine, MD I. Introduction ........................................27 II. Initial Consultation ..................................28 III. Assessment of Disease Status ..........................31 IV. Assessment of Physiologic Status .......................33 V. Psychological, Financial, and Caregiver Considerations .....39 VI. References/Suggested Readings ........................41 4. Patient Evaluation Before Transplantation (Pediatric) ......45 Nancy A. Kernan, MD I. Overview ..........................................45 II. Assessment at Time of Referral ........................46 III. Assessment of Disease Status ......................... 46 IV. Assessment of Physiologic Function ....................47 5. Conditioning Regimens ..................................51 Javier Bolaños-Meade, MD, and Richard J.Jones, MD I. Introduction ........................................51 II. Common Myeloablative Regimens ......................52 xi jdi HEMATOPOIETIC STEM CELL TRANSPLANTATION III. Common Nonmyeloablative/Reduced-Intensity Conditioning Regimens ............................54 IV. Toxitítíes ..........................................54 V. Anti-Emetic Management ............................55 VI. Selecting the Optimal Regimen ........................56 VII. References/Suggested Readings .......................59 6. HLA ..................................................61 , Effie W. Petersdorf, MD I. The Major Histocompatibility Complex .................61 і II. HLA Typing in Support of AUogeneic Transplant Programs .......................................66 III. The Transplant Barrier ..............................71 IV. References/Suggested Readings .......................74 7. Optimal Donor Selection for Allogeneic Hematopoietic Stem Cell Transplantation ............................77 Marde Tomblyn, MD, MS, and Daniel J. Weisdorf, MD I. Introduction .......................................77 И. Related Donors .....................................77 HI. Adult Volunteer Unrelated Donors .....................79 IV. Umbilical Cord Blood ................................82 V. Summary ..........................................86 VI. References/Suggested Readings .......................86 8. Hematopoietic Progenitor Cell Donor Evaluation ..........89 John P. Milkr, MD, PhD I. Introduction .......................................89 II. Types of Hematopoietic Progenitor Cell Donation ........89 HI. Medical Evaluation of HPC Donors ....................90 IV. Donor Consent for HPC Donation .....................97 V. Subsequent Donations ..............................101 VI. Summary .........................................102 VII. References/Suggested Readings ......................102 9. Stem Cell Grafts .......................................105 Martin Körbling, MD I. Introduction ......................................105 II. Biology of Cell Populations Contained in Hematopoietic Tissue-Derived Stem Cell Grafts ....................106 IH. Quantification of Graft-Containing Cells ...............109 TABLE OF CONTENTS xiii IV. Engraftment Potential ............................. ПО V. Choice of Stem Cell Source in Adult Transplantation ___113 VI. References/Suggested Readings ...................... 113 10. Stem Cell Collection Techniques ........................ 115 Ivana N.M. Micallef, MD, FRCPfC), and Dennis A. Gastineau, MD I. Marrow Harvesting ................................ 115 II. Peripheral Blood Stem Cell Mobilization .............. 116 III Autologous Transplantation ......................... 117 IV. Allogeneic Transplantation .......................... 121 V. References/Suggested Readings ...................... 122 11. Cord Blood Graft Collection and Processing ............. 125 Sue Armitage, BSc, and Elizabeth J. Shpall, MD I. Overview ........................................ 125 II. Types of Cord Blood Banking ....................... 126 HI. Advantages of Cord Blood as a Source of Hematopoietic Stem Cells ........................ 126 IV. Disadvantages of Cord Blood as a Source of Hematopoietic Stem Cells ........................ 126 V. Cord Blood Banking Operations ...................... 127 VI. Registration of Units ............................... 131 VII. Clinical Results of Cord Blood Transplantation ......... 134 VIII. References/Suggested Readings ..................... 134 12. Laboratory Processing of Hematopoietic Progenitor Cells .............................................. 137 Douglas J. Padley, MT(ASCP), and Dennis A. Gastineau, MD I. Introduction ...................................... 137 II. Manufacturing in the Cell Processing Laboratory ....... 138 III. Plasma or Red Cell Incompatibility ................... 142 IV. Donor Lymphocyte Infusion ......................... 145 V. HPC Product Testing ............................... 146 VI. Regulatory and Accreditation Issues and Process Control ........................................ 146 VII. Other Products and Product Manufacturing ............ 147 VIII. Administration of HPC Products ..................... 148 IX. References/Suggested Readings ...................... 148 XIV HEMATOPOIETIC STEM CELL TRANSPLANTATION 13. Hematopoietic Progenitor Cell Administration ...........151 Christopher A. Tormey, MD, and Edward L. Snyder, MD I. Overview of HPC Components ......................151 II. Basics of Administration ............................152 III. ABO and Rh Incompatibility .........................154 IV. Adverse Events Associated with HPC Administration: Complications and Management ...................155 V. References/Suggested Readings ......................161 14. Engraftment ..........................................163 Paul V. O Donnell, MD, PhD, FACP I. Introduction ......................................163 II. Engraftment Syndrome .............................164 III. Factors Affecting Engraftment .......................166 IV. Chimerism ........................................169 V. Erythroid Engraftment ..............................172 VI. Engraftment Following Allogeneic Transplantation from Alternative Donors ..............................173 VII. References/Suggested Readings ......................178 15. Immune Reconstitution ................................181 Yubin Kang, MD, and Nelson J. Chao, MD, MBA I. Overview of the Human Immune System ..............181 II. Assays for Monitoring Immune Reconstitution ..........183 HI. Immune Reconstitution .............................184 IV. Immunomodulation and Immunoenhancement.........192 V. Conclusions .......................................194 VI. References/Suggested Readings ......................194 16. Infections Prior to Engraftment .........................197 John R. Wmgard MD I. Introduction ......................................197 II. Risk Factors for Infection ............................197 III. Neutropenic Fever ................................. 1 97 FV. Infectious Syndromes ...............................201 V . Prophylaxis .......................................204 VI. References/Suggested Readings ......................204 TABLE OF CONTENTS 1 7. Transfusion Support of HSCT Recipients ................207 Erin KG. Meyer, DO, and Zbigniew M. Szczepiorkowski, MD, PhD I. Blood Component Collection and Testing ..............207 II. Blood Components—Types and Indications ............210 III. Blood Components—Modifications ....................215 IV. Adverse Events Related to Transfusion of Blood Components ...................................217 V. Transfusion Support for RBC-incompatible Transplants .. 217 VI. Therapeutic Apheresis .............................218 VII. References/Suggested Readings ......................225 18. Hematopoietic Growth Factors .........................227 Hong Yen Ng, BSc (Pharm) (Hons), BCOP I. Red Cell Growth Factors ............................227 II. White Cell Growth Factors ..........................238 III. Megakaryocytic Growth Factors ......................243 IV. References/Suggested Readings ......................245 19. Venous Access for Hematopoietic Stem Cell Transplant Patients .................................249 James С Andrews, MD, FSIR I. General Principles .................................249 II. Options for Chronic Central Venous Access ............255 III. Managing Central Venous Access Problems ............258 IV. Summary ........................................264 V. References/Suggested Readings ......................264 20. Medical Nutrition Therapy in Hematopoietic Stem Cell Transplantation ....................................267 Alison Winter-Lai, MS, RD, CSO, CDN; Courtney Santagata, MS, RD, CSO, CDN; and Deborah FordHanel, MS, RD, FADA, CDN I. Nutrition Assessment Before Hematopoietic Stem Cell Transplantation .................................267 II. HSCT and Energy/Protein Needs in Adults ............270 HI. HSCT and Energy/Protein Needs in Pediatrics ..........270 IV. Maintenance Fluid Needs ...........................271 V. Vitamins/Minerals.................................273 VI. Eating Problems During and After Hematopoietic Stem Cell Transplantation ........................273 HEMATOPOIETIC STEM CELL TRANSPLANTATION VII. Dietary Guidelines for Immunosuppressed Patients ......273 VIII. Nutrition Support ..................................277 IX. Long-Term Nutrition Considerations Following HSCT .... 278\| X. Summary .........................................278 XI. References/Suggested Readings ......................282 21. Fluid and Electrolyte Management ......................283 Tippu S. Khan, PharmD, BCOP I. Management of Fluid Balance ........................283 H. Management of Electrolyte Abnormalities ..............287 III. References/Suggested Readings ......................292 22. Viral Infections after Engraftment ......................293 Michael Boeckk MD, and Helen Leather, BPharm I. Herpesviruses .....................................293 II. Respiratory Viruses ................................306 HI. Adenoviruses .....................................309 IV. Polyomavirases ....................................310 V. References/Suggested Readings ......................310 23. Fungal Infections ......................................313 Ben E. de Pauw, MD. PhD. and Nicole M. Blijievens, MD, PhD I. Pathogenesis of Invasive Fungal Infections .............313 H. Clinical Vigilance and Diagnostic Options ..............316 III. Treatment Strategy .................................319 IV. References/Suggested Readings ......................328 24. Acute Graft-vs-Host Disease ............................331 Corey Cutler, MD, MPH, FRCPfC) I. Acute GVHD Pathobiology and Risk Factors ...........331 II. GVHD Prophylaxis .................................333 HI. Diagnosis, Epidemiology, and Clinical Manifestations of Acute GVHD .................................338 IV. Treatment and Outcome of Acute GVHD ..............339 V. References/Suggested Readings ......................343 25. Chronic Graft-vs-Host Disease ..........................34g ¡skra Pusic. MD: Georgia В. Vogelsang, MD; and Steven Z. Pavletic, MD I. Pathophysiology of Chronic GVHD ...................346 TABLK OF CONTENTS xvii И. Risk Factors ...................................... 346 ill. Diagnosis ........................................ 346 IV. Classification ..................................... 350 V. Staging .......................................... 350 VI. Clinical Manifestations .............................. 352 VII. Graft-vs-Tumor Effect .............................. 352 VIII. Prevention ....................................... 356 IX. Treatment ....................................... 356 X. Measuring the Response to Therapy .................. 361 XL Monitoring of Patients With Chronic GVHD ........... 363 XII. Prognosis of Chronic GVHD ......................... 363 XIII. References/Suggested Readings ...................... 363 26. Liver Disease after Hematopoietic Stem Cell Transplant .. 365 Jan S. Moreb, MD I. Introduction ...................................... 365 II. Liver Problems During Pretransplant Evaluation ........ 366 III. Drag-induced Hepatobiliary Abnormalities Following HSCT ................................ 368 IV. Non-Drag-Related Liver Problems in the First 100 Days ...................................... 373 V. Liver Abnormalities Beyond Day 100................ 375 VI. References/Suggested Readings ...................... 376 27. Infectious Hepatitis in HSCT ........................... 379 Richard A, Zuckerman, MD, MPH I. Introduction ...................................... 379 II. Pretransplant Evaluations ........................... 379 III. Hepatitis A Virus .................................. 380 IV. Hepatitis В Viras.................................. 381 V. Hepatitis С Viras .................................. 388 VI. Posttransplant Concerns ............................ 390 VII. Peritransplant Immunization......................... 395 VIII. References/Suggested Readings ...................... 396 28. Oral Complications in Hematopoietic Stem Cell Transplantation .................................... 397 Nathaniel S. Treister, DMD, DMSc, and Stephen T. Sonis, DMD, DMSc I. Introduction ...................................... 397 II. Pretransplantation Dental Evaluation ................. 399 HEMATOPOIETIC STEM CELL TRANSPLANTATION HI. Oral Mucosffis .....................................401 IV. Oral Infections ....................................403 V. Noninfectious Causes of Orofacial Pain ................407 VI. Graft-vs-Host Disease ...............................407 VII. Second Malignancy ................................410 VIII. References/Suggested Readings ......................410 29. Gastrointestinal Complications of Hematopoietic Stem Cell Transplantation ...........................411 Stephen T. Sottis, DMD, DMSc; Nathaniel S. Treister, DMD, DMSc; Judith Lees, BPharm; and Dorothy M. Keefe, MD I. Introduction ......................................411 II. Nausea and Vomiting ...............................412 HI. Esophageal/Gastric Mucositis ........................416 IV. Small Intestinal/Colonic Mucositis and Diarrhea .........416 V. Constipation ......................................418 VI. References/Suggested Readings ......................418 30. Lung Injury Following Hematopoietic Stem Cell Transplantation ....................................419 Kenneth R. Cooke. MD, and Gregory A. Yanik, MD I Introduction ......................................419 I. infectious Interstitial Pneumonias .....................420 Ш. Idiopathic Pneumonia Syndrome .....................422 IV. Chronic Pulmonary Dysfunction After HSCT ...........431 V. Conclusion .......................................436 VI. References/Suggested Readings ......................436 31. Management of Pain in the Hematopoietic Stem Cell Transplantation Patient .............................439 Laura E. Wiggins, PhamD, BCOP f. Overview .........................................439 II. Pathophysiology of Pain .............................439 III. Types of Pain in the HSCT Patient ....................440 IV. Diagnosis of Pain ..................................443 V. Management of Pain ...............................443 VI. Summary .........................................452 VII. References/Suggested Readings ......................452 TABLE OF CONTENTS xix 32. Hemorrhagic Cystitis: Pathogenesis and Management in Hematopoietic Stem Cell Transplantation .............453 Zuzana Hassan, MD, PhD; Tim Dalianis, MD, PhD; Katarina Le Blanc, MD, PhD; and Olie Ringden, MD, PhD I. Overview ........................................453 II. Pathogenesis and Role of Infection ...................456 III. Management .....................................457 IV. References/Suggested Readings ......................459 33. Posttransplant Vaccination Strategies ................... 463 Ernesto Ayala, MD, and Claudio Anasetti, MD I. Introduction ...................................... 463 II. General Concepts ................................. 463 III. Vaccines Against Bacteria ........................... 464 IV. Vaccines Against Viruses ........................... 468 V. Serologie Testing .................................. 470 VI. Donor Vaccination ................................ 471 VII. Immunization of Family Members and Health-Care Workers1 ...................................... 471 VIII. References/Suggested Readings ...................... 472 34. Late Complications: Screening and Management .........473 Navneet S. Majhail, MD, MS, and]. Douglas Rizzo, MD, MS I. Overview ........................................473 II. Neuropsychologie Complications .....................476 III. Ocular Complications ..............................477 IV. Oral Complications ................................478 V. Respiratory Complications ..........................478 VI. Cardiovascular Complications .......................479 VII. Hepatic Complications ..............................480 VIII. Renal Complications ...............................481 IX. Genitourinary Complications and Infertility ............481 X. Musculoskeletal Complications .......................482 XI. Endocrine Complications ...........................483 XII. General Screening and Preventive Health ..............484 XIII. References/Suggested Readings ......................484 HEMATOPOIETIC STEM CELL TRANSPLANTATION 35. Neuropsychiatrie Complications of Hematopoietic Stem Cell Transplantation ...........................487 Mitchell R. Levy, MD, and Jesse R. Fann, MD, МРН . General Principles of Assessment and Management ......487 II. Level of Distress ...................................491 HI. Severe Neuropsychiatrie Complications ................501 IV. Cancer-Related Fatigue .............................501 V. Somatization ......................................503 VI. Survivorship ......................................503 VII. References/Suggested Readings ......................504 36. Psychosocial Sequelae of HSCT in Survivors and Caregivers .........................................507 Michelle M. Bishop, PhD I. Introduction ......................................507 II. Major Psychosocial Sequelae After Hematopoietic Stem Cell Transplantation .........................509 III. Family Caregivers ..................................523 IV. References/Suggested Readings ......................524 37. Second Cancers .......................................527 Smita Bhatia, MD. MPH . Overview .........................................527 II. Therapy-Related Myelodysplasia and Acute Myeloid Leukemia After Autologous HSCT .................528 Ш. Donor-Derived Hematologic Malignancies After HSCT ... 532 IV. Lymphomas ......................................533 V. Solid Tumors .....................................535 VI. Conclusions .......................................538 VII. References/Suggested Readings ......................538 38. Relapse after Hematopoietic Stem Cell Transplantation ... 541 Ginna G. Lapori, MD I Management of Relapse After Allogeneic HSCT .........541 íl. Management of Relapse After Autologous HSCT ........546 III. Conclusion .......................................551 IV. References/Suggested Readings ......................551 TABLE OF CONTENTS xxi 39. Donor Lymphocyte Infusion and Graft-vs-Leukemia Effects of Allogeneic Transplantation ................555 Hans-Jochem Kolb, Prof. Dr. med., and Raymund Bukmann, Dr. med. I. Separation of Graft-vs-Leukemia Effects and Graft-vs-Host Disease ............................ 557 II. Chronic Myelogenous Leukemia .....................559 III. Acute Myelogenous Leukemia and Myelodysplastic Syndrome .....................................562 IV. DLI for Acute Lymphoblastic Leukemia ...............563 V. Chronic Lymphocytic Leukemia and Lymphoma ........563 VI. Multiple Myeloma .................................564 VII. Solid Tumors .....................................565 VIII. Immunotherapy in Patients with HLA-Haploidentical Donors ........................................565 IX. Lessons from the Treatment of Viral Infections With Donor Lymphocytes ........................ 566 X. Do Donor Lymphocytes Eliminate Leukemia Stem Cells? .........................................567 XI. Failures of Durable Control-Immune Escape Mechanisms ....................................567 XII. Outlook ..........................................568 XIII. References/Suggested Readings ......................569 40. Management of Coagulopathies/Transplant-Associated Microangiopathy ...................................573 Yanyun Wu, MD, PhD, and Peter W. Marks, MD, PhD I. Hemorrhagic Complications ......................... 573 II. Thrombotic Complications ..........................578 III. References/Suggested Readings ......................581 41. Gynecologic Management of Fertility ....................583 Jason G. Bromer, MD, and Pasquale Patrizio, MD, MBE I. Introduction ......................................583 II. The Effect of Gonadotoxic Agents on Fertility ..........584 III. Established Strategies for Fertility Preservation .........585 IV. Experimental Strategies for Fertility Preservation .......587 V. Ethical Considerations in Fertility Preservation .........590 VI. Summary and Conclusions ..........................593 VII. References/Suggested Readings ......................593 ххИ HEMATOPOIETIC STEM CELL TRANSPLANTATION 42. Pediatrie Aspects of Hematopoietic Stem Cell Transplantation ....................................595 Kimberly A. Kasow, DO, and Gregory A. Hale, MD I. Overview .........................................595 II. Malignant Indications for Allogeneic Transplantation .....595 III. Nonmalignant Indications for Transplantation ...........597 IV. Indications for Autologous Transplantation .............601 V. Hematopoietic Stem Cell Sources .....................602 VI. Cellular Therapies .................................602 VII. Marrow Issues .....................................603 VIII. Apheresis Issues ...................................603 IX. Conditioning Regimen Issues .........................604 X. Pharmaceutical Aspects .............................604 XI. Acute and Chronic GVHD ...........................604 XII. Supportive Care Issues ..............................605 XIII. Prophylaxis .......................................607 XIV. Late Effects .......................................607 XV. References/Suggested Readings ......................610 43. Data Collection and Management for Hematopoietic Stem Cell Transplant Centers ........................617 Mary M Horowitz, MD, MS I. Introduction-Why Collect Data? .....................617 II. Data Collection at the Transplant Center—Ensuring Quality and Addressing Local Research Needs ........618 III. Outcomes Registries—Contributing to the National and International Research Enterprise ..............619 IV. Addressing Federal Requirements-The US SCTOD .....625 V. Summary .........................................628 VI. Reference/Suggested Readings .......................628 44. Sources of Stem Cells ..................................629 Bimalangshu R. Dey, MD, PhD, and Thomas R. Spitzer, MD I. Introduction ......................................529 Ił. Marrow Aspiration and Biopsy .......................629 HI. Skin Biopsy .......................................632 IV. Lumbar Puncture ..................................§34 V. Marrow Harvest ...................................§36 VI. Apheresis ........................................638 VII. Umbilical Cord Blood ............................... 640 VIII. References/Suggested Readings ......................640 TABLE OF CONTENTS xxiii 45. Dosing Considerations in Overweight and Obese Patients Receiving High-Dose Chemotherapy and Hematopoietic Stem Cell Transplantation .............643 Dennis L Cooper, MD I. Overview ........................................643 II. Dosing for Overweight Patients ......................644 III. Dosing for Underweight Patients .....................647 IV. References/Suggested Readings ......................647 Appendices Appendix 1. Antibacterial Adult Dosage Guidelines for Patients with Normal Renal Function and Renal Insufficiency (as of November 2008)....................................649 Appendix 2. Antifungal Adult Dosage Guidelines for Patients with Normal Renal Function and Renal Insufficiency (as of November 2008)....................................665 Appendix 3. Antiviral Adult Dosage Guidelines for Renal Insufficiency (as of November 2008).........................670 Appendix 4. Drug Interactions with Antifungal Agents: Cytochrome P450 Isoenzymes Involved in Drag Metabolism .....675 Appendix 5. Pharmacodynamic Drug Interactions with Amphotericin В ..........................................676 Appendix 6. Clinically Relevant Pharmacokinetic Drug Interactions with Ketoconazole ..............................677 Appendix 7. Clinically Relevant Pharmacokinetic Drug Interactions with Fluconazole ..............................679 Appendix 8. Clinically Relevant Pharmacokinetic Drag Interactions with Itraconazole ..............................681 Appendix 9. Clinically Relevant Pharmacokinetic Drug Interactions with Voriconazole: Effect of Voriconazole on the Pharmacokinetics of Other Drugs ............................684 Appendix 10. Clinically Relevant Pharmacokinetic Drag Interactions with Voriconazole: Effect of Other Drags on the Pharmacokinetics of Voriconazole ...........................687 Appendix 11. Clinically Relevant Pharmacokinetic Drag Interactions with Posaconazole ..............................689 Appendix 12. Clinically Relevant Pharmacokinetic Drag Interactions with Tacrolimus ................................691 Appendix 13. Clinically Relevant Pharmacokinetic Drag Interactions with Cyclosporine ..............................692 HEMATOroiETlC STEM CELL TRANSPLANTATION Appendix 14. Clinically Relevant Pharmacokinetic Drag Interactions with Sirolimus ..................................694 Appendix 15. Cyclosporine Dosing and Monitoring Guidelines ......696 Appendix 16. Tacrolimus Dosing and Monitoring Guidelines ........698 Index .....................................................701
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id	DE-604.BV036851938
illustrated	Illustrated
indexdate	2024-07-09T22:49:23Z
institution	BVB
institution_GND	(DE-588)1030446-0
isbn	9783805595766 380559576X 9781563952975
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-020767880
oclc_num	706033032
open_access_boolean
owner	DE-355 DE-BY-UBR
owner_facet	DE-355 DE-BY-UBR
physical	XXVII, 729 S. Ill., graph. Darst.
publishDate	2010
publishDateSearch	2010
publishDateSort	2010
publisher	[Karger] AABB Press
record_format	marc
spelling	Hematopoietic stem cell transplantation a handbook for clinicians ed.: John R. Wingard ... [Basel] [Karger] [2010] Bethesda, Md. AABB Press XXVII, 729 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier ©2009 Periphere Stammzellentransplantation (DE-588)4432541-1 gnd rswk-swf Periphere Stammzellentransplantation (DE-588)4432541-1 s DE-604 Wingard, John R. Sonstige oth American Association of Blood Banks Sonstige (DE-588)1030446-0 oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020767880&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Hematopoietic stem cell transplantation a handbook for clinicians Periphere Stammzellentransplantation (DE-588)4432541-1 gnd
subject_GND	(DE-588)4432541-1
title	Hematopoietic stem cell transplantation a handbook for clinicians
title_auth	Hematopoietic stem cell transplantation a handbook for clinicians
title_exact_search	Hematopoietic stem cell transplantation a handbook for clinicians
title_full	Hematopoietic stem cell transplantation a handbook for clinicians ed.: John R. Wingard ...
title_fullStr	Hematopoietic stem cell transplantation a handbook for clinicians ed.: John R. Wingard ...
title_full_unstemmed	Hematopoietic stem cell transplantation a handbook for clinicians ed.: John R. Wingard ...
title_short	Hematopoietic stem cell transplantation
title_sort	hematopoietic stem cell transplantation a handbook for clinicians
title_sub	a handbook for clinicians
topic	Periphere Stammzellentransplantation (DE-588)4432541-1 gnd
topic_facet	Periphere Stammzellentransplantation
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020767880&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT wingardjohnr hematopoieticstemcelltransplantationahandbookforclinicians AT americanassociationofbloodbanks hematopoieticstemcelltransplantationahandbookforclinicians

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