Chemokine receptors as drug targets:
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| Format: | Book |
| Language: | English |
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Weinheim
Wiley-VCH
2011
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| Series: | Methods and principles in medicinal chemistry
46 |
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | XXIV, 384 S. Ill., graph. Darst. |
| ISBN: | 9783527321186 |
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| 245 | 1 | 0 | |a Chemokine receptors as drug targets |c ed. by Martine J. Smit ... |
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| 300 | |a XXIV, 384 S. |b Ill., graph. Darst. | ||
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IMAGE 1
CONTENTS
LIST OF CONTRIBUTORS XV PREFACE XXI
A PERSONAL FOREWORD XXIII
PART ONE FUNDAMENTALS OF CHEMOKINES AND CHEMOKINE RECEPTORS I
1 STRUCTURAL ASPECTS OF CHEMOKINES AND THEIR INTERACTIONS WITH RECEPTORS
AND CLYCOSAMINOGLYCANS 3 AMANDA E. I. PROUDFOOT, INDIA SEVERIN, DAMON
HAMEL, AND TRACY M. HANDEL 1.1 INTRODUCTION 3
1.2 RECEPTOR-LIGAND INTERACTIONS 5 1.3 IIGAND STRUCTURE 8
1.3.1 TERTIARY AND QUATERNARY STRUCTURES 8 1.3.2 FUNCTIONAL ROLE OF
TERTIARY AND QUATERNARY STRUCTURES 12 1.3.3 HETERO-OLIGOMERIZATION 13
1.4 RECEPTOR STRUCTURE 13
1.4.1 MODIFICATIONS TO THE N-TERMINI OF CHEMOKINES AND THEIR EFFECT ON
RECEPTOR ACTIVATION 16 1.5 GLYCOSAMINOGLYCAN BINDING SITES 17 1.6
CHEMOKINE ANALOGS- RESEARCH TOOLS AND POTENTIAL THERAPEUTICS? 20
REFERENCES 23
2 STRUCTURAL INSIGHTS FOR HOMOLOGY MODELING OF CHEMOKINE RECEPTORS 33
LEONARDO PARDO, XAVIER DEUPI, ARNAU CORDOMI, CEDRIC COVAERTS, AND
MERCEDES CAMPILLO 2.1 INTRODUCTION 33
2.2 CHEMOKINES 35
2.3 THE TRANSMEMBRANE DOMAIN OF CHEMOKINE RECEPTORS 36 2.3.1
TRANSMEMBRANE HELIX 1 37 2.3.2 TRANSMEMBRANE HELIX 2 37
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1002408105
DIGITALISIERT DURCH
IMAGE 2
VI CONTENTS
2.3.3 TRANSMEMBRANE HELIX 3 38
23.4 TRANSMEMBRANE HELIX 4 38 2.3.5 TRANSMEMBRANE HELIX 5 39 2.3.6
TRANSMEMBRANE HELIX 6 39
2.3.7 TRANSMEMBRANE HELIX 7 39 2.4 STRUCTURAL AND FUNCTIONAL ROLE OF
INTERNAL WATER MOLECULES 40 2.5 THE STRUCTURE OF THE EXTRACELLULAR
DOMAIN OF CHEMOKINE RECEPTORS 41 2.6 THE STRUCTURE OF THE INTRACELLULAR
DOMAIN 41 2.7 THE BINDING OF CHEMOKINES TO CHEMOKINE RECEPTORS 41 2.8
THE BINDING OF SMALL-MOLECULE LIGANDS TO CHEMOKINE RECEPTORS 42 2.9
MOLECULAR PROCESSES OF RECEPTOR ACTIVATION 42 2.10 THE BINDING OF THE G
PROTEIN 44
2.11 RECEPTOR OLIGOMERIZATION 45 2.12 CONCLUSIONS 45
REFERENCES 45
3 SIGNALING EVENTS INVOLVED IN CHEMOKINE-DIRECTED T LYMPHOCYTE MIGRATION
51 STEPHEN C. WARD
3.1 THE ROLE OF GTPASES IN CHEMOKINE-DIRECTED LYMPHOCYTE MIGRATION 51
3.2 CLASS 1 PI3KS AND THEIR ROLE IN CELL MIGRATION: AN OVERVIEW 52 3.3
DO PI3K-DEPENDENT SIGNALS CONTRIBUTE TO T LYMPHOCYTE
MIGRATION IN RESPONSE TO CHEMOKINES? 53 3.4 ROLE OF PI3K IN T LYMPHOCYTE
HOMING AND MIGRATION IN VIVO 54 3.5 ROLE OF PI3K IN INTERSTITIAL T
LYMPHOCYTE MOTILITY 55 3.6 ROLE OF PHOSPHOLIPASE C AND PROTEIN KINASE C
SIGNALING
IN CHEMOKINE-DIRECTED T LYMPHOCYTE MIGRATION 56 3.7 CONCLUDING REMARKS
AND FUTURE DIRECTIONS 57 REFERENCES 59
4 THE ATYPICAL CHEMOKINE RECEPTORS 67 MARK D. SINGH, ROBERT J. B. NIBBS,
AND GERARD J. GRAHAM 4.1 D6, AN ATYPICAL RECEPTOR FOR PRO-INFLAMMATORY
CC CHEMOKINES 67 4.1.1 D6 SCAVENGES CHEMOKINES IN VITRO 68
4.1.2 D6 EXPRESSION IN VIVO 69
4.1.3 EXPLORATIONS OF D6 FUNCTION IN VIVO 70 4.2 CCX-CKR, AN ATYPICAL
RECEPTOR FOR HOMEOSTATIC CC CHEMOKINES 73 4.3 CXCR7: A SECOND RECEPTOR
FOR CXCL11 AND CXCL12 WITH CRITICAL ROLES IN DEVELOPMENT AND
TUMORIGENESIS 75
4.3.1 CXCR7 IN DEVELOPMENT 75 4.3.2 CXCR7 IN CANCER 76
4.4 DARC: A PROMISCUOUS PRO-INFLAMMATORY ATYPICAL CHEMOKINE RECEPTOR ON
RED BLOOD CELLS AND ENDOTHELIAL CELLS 77 4.4.1 FUNCTION OF CHEMOKINE
BINDING TO DARC 77
IMAGE 3
CONTENTS VII
4.4.2 DARC INTERACTS WITH NON-CHEMOKINE PROTEINS 78
4.4.3 WHAT CAN DARC NEGATIVE PEOPLE TELL US ABOUT DARC FUNCTION? 79 4.5
SUMMARY 79
REFERENCES 79
5 TARGETING CHEMOKINE RECEPTOR DIMERS: ARE THERE TWO (OR MORE) TO TANGO?
85 HENRY F. WISCHER, SASKIA NIJMEIJER, AND MARC PARMENTIER
5.1 INTRODUCTION 85
5.2 CHEMOKINES AND THEIR RECEPTORS 85 5.3 GPCRS EXIST AND FUNCTION AS
DIMERS 86 5.4 DETECTION OF GPCR DIMERIZATION 87 5.5 CHEMOKINE RECEPTOR
DIMERIZATION 90 5.6 CONSTITUTIVE VERSUS INDUCED CHEMOKINE RECEPTOR
DIMERIZATION 93 5.7 FUNCTIONAL CONSEQUENCES OF CHEMOKINE RECEPTOR
DIMERIZATION 95 5.8 (PATHO-)PHYSIOLOGICAL CONSEQUENCES OF CHEMOKINE
RECEPTOR
DIMERIZATION 95
5.8.1 CHEMOKINE RECEPTOR HETERODIMERIZATION WITH CHEMOKINE RECEPTORS 96
5.8.2 CHEMOKINE RECEPTOR HETERODIMERIZATION WITH DECOY CHEMOKINE
RECEPTOR 96
5.8.3 CHEMOKINE RECEPTOR HETERODIMERIZATION WITH VIRALLY ENCODED GPCRS
96 5.8.4 CHEMOKINE RECEPTOR HETERODIMERIZATION WITH OPIOID RECEPTORS 97
5.8.5 CHEMOKINE RECEPTOR HETERODIMERS: INNOVATIVE DRUG TARGETS? 97
REFERENCES 98
PART TWO CHEMOKINE RECEPTORS IN DISEASE 105
6 CHEMOKINE RECEPTORS IN INFLAMMATORY DISEASES 107 ALETTA D. KRANEVELD,
SASKIA BRABER, SASKIA OVERBEEK, PETRA DE KRUIJF, PIRN KOELINK, AND
MARTINE J. SMIT 6.1 INTRODUCTION 107
6.2 CHEMOKINE RECEPTORS ON INFLAMMATORY/IMMUNE CELLS 108 6.2.1 CHEMOKINE
RECEPTORS AND INNATE IMMUNE CELLS 108 6.2.1.1 MONOCYTES AND MACROPHAGES
108 6.2.1.2 DENDRITIC CELLS 109
6.2.1.3 NEUTROPHILS 109 6.2.1.4 EOSINOPHILS 110 6.2.1.5 BASOPHILS 110
6.2.1.6 MAST CELLS 111 6.2.1.7 NATURAL KILLER CELLS 111 6.2.2 CHEMOKINE
RECEPTORS AND ADAPTIVE IMMUNE CELLS 112
6.2.2.1 B LYMPHOCYTES 112 6.2.2.2 T LYMPHOCYTES 113
IMAGE 4
VIII CONTENTS
6.2.3 CONCLUSION 114
6.3 CHEMOKINE RECEPTORS AND INFLAMMATORY LUNG DISEASES 114 6.3.1 COPD
116
6.3.2 CHEMOKINE RECEPTORS IN COPD 116 6.3.3 ASTHMA 118
6.3.4 CHEMOKINE TARGETS IN ASTHMA 119 6.4 CHEMOKINE AND INFLAMMATORY
BOWEL DISEASES 121 6.4.1 INFLAMMATORY BOWEL DISEASE 121 6.4.2 CHEMOKINE
RECEPTORS IN INFLAMMATORY BOWEL DISEASE 122
6.4.3 CHEMOKINE-MEDIATED NEURONAL ACTIVATION IN INFLAMMATORY BOWEL
DISEASE 124 6.5 CHEMOKINE RECEPTORS AND RHEUMATOID ARTHRITIS 125 6.5.1
RHEUMATOID ARTHRITIS 125 6.5.2 CHEMOKINE RECEPTORS AND THEIR LIGANDS IN
RHEUMATOID ARTHRITIS 126
6.6 CHEMOKINE RECEPTORS AND ATHEROSCLEROSIS 128 6.6.1 ATHEROSCLEROSIS
128 6.6.2 CHEMOKINE AND THEIR RECEPTORS IN ATHEROSCLEROSIS 129 6.7
CHEMOKINE RECEPTORS IN MULTIPLE SCLEROSIS 131 6.7.1 MULTIPLE SCLEROSIS
232
6.7.2 CHEMOKINES AND THEIR RECEPTORS IN MULTIPLE SCLEROSIS 132 6.8
CHEMOKINE RECEPTORS AND PSORIASIS 134 6.8.1 PSORIASIS 134
6.8.2 CHEMOKINES AND THEIR RECEPTORS IN PSORIASIS 135 6.9 CONCLUDING
REMARKS 136
REFERENCES 137
7 CHEMOKINES AND THEIR RECEPTORS IN CENTRAL NERVOUS SYSTEM DISEASE 151
KNUT BIBER AND HENDRIKUS W. C. M. BODDEKE 7.1 INTRODUCTION 252
7.2 FAMILIES OF CHEMOKINES 252
7.3 CHEMOKINE PHARMACOLOGY 252 7.4 CHEMOKINES AND CHEMOKINE RECEPTORS: A
COMPLEX SYSTEM 252 7.4.1 EXPRESSION OF CHEMOKINES AND THEIR RECEPTORS IN
THE CNS 253
7.4.2 INVOLVEMENT OF CHEMOKINES IN BLOOD-BRAIN BARRIER DISRUPTION
ASSOCIATED WITH NEURODEGENERATIVE DISEASE 153 7.5 THE ROLE OF THE
CHEMOKINERGIC SYSTEM IN MULTIPLE SCLEROSIS AND EXPERIMENTAL AUTOIMMUNE
ENCEPHALITIS 254 7.5.1 CHEMOKINES: ATTRACTORS FOR BLOOD LYMPHOCYTES IN
MS AND EAE? 254
7.6 THE ROLE OF CHEMOKINES IN BRAIN ISCHEMIA 255 7.6.1 FUNCTIONAL
INVOLVEMENT OF CHEMOKINES IN ISCHEMIE NEURODEGENERATION 156 7.7
CHEMOKINES IN HIV-ASSOCIATED DEMENTIA 257 7.7.1 INVOLVEMENT OF CHEMOKINE
RECEPTORS IN HIV INFECTION
OF THE BRAIN 257
IMAGE 5
CONTENTS IX
7.7.2 INVOLVEMENT OF CXCR4 IN GPL20-INDUCED NEUROTOXICITY 157
7.7.3 THEROLEOFCXSCLLINHAD 258 7.8 CHEMOKINES IN NEUROPATHIC PAIN 259
7.9 CONCLUSIONS 260
REFERENCES 260
8 CHEMOKINES AND CANCER METASTASIS 267 AMANDA BURKHARDT AND ALBERT
ZLOTNIK 8.1 INTRODUCTION 267
8.2 CXCR4 AND CCR7 RECEPTORS PLAY SPECIAL ROLES IN CANCER METASTASIS 268
8.3 RETROSPECTIVE CLINICAL DATA SUPPORTS A ROLE FOR CHEMOKINES IN CANCER
METASTASIS 269 8.4 HOW DOES THE CXCR4/CXCL12 AXIS INFLUENCE THE
DEVELOPMENT
OF METASTATIC LESIONS? 270 8.5 CXCR4 IS A KEY PLAYER IN THE DEVELOPMENT
OF ZEBRAFISH; ROLEOFCXCR7 270 8.6 THE CXCR4/CXCL12 AXIS IN STEM CELL
HOMING IN THE BONE
MARROW 272
8.7 CONCLUSIONS AND FUTURE DIRECTIONS 172 REFERENCES 273
9 CONSTITUTIVELY ACTIVE VIRAL CHEMOKINE RECEPTORS: TOOLS FOR IMMUNE
SUBVERSION AND PATHOGENESIS 277 DAVID MAUSSANG, GEROLD BONGERS, SERGIO
A. LIRA, AND MARTINE J. SMIT
9.1 INTRODUCTION 277
9.2 HERPESVIRUSES AND VIRAL DISEASES 280 9.2.1 THE BETAHERPESVIRIDAE
SUBFAMILY 280 9.2.1.1 THE CYTOMEGALOVIRUS GENUS: HHV-5/HCMV 180 9.2.1.2
THE RHESOLOVIRUS GENUS: HHV-6 AND HHV-7 283 9.2.2 THE GAMMAHERPESVIRIDAE
SUBFAMILY 283 9.2.2.1 THE LYMPHOCRYPTOVIRUS GENUS: HHV-4/EBV 283 9.2.2.2
THE RHADINOVIRUS GENUS: HHV-8/KSHV 283 9.3 HERPESVIRUSES ENCODE
CONSTITUTIVELY ACTIVE VIRAL CHEMOKINE
RECEPTORS 284
9.3.1 HUMAN CYTOMEGALOVIRUS ENCODES FOUR DIFFERENT VIRAL G
PROTEIN-COUPLED RECEPTORS 284 9.3.1.1 THE CHEMOKINE RECEPTOR US28
MEDIATES HCMV-INDUCED (PATHO)PHYSIOLOGICAL EFFECTS 284 9.3.1.2 THE
CONSTITUTIVELY ACTIVE ORPHAN CHEMOKINE RECEPTOR
UL33 288
9.3.1.3 THE CHEMOKINE RECEPTOR-RELATED US27 AND UL78 ORPHAN RECEPTORS
288 9.3.2 ROSEOLOVIRUSES-ENCODED CHEMOKINE RECEPTORS: THE U12 AND U51
GENES 289
IMAGE 6
CONTENTS
9.3.3 EBV-ENCODED CONSTITUTIVELY ACTIVE ORPHAN VGPCR BILF1 290
9.3.4 ORF74, THE TUMORIGENIC CONSTITUTIVELY ACTIVE CHEMOKINE RECEPTOR
ENCODED BY KS H V 290 9.3.4.1 ORF74 CONSTITUTIVELY ACTIVATES MULTIPLE
SIGNALING PATHWAYS IN DIFFERENT CELL TYPES 2 92 9.3.4.2 ORF74 EXPRESSION
MIMICS KSHV-INDUCED TRANSFORMATION 193
9.4 CONCLUDING REMARKS 294
REFERENCES 296
PART THREE TARGETING CHEMOKINE RECEPTORS 207
10 CCR5 ANTAGONISTS IN HIV 209
DAVID C. PRYDE AND CHRISTOPHER G. BARBER 10.1 INTRODUCTION 209
10.1.1 HIV AND AIDS 209 10.1.2 VIRAL ENTRY AS A THERAPEUTIC TARGET 220
10.1.3 CCR5 AS A THERAPEUTIC TARGET 212 10.1.4 ENABLING DRUG DISCOVERY
PROGRAMS TARGETING CCR5 222 10.2 CCR5 ANTAGONIST PROGRAMS 222 10.2.1
MERCK 212
10.2.2 NOVARTIS 214
10.2.3 PFIZER 215
10.2.4 INCYTE 228
10.2.5 SCHERING PLOUGH 228 10.2.6 BERLEX 220
10.2.7 GLAXOSMITHKLINE/ONO 220 10.2.8 TAKEDA 222
10.2.9 ASTRAZENECA 222 10.2.10 RECENT DISCLOSURES 222 10.2.11 OVERVIEW
OF PUBLISHED CCR5 ANTAGONISTS 224 10.3 MOLECULAR INTERACTIONS AND
BINDING MODES OF CCR5 RECEPTOR
ANTAGONISTS 225
10.4 RESISTANCE TO CCR5 RECEPTOR ANTAGONISTS 227 10.5 OUTLOOK 228
REFERENCES 229
11 CXCR4 AS A THERAPEUTIC TARGET 239 KEN Y.C. CHOW AND FRANCOISE
BACHELERIE 11.1 BIOLOGY AND PHYSIOLOGICAL ROLE OF CXCR4 239 11.1.1
GENERAL INTRODUCTION 239
11.1.2 REGULATION OF CXCR4 EXPRESSION 240 11.1.2.1 TRANSCRIPTIONAL
REGULATION 240 11.1.2.2 POST-TRANSCRIPTIONAL REGULATION 242
11.1.3 PHYSIOLOGICAL FUNCTIONS OF THE CXCR4 RECEPTOR 242 11.1.3.1 ROLE
IN LEUKOCYTES TRAFFICKING AND DEVELOPMENT 242
IMAGE 7
CONTENTS XI
11.1.3.2 ROLE IN NEOVASCULARIZATION AND ANGIOGENESIS
(PRE- AND POST-NATAL) 243 11.1.3.3 ROLE IN EMBRYONIC DEVELOPMENT:
PHENOTYPES OF CXCL12 AND CXCR4-KNOCKOUT MICE 244 11.1.3.4 ROLE IN
EMBRYONIC DEVELOPMENT: INSIGHTS FROM THE
ZEBRA FISH MODEL 245 11.1.4 SIGNAL TRANSDUCTION VIA THE CXCR4 RECEPTOR
246 11.1.4.1 INTERACTION WITH THE COGNATE LIGAND - CXCL12 246 11.1.4.2
ACTIVATION OF HETEROTRIMERIC G PROTEINS 247 11.1.4.3 REGULATION OF CXCR4
G PROTEIN-DEPENDENT SIGNALING 247 11.1.4.4 ACTIVATION AND REGULATION OF
SS-ARRESTIN-DEPENDENT SIGNALING
PATHWAYS 248
11.1.4.5 OTHER FACTORS AFFECTING CXCR4 SIGNALING: ROLE OF RECEPTOR
OLIGOMERISATION 248 11.2 PATHO-PHYSIOLOGICAL ROLE OF CXCR4: POTENTIAL AS
A THERAPEUTIC TARGET 249
11.2.1 ROLE IN HIV INFECTION 249 11.2.2 ROLE IN INFLAMMATORY DISEASES
250 11.2.3 ROLE IN CANCER DEVELOPMENT 252 11.2.4 THE WHIM SYNDROME (WS)
252 11.2.5 POTENTIAL OF CXCR4 AS THERAPEUTIC TARGET 252 11.2.5.1
APPLICATION IN HIV-INFECTION 252 11.2.5.2 APPLICATION IN THE DEVELOPMENT
OF CANCER AND STEM CELL
MOBILIZATION 254
11.3 CONCLUDING REMARKS 255 REFERENCES 256
12 LOW MOLECULAR WEIGHT CXCR2 ANTAGONISTS AS PROMISING THERAPEUTICS 279
KATSUHIRO MIHARA ANDJAC WIJKMANS 12.1 INTRODUCTION 279
12.2 CXCR2 IIGANDS AND SIGNAL TRANSDUCTION 279 12.3 BIOLOGICAL FUNCTIONS
280 12.3.1 LEUKOCYTES 280 12.3.2 NONHEMATOPOIETIC CELLS AND CELLS OF THE
CENTRAL NERVOUS
SYSTEM 282
12.4 CXCR2 IN INFLAMMATORY DISORDERS 282 12.4.1 CHRONIC OBSTRUCTIVE
PULMONARY DISEASE 282 12.4.2 ASTHMA 282
12.4.3 ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME 283
12.4.4 ATHEROSCLEROSIS 283 12.4.5 OTHER INFLAMMATORY DISORDERS 283 12.5
LOW MOLECULAR WEIGHT CXCR2 ANTAGONISTS 284 12.5.1 2-HYDROXYPHENYL UREAS
284 12.5.2 UREA ISOSTERES 286
IMAGE 8
XII CONTENTS
12.5.3 THIAZOLOPYRIMIDINES 289
12.5.4 TRIAZOLETHIOLS 290 12.5.5 2-AMINO-3-HETEROARYL QUINAZOLINES 290
12.5.6 INDOLYLBUTERIC ACID DERIVATIVES 292 12.5.7 2-IMIDAZOLYL
PYRIMIDINES 291
12.5.8 NICOTINAMIDE N-OXIDES 291 12.5.9 2-ARYLPROPIONIC ACID DERIVATIVES
292 12.5.10 DIARYL ISOXAZOLES 293 12.6 CHALLENGES AND FUTURE
PERSPECTIVES 293
REFERENCES 294
13 THERAPEUTIC TARGETING OF THE CXCR3 RECEPTOR 301 MAIKEL WIJTMANS,
IWANJ. P. DE ESCH, AND ROB LEURS 13.1 THE CXCR3 RECEPTOR 301 13.2 CXCR3
AS A POTENTIAL DRUG TARGET 302 13.2.1 USEOFCXCRS-KOMICE 302 13.2.2
TARGETING OF CXCR3 OR ITS ENDOGENOUS IIGANDS BY ANTIBODIES 303 13.3 THE
DEVELOPMENT OF CXCR3 ANTAGONISTS 303 13.3.1 PUBLICATIONS ON SMALL CXCR3
ANTAGONISTS 304 13.3.2 PATENTS ON SMALL CXCR3 ANTAGONISTS 320
13.3.3 PROTEIN-BASED CXCR3 ANTAGONISTS 322 13.4 CXCR3 ANTAGONISTS IN
DISEASE MODELS AND IN THE CLINIC 312 13.5 CONCLUSION AND OUTLOOK 325
REFERENCES 325
14 TARGETING CCR1 323
RICHARD HORUK
14.1 INTRODUCTION 323
14.2 CCR1 AS A DRUG TARGET 324
14.3 CCR1 ANTAGONISTS 325 14.4 CONCLUSIONS 333
REFERENCES 333
15 TARGETING CCR3 339
JAMES EDWARD PEASE 15.1 INTRODUCTION 339
15.2 CCR3 AND THE EOTAXIN FAMILY OF CHEMOKINES 339 15.3
STRUCTURE-FUNCTION STUDIES OF CCR3 AND ITS IIGANDS 342 15.4 CCR3 AND ITS
IIGANDS IN THE PATHOGENESIS OF ALLERGIC DISEASE 342 15.4.1 SUPPORTING
EVIDENCE FROM ANIMAL MODELS 342
15.4.2 SUPPORTING EVIDENCE FROM CLINICAL STUDIES 343 15.5 TARGETING CCR3
FUNCTION 344 15.6 SMALL-MOLECULE CCR3 ANTAGONISTS WITH IN VIVO ACTIVITY
348 15.7 SUMMARY 349
REFERENCES 350
IMAGE 9
CONTENTS XIII
16 CHEMOKINE BINDING PROTEINS AS THERAPEUTICS 359
AH ALEJO AND ANTONIO ALCAMI 16.1 IMMUNE MODULATION BY SECRETED CHEMOKINE
BINDING PROTEINS (CKBPS) 359 16.2 VIRAL CKBPS (VCKBPS) 362 16.2.1 VCKBPS
AS THERAPEUTICS 362 16.2.1.1 THE POXVIRUS 35-KDA PROTEIN 361 16.2.1.2
THE GAMMAHERPESVIRUS M3 PROTEIN 362 16.2.1.3 THE MYXV M-T7 PROTEIN 363
16.2.2 OTHER VCKBPS 364 16.2.2.1 THE SMALLPOX VIRUS-ENCODED CHEMOKINE
RECEPTOR (SECRET)
DOMAIN FROM POXVIRUSES 365 16.2.2.2 THE POXVIRUS A41 PROTEIN 366
16.2.2.3 THE ALPHAHERPESVIRUS GLYCOPROTEIN G (GG) 366 16.2.2.4 THE HUMAN
CYTOMEGALOVIRUS PUL21.5 PROTEIN 366 16.3 THE SCHISTOSOMA MANSONI CKBP
366 16.4 EVASINS, A FAMILY OF CKBPS FROM TICKS 367 16.5 ADVANTAGES AND
LIMITATIONS OF THE USE OF CKBPS AS THERAPEUTICS 367
REFERENCES 370
INDEX 375 |
| any_adam_object | 1 |
| author2 | Smit, Martine J. |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV036764245 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T10:51:17Z |
| institution | BVB |
| isbn | 9783527321186 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020681221 |
| oclc_num | 705951858 |
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| owner_facet | DE-20 DE-11 DE-M49 DE-BY-TUM DE-19 DE-BY-UBM DE-355 DE-BY-UBR |
| physical | XXIV, 384 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Wiley-VCH |
| record_format | marc |
| series | Methods and principles in medicinal chemistry |
| series2 | Methods and principles in medicinal chemistry |
| spelling | Chemokine receptors as drug targets ed. by Martine J. Smit ... Weinheim Wiley-VCH 2011 XXIV, 384 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods and principles in medicinal chemistry 46 Arzneistoffträger (DE-588)4278196-6 gnd rswk-swf Zellrezeptor (DE-588)4133853-4 gnd rswk-swf Chemokine (DE-588)4429989-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Chemokine (DE-588)4429989-8 s Zellrezeptor (DE-588)4133853-4 s Arzneistoffträger (DE-588)4278196-6 s DE-604 Smit, Martine J. edt Methods and principles in medicinal chemistry 46 (DE-604)BV035418617 46 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3474319&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020681221&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chemokine receptors as drug targets Methods and principles in medicinal chemistry Arzneistoffträger (DE-588)4278196-6 gnd Zellrezeptor (DE-588)4133853-4 gnd Chemokine (DE-588)4429989-8 gnd |
| subject_GND | (DE-588)4278196-6 (DE-588)4133853-4 (DE-588)4429989-8 (DE-588)4143413-4 |
| title | Chemokine receptors as drug targets |
| title_auth | Chemokine receptors as drug targets |
| title_exact_search | Chemokine receptors as drug targets |
| title_full | Chemokine receptors as drug targets ed. by Martine J. Smit ... |
| title_fullStr | Chemokine receptors as drug targets ed. by Martine J. Smit ... |
| title_full_unstemmed | Chemokine receptors as drug targets ed. by Martine J. Smit ... |
| title_short | Chemokine receptors as drug targets |
| title_sort | chemokine receptors as drug targets |
| topic | Arzneistoffträger (DE-588)4278196-6 gnd Zellrezeptor (DE-588)4133853-4 gnd Chemokine (DE-588)4429989-8 gnd |
| topic_facet | Arzneistoffträger Zellrezeptor Chemokine Aufsatzsammlung |
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| volume_link | (DE-604)BV035418617 |
| work_keys_str_mv | AT smitmartinej chemokinereceptorsasdrugtargets |