Biochemistry:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Hoboken, NJ
Wiley
2011
|
| Edition: | 4. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXV, 1428 S., 53 S. Ill., graph. Darst. |
| ISBN: | 0470570954 9780470570951 9780470917459 |
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| adam_text | BRÍEF
CONTENTS
Guide to Media Resources
xvi
PART
1
INTRODUCTION AND
BACKGROUND
1
1
Life
з
2
Aqueous Solutions
40
3
Thermodynamic Principles: A Review
52
PART II BtOMOLECULES
65
4
Amino
Acids
67
5
Nucleic Acids, Gene Expression, and
Recombinant
DNA
Technology
82
6
Techniques of Protein and Nucleic Acid Purifications
129
7
Covalent Structures of Proteins and Nucleic Acids
163
8
Three-Dimensional Structures of Proteins
221
9
Protein Folding, Dynamics, and Structural Evolution
278
10
Hemoglobin: Protein Function in Microcosm
323
11
Sugars and Polysaccharides
359
1 2
Lipids and Membranes
386
PART III MECHANISMS OF ENZYME ACTION
467
13
Introduction to Enzymes
469
14
Rates of Enzymatic Reactions
482
15
Enzymatic Catalysis 506
PART IV METABOLISM
557
1 €»
Introduction to Metabolism
559
17
Glycolysis
593
18
Glycogen Metabolism
6З8
19
Signal Transduction
671
20 Transport through Membranes
744
21
Citric Acid Cycle
789
22
Electron Transport and Oxidative Phosphorylation
823
23
Other Pathways of Carbohydrate Metabolism
871
24
Photosynthesis
901
25
Lipid
Metabolism
940
26
Amino
Acid Metabolism
1019
27
Energy Metabolism: Integration and Organ Specialization 1088
28
Nucleotide Metabolism
1107
PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION
1143
29
Nucleic Acid Structures
1146
30
DNA
Replication, Repair, and Recombination
1173
31
Transcription
126О
32
Translation
1338
33
Viruses: Paradigms for Cellular Function W-1
34
Eukaryotic Gene Expression w-53
35
Molecular Physiology
(Chapters
33-35
are available on our website, www.wiley.com/coilege/voet)
xii
CONTENTS
Guide
to
Media Resources xvi
PART
I
INTRODUCTION AND BACKGROUND 1
Chapter
1 Life
з
1. Prokaryotes 3
Z. Eukaryotes 6
3.
Biochemistry: A Prologue
14
4.
Genetics: A Review
19
5.
The Origin of Life
28
6.
The Biochemical Literature
34
Chapter
2
Aqueous Solutions
40
1.
Properties of Water
40
2.
Acids, Bases, and Buffers
45
Chapter
3
Thermodynamic Principles:
A Review
52
1.
First Law of Thermodynamics: Energy Is
Conserved
52
2.
Second Law of Thermodynamics: The Universe
Tends Toward Maximum Disorder
54
3.
Free Energy: The Indicator of Spontaneity
57
4.
Chemical Equilibria
58
APPENDIX: Concentration Dependence of
Free Energy
61
PART II
BIOMOLECULES
65
Chapter
4
Amino
Acids
67
1.
The
Amino
Acids of Proteins
67
2.
Optical Activity
73
3.
Nonstandard Amino
Acids
78
Chapter
5
Nucleic Acids, Gene
Expression, and
Recombinant
DNA
Technology
82
1.
Nucleotides and Nucleic Acids
82
2. DNA
Is the Carrier of Genetic Information
85
3.
Double Helical
DNA 88
4.
Gene Expression and Replication.
An Overview
95
5. Molecular Cloning
104
Chapter
6
Techniques of Protein and
Nucleic Acid Purifications
129
1.
Protein Isolation
129
2.
Solubilities of Proteins
133
3. Chromatographie
Separations
135
4,
Electrophoresis
146
5, Ultracentrifugation
152
6,
Nucleic Acid Fractionation
156
Chapter
7
Covalent Structures of
Proteins and Nucleic Acids 163
1.
Primary Structure Determination of Proteins
164
2.
Nucleic Acid Sequencing
176
3.
Chemical Evolution
185
4.
Bioinformatics: An Introduction
194
5.
Chemical Synthesis of Polypeptides
205
6.
Chemical Synthesis of Oligonucleotides
209
Chapter
8
Three-Dimensional
Structures of Proteins
221
1.
Secondary Structure
221
2.
Fibrous Proteins
232
3.
Globular Proteins
241
4.
Protein Stability
259
5.
Quaternary Structure
266
APPENDIX: Viewing Stereo Pictures
271
Chapter
9
Protein Folding, Dynamics,
and Structural Evolution
278
1.
Protein Folding: Theory and Experiment
278
2.
Folding Accessory Proteins
290
3.
Protein Structure Prediction and Design
302
4.
Protein Dynamics
306
5.
Conformational Diseases: Amyloids
and
Prions
309
6.
Structural Evolution
316
Chapter
1
0 Hemoglobin:
Protein
Function in Microcosm
323
1.
Hemoglobin and Myoglobin Function
323
2.
Structure and Mechanism
331
3.
Abnormal Hemoglobins
341
4.
Allosteric Regulation
347
APPENDIX: Derivation of Symmetry Model
Equations
354
Chapter
11
Sugars and
Polysaccharides
359
1.
Monosaccharides
359
2.
Polysaccharides
365
3.
Glycoproteins
373
Chapter
12
Lìpide
and Membranes
зее
1,
Lipid
Classification
386
2.
Properties of
Lipid
Aggregates
393
xiii
xiv Contents
3.
Biological Membranes
399
4.
Membrane Assembly and Protein Targeting
41 8
5.
Lipoproteins
449
PART III
MECHANISMS OF ENZYME ACTION
467
Chapter
13
Introduction to Enzymes
469
1.
Historical Perspective
469
2.
Substrate Specificity
470
3.
Coenzymes
473
4.
Regulation of Enzymatic Activity
474
5.
A Primer of Enzyme Nomenclature
479
Chapter
14
Rates of Enzymatic
Reactions
482
1.
Chemical Kinetics
482
2.
Enzyme Kinetics
487
3.
Inhibition
492
4.
Effects of
pH 496
5. Bisubstrate Reactions
497
APPENDIX: Derivations of Michaelis-Menten
Equation Variants
501
Chapter
15
Enzymatic Catalysis 506
1.
Catalytic Mechanisms
506
2.
Lysozyme
517
3.
Serine
Proteases
4.
Drug Design
539
PART IV
METABOLISM
557
Chapter
16
Introduction to
Metabolism
559
1.
Metabolic Pathways
559
2,
Organic Reaction Mechanisms
562
3.
Experimental Approaches to the Study
of Metabolism
569
4.
Thermodynamics of Phosphate
Compounds
578
5,
Oxidation—Reduction Reactions
583
6,
Thermodynamics of Life
586
Chapter
17
Glycolysis
593
t
.
The Glycolytic Pathway
593
2,
The Reactions of Glycolysis
595
3,
Fermentation: The Anaerobic Fate
of Pyruvate
614
4.
Metabolic Regulation and Control
619
5.
Metabolism of Hexoses Other than Glucose
630
Chapter
18
Glycogen Metabolism
взе
1.
Glycogen Breakdown
638
2.
Glycogen Synthesis
644
3.
Control of Glycogen Metabolism
647
4.
Glycogen Storage Diseases
666
Chapter
19
Signal Transduction 671
1.
Hormones
671
2.
Heterotrimeric
G
Proteins
688
3.
Tyrosine Kinase-Based Signaling
699
4.
The Phosphoinositide Cascade
725
Chapter 2O Transport through
Membranes
744
1.
Thermodynamics of Transport
744
2.
Kinetics and Mechanisms of Transport
745
3.
ATP-Driven Active Transport
758
4.
Ion Gradient-Driven Active Transport
768
5.
Neurotransmission
771
Chapter
21
Citric Acid Cycle
789
1.
Cycle Overview
789
2.
Metabolic Sources of Acetyl-Coenzyme A
792
3.
Enzymes of the Citric Acid Cycle
806
4.
Regulation of the Citric Acid Cycle
815
5.
The Amphibolic Nature of the Citric
Acid Cycle
81 7
Chapter
22
Electron Transport and
Oxidative Phosphorylation
823
1.
The Mitochondrion
823
2.
Electron Transport
828
3.
Oxidative Phosphorylation
845
4.
Control of ATP Production
862
Chapter
23
Other Pathways of
Carbohydrate Metabolism 87i
1.
Gluconeogenesis
871
2.
The Glyoxylate Cycle
880
3.
Biosynthesis of Oligosaccharides and
Glycoproteins
880
4.
The Pentose Phosphate Pathway
892
Chapter
24
Photosynthesis
901
1.
Chloroplasts
901
2.
Light Reactions
903
3.
Dark Reactions
926
Chapter
25
Lipid
Metabolism
940
1.
Lipid
Digestion, Absorption, and Transport
940
2,
Fatty Acid Oxidation
945
3,
Ketone
Bodies
959
4.
Fatty Acid Biosynthesis
961
Contents xv
5. Regulation
of Fatty Acid Metabolism
973
6.
Cholesterol Metabolism
975
7.
Eicosanoid Metabolism: Prostaglandins,
Prostacyclins, Thromboxanes, Leukotrienes,
and Lipoxins
993
S. Phospholipid and Glycolipid Metabolism
1004
Chapter
26
Amino
Acid
Metabolism
1019
1.
Amino
Acid Deamination
1019
2.
The Urea Cycle
1 025
3.
Metabolic Breakdown of Individual
Amino
Acids
1 029
4.
Amino
Acids as Biosynthetic Precursors
1 047
5.
Amino
Acid Biosynthesis
1 064
β.
Nitrogen Fixation
1078
Chapter
27
Energy Metabolism:
Integration and Organ
Specialization loss
1.
Major Pathways and Strategies of Energy
Metabolism: A Summary
1088
2.
Organ Specialization
1 090
3.
Metabolic Homeostasis: Regulation of Appetite,
Energy Expenditure, and Body Weight
1 095
4.
Metabolic Adaptation
1101
Chapter
28
Nucleotide
Metabolism
1107
1.
Synthesis of
Purine Ribonucleotides
1107
2.
Synthesis of Pyrimidine Ribonucleotides
1114
3.
Formation of Deoxyribonucleotides
1119
4.
Nucleotide Degradation
1130
5.
Biosynthesis of Nucleotide Coenzymes
11 36
PART V
EXPRESSION AND TRANSMISSION
OF GENETIC INFORMATION
1143
Chapter
29
Nucleic Acid
Structures
1145
1 ■
Double Helical Structures
1145
2.
Forces Stabilizing Nucleic Acid Structures
1151
3.
Supercoiled
DNA 1158
Chapter
ЗО
DNA
Replication, Repair,
and Recombination
1173
1 · DNA
Replication: An Overview
1173
2,
Enzymes of Replication
11 76
3.
Prokaryotic Replication
1190
4.
Eukaryotic Replication
1 201
5.
Repair of
DNA 1 21 3
6.
Recombination and Mobile Genetic
Elements
1225
7. DNA Methylation
and Trinucleotide
Repeat Expansions
1 246
Chapter
31
Transcription 1260
1.
The Role of
RNA
in Protein Synthesis
1 260
2.
RNA Polymerase
1 265
3.
Control of Transcription in Prokaryotes
1 283
4·.
Post-Transcriptional Processing
1301
Chapter
32
Translation
іззв
1.
The Genetic Code
1 338
2.
Transfer
RNA
and Its Aminoacylation
1 345
3.
Ribosomes
1362
4.
Control of Eukaryotic Translation
1 398
5.
Post-Translational Modification
1403
6.
Protein Degradation
1408
*Chapter
33
Viruses: Paradigms for
Cellular Function w-i
1 ■
Tobacco Mosaic Virus W-3
2.
Icosahedral Viruses W-8
3.
Bacteriophage
λ
W-20
4.
Influenzavírus W-40
*Chapter
34
Eukaryotic Gene
Expression
1.
Chromosome Structure
2.
Genomic Organization
3.
Control of Expression
4.
Cell Differentiation
*Chapter
35
Molecular Physiology
1.
Blood Clotting
2.
Immunity
3.
Motility: Muscles, Vesicle Transport,
Cilia, and
Flagella
Index
m
Chapters
33, 34,
and
35
are available on our book
companion website, www.wiley.com/college/voeL
|
| any_adam_object | 1 |
| author | Voet, Donald 1938- Voet, Judith G. |
| author_GND | (DE-588)132545799 (DE-588)132546159 |
| author_facet | Voet, Donald 1938- Voet, Judith G. |
| author_role | aut aut |
| author_sort | Voet, Donald 1938- |
| author_variant | d v dv j g v jg jgv |
| building | Verbundindex |
| bvnumber | BV036733229 |
| classification_rvk | WD 4010 |
| ctrlnum | (OCoLC)705919510 (DE-599)BVBBV036733229 |
| discipline | Biologie |
| edition | 4. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV036733229 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:46:51Z |
| institution | BVB |
| isbn | 0470570954 9780470570951 9780470917459 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020650857 |
| oclc_num | 705919510 |
| open_access_boolean | |
| owner | DE-83 DE-29T DE-355 DE-BY-UBR DE-11 DE-29 DE-20 DE-19 DE-BY-UBM DE-634 DE-578 |
| owner_facet | DE-83 DE-29T DE-355 DE-BY-UBR DE-11 DE-29 DE-20 DE-19 DE-BY-UBM DE-634 DE-578 |
| physical | XXV, 1428 S., 53 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Wiley |
| record_format | marc |
| spelling | Voet, Donald 1938- Verfasser (DE-588)132545799 aut Biochemistry Donald Voet ; Judith G. Voet 4. ed. Hoboken, NJ Wiley 2011 XXV, 1428 S., 53 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Biochemie (DE-588)4006777-4 s DE-604 Physiologische Chemie (DE-588)4076124-1 s 1\p DE-604 Molekulargenetik (DE-588)4039987-4 s 2\p DE-604 Molekularbiologie (DE-588)4039983-7 s 3\p DE-604 Voet, Judith G. Verfasser (DE-588)132546159 aut Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020650857&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Voet, Donald 1938- Voet, Judith G. Biochemistry Molekularbiologie (DE-588)4039983-7 gnd Physiologische Chemie (DE-588)4076124-1 gnd Biochemie (DE-588)4006777-4 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4076124-1 (DE-588)4006777-4 (DE-588)4039987-4 (DE-588)4123623-3 |
| title | Biochemistry |
| title_auth | Biochemistry |
| title_exact_search | Biochemistry |
| title_full | Biochemistry Donald Voet ; Judith G. Voet |
| title_fullStr | Biochemistry Donald Voet ; Judith G. Voet |
| title_full_unstemmed | Biochemistry Donald Voet ; Judith G. Voet |
| title_short | Biochemistry |
| title_sort | biochemistry |
| topic | Molekularbiologie (DE-588)4039983-7 gnd Physiologische Chemie (DE-588)4076124-1 gnd Biochemie (DE-588)4006777-4 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| topic_facet | Molekularbiologie Physiologische Chemie Biochemie Molekulargenetik Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020650857&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT voetdonald biochemistry AT voetjudithg biochemistry |