Essential concepts in molecular pathology:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2010
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXI, 440 S. Ill., graph. Darst. |
| ISBN: | 9780123744180 0123744180 |
Staff View
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| 245 | 1 | 0 | |a Essential concepts in molecular pathology |c ed. by William B. Coleman ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2010 | |
| 300 | |a XXI, 440 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Pathology, Molecular | |
| 650 | 4 | |a Molecular Biology |x methods | |
| 650 | 4 | |a Pathology, Clinical |x methods | |
| 650 | 4 | |a Cytogenetic Analysis |x methods | |
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Record in the Search Index
| _version_ | 1804143299973349376 |
|---|---|
| adam_text | List of Contributors
xiii
Preface
xvii
Foreword
xix
Acknowledgments
xxi
ITpart
I Essential Pathology
-
Mechanisms of Disease
Chapter
1
Molecular Mechanisms of Cell Death
3
John J. Lemasters, M.D., Ph.D.
Introduction
3
Modes of Cell Death
3
Structural Features of Necrosis and Apoptosis
3
Cellular and Molecular Mechanisms Underlying
Necrotic Cell Death
5
Pathways to Apoptosis
8
Mitochondria
10
Nucleus
12
Endoplasmic Reticulum
12
Lysosomes
13
Concluding Remark
13
Acknowledgments
13
Key Concepts
13
Suggested Readings
14
Chapter
2
Acute and Chronic Inflammation Induces
Disease Pathogenesis
15
Vladislav Dolgachev, Ph.D., and Nicholas W.
Lukacs,
Ph.D.
Introduction
15
Leukocyte Adhesion, Migration, and Activation
15
Acute Inflammation and Disease Pathogenesis
17
Pattern Recognition Receptors and Inflammatory
Responses
18
Chronic Inflammation and Acquired Immune
Responses
20
Tissue Remodeling During Acute and Chronic
Inflammatory Disease
22
Key Concepts
24
Suggested Readings
24
Chapter
3
Infection and Host Response
25
Margret
D.
Oethinger, M.D.,
Ph.D., and Sheldon M.
Campbell, M.D., Ph.D.
Microbes and Hosts
—
Balance of Power?
25
The Structure of the Immune Response
25
Regulation of Immunity
26
Pathogen Strategies
26
The African Trypanosome and Antibody Diversity:
Dueling Genomes
27
Siaphylococcus Aureus: The Extracellular
Battleground
29
Mycobaclerium Tuberculosis and the
Macrophage
34
Herpes Simplex Virus: Taking Over
36
HIV: The Immune Guerilla
38
Perspectives
42
Key Concepts
42
Suggested Readings
42
Chapter
4
Neoplasia
45
William B. Coleman, Ph.D., and
Tara C.
Rubinas, M.D.
Introduction
45
Cancer Statistics and Epidemiology
45
Classification of Neoplastic Diseases
50
Characteristics of Benign and Malignant
Neoplasms
56
Clinical Aspects of
Neoplasia
59
Key Concepts
60
Suggested Readings
61
PART
II
Concepts in Molecular
Biology and Genetics
Chapter
5
Basic Concepts in Human Molecular
Genetics
65
Kara A. Mensink, M.S., C.G.C., and W. Edward
Highsmith.Jr., Ph.D.
Introduction
65
Molecular Structure of
DNA 65
Modes of Inheritance
66
Contents
Central Dogma and Rationale
for Genetic Testing
71
Allelic
Heterogeneity and Choice of Analytical
Methodology
74
Conclusion
75
Key Concepts
76
Suggested Readings
76
Chapter
6
The Human Genome: Implications for the
Understanding of Human Disease
77
Ashley
G. Rivenbark,
Ph.D.
Introduction
77
Structure and Organization of the Human Genome
77
Overview of the Human Genome Project
79
Impact of the Human Genome Project on the
Identification of Disease-Related Genes
81
Sources of Variation in the Human Genome
83
Types of Genetic Diseases
83
Genetic Diseases and Cancer
84
Perspectives
86
Key Concepts
86
Suggested Readings
87
Chapter
7
The Human Transcriptome: Implications
for the Understanding of Human Disease
89
Christine Sers,
Ph.D., Wolfgang Kemmner, Ph.D., and
Reinhold Schäfer,
Ph.D.
Introduction
89
Gene Expression Profiling: The Search for Candidate
Genes Involved in Pathogenesis
89
Transcriptome Analysis Based on Microarrays: Technical
Prerequisites
91
Microarrays: Applications in Basic Research and
Translational Medicine
92
Perspectives
101
Key Concepts
101
Suggested Readings
103
Chapter
8
The Human Epigenome: Implications for
the Understanding of Human Disease
105
Maria Berdasco, Ph.D., and Manel Esteller, Ph.D.
Introduction
105
Epigenetic Regulation of the Genome
105
Genomic Imprinting
106
Cancer Epigenetics
108
Human Disorders Associated with Epigenetics
110
Key Concepts
112
Suggested Readings
112
Understanding Cancer at the Molecular Level: An
Evolving Frontier
113
Microdisseftion Technology Brings Molecuku Analysis
to the Tissue Level
113
Serum Proteomics: An Emerging Landscape (or b .uiv
Stage Cancer Detection
118
Key Concepts
122
Suggested Readings
122
Chapter
10
Integrative
Systems Biology: Implications
for the Understanding of Human
Disease
125
M. Michael Barmada, Ph.D., and David C.
Whitcomb, M.D., Ph.D.
Introduction
125
Data Generation
126
Data Integration
128
Modeling Systems
129
Implications for Understanding Disease
130
Discussion
132
Key Concepts
133
Suggested Readings
133
RT
Chapter
9
Clinical Proteomics and Molecular
Pathology
113
Mattia
Cremona, Virginia
Espina,
M.S., M.T.,
Alessandra
Luchini,
Ph.D.,
Emanuel
Petricoin, Ph.D., and Lance A.
Liotta, M.D., Ph.D.
Ill Principles and Practice of
Molecular Pathology
Chapter
11
Pathology: The Clinical Description of
Human Disease
137
William K. Funkhouser, M.D., Ph.D.
Current Practice of Pathology
137
The Future of Diagnostic Pathology
140
Conclusion
141
Key Concepts
141
Suggested Readings
141
Chapter
12
Understanding Molecular Pathogenesis: The
Biological Basis of Human Disease and
Implications for Improved Treatment of
Human Disease
143
William B. Coleman, Ph.D., and GregoryJ.
Tsongalis, Ph.D.
Introduction
143
Hepatitis
С
Virus Infection
143
Acute Myeloid Leukemia
146
Cystic Fibrosis
148
Key Concepts
151
Suggested Readings
151
Contents
Chapter
13
Integration of Molecular and Cellular
Pathogenesis: A Bioinformatics Approach
153
Jason H. Moore, Ph.D., and
С
Harker
Rhodes, M.D., Ph.D.
Chapter
17
Introduction
153
Overview of Bioinformatics
Database Resources
155
Data Analysis
156
The Future
157
Key Concepts
158
Suggested Readings
158
154
Molecular Basis of Diseases of Immunity
205
David
O. Beenhouwer, M.D.
Introduction
205
Normal Immune System
205
Major Syndromes
208
Key Concepts
215
Suggested Readings
215
Chapter
18
Molecular Basis of Pulmonary Disease
217
Carol F. Farver, M.D., and
Dani S.
Zander, M.D.
IV Molecular Pathology of
Human Disease
Introduction
217
Neoplastic Lung and
Pleural
Diseases
Obstructive Lung Diseases
228
Interstitial Lung Diseases
235
Pulmonary Vascular Diseases
238
Developmental Abnormalities
240
Key Concepts
242
Suggested Readings
242
217
Chapter
14
Molecular Basis of Cardiovascular Disease
Amber Chang Liu, and Avrum I. Gotlieb, M.D.CM.
General Molecular Principles of Cardiovascular
Diseases
161
The Cells of Cardiovascular Organs
161
Atherosclerosis
164
Ischemic
Heart Disease
167
Aneurysms
167
Valvular Heart Disease
168
Cardiomyopathies
169
Key Concepts
173
Suggested Readings
173
Chapter
15
Molecular Basis of
Hemostatic
and
Thrombotic Diseases
175
Alice D.
Ma, M.D.,
and Nigel S. Key, M.D.
Introduction and Overview of Coagulation
175
Disorders of Soluble Clotting Factors
177
Disorders of Platelet Number or Function
182
Thrombophilia
185
Key Concepts
187
Suggested Readings
187
Chapter
16
Molecular Basis of Lymphoid and Myeloid
Diseases
189
Joseph R. Biggs, Ph.D., and Dong-Er Zhang, Ph.D.
Development of the Blood and Lymphoid
Organs
189
Myeloid Disorders
193
Lymphocyte Disorders
198
Key Concepts
202
Suggested Readings
202
Chapter
19
Molecular Basis of Diseases of the
Gastrointestinal Tract
243
Antonia
R. Sepulveda, M.D.,
Ph.D., and
Dara
L.
Aisner, M.D.,
Ph.D.
Gastric Cancer
243
Colorectal Cancer
248
Key Concepts
260
Suggested Readings
261
Chapter
20
Molecular Basis of Liver Disease
263
Satdarshan P. Singh
Monga,
M.D.,
and Jaideep
Behari, M.D.,
Ph.D.
Introduction
263
Molecular Basis of Liver Development
263
Molecular Basis of Liver Regeneration
265
Adult Liver Stem Cells in Liver Health and Disease
266
Molecular Basis of Hepatocyte Death
267
Molecular Basis of Nonalcoholic Fatty Liver Disease
268
Molecular Basis of Alcoholic Liver Disease
271
Molecular Basis of Hepatic Fibrosis and
Cirrhosis
272
Molecular Basis of Hepatic Tumors
274
Key Concepts
277
Suggested Readings
277
Chapter
21
Molecular Basis of Diseases of the
Exocrine
Pancreas
279
Matthias Sendler, Ph.D., Julia Mayerle, Ph.D., and
Markus
M. Lerch, M.D.
Acute Pancreatitis
279
Chronic and Hereditary Pancreatitis
284
Key Concepts
287
Suggested Readings
288
Contents
Chapter
22
Molecular Basis of Diseases of the Endocrine
System
289
Alan Lap-Ym
Pang, Ph.D., and Wai-Yee Chan, Ph.D.
Introduction
289
The Pituitary Gland
289
The Thyroid Gland
292
Familial Nonautoimmune Hyperthyroidism
295
The Parathyroid Gland
296
The Adrenal Gland
299
Puberty
302
Key Concepts
306
Suggested Readings
306
Chapter
23
Molecular Basis of Gynecologic Diseases
309
Samuel
С. Мок,
Ph.D., Kwong-kwok Wong, Ph.D.,
Karen
Lu, M.D.,
Karl Munger,
Ph.D., and
Zoltán
Nagymanyoki, M.D.,
Ph.D.
Introduction
309
Benign and Malignant Tumors of the Female
Reproductive Tract
309
Disorders Related to Pregnancy
319
Key Concepts
321
Suggested Readings
322
Chapter
24
Molecular Pathogenesis of Diseases of the
Kidney
323
Amy K.
Motti,
M.D., M.P.H., and
Carla
Nester,
M.D., M.S.A.
Introduction
323
Normal Kidney Function
323
Focal
Segmental Glomerulosclerosis
Fabry Disease
325
Polycystic Kidney Disease
327
Disorders of Renal Tubular Function
Key Concepts
332
Suggested Readings
332
323
330
Chapter
26
Molecular Biology of Breast Cancer
341
Natasa
Snoj, M.D., Phuong Dinh, M.D., Philippe Bedard,
M.D., and
Christos
Sotiriou, M.D., Ph.D.
Introduction
341
Traditional Breast Cancer Classification
341
Biomarkers
343
Gene Expression Profiling
346
Conclusion
348
Key Concepts
348
Suggested Readings
348
Chapter
27
Molecular Basis of Skin Disease
351
Vesarat
Wessagowit, M.D., Ph.D.
Molecular Basis of Healthy Skin
351
Skin Development and Maintenance Provide New
Insight into Molecular Mechanisms of
Disease
352
Molecular Pathology of Mendelian Genetic Skin
Disorders
354
Molecular Pathology of Common Inflammatory Skin
Diseases
359
Skin Proteins as Targets for Inherited and Acquired
Disorders
361
Molecular Pathology of Skin Cancer
364
Molecular Diagnosis of Skin Disease
368
New Molecular Mechanisms and Novel
Therapies
370
Key Concepts
372
Suggested Readings
372
Chapter
28
Molecular Pathology: Neuropathology
373
Joshua A.
Sonnen,
Ph.D.,
С
Dirk Keene, M.D., Ph.D.,
Robert F. Hevner, Ph.D., M.D., and Thomas J.
Montine,
M.D., Ph.D.
Anatomy of the Central Nervous System
373
Neurodevelopmental Disorders
376
Neurological Injury: Stroke, Neurodegeneration,
and Toxicants
380
Neoplasia
390
Disorders of
Myelin 394
Key Concepts
397
Suggested Readings
397
Chapter
25
Molecular Pathogenesis of Prostate Cancer:
Somatic, Epigenetic, and Genetic
Alterations
335
Carlise R. Bethel, Ph.D.,
Angelo
M.
De Marzo, M.D.,
Ph.D.,
and
William G. Nelson, M.D.,
Ph.D.
V
Practice of Molecular
Medicine
Introduction
335
Hereditary Component of Prostate Cancer Risk
Somatic Alterations in Gene Expression
336
Epigenetics
338
Conclusion
339
Acknowledgments
339
Key Concepts
340
Suggested Readings
340
336
Chapter
29
Molecular Diagnosis of Human Disease
401
Lawrence M.
Silverman,
Ph.D., and Grant C. Bullock,
M.D., Ph.D.
Introduction
401
History of Molecular Diagnostics
401
Contents
Molecular
Laboratory Subspecialties
Key Concepts
411
Suggested Readings
411
403
Chapter
30
Molecular Assessment of Human Disease in
the Clinical Laboratory
413
Joel A. Lefferts, and Gregory J. Tsongalis, Ph.D.
Introduction
413
The Current Molecular Infectious Disease Paradigm
414
A New Paradigm for Molecular Diagnostic
Applications
415
BCR-ABL: A Model for the New Paradigm
418
Index
429
Conclusion
420
Key Concepts
420
Suggested Readings
420
Chapter
31
Pharmacogenomics and Personalized
Medicine in the Treatment of Human
Diseases
421
Hong Kee Lee, Ph.D., and Gregory J. Tsongalis, Ph.D.
Introduction
421
Conclusion
428
Key Concepts
428
Suggested Readings
428
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| id | DE-604.BV036674011 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:45:28Z |
| institution | BVB |
| isbn | 9780123744180 0123744180 |
| language | English |
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| spelling | Essential concepts in molecular pathology ed. by William B. Coleman ... Amsterdam [u.a.] Elsevier, Acad. Press 2010 XXI, 440 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Pathology, Molecular Molecular Biology methods Pathology, Clinical methods Cytogenetic Analysis methods Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 s DE-604 Coleman, William B. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020593035&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Essential concepts in molecular pathology Pathology, Molecular Molecular Biology methods Pathology, Clinical methods Cytogenetic Analysis methods Molekularpathologie (DE-588)4170396-0 gnd |
| subject_GND | (DE-588)4170396-0 |
| title | Essential concepts in molecular pathology |
| title_auth | Essential concepts in molecular pathology |
| title_exact_search | Essential concepts in molecular pathology |
| title_full | Essential concepts in molecular pathology ed. by William B. Coleman ... |
| title_fullStr | Essential concepts in molecular pathology ed. by William B. Coleman ... |
| title_full_unstemmed | Essential concepts in molecular pathology ed. by William B. Coleman ... |
| title_short | Essential concepts in molecular pathology |
| title_sort | essential concepts in molecular pathology |
| topic | Pathology, Molecular Molecular Biology methods Pathology, Clinical methods Cytogenetic Analysis methods Molekularpathologie (DE-588)4170396-0 gnd |
| topic_facet | Pathology, Molecular Molecular Biology methods Pathology, Clinical methods Cytogenetic Analysis methods Molekularpathologie |
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