Multiple myeloma:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin ; Heidelberg
Springer
2011
|
| Series: | Recent results in cancer research
183 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIII, 339 S. Ill., graph. Darst. |
| ISBN: | 9783540857716 |
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Record in the Search Index
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| adam_text | IMAGE 1
PART I HISTORY AND EPIDEMIOLOGY
1 HISTORY OF MULTIPLE MYELOMA 3
ROBERT A. KYLE AND DAVID P. STEENSMA
1.1 ANCIENT ORIGINS 4
1.1.1 EARLY WELL-DOCUMENTED CASES 4
1.2 HENRY BENCE JONES (1813-1873) 7
1.3 OTHER CONTRIBUTIONS TO BENCE JONES PROTEINURIA 10
1.4 OTHER EARLY CASES OF MULTIPLE MYELOMA 11
1.4.1 THE CASE OF DR. LOOS 11
1.4.2 THE FIRST MYELOMA CASE IN AMERICA 12
1.4.3 RECOGNITION OF THE POOR PROGNOSIS ASSOCIATED WITH BENCE JONES
PROTEIN 13
1.4.4 CASE SERIES 13
1.4.5 PLASMA CELLS 13
1.4.6 ANTIBODIES 14
1.4.7 ELECTROPHORESIS 14
1.4.8 MONOCLONAL VERSUS POLYCLONAL GAMMOPATHIES 15
1.5 ALKYLATOR AND CORTICOSTEROID-BASED THERAPY 15
1.5.1 URETHANE 15
1.5.2 MELPHALAN 16
1.5.3 PREDNISONE 16
1.5.4 ALKYLATOR COMBINATIONS 16
1.6 STEM CELL TRANSPLANTATION 17
1.6.1 NOVEL AGENTS 17
REFERENCES 19
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/989960765
DIGITALISIERT DURCH
IMAGE 2
XIV CONTENTS
2 EPIDEMIOLOGY OF MULTIPLE MYELOMA 25
NIKOLAUS BECKER
2.1 DESCRIPTIVE EPIDEMIOLOGY 26
2.2 ETIOLOGY 26
2.2.1 TOBACCO 26
2.2.2 ALCOHOL 29
2.2.3 DIET 29
2.2.4 OBESITY 29
2.2.5 PHYSICAL ACTIVITY 30
2.2.6 HORMONAL FACTORS 30
2.2.7 ENVIRONMENT AND OCCUPATION 30
2.2.8 IONIZING RADIATION 30
2.2.9 INHERITANCE 31
2.2.10 MEDICAL HISTORY, VIRUSES, IMMUNOLOGICAL CONDITIONS 31
2.3 SUMMARY 31
PART II PATHOPHYSIOLOGY
3 MOLECULAR PATHOGENESIS OF MULTIPLE MYELOMA: CHROMOSOMAL ABERRATIONS,
CHANGES IN GENE EXPRESSION, CYTOKINE NETWORKS, AND THE BONE MARROW
MICROENVIRONMENT 39 BERNARD KLEIN, ANJA SECKINGER, THOMAS MOEHLER, AND
DIRK HOSE
3.1 SURVIVAL, GROWTH, AND INHIBITORY FACTORS OF NORMAL PLASMA CELLS 40
3.1.1 SURVIVAL AND GROWTH FACTORS OF NORMAL PLASMA CELLS AND THEIR
GENERATION 40
3.1.2 INHIBITORY FACTORS EXPRESSED BY NORMAL PLASMA CELLS 43
3.2 CHROMOSOMAL ABERRATIONS 44
3.2.1 BACKGROUND AND METHODS 44
3.2.2 TYPES OF CHROMOSOMAL ABERRATIONS 46
3.2.3 ASSOCIATION OF CHROMOSOMAL ABERRATIONS 47
3.2.4 CLONAL, SUBCLONAL, AND PROGRESSION-RELATED ABERRATIONS AND
CHROMOSOMAL INSTABILITY 47
3.2.5 PROGNOSTIC RELEVANCE OF CHROMOSOMAL ABERRATIONS 48
3.3 CHANGES IN GENE EXPRESSION IN MULTIPLE MYELOMA 50
3.3.1 GENE EXPRESSION-BASED CLASSIFICATIONS IN MYELOMA 50
3.3.2 GENE EXPRESSION AND RISK STRATIFICATION 51
3.4 PROLIFERATION AND CELL CYCLE REGULATION 52
3.4.1 POTENTIAL TO PROLIFERATE OF NORMAL PLASMA CELLS 52
3.4.2 D-TYPE CYCLIN EXPRESSION IN MYELOMA 53
3.4.3 PROLIFERATION OF MALIGNANT PLASMA CELLS 53
3.5 MYELOMA CELL SURVIVAL AND PROLIFERATION FACTORS 54
IMAGE 3
CONTENTS
3.5.1 INTERFERON ALPHA/INTERLEUKIN-6 FAMILY AND ACTIVATION OF THE
JAK/STAT AND MAP KINASE PATHWAYS 55
3.5.2 FACTORS ACTIVATING THE PI-3 AND MAP KINASE PATHWAYS: INSULIN-LIKE
GROWTH FACTOR 1, HEPARIN-BINDING GROWTH FACTORS 56 3.5.3 HEPARIN-BINDING
FACTORS 58
3.5.4 FACTORS ACTIVATING NF-KAPPAB: BAFF FAMILY 59
3.5.5 HIERARCHY OF MYELOMA CELL GROWTH FACTORS AND POTENTIAL CLINICAL
APPLICATIONS 59
3.6 MULTIPLE MYELOMA CELLS AND THE MICROENVIRONMENT 60
3.6.1 PATHOGENESIS OF MYELOMA-INDUCED BONE DISEASE 61
3.6.2 PATTERNS AND HEALING OF BONE DEFECTS 63
3.6.3 THERAPEUTIC STRATEGIES FOR TREATMENT AND PREVENTION OF MYELOMA
BONE DISEASE 64
3.7 PATHOGENETIC MODEL OF MULTIPLE MYELOMA 64
3.7.1 DISEASE ACTIVITY, TUMOR LOAD, AND MOLECULAR CHARACTERISTICS OF
MYELOMA CELLS 67
3.7.2 MULTISTEP TRANSFORMATION OF MYELOMA CELL MODEL 69
3.7.3 TRANSFORMATION OF BONE MARROW MICROENVIRONMENT MODEL 70
4 ANGIOGENESIS AND VASCULOGENESIS IN MULTIPLE MYELOMA: ROLE OF
INFLAMMATORY CELLS 87
ANGELO VACCA AND DOMENICO RIBATTI
4.1 INTRODUCTION 87
4.2 ANGIOGENESIS AND ANTIANGIOGENESIS IN MULTIPLE MYELOMA 88 4.3 THE
ROLE OF INFLAMMATORY CELLS IN TUMOR ANGIOGENESIS 89
4.4 THE INVOLVEMENT OF MACROPHAGES IN VASCULAR MIMICRY IN MM 90 4.5 THE
INVOLVEMENT OF MAST CELLS IN VASCULAR MIMICRY IN MM 91 4.6
VASCULOGENESIS BY HEMATOPOIETIC STEM AND PROGENITOR CELLS 92 4.7
CONCLUDING REMARKS 93
5 IMMUNOLOGY AND IMMUNOTHERAPEUTIC APPROACHES IN MULTIPLE MYELOMA 97
CHRISTOPH SCHLUDE AND PHILIPP BECKHOVE
5.1 INTRODUCTION 97
5.2 MYELOMA-ASSOCIATED ANTIGENS 98
5.3 VACCINATION 99
5.4 IMMUNE EVASION 101
5.5 REGULATORY T CELLS 102
5.6 HUMORAL IMMUNOTHERAPY 102
5.7 ADOPTIVE CELLULAR THERAPY 103
5.8 CONCLUSION 104
IMAGE 4
XVI CONTENTS
PART III CLINICAL FEATURES
6 MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA: DIAGNOSIS,
STAGING, PROGNOSIS, MANAGEMENT 113 JENS HILLENGASS, THOMAS MOEHLER, AND
MICHAEL HUNDEMER
6.1 DEFINITION OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
(MGUS) AND SMOLDERING MULTIPLE MYELOMA (SMM) 114 6.2 PREVALENCE OF MGUS
114
6.3 DIFFERENTIAL DIAGNOSIS AND DIAGNOSTIC ASSESSMENT 116
6.3.1 INITIAL DIAGNOSTIC ASSESSMENT 116
6.3.2 FOLLOW-UP RECOMMENDATIONS 117
6.4 RISK FACTORS FOR PROGRESSION 118
6.4.1 PROGNOSTIC FACTORS FOR PROGRESSION FOR PATIENTS WITH MGUS 118
6.4.2 PROGNOSTIC FACTORS FOR PROGRESSION OF SMM 119
6.4.3 GENETIC RISK STRATIFICATION 122
6.5 ETIOLOGY AND PATHOGENESIS OF MGUS AND SMM AND CONSIDERATIONS
REGARDING PRIMARY PREVENTION 122
6.5.1 POPULATION-BASED STUDIES 122
6.5.2 CONCEPT OF CHRONIC ANTIGENIC STIMULATION 122
6.5.3 MOLECULAR GENETICS AND CYTOGENETICS 123
6.5.4 CONCEPTS FOR SECONDARY PREVENTION OF PROGRESSION TO MULTIPLE
MYELOMA AND OTHER LYMPHOPROLIFERATIVE DISEASES 124 6.5.5 SUMMARY OF
CLINICAL STUDIES TO HALT PROGRESSION 124
6.6 SUMMARY AND CONCLUSIONS 126
7 IMAGING IN MULTIPLE MYELOMA 133
STEFAN DELORME AND ANDREA BAUR-MELNYK
7.1 INTRODUCTION 133
7.2 IMAGING METHODS 134
7.2.1 MORPHOLOGIC IMAGING 134
7.2.2 FUNCTIONAL IMAGING 135
7.3 RADIOLOGICAL-PATHOLOGICAL CORRELATION 136
7.4 DIFFERENTIAL DIAGNOSIS 142
7.5 STAGING 143
7.6 TREATMENT EFFECTS 144
7.7 PROGNOSTIC FACTORS 144
7.8 THE RADIOLOGIST S TASKS 145
PART IV THERAPY
8 NOVEL DRUGS IN MYELOMA: HARNESSING TUMOUR BIOLOGY TO TREAT MYELOMA 151
KEVIN BOYD, FAITH E. DAVIES, AND GARETH J. MORGAN
8.1 INTRODUCTION 151
8.2 INTRACELLULAR DRUG TARGETS 152
IMAGE 5
CONTENTS XVII
8.2.1 TARGETING SIGNALLING PATHWAYS WITHIN MYELOMA CELLS 152
8.2.2 TARGETING THE UNFOLDED PROTEIN RESPONSE 158
8.2.3 TARGETING CHROMATIN 159
8.2.4 TARGETING INTRACELLULAR CELL CYCLE REGULATORY PROTEINS 162
8.3 EXTRACELLULAR DRUG TARGETS 163
8.3.1 TARGETING CYTOKINES OR THEIR RECEPTORS 163
8.3.2 TARGETING MYELOMA CELL ADHESION MOLECULES 167
8.3.3 TARGETING THE HOST IMMUNE SYSTEM 169
8.3.4 TARGETING BONE DISEASE 171
8.4 CONCLUSION 173
9 FIRSTLINE TREATMENT AND MAINTENANCE IN NEWLY DIAGNOSED MULTIPLE
MYELOMA PATIENTS 189
MURIELLE ROUSSEL, THIERRY FACON, PHILIPPE MOREAU, JEAN-LUC HAROUSSEAU,
AND MICHEL ATTAL
9.1 FRONTLINE TREATMENT IN MM PATIENTS ELIGIBLE FOR HIGH-DOSE THERAPY
190
9.1.1 INDUCTION TREATMENT: WHAT COMBINATION OF NEW DRUGS? 190 9.1.2
AUTOLOGOUS STEM CELL TRANSPLANTATION UPFRONT OR AT THE TIME OF RELAPSE?
194
9.1.3 MAINTENANCE/CONSOLIDATION TREATMENT 195
9.2 FRONTLINE TREATMENT IN ELDERLY MM PATIENTS 196
9.2.1 WHAT IS THE BEST COMBINATION WITH ALKYLATING AGENTS? 197
9.2.2 FIRSTLINE TREATMENT: CAN NEW AGENTS REPLACE ALKYLATORS? 200 9.2.3
CAN WE REDUCE TOXICITIES OF NEW DRUGS-INCORPORATING REGIMENS? 201 9.2.4
MAINTENANCE THERAPY IN ELDERLY 202
10 HIGH-DOSE THERAPY AND AUTOLOGOUS PERIPHERAL BLOOD STEM CELL
TRANSPLANTATION IN PATIENTS WITH MULTIPLE MYELOMA 207
RAINER HAAS, INGMAR BRUNS, GUIDO KOBBE, AND ROLAND FENK
10.1 INTRODUCTION 208
10.2 PERIPHERAL BLOOD STEM CELL MOBILIZATION 208
10.2.1 THE ROLE OF ADHESION MOLECULES 208
10.2.2 THE ROLE OF HEMATOPOIETIC GROWTH FACTORS 210
10.2.3 THE ROLE OF CYTOTOXIC STEM CELL MOBILIZATION 212
10.2.4 THE ROLE OF PEGFILGRASTIM FOR STEM CELL MOBILIZATION 213
10.3 HIGH-DOSE THERAPY AND AUTOLOGOUS STEM CELL TRANSPLANTATION 215
10.3.1 THE BEGINNING OF HIGH-DOSE THERAPY IN THE 1980 215
10.3.2 THE ROLE OF PURGING OF THE AUTOGRAFT 216
10.3.3 THE ROLE OF THE CONDITIONING REGIMEN 217
10.3.4 SUPPORTIVE CARE DURING HIGH-DOSE CHEMOTHERAPY 218
10.3.5 HIGH-DOSE CHEMOTHERAPY IS SUPERIOR TO CONVENTIONAL CHEMOTHERAPY
219
10.3.6 TIMING OF HIGH-DOSE CHEMOTHERAPY 221
10.3.7 TANDEM AUTOLOGOUS TRANSPLANTATION 221
IMAGE 6
CONTENTS
10.3.8 THE ROLE OF INDUCTION TREATMENT 222
10.3.9 THE ROLE OF CONSOLIDATION OR MAINTENANCE TREATMENT 223
10.3.10 PROGNOSTIC FACTORS 224
10.3.11 TARGETED VERSUS HIGH-DOSE CHEMOTHERAPY 226
11 THERAPY OF RELAPSED AND REFRACTORY MULTIPLE MYELOMA 239
THOMAS MOEHLER AND HARTMUT GOLDSCHMIDT
11.1 INTRODUCTION 240
11.2 DIAGNOSTIC WORKUP OF PATIENTS AT RELAPSE 240
11.3 CONVENTIONAL TREATMENT OF RELAPSED/REFRACTORY DISEASE 240 11.4
HIGH-DOSE CHEMOTHERAPY (HDCT) SUPPORTED BY AUTOLOGOUS STEM CELL
TRANSPLANTATION 241
11.5 ALLOGENEIC STEM CELL TRANSPLANTATION 242
11.6 THALIDOMIDE AND IMMUNOMODULATORY DRUGS 245
11.6.1 THALIDOMIDE AS SINGLE AGENT AND COMBINED WITH CORTICOSTEROIDS 245
11.6.2 THALIDOMIDE IN COMBINATION WITH CHEMOTHERAPY/CORTICOSTEROIDS 246
11.6.3 LENALIDOMIDE 249
11.6.4 LENALIDOMIDE COMBINATION THERAPIES 249
11.6.5 POMALIDOMIDE 251
11.7 BORTEZOMIB 251
11.7.1 BORTEZOMIB SINGLE AGENT 251
11.7.2 BORTEZOMIB COMBINATION THERAPY 252
11.8 NOVEL PROTEASOME INHIBITORS 254
11.9 COMBINATION OF NOVEL AGENTS 255
11.10 EMERGING THERAPIES AND NOVEL PATHWAYS 260
11.11 PROGNOSTIC FACTORS 260
11.12 THERAPEUTIC STRATEGY FOR RELAPSED/REFRACTORY MYELOMA PATIENTS 260
12 ALLOGENEIC TRANSPLANTATION IN MULTIPLE MYELOMA 273
GOESTA GAHRTON
12.1 INTRODUCTION 274
12.2 MYELOABLATIVE HIGH DOSE CONDITIONING 274
12.3 MOLECULAR REMISSION 275
12.4 SOURCE OF STEM CELLS 275
12.5 REDUCED INTENSITY CONDITIONING (RIC) 276
12.5.1 RETROSPECTIVE STUDIES 276
12.5.2 PROSPECTIVE STUDIES 276
12.6 HOW TO IMPROVE RESULTS OF ALLOGENEIC TRANSPLANTATION? 279
12.6.1 DONOR LYMPHOCYTE TRANSFUSIONS 279
12.6.2 NK CELLS HAVE ANTIMYELOMA EFFECT AND MODERATE GVHD 280 12.6.3
ROLE OF IMMUNOSUPPRESSIVE AGENTS IN THE CONDITIONING THERAPY 280 12.6.4
TARGETED DRUGS PRETRANSPLANT OR POSTTRANSPLANT 281
12.7 CONCLUSIONS 281
IMAGE 7
CONTENTS
13 RADIOTHERAPY 285
SONJA KRAUSE, JUERGEN DEBUS, AND DIRK NEUHOF
13.1 SOLITARY PLASMOCYTOMA 285
13.1.1 DIAGNOSTIC WORKUP 286
13.1.2 RADIOTHERAPY OF SBP 286
13.1.3 RADIOTHERAPY OF EP 287
13.1.4 TREATMENT TOXICITY 287
13.2 PALLIATIVE TREATMENT OF MULTIPLE MYELOMA 287
13.2.1 PAIN CONTROL 288
13.2.2 RECALCIFICATION 288
13.3 TOTAL BODY IRRADIATION (TBI) 289
14 OSTEOPLASTIE PROCEDURES FOR THE TREATMENT OF VERTEBRAL COMPLICATIONS
IN MULTIPLE MYELOMA PATIENTS 293
CHRISTIAN KASPERK AND INGO GRAFE
14.1 INTRODUCTION 294
14.2 OSTEOPLASTIE PROCEDURES 294
14.3 BALLOON KYPHOPLASTY 294
14.4 VERTEBROPLASTY 295
14.5 COMPARISON OF KYPHOPLASTY AND VERTEBROPLASTY 296
14.6 INDICATIONS AND CONTRAINDICATIONS 296
14.7 RANDOMIZED CONTROLLED STUDIES OF OSTEOPLASTIE PROCEDURES FOR
VERTEBRAL OSTEOPOROTIC FRACTURES 297
14.8 STUDIES USING KYPHOPLASTY AND VERTEBROPLASTY IN PATIENTS WITH
MULTIPLE MYELOMA 298
15 SUPPORTIVE THERAPY IN MULTIPLE MYELOMA 307
HEINZ LUDWIG AND NIKLAS ZOJER
15.1 INTRODUCTION 307
15.2 MYELOMA BONE DISEASE 308
15.2.1 MECHANISMS OF BONE DISEASE 308
15.2.2 BONE FRACTURES 309
15.2.3 VERTEBRAL LESIONS 309
15.2.4 BISPHOSPHONATES 309
15.3 HYPERCALCEMIA 314
15.3.1 DIAGNOSIS AND SYMPTOMS 314
15.3.2 TREATMENT OF HYPERCALCEMIA 315
15.4 ANEMIA 316
15.4.1 PATHOGENESIS OF ANEMIA 316
15.4.2 CLINICAL SYMPTOMS OF ANEMIA 316
15.4.3 TREATMENT OF ANEMIA 317
15.5 INFECTIONS 320
IMAGE 8
XX CONTENTS
15.5.1 CAUSES OF INFECTIONS 320
15.5.2 PROPHYLAXIS OF INFECTIONS 321
15.5.3 VACCINATION 322
15.5.4 TREATMENT OF INFECTIONS 322
15.6 PAIN 323
15.6.1 CHARACTERISTICS AND CAUSES OF PAIN 323
15.6.2 MEDICAL PAIN TREATMENT 324
15.7 RENAL FAILURE 325
15.7.1 PREVALENCE AND CAUSES OF RENAL FAILURE 325
15.7.2 MANAGEMENT OF MYELOMA-INDUCED RENAL FAILURE 326
APPENDIX 335
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| owner_facet | DE-29 DE-19 DE-BY-UBM |
| physical | XXIII, 339 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Springer |
| record_format | marc |
| series | Recent results in cancer research |
| series2 | Recent results in cancer research |
| spelling | Multiple myeloma Thomas Moehler ... (ed.) Berlin ; Heidelberg Springer 2011 XXIII, 339 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 183 Plasmozytom (DE-588)4127837-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Plasmozytom (DE-588)4127837-9 s DE-604 Möhler, Thomas Sonstige (DE-588)1014877261 oth Erscheint auch als Online-Ausgabe 978-3-540-85772-3 Recent results in cancer research 183 (DE-604)BV000000043 183 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020589458&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Multiple myeloma Recent results in cancer research Plasmozytom (DE-588)4127837-9 gnd |
| subject_GND | (DE-588)4127837-9 (DE-588)4143413-4 |
| title | Multiple myeloma |
| title_auth | Multiple myeloma |
| title_exact_search | Multiple myeloma |
| title_full | Multiple myeloma Thomas Moehler ... (ed.) |
| title_fullStr | Multiple myeloma Thomas Moehler ... (ed.) |
| title_full_unstemmed | Multiple myeloma Thomas Moehler ... (ed.) |
| title_short | Multiple myeloma |
| title_sort | multiple myeloma |
| topic | Plasmozytom (DE-588)4127837-9 gnd |
| topic_facet | Plasmozytom Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020589458&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000043 |
| work_keys_str_mv | AT mohlerthomas multiplemyeloma |