Hyaluronan in cancer biology:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2009
|
| Edition: | 1. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXVII, 426 S. Ill., graph. Darst. |
| ISBN: | 9780123741783 0123741785 |
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| 245 | 1 | 0 | |a Hyaluronan in cancer biology |c ed. by Robert Stern |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2009 | |
| 300 | |a XXVII, 426 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Hyaluronic acid |x Pathophysiology | |
| 650 | 4 | |a Carcinogenesis | |
| 650 | 4 | |a Hyaluronic Acid |x metabolism | |
| 650 | 4 | |a Neoplasms |x metabolism | |
| 650 | 4 | |a Antigens, CD44 |x metabolism | |
| 650 | 4 | |a Disease Progression | |
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| adam_text | Titel: Hyaluronan in cancer biology
Autor: Stern, Robert
Jahr: 2009
Short Contents
I
HISTORICAL OVERVIEW
1. Association Between Cancer and Acid Mucopolysaccharides : An Old Concept
Comes of Age, Finally 3
II
CELL BIOLOGY OF HYALURONAN IN CANCER
2. Hyaluronan-CD44 Interactions and Chemoresistance in Cancer Cells 19
3. Growth Factor Regulation of Hyaluronan Deposition in Malignancies 37
4. Hyaluronan Binding Protein 1 (HABPl/p32/gClqR): A New Perspective in Tumor
Development 51
III
HYALURONAN RECEPTORS AND SIGNAL
TRANSDUCTION PATHWAYS
5. CD44 Meets Merlin and Ezrin: Their Interplay Mediates the Pro-Tumor Activity of
CD44 and Tumor-Suppressing Effect of Merlin 71
6. Hyaluronan-Mediated CD44 Interaction with Receptor and Non-Receptor Kinases
Promotes Oncogenic Signaling, Cytoskeleton Activation and Tumor
Progression 89
7. Adhesion and Penetration: Two Sides of CD44 Signal Transduction Cascades in
the Context of Cancer Cell Metastasis 109
8. Involvement of CD44, a Molecule with a Thousand Faces, in Cancer
Dissemination 127
9. RHAMM/HMMR: An Itinerant and Multifunctional Hyaluronan Binding Protein
that Modifies CD44 Signaling and Mitotic Spindle Formation 147
vii
viii SHORT CONTENTS
IV
HYALURONAN SYNTHESIS
10. Altered Hyaluronan Biosynthesis in Cancer Progression 171
V
HYALURONAN DEGRADATION, THE
HYALURONIDASES, AND THE PRODUCTS
OF DEGRADATION
11. Hyaluronidase: Both a Tumor Promoter and Suppressor 189
12. Hyaluronidases in Cancer Biology 207
13. Hyaluronan Fragments: Informational Polymers Commandeered
by Cancers 221
VI
HYALURONAN IN CANCER EPITHELIAL-
STROMAL INTERACTIONS
14. Hyaluronan in Human Tumors: Importance of Stromal and Cancer
Cell-Associated Hyaluronan 257
15. The Oncofetal Paradigm Revisited: MSF and HA as Contextual Drivers of Cancer
Progression 285
VII
HYALURONAN AND INDIVIDUAL CANCERS
16. Hyaluronan Synthesis and Turnover in Prostate Cancer 309
17. Role of Hyaluronan and CD44 in Melanoma Progression 329
18. Role of Hyaluronan Metabolism in the Initiation, Invasion and Metastasis of Breast
Cancer 341
SHORT CONTENTS ix
VIII
CLINICAL USES OF HYALURONAN-
RELATED BIOMATERIALS
AS ANTI-CANCER AGENTS
19. Clinical Use of Hyaluronidase in Combination Cancer Chemotherapy:
A Historic Perspective 363
20. Exploiting the Hyaluronan-CD44 Interaction for Cancer Therapy 379
IX
A NEW PERSPECTIVE
21. Hyaluronidase-2 and Its Role as a Cell-Entry Receptor for Sheep Retroviruses that
Cause Contagious Respiratory Tract Cancers 407
Full Contents
Preface xix
Foreword xxiii
List of Contributors xxv
I
HISTORICAL OVERVIEW
1. Association Between Cancer and Acid Mucopolysaccharides :
An Old Concept Comes of Age, Finally
ROBERT STERN
Introduction 4
Hyaluronan 4
Stromal-Epithelial Interaction in Cancer 7
Hyaluronan in Cancer 9
Abnormalities in Other Glycosaminoglycans Occur in Malignancy 11
Conclusions 12
II
CELL BIOLOGY OF HYALURONAN IN CANCER
2. Hyaluronan - CD44 Interactions and Chemoresistance
in Cancer Cells
MARK G. SLOMIANY AND BRYAN P. TOOLE
Introduction 19
Hyaluronan, CD44, and Drug Resistance 20
Cell-Autonomous Regulation of Cell Survival Signaling Pathways by Hyaluronan
andCD44 21
Hyaluronan, CD44, and Drug Transporters 23
Hyaluronan, Emmprin, and the Glycolytic Phenotype 25
Hyaluronan, Cancer Stem Cells, and Drug Resistance 26
Conclusions 28
Acknowledgments 29
xi
xii FULL CONTENTS
3. Growth Factor Regulation of Hyaluronan Deposition
in Malignancies
PARASKEVI HELDIN, EUGENIA KAROUSOU, AND SPYROS S. SKANDALIS
Introduction 37
Expression of Hyaluronan Synthases and Hyaluronidases 39
Hyaluronan Signaling Promotes the Malignant Phenotype of Tumor Cells 40
Regulation of Hyaluronan Levels Produced by Tumor Cells 43
Regulation of Hyaluronan Synthesis by Peritumoral Stroma Cells 44
Future Perspectives 46
Acknowledgments 46
4. Hyaluronan Binding Protein 1 (HABPl/p32/gClqR): A New
Perspective in Tumor Development
ANINDYA ROY CHOWDHURY, ANUPAMA KAMAL, 1LORA GHOSH,
AND KASTURI DATTA
Hyaluronan Binding Protein 1 (HABP1) 53
Evidence for HABP1 to Be Involved in Tumor Development 58
Ectopic Expression of HABP1 Induces Apoptosis, Autophagic Vacuoles, and
Mitochondrial Dysfunction 61
Association of Allelic Loss at 17pl3.3 Chromosome with Cancer Initiation and
Promotion 64
Conclusion 65
Acknowledgments 66
III
HYALURONAN RECEPTORS AND SIGNAL
TRANSDUCTION PATHWAYS
5. CD44 Meets Merlin and Ezrin: Their Interplay Mediates
the Pro-Tumor Activity of CD44 and Tumor-Suppressing
Effect of Merlin
IVAN STAMENKOVIC AND QIN YU
CD44 Promotes Tumor Invasion and Metastasis 72
CD44-Mediated Signals and the Downstream Effectors of CD44 74
Merlin Acts as a Tumor Suppressor, and the Mutant Forms of this Protein Promote
Tumorigenesis 76
The Function of Merlin Is Regulated by Its Posttranslational Modifications 76
Merlin Counteracts the Effect of Ezrin and Inhibits the CD44-HA Interaction and
CD44 Function 77
Merlin Is Involved in Several Important Signal Transduction Pathways 78
FULL CONTENTS xiii
Merlin Acts Upstream of the Hippo Signaling Pathway in Drosophila 79
A Model for CD44 Signaling Through Merlin and the ERM Proteins 81
Acknowledgments 82
6. Hyaluronan-Mediated CD44 Interaction With Receptor and
Non-Receptor Kinases Promotes Oncogenic Signaling,
Cytoskeleton Activation and Tumor Progression
LILLY Y.W. BOURGUIGNON
Hyaluronan (HA) Metabolism in Cancer Progression 89
CD44 (an HA Receptor) in Tumor Progression 91
Acknowledgments 101
7. Adhesion and Penetration: Two Sides of CD44 Signal
Transduction Cascades in the Context of Cancer Cell Metastasis
DAVID ].]. WAUGH, ASHLEIGH McCLATCHEY, NICOLA MONTGOMERY,
AND SUZANNE McFARLANE
Introduction: HA, CD44, the Tumor Microenvironment, and Metastasis 109
Penetration: CD44 Promoted Invasion and Intravasation 111
Cell-Cell Adhesion: Role of CD44 in Promoting Extravasation 117
The Role of CD44 in Promoting Tissue-Specific Metastasis 121
Conclusions 122
8. Involvement of CD44, a Molecule with a Thousand Faces, in
Cancer Dissemination
DAVID NAOR, SHULAMIT B. WALLACH-DAYAN, MUAYAD A. ZAHALKA,
AND RONIT VOGT SIONOV
Prologue 128
CD44, a Polygamic Molecule, Interacting with Multiple Ligands 130
The Interaction Between the CD44 of LB Cells and Hyaluronate - In Vitro
Studies 132
Elucidation of HA Binding Mechanism in LB Cells 135
Therapy of the Malignant Lymphoma: Blocking the Interaction Between
CD44 and Its Ligand by Targeting the CD44 Variant with Relevant
Antibody 138
Gene Vaccination with CD44 Variant Construct, Rather Than with Standard
CD44 Construct, Generates Resistance to Tumor Growth 140
Epilogue 141
Acknowledgments 143
9. RHAMM/HMMR: An Itinerant and Multifunctional
Hyaluronan Binding Protein that Modifies CD44 Signaling and
Mitotic Spindle Formation
james b. McCarthy and eva a. turley
xiv FULL CONTENTS
Introduction 147
RHAMM and Cancer 149
Extracellular and Intracellular RHAMM Oncogenic Functions In Culture 152
RHAMM Protein Forms Control Multiple Signaling Networks 157
Conclusions 165
Acknowledgments 165
IV
HYALURONAN SYNTHESIS
10. Altered Hyaluronan Biosynthesis in Cancer Progression
NAOKIITANO AND KOJI KIMATA
Introduction 171
HA Biosynthesis 172
Altered HA Synthesis in Cancer 173
Tumor-Stromal Interaction 174
Novel Function of HA in Stromal Cell Recruitment 176
Epithelial-Mesenchymal Transition Caused by HA Overproduction 178
Roles of H A-Rich ECM in Tumor Angiogenesis 179
Conclusion and Perspectives 181
Acknowledgments 182
V
HYALURONAN DEGRADATION, THE
HYALURONIDASES, AND THE PRODUCTS OF
DEGRADATION
11. Hyaluronidase: Both a Tumor Promoter and Suppressor
VINATA B. LOKESHWAR AND MARIE G. SELZER
Introduction 189
Hyaluronidases 190
HAase Expression in Tumor Cells 192
HAase Functions in Genito-Urinary Tumors 194
Regulation of HAase Gene Expression 197
HAase and Signaling 198
Acknowledgment 202
FULL CONTENTS XV
12. Hyaluronidases in Cancer Biology
ROBERT STERN
Introduction 207
Hyaluronidases and Their Structure 209
A Catabolic Scheme for Hyaluronan 210
The Warburg Effect 210
Hyaluronidase Inhibitors 212
Hyaluronidase Modulates CD44 Expression 213
Hyaluronan Fragmentation 213
Hyaluronidases as Anti-Cancer Chemotherapeutic Agents 215
Hyaluronidases in Cancer Progression 216
The Conundrums Involving Hyaluronidases in Malignancy 216
13. Hyaluronan Fragments: Informational Polymers
Commandeered by Cancers
KAZUKI N. SUGAHARA
Introduction 221
Production of HA Fragments 222
Receptors of HA Fragments 224
Different Sizes of HA Have Different Biological Functions 230
Conclusions and Future Prospects 246
Acknowledgments 249
VI
HYALURONAN IN CANCER
EPITHELIAL-STROMAL INTERACTIONS
14. Hyaluronan in Human Tumors: Importance of Stromal and
Cancer Cell-Associated Hyaluronan
RAIJA H. TAMMI, ANNE H. KULTTI, VELI-MATT1 KOSMA, RISTO PIR1NEN, PAIV1
AUV1NEN, AND MARKKU I. TAMMI
Hyaluronan Accumulation in Malignant Tumors 258
Hyaluronan Associated with Cancer Cells 259
Stromal Accumulation of Hyaluronan 267
Mechanisms of Hyaluronan Accumulation in Tumors 270
How Does Hyaluronan Contribute to Cancer Progression? 274
Conclusions 278
Acknowledgments 278
Xvi FULL CONTENTS
15. The Oncofetal Paradigm Revisited: MSF and HA as
Contextual Drivers of Cancer Progression
SETH L. SCHOR, ANA M. SCHOR, IAN R. ELLIS, SARAH J. JONES, MARGARET
FLORENCE, JACQUELINE COX, AND ANNE-MARIE WOOLSTON
Introduction 286
MSF: Its Molecular Characterization and Spectrum of Bioactivities 287
The Oncofetal Pattern of MSF Expression: Contextual Control by ECM and
Soluble Factors 292
The Contextual Control of Target Cell Response to MSF by ECM and Soluble
Factors 297
An Extended Oncofetal Paradigm of Cancer Pathogenesis: The Inter dependent
Contribution of Genetic and Epigenetic Mechanisms 300
Acknowledgments 303
VII
HYALURONAN AND INDIVIDUAL CANCERS
16. Hyaluronan Synthesis and Turnover in Prostate Cancer
MELANIE A. SIMPSON
Overview of Prostate Cancer Progression 309
HA Synthases and Hyaluronidases 310
Genetic Susceptibility to Prostate Cancer 311
Inflammation Response and Hypoxia 311
Tumorigenesis 313
Angiogenesis and Lymphangiogenesis 318
Metastasis and Bone Turnover 319
17. Role of Hyaluronan and CD44 in Melanoma Progression
CARL GEBHARDT, MARCO AVERBECK, ULF ANDEREGG,
AND JAN C. SIMON
Hyaluronan and Melanoma 329
Interaction of Hyaluronan and Melanoma Cells 331
Hyaluronan Metabolism, Melanoma, and UV-B 334
Conclusion and Perspectives 336
Acknowledgment 337
18. Role of Hyaluronan Metabolism in the Initiation, Invasion
and Metastasis of Breast Cancer
TRACEY J. BROWN AND NATALIE K. THOMAS
FULL CONTENTS xvii
The Tumor Microenvironment of Breast Cancer 341
Intratumoral Hyaluronan Localization During Breast Cancer
Tumorigenesis and Proliferation 342
Metabolism of Hyaluronan in Breast Cancer - Dysregulation
of a Finely Tuned Process 343
The Co-Ordinated Function and Importance of HA
Metabolism in Breast Cancer 353
Conclusions 355
VIII
CLINICAL USES OF HYALURONAN-RELATED
BIOMATERIALS AS ANTI-CANCER AGENTS
19. Clinical Use of Hyaluronidase in Combination Cancer
Chemotherapy: A Historic Perspective
GERHARD BAUMGARTNER AND GERHARD HAMILTON
Introduction 363
Clinical Application of Hyaluronidase in Peripheral Circulatory Disorder 365
Clinical Applications of Hyaluronidase in Malignant Disease 365
Hyaluronidase Preparations in Additional Clinical Studies in Vienna 366
Extended Studies of the Use of Hyaluronidase as Adjuncts in Cancer
Chemotherapy 367
Side Effects Observed During Clinical and Experimental Uses of
Hyaluronidase 370
Application of Hyaluronidase in Experimental Animal Models of Cancer 371
Overview and Additional Observations 372
Concluding Remarks and Summary 374
20. Exploiting the Hyaluronan-CD44 Interaction for Cancer
Therapy
VIRGINIA M. PLATT AND FRANCIS C. SZOKA, Jr.
Exploiting the Hyaluronan-CD44 Interaction for Cancer Therapy 380
Interference with CD44-HA Interactions 381
HA-Induced Sensitization to Chemotherapeutics 392
Targeting Chemotherapeutics 392
CD44 Mediated Cancer Immunotherapy 395
Gene Therapy by Down Regulation of CD44 Production 396
Gene Therapy by Production of Cytotoxic Genes Through CD44 Regulation 397
Conclusion 398
Acknowledgment 399
xviii FULL CONTENTS
IX
A NEW PERSPECTIVE
21. Hyaluronidase-2 and Its Role as a Cell-Entry Receptor for Sheep
Retrovimses that Cause Contagious Respiratory Tract Cancers
A. DUSTY MILLER
Oncogenic Sheep Retroviruses 407
Identification of HYAL-2 as the Cell-Entry Receptor for JSRV and ENTV 409
HYAL-2 Location and Enzymatic Activity 412
HYAL-2 Role in Sheep Retrovirus Oncogenesis? 414
HYAL-2 Role in Sheep Placental Morphogenesis 416
Acknowledgments 416
Index 419
Color Plate Section at the End of the Book
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| id | DE-604.BV036584356 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:43:27Z |
| institution | BVB |
| isbn | 9780123741783 0123741785 |
| language | English |
| lccn | 2008054964 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020505202 |
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXVII, 426 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Elsevier, Acad. Press |
| record_format | marc |
| spelling | Hyaluronan in cancer biology ed. by Robert Stern 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2009 XXVII, 426 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Hyaluronic acid Pathophysiology Carcinogenesis Hyaluronic Acid metabolism Neoplasms metabolism Antigens, CD44 metabolism Disease Progression Hyaluronic Acid therapeutic use Hyaluronsäure (DE-588)4160834-3 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Hyaluronsäure (DE-588)4160834-3 s DE-604 Stern, Robert Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020505202&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hyaluronan in cancer biology Hyaluronic acid Pathophysiology Carcinogenesis Hyaluronic Acid metabolism Neoplasms metabolism Antigens, CD44 metabolism Disease Progression Hyaluronic Acid therapeutic use Hyaluronsäure (DE-588)4160834-3 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4160834-3 (DE-588)4073781-0 |
| title | Hyaluronan in cancer biology |
| title_auth | Hyaluronan in cancer biology |
| title_exact_search | Hyaluronan in cancer biology |
| title_full | Hyaluronan in cancer biology ed. by Robert Stern |
| title_fullStr | Hyaluronan in cancer biology ed. by Robert Stern |
| title_full_unstemmed | Hyaluronan in cancer biology ed. by Robert Stern |
| title_short | Hyaluronan in cancer biology |
| title_sort | hyaluronan in cancer biology |
| topic | Hyaluronic acid Pathophysiology Carcinogenesis Hyaluronic Acid metabolism Neoplasms metabolism Antigens, CD44 metabolism Disease Progression Hyaluronic Acid therapeutic use Hyaluronsäure (DE-588)4160834-3 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Hyaluronic acid Pathophysiology Carcinogenesis Hyaluronic Acid metabolism Neoplasms metabolism Antigens, CD44 metabolism Disease Progression Hyaluronic Acid therapeutic use Hyaluronsäure Krebs Medizin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020505202&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sternrobert hyaluronanincancerbiology |