Introduction to proteomics: principles and applications
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Hoboken, NJ
Wiley
2010
|
| Series: | Methods of biochemical analysis
[53] |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Item Description: | Serienzählung fälschlicherweise mit 146 angegeben. - Lt. Erratum fälschlicherweise mit 52 angegeben. - Lt. Verlagsauskunft (direkt erfragt vom Hbz-Verbund) ist 53 korrekt! Literaturangaben |
| Physical Description: | XX, 180 S. Ill., graph. Darst. |
| ISBN: | 9780471754022 0471754021 |
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
FOREWORD
xi
PREFACE
xiii
ABOUT THE AUTHOR
xix
CHAPTER
1
HISTORICAL PERSPECTIVES
1
1.1.
Introduction to Proteomics
/ 3
1.2.
Proteome and Proteomics
/ 7
1.3.
Genetics of Proteins
/ 9
1.4.
Molecular Biology of Genes and Proteins
/ 20
1.5.
Protein Chemistry Before Proteomics
/ 24
References
/ 34
Further Reading
/ 37
CHAPTER
2
PROTEOMICS
-
RELATION TO
GENOMICS, BIOINFORMATICS
39
2.1.
Genomics
/ 40
2.2.
Bioinformatics and Computational Biology
/ 57
References
/ 58
Further Reading
/ 59
vii
VIU
CONTENTS
CHAPTER
3
METHODOLOGY FOR SEPARATION AND
IDENTIFICATION OF PROTEINS AND
THEIR INTERACTIONS
61
3.1.
Separation of Proteins Via a
Multidimensional Approach
/61
3.2.
Determination of the Primary Structure of
Proteins
/ 70
3.3.
Determination of the
3D
Structure of a Protein
/ 83
3.4.
Determination of the Amount of Proteins
/ 86
3.5.
Structural and Functional Proteomics
/ 89
References
/ 99
Further Reading
/ 101
CHAPTER
4
PROTEOMICS OF PROTEIN
MODIFICATIONS
103
4.1.
Phosphorylation and Phosphoproteomics
/104
4.2.
Glycosylation and Glycoproteomics
/ 107
4.3.
Ubiquitination and Ubiquitinomics
/110
4.4.
Miscellaneous Modifications of Proteins
/ 112
References
/113
Further Reading
/113
CHAPTER
5
PROTEOMICS OF PROTEIN-PROTEIN
INTERACTIONS/INTERACTOMES
115
5.1.
Protein
—
Protein Interactions
(PPI)
in Vivo
/116
5.2.
Analysis of Protein Interactions in Vitro
/ 118
5.3.
Analysis of Protein Interactions in Silico
/ 124
5.4.
Synthetic Genetic Methods to Determine
Protein Interactions
/125
5.5.
Interactomes
/ 125
5.6.
Evolution and Conservation of Interactomes
/132
5.7.
Interactomes and the Complexity of
Organisms: It is the Number of Interactomes
that Matters in Understanding the
Complexity of an Organism and not the
Number of Genes
/ 133
5.8.
Interaction of Proteins with Small Molecules
/ 133
CONTENTS
IX
CHAPTER
6
References
/134
Further Reading
/ 134
APPLICATIONS OF PROTEOMICS I:
PROTEOMICS, HUMAN DISEASE, AND
MEDICINE
137
6.1.
Diseasome
/139
6.2.
Medical Proteomics
/ 139
6.3.
Clinical Proteomics
/ 148
6.4.
Metaproteomics and Human Health
/153
6.5.
Proteomics in Biotechnology and Industry
of Drug Production
/154
6.6.
Metaproteomics of Microbial Fermentation
/155
6.7.
Beef Industry
/ 158
6.8.
Bioterrorism
and Biodefense
/158
References
/159
Further Reading
/ 160
CHAPTER
7
PROTEOMICS-FUTURE DEVELOPMENTS
163
7.1.
Technical Scope of Proteomics
—
Beyond
Protein Identification
/163
7.2.
Scientific Scope of Proteomics
—
Control of
Epigénesis
/165
7.3.
Medical Scope of Proteomics
/ 166
7.4.
Proteomics, Energy Production, and
Bioremediation
/169
7.5.
Proteomics and Biodefense
/ 170
References
/ 170
Further Reading
/ 170
INDEX
171
A WORLD-CLASS, CONCISE GUIDE TO
IM
íC
I
L· L· í í í í
V4 Ji
Õ
Γ
r^XJ Ii.
^nr^his
book provides a highly authoritative introduction to the promising and fast-
JL advancing field of proteomics, examining the role proteomics plays in the study
of biological systems in general and disease in particular. It helps readers understand the
structure, function, and interactions of proteins and how this knowledge is used for identify¬
ing diseases and developing new drugs.
Nawin Mishra, a world-renowned speaker and leader in proteomics studies who has worked
with the late Nobel Laureate
E. L.
Tatum when proteomics was in its infancy, offers an expert
perspective on the entire field, including:
c Easily accessible overview of the principles of proteomics
° Coverage of real-world, cutting-edge medical applications, including
personalized medicine
° Clear guidelines on how to operate the complex instrumentation involved
in
proteomics
° Discussion of the future of proteomics
Complete with handy study questions and assuming only a basic understanding of biology,
Introduction to Proteomics is an invaluable reference for novices and research scientists alike.
ľ
:і*Л
ł Ł.
лиЪИ&Л-,
rilu,
is an Emeritus Professor of Molecular Genetics and
Genomics at the Department of Biological Sciences at the University of South Carolina.
Professor Mishra has also served as a scientific consultant to the
FAO
of the United
Nations, as Chairman of the Program Committee of the Genetics Society of America, and
on the review panel of the Human Genome Project for the United States DOE. Professor
Mishra has published over sixty articles in prominent research journals, including Nature,
the Proceedings of the United States National Academy of Sciences, and Genetics.
|
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| isbn | 9780471754022 0471754021 |
| language | English |
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| physical | XX, 180 S. Ill., graph. Darst. |
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| spelling | Mishra, Nawin C. Verfasser (DE-588)142049646 aut Introduction to proteomics principles and applications Nawin Mishra Hoboken, NJ Wiley 2010 XX, 180 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods of biochemical analysis [53] Serienzählung fälschlicherweise mit 146 angegeben. - Lt. Erratum fälschlicherweise mit 52 angegeben. - Lt. Verlagsauskunft (direkt erfragt vom Hbz-Verbund) ist 53 korrekt! Literaturangaben Proteomanalyse (DE-588)4596545-6 gnd rswk-swf Proteomics--Textbooks. Proteomanalyse (DE-588)4596545-6 s DE-604 Methods of biochemical analysis [53] (DE-604)BV002528856 53 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020494889&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020494889&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Mishra, Nawin C. Introduction to proteomics principles and applications Methods of biochemical analysis Proteomanalyse (DE-588)4596545-6 gnd |
| subject_GND | (DE-588)4596545-6 |
| title | Introduction to proteomics principles and applications |
| title_auth | Introduction to proteomics principles and applications |
| title_exact_search | Introduction to proteomics principles and applications |
| title_full | Introduction to proteomics principles and applications Nawin Mishra |
| title_fullStr | Introduction to proteomics principles and applications Nawin Mishra |
| title_full_unstemmed | Introduction to proteomics principles and applications Nawin Mishra |
| title_short | Introduction to proteomics |
| title_sort | introduction to proteomics principles and applications |
| title_sub | principles and applications |
| topic | Proteomanalyse (DE-588)4596545-6 gnd |
| topic_facet | Proteomanalyse |
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