Introduction to modern virology:
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Malden, MA [u.a.]
Blackwell
2007
|
| Edition: | 6. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 516 S. zahlr. Ill., graph. Darst., Kt. |
| ISBN: | 1405136456 9781405136457 |
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
PREFACE XII
PART I: WHAT IS A VIRUS? 1
1 TOWARDS A DEFINITION OF A VIRUS 3
1.1 DISCOVERY OF VIRUSES 4
1.2 DEVELOPMENT OF VIRUS ASSAYS 6
1.3 MULTIPLICATION OF VIRUSES 8
1.4 THE VIRUS MULTIPLICATION CYCLE 9
1.5 VIRUSES CAN BE DEFINED IN CHEMICAL TERMS 10
1.6 MULTIPLICATION OF BACTERIAL AND ANIMAL VIRUSES IS FUNDAMENTALLY
SIMILAR 13 1.7 VIRUSES CAN BE MANIPULATED GENETICALLY 14
1.8 PROPERTIES OF VIRUSES 15
1.9 ORIGIN OF VIRUSES 15
KEY POINTS 16
FURTHER READING 17
2 SOME METHODS FOR STUDYING ANIMAL VIRUSES 18
2.1 SELECTION OF A CULTURE SYSTEM 18
2.2 IDENTIFICATION OF VIRUSES USING ANTIBODIES (SEROLOGY) 23
2.3 DETECTION, IDENTIFICATION, AND CLONING OF VIRUS GENOMES USING PCR
AND RT-PCR 27 KEY POINTS 28
FURTHER READING 29
3 THE STRUCTURE OF VIRUS PARTICLES 30
3.1 VIRUS PARTICLES ARE CONSTRUCTED FROM SUBUNITS 30
3.2 THE STRUCTURE OF FILAMENTOUS VIRUSES AND NUCLEOPROTEINS 32
3.3 THE STRUCTURE OF ISOMETRIC VIRUS PARTICLES 32
3.4 ENVELOPED (MEMBRANE-BOUND) VIRUS PARTICLES 42
3.5 VIRUS PARTICLES WITH HEAD-TAIL MORPHOLOGY 45
3.6 FREQUENCY OF OCCURRENCE OF DIFFERENT VIRUS PARTICLE MORPHOLOGIES 47
3.7 PRINCIPLES OF DISASSEMBLY: VIRUS PARTICLES ARE METASTABLE 47
KEY POINTS 47
FURTHER READING 48
IMAGE 2
11 THE PROCESS OF INFECTION: IV. THE ASSEMBLY OF VIRUSES 172
11.1 SELF-ASSEMBLY FROM MATURE VIRION COMPONENTS 173
11.2 ASSEMBLY OF VIRUSES WITH A HELICAL STRUCTURE 174
11.3 ASSEMBLY OF VIRUSES WITH AN ISOMETRIC STRUCTURE 177
11.4 ASSEMBLY OF COMPLEX VIRUSES 180
11.5 SEQUENCE-DEPENDENT AND -INDEPENDENT PACKAGING OF VIRUS DNA IN VIRUS
PARTICLES 181
11.6 THE ASSEMBLY OF ENVELOPED VIRUSES 183
11.7 MATURATION OF VIRUS PARTICLES 187
KEY POINTS 189
QUESTIONS 189
FURTHER READING 189
PART III: VIRUS INTERACTIONS WITH THE WHOLE ORGANISM 191
12 THE IMMUNE SYSTEM AND VIRUS NEUTRALIZATION 193
12.1 VIRUSES AND THE IMMUNE SYSTEM - AN OVERVIEW 195
12.2 INNATE IMMUNITY 197
12.3 ADAPTIVE IMMUNITY 200
12.4 UNDERSTANDING VIRUS NEUTRALIZATION BY ANTIBODY 209
12.5 AGE AND IMMUNITY 212
KEY POINTS 212
QUESTIONS 213
FURTHER READING 213
13 INTERACTIONS BETWEEN ANIMAL VIRUSES AND CELLS 214
13.1 ACUTELY CYTOPATHOGENIC INFECTIONS 214
13.2 PERSISTENT INFECTIONS 216
13.3 LALENT INFECTIONS 219
13.4 TRANSFORMING INFECTIONS 221
13.5 ABORTIVE INFECTIONS 222
13.6 NULL INFECTIONS 223
13.7 HOW DO ANIMAL VIRUSES KILL CELLS? 223
KEY POINTS 224
QUESTIONS 225
FURTHER READING 225
14 ANIMAL VIRUS-HOST INTERACTIONS 226
14.1 CAUSE AND EFFECT: KOCH S POSTULATES 226
14.2 A CLASSIFICATION OF VIRUS-HOST INTERACTIONS 227
14.3 ACUTE INFECTIONS 230
14.4 SUBCLINICAL INFECTIONS 234
14.5 PERSISTENT AND CHRONIC INFECTIONS 234
14.6 LATENT INFECTIONS 237
14.7 SLOWLY PROGRESSIVE DISEASES 238
14.8 VIRUS-INDUCED TUMORS 240
IMAGE 3
KEY POINTS 242
QUESTIONS 242
FURTHER READING 242
15 MECHANISMS IN VIRUS LATENCY 243
15.1 THE LATENT INTERACTION OF VIRUS AND HOST 244
15.2 GENE EXPRESSION IN THE LYTIC CYCLE OF BACTERIOPHAGE X 245
15.3 ESTABLISHMENT AND MAINTENANCE BACTERIOPHAGE X LYSOGENY 247
15.4 INDUCTION AND EXCISION OF THE BACTERIOPHAGE X IYSOGEN DNA 249
15.5 IMMUNITY TO SUPERINFECTION 251
15.6 THE BENEFITS OF LYSOGENY 251
15.7 HERPES SIMPLEX VIRUS LATENCY 252
15.8 EPSTEIN-BARR VIRUS LATENCY 255
15.9 LATENCY IN OTHER HERPESVIRUSES 2 56
15.10 HIV-1 LATENCY 258
KEY POINTS 2 59
QUESTIONS 259
FURTHER READING 2 59
16 TRANSMISSION OF VIRUSES 260
16.1 HORIZONTAL TRANSMISSION 261
16.2 VERTICAL TRANSMISSION 267
16.3 ZOONOSES 268
KEY POINTS 269
QUESTIONS 270
FURTHER READING 270
17 THE EVOLUTION OF VIRUSES 271
17.1 THE POTENTIAL FOR RAPID EVOLUTION IN RNA VIRUSES: QUASISPECIES AND
RAPID EVOLUTION 272
17.2 RAPID EVOLUTION: RECOMBINATION 273
17.3 EVOLUTION OF MEASLES VIRUS 274
17.4 EVOLUTION OF MYXOMA VIRUS 275
17.5 EVOLUTION OF INFLUENZA VIRUS 277
KEY POINTS 288
QUESTIONS 289
FURTHER READING 289
PART IV: VIRUSES AND DISEASE 291
18 HUMAN VIRAL DISEASE: AN OVERVIEW 293
18.1 A BRIEF SURVEY OF HUMAN VIRAL PATHOGENS 295
18.2 FACTORS AFFECTING THE RELATIVE INCIDENCE OF VIRAL DISEASE 295
18.3 FACTORS DETERMINING THE NATURE AND SEVERITY OF VIRAL DISEASE 298
18.4 COMMON SIGNS AND SYMPTOMS OF VIRAL INFECTION 300
IMAGE 4
X CONTENTS
18.5 ACUTE VIRAL INFECTION 1: GASTROINTESTINAL INFECTIONS 301
18.6 ACUTE VIRAL INFECTION 2: RESPIRATORY INFECTIONS 303
18.7 ACUTE VIRAL INFECTION 3: INFECTIONS OF THE LIVER 305
18.8 ACUTE VIRAL INFECTION 4: SYSTEMIC SPREAD 306
18.9 ACUTE VIRAL DISEASE: CONCLUSIONS 308
KEY POINTS 308
QUESTIONS 309
FURTHER READING 309
19 HIV AND AIDS 310
19.1 THE BIOLOGY OF HIV INFECTION 311
19.2 MOLECULAR BIOLOGY OF HIV-1 315
19.3 HIV TRANSMISSION 320
19.4 COURSE OF HIV INFECTION AND DISEASE 321
19.5 DEATH AND AIDS 323
19.6 IMMUNOLOGICAL ABNORMALITIES 324
19.7 WHY IS THE INCUBATION PERIOD OF AIDS SO LONG? 325
19.8 PREVENTION AND CONTROL OF HIV INFECTION 327
19.9 THE COST OF THE HIV PANDEMIC 337
19.10 UNRESOLVED ISSUES 338
KEY POINTS 338
QUESTIONS 339
FURTHER READING 339
20 CARCINOGENESIS AND TUMOR VIRUSES 341
20.1 IMMORTALIZATION, TRANSFORMATION, AND TUMORIGENESIS 343
20.2 ONCOGENIC VIRUSES 345
20.3 POLYOMAVIRUSES, PAPILLOMAVIRUSES, AND ADENOVIRUSES: THE SMALL DNA
TUMOR VIRUSES AS EXPERIMENTAL MODELS 347
20.4 PAPILLOMAVIRUSES, SV40, AND HUMAN CANCER 352
20.5 HERPESVIRUS INVOLVEMENT IN HUMAN CANCERS 354
20.6 RETROVIRUSES AS EXPERIMENTAL MODEL TUMOR VIRUSES 356
20.7 RETROVIRUSES AND NATURALLY OCCURRING TUMORS 358
20.8 HEPATITIS VIRUSES AND LIVER CANCER 359
20.9 PROSPECTS FOR THE CONTROL OF VIRUS-ASSOCIATED CANCERS 360
KEY POINTS 362
QUESTIONS 362
FURTHER READING 362
2 1 VACCINES AND ANTIVIRALS: THE JIREVENTION AND TREATMENT OF VIRUS
DISEASES 364 21.1 PRINCIPAL REQUIREMENTS OF A VACCINE 365
21.2 ADVANTAGES, DISADVANTAGES, AND DIFFICULTIES ASSOCIATED WITH LIVE
AND KILLED VACCINES 370
21.3 PEPTIDE VACCINES 375
21.4 GENETICALLY ENGINEERED VACCINES 377
IMAGE 5
XI
21.5 INFECTIOUS DISEASE WORLDWIDE 381
21.6 ELIMINATION OF VIRUS DISEASES BY VACCINATION 381
21.7 CLINICAL COMPLICATIONS WITH VACCINES AND IMMUNOTHERAPY 388
21.8 PROPHYLAXIS AND THERAPY WITH ANTIVIRAL DRUGS 390
KEY POINTS 399
QUESTIONS 399
FURTHER READING 400
22 PRION DISEASES 401
22.1 THE SPECTRUM OF PRION DISEASES 401
22.2 THE PRION HYPOTHESIS 403
22.3 THE ETIOLOGY OF PRION DISEASES 405
22.4 PRION DISEASE PATHOGENESIS 407
22.5 BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) 409
22.6 BSE AND THE EMERGENCE OF VARIANT CJD 411
22.7 UNRESOLVED ISSUES 413
KEY POINTS 414
QUESTIONS 414
FURTHER READING 415
23 HORIZONS IN HUMAN VIROLOGY 416
23.1 TECHNICAL ADVANCES 417
23.2 RECOMBINANT VIRUSES AS GENE THERAPY VECTORS 422
23.3 SUBTLE AND INSIDIOUS VIRUS-HOST INTERACTIONS 428
23.4 EMERGING VIRUS INFECTIONS 433
23.5 VIROLOGY AND SOCIETY: FOR GOOD OR ILL 441
KEY POINTS 442
QUESTIONS 442
FURTHER READING 442
APPENDIXES: SURVEY OF VIRUS PROPERTIES 444
1 VIRUSES THAT MULTIPLY IN VERTEBRATE AND INVERTEBRATE ANIMALS 445
2 VIRUSES THAT MULTIPLY IN PLANTS 460
3 VIRUSES THAT MULTIPLY IN ALGAE, FUNGI, AND PROTOZOA 469
4 VIRUSES (PHAGES) THAT MULTIPLY IN ARCHAEA, BACTERIA, MYCOPLASMA, AND
SPIROPLASMA 472 5 SATELLITE VIRUSES AND SATELLITE NUCLEIC ACIDS OF
VIRUSES OF ANIMALS, PLANTS, AND BACTERIA 476 6 VIROIDS (GENOME
UNCLASSIFIED AS THEY SYNTHESIZE NO MRNA) 478
7 FURTHER READING 479
INDEX 480
|
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| author | Dimmock, Nigel J. Easton, Andrew Leppard, Keith N. |
| author_facet | Dimmock, Nigel J. Easton, Andrew Leppard, Keith N. |
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| author_sort | Dimmock, Nigel J. |
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| discipline | Biologie Medizin |
| edition | 6. ed. |
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| indexdate | 2024-07-09T22:41:33Z |
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| publisher | Blackwell |
| record_format | marc |
| spelling | Dimmock, Nigel J. Verfasser aut Introduction to modern virology N. J. Dimmock ; A. J. Easton ; K. N. Leppard 6. ed. Malden, MA [u.a.] Blackwell 2007 XIV, 516 S. zahlr. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Virology cabt Viruses cabt Viral Diseases cabt Virology Virus diseases Viruses Virus Diseases Viren (DE-588)4063589-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Molekulare Virologie (DE-588)4170393-5 gnd rswk-swf Virologie (DE-588)4063597-1 gnd rswk-swf 1\p (DE-588)4151278-9 Einführung gnd-content 2\p (DE-588)4123623-3 Lehrbuch gnd-content Viren (DE-588)4063589-2 s Molekularbiologie (DE-588)4039983-7 s DE-604 Molekulare Virologie (DE-588)4170393-5 s Virologie (DE-588)4063597-1 s 3\p DE-604 Easton, Andrew Verfasser aut Leppard, Keith N. Verfasser aut SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020414701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Dimmock, Nigel J. Easton, Andrew Leppard, Keith N. Introduction to modern virology Virology cabt Viruses cabt Viral Diseases cabt Virology Virus diseases Viruses Virus Diseases Viren (DE-588)4063589-2 gnd Molekularbiologie (DE-588)4039983-7 gnd Molekulare Virologie (DE-588)4170393-5 gnd Virologie (DE-588)4063597-1 gnd |
| subject_GND | (DE-588)4063589-2 (DE-588)4039983-7 (DE-588)4170393-5 (DE-588)4063597-1 (DE-588)4151278-9 (DE-588)4123623-3 |
| title | Introduction to modern virology |
| title_auth | Introduction to modern virology |
| title_exact_search | Introduction to modern virology |
| title_full | Introduction to modern virology N. J. Dimmock ; A. J. Easton ; K. N. Leppard |
| title_fullStr | Introduction to modern virology N. J. Dimmock ; A. J. Easton ; K. N. Leppard |
| title_full_unstemmed | Introduction to modern virology N. J. Dimmock ; A. J. Easton ; K. N. Leppard |
| title_short | Introduction to modern virology |
| title_sort | introduction to modern virology |
| topic | Virology cabt Viruses cabt Viral Diseases cabt Virology Virus diseases Viruses Virus Diseases Viren (DE-588)4063589-2 gnd Molekularbiologie (DE-588)4039983-7 gnd Molekulare Virologie (DE-588)4170393-5 gnd Virologie (DE-588)4063597-1 gnd |
| topic_facet | Virology Viruses Viral Diseases Virus diseases Virus Diseases Viren Molekularbiologie Molekulare Virologie Virologie Einführung Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020414701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT dimmocknigelj introductiontomodernvirology AT eastonandrew introductiontomodernvirology AT leppardkeithn introductiontomodernvirology |