Mitochondrial genetics and cancer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2010
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| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XV, 356 S. Ill. |
| ISBN: | 9783642114151 |
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REFERENCES 34 CONTENTS PART I GENERAL OVERVIEW OF MITOCHONDRIA! GENETICS
AND FUNCTIONS 1 BASIC MITOCHONDRIAL GENETICS, BIOENERGETICS, AND
BIOGENESIS 3 1 .1 INTRODUCTION 3 1.2 THE MITOCHONDRION 4 1.3 CONTRASTING
FEATURES OF MITOCHONDRIAL AND NUCLEAR GENETICS 5 1.4 MITOCHONDRIAL
GENOMIC STRUCTURE AND ORGANIZATION 13 1.5 MITOCHONDRIAL MICROSATELLITES
AND D310 14 1.6 MITOCHONDRIAL PSEUDOGENES 15 1.7 THE RESPIRATORY CHAIN
16 1.7.1 THE ELECTRON TRANSPORT CHAIN 16 1.7.2 COUPLING OF THE PROTON
GRADIENT WITH OXIDATIVE PHOSPHORYLATION 21 1.7.3 THE RESPIRATORY CHAIN
AND REACTIVE OXYGEN SPECIES PRODUCTION 21 1.8 MITOCHONDRIAL BIOGENESIS
22 1.8.1 MITOCHONDRIAL GENOME REPLICATION 22 1.8.2 MITOCHONDRIAL GENOME
TRANSCRIPTION 24 1.9 CONTROL OF MITOCHONDRIAL BIOGENESIS 28 1.9.1
HORMONAL CONTROL 28 1.9.2 NUCLEAR RESPIRATORY FACTORS 29 1.9.3
PEROXISOMAL PROLIFERATOR ACTIVATOR RECEPTOR GAMMA CO-ACTIVATOR-LA 30
1.9.4 REGULATION OF PGC-1 30 1.9.5 PGC-LA-RELATED COACTIVATOR 32 1.9.6
MYC ONCOGENE AND MITOCHONDRIAL BIOGENESIS 32 1.10 IMPORT OF
NUCLEAR-ENCODED PROTEINS INTO MITOCHONDRIA 32 1.11 MITOCHONDRIAL IMPORT
OF CYTOSOLIC TRANSFER RNA 33 1.12 CONCLUSION 33 BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/1000033627 DIGITALISIERT DURCH CONTENTS
THE WARBURG PHENOMENON AND OTHER METABOLIC ALTERATIONS OF CANCER CELLS
39 2.1 INTRODUCTION 39 2.2 BIOENERGETICS OF NORMAL CELLS 40 2.3 THE
CRABTREE EFFECT 40 2.4 THE WARBURG PHENOMENON 42 2.5 MOLECULAR BASIS OF
THE WARBURG PHENOMENON 46 2.5.1 HK AND GLYCOLYSIS 48 2.5.2 THE PI3K/AKT
SIGNALING PATHWAY AND GLYCOLYSIS 49 2.5.3 THE MYC ONCOGENE AND
GLYCOLYSIS 50 2.5.4 HYPOXIA-INDUCIBLE FACTOR PATHWAY AND GLYCOLYSIS 51
2.5.5 P53 AND GLYCOLYSIS 55 2.6 GLUTAMINE METABOLISM IN CANCER CELLS 56
2.7 LIPID METABOLISM IN CANCER CELLS 57 2.8 CITRATE METABOLISM BY
PROSTATE GLANDULAR EPITHELIAL CELLS 58 2.9 CLINICAL IMPLICATIONS OF
ALTERED PCA METABOLISM 59 2.9.1 DIAGNOSTIC IMAGING OF PCA 60 2.9.2
SCREENING FOR PCA USING BIOFLUIDS 61 2.9.3 PCA PREVENTION AND TREATMENT
61 2.10 CONCLUSION 62 REFERENCES 62 MITOCHONDRIA! CONTROL OF APOPTOSIS
AND CANCER 67 3. 1 INTRODUCTION 67 3.2 CELL DEATH PROCESSES: THE
CONUNDRUM OF SEMANTICS 68 3.3 PHYSIOLOGIC IMPORTANCE OF APOPTOSIS 69 3.4
CASPASE CASCADE 69 3.5 THE INTRINSIC OR MITOCHONDRIAL APOPTOTIC PATHWAY
70 3.5.1 MITOCHONDRIAL MEMBRANE PERMEABILIZATION 70 3.5.2 BCL-2 FAMILY
MEMBERS AND REGULATION OF MITOCHONDRIAL MEMBRANE PERMEABILIZATION 72
3.5.3 THE EXECUTION OF MITOCHONDRIAL APOPTOSIS 75 3.5.4 VIRAL CONTROL OF
MITOCHONDRIAL APOPTOSIS 76 3.5. CONTENTS XI 4 MITOCHONDRIAL-TO-NUCLEAR
COMMUNICATIONS IN CANCER 93 4.1 INTRODUCTION 93 4.2 SUCCINATE
DEHYDROGENASE AND FUMARATE HYDRATASE MUTATIONS AND CANCER 94 4.2.1 SDH
MUTATIONS AND CANCER 95 4.2.2 GENETICS AND CLINICAL FEATURES OF FUMARATE
HYDRATASE MUTATIONS 100 4.2.3 GENETIC TESTING AND COUNSELING FOR SDH AND
F/ZMUTATIONS 102 4.2.4 MECHANISM OF TUMOR INDUCTION BY SDH AND FUMARATE
HYDRATASE MUTATIONS 105 4.3 MITOCHONDRIA-TO-NUCLEAR STRESS SIGNALING IN
CANCER 108 4.4 NUCLEAR INTEGRATION OF MITOCHONDRIAL GENOME FRAGMENTS AND
POSSIBLE ONCOGENE INDUCTION 110 4.5 CONCLUSION ILL REFERENCES 112 PART
II MITOCHONDRIAL GENETIC ALTERATIONS IN CANCER 5 TYPES OF MITOCHONDRIAL
GENETIC ALTERATIONS IN CANCER 119 5.1 INTRODUCTION 119 5.2 MITOCHONDRIAL
HAPLOTYPES AND HAPLOGROUPS 120 5.3 MITOCHONDRIAL DNA POLYMORPHISMS AND
SOMATIC MUTATIONS . 121 5.4 MITOCHONDRIAL MICROSATELLITES 123 5.4.1
DISCOVERY OF D310 INSTABILITY AS A MUTATIONAL HOT-SPOT IN CANCER 123
5.4.2 MECHANISM OF MTMSI 124 5.4.3 CLINICAL UTILITY OF MTMSI 124 5.5
MITOCHONDRIAL GENOME REARRANGEMENTS 125 5. JU CONTENTS 6.2 SKINCANCER
136 6.2.1 MELANOMA 137 6.2.2 NONMELANOMA SKIN CANCER 139 6.3 HEAD AND
NECK CANCER 139 6.4 SALIVARY GLAND CANCER 142 6.5 THYROID CANCER AND
PARATHYROID ADENOMA 142 6.6 BREASTCANCER 145 6.7 LUNGCANCER 149 6.8
ESOPHAGEAL CANCER 150 6.9 GASTRIC CANCER 151 6.10 COLORECTAL CANCER 153
6.11 PANCREATIC CANCER 156 6.12 HEPATOCELLULAR CARCINOMA 157 6.13
GALLBLADDER CANCER 159 6.14 CONCLUSION 159 REFERENCES 159 7
MITOCHONDRIAL GENETIC ALTERATIONS IN CANCER II: RENAL, URINARY BLADDER,
PROSTATE, OVARIAN, ENDOMETRIAL, CERVICAL, NERVOUS SYSTEM, HEMATOLOGIE,
AND CONNECTIVE TISSUE CANCERS 167 7.1 INTRODUCTION 167 7.2 RENAL CANCER
167 7.3 BLADDER CANCER 170 7.4 PROSTATE CANCER 170 7.5 OVARIAN CANCER
173 7.6 ENDOMETRIAL CANCER 175 7.7 CERVICAL CANCER 176 7.8 NERVOUS
SYSTEM TUMORS 177 7.9 HEMATOLOGIE MALIGNANCY 178 7.10 CONNECTIVE TISSUE
CANCER 181 7.11 CONCLUSION 182 REFERENCES 182 8 MITOCHONDRIAL GENOME
REARRANGEMENTS AND COPY NUMBER CHANGES IN CANCER 187 8.1 INTRODUCTION
187 8.2 OVERVIEW OF MTDNA DELETION DISORDERS 188 8.3 MITOCHONDRIAL
GENOME DELETIONS IN CANCER 188 8.4 IS THE CD A TUMOR SUPPRESSOR? 198 8.5
MTDNA CONTENT ALTERATIONS IN CANCER 198 8.5. CONTENTS XIII 8.6.1
INCREASED MTDNA COPY NUMBER 203 8.6.2 DECREASED MTDNA COPY NUMBER 204
8.7 POSTULATED MECHANISMS OF DELETION FORMATION 204 8.8 CONTROL OF MTDNA
DELETIONS 206 8.9 CONCLUSION 207 REFERENCES 207 9 FUNCTIONAL IMPORTANCE
OF MITOCHONDRIAL GENETIC ALTERATIONS IN CANCER 213 9.1 INTRODUCTION 213
9.2 MITOCHONDRIAL DNA MUTATIONS IN CANCER: CAUSE OR CONSEQUENCE? 214 9.3
FUNCTIONAL CONSEQUENCES OF MITOCHONDRIAL DNA MUTATIONS ON MITOCHONDRIAL
BIOGENESIS IN CANCER 215 9.4 TECHNIQUES EMPLOYED TO STUDY THE
CONTRIBUTION OF MITOCHONDRIAL DNA MUTATIONS IN CANCER 217 9.4.1
GENERATING PO CELLS 218 9.4.2 PRODUCING TRANSMITOCHONDRIAL HYBRIDS
(CYBRIDS) 219 9.4.3 NUCLEAR TRANSFECTION OF MUTANT MITOCHONDRIAL DNA 220
9.5 CONTRIBUTION OF MITOCHONDRIAL DNA CHANGES TO CANCER BIOLOGY 221
9.5.1 CANCER RISK PREDISPOSITION 221 9.5.2 CANCER INITIATION 222 9.5.3
CANCER CELL PROLIFERATION AND GROWTH 224 9.5.4 CANCER PROGRESSION AND
METASTASIS 226 9.5.5 ACQUISITION OF HORMONAL INDEPENDENCE AND
CHEMORESISTANCE BY CANCER CELLS 227 9.5.6 CONTRIBUTION OF MITOCHONDRIAL
GENOME CHANGES TO THE DEVELOPMENT OF ONCOCYTIC TUMORS 228 9.6
MITOCHONDRIAL MEMBRANE POTENTIAL AND CANCER 230 9.7 COLLABORATIVE
EVIDENCES FROM CLINICAL STUDIES 231 9.8 CONCLUSION 232 REFERENCES 233 10
THE ROLE OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES I CONTENTS 10.7.2
PI3K/AKT PATHWAY 246 10.7.3 NUCLEAR FACTOR KAPPA-LIGHT-CHAIN-ENHANCER OF
ACTIVATED B CELLS PATHWAY 246 10.7.4 ACTIVATOR PROTEIN 1 247 10.7.5
PROTEIN KINASE C 247 10.7.6 MYC ONCOGENE 248 10.8 ROS AND CARCINOGENESIS
248 10.9 AMELIORATING THE HARMFUL EFFECTS OF ROS 250 10.10 CONCLUSION
252 REFERENCES 252 PART III CLINICAL APPLICATIONS OF MITOCHONDRIAL
GENOME CHANGES IN CANCER 11 MITOCHONDRIAL DNA MEASUREMENT IN EXFOLIATED
CELLS FOR CANCER DETECTION AND MONITORING: THE COPY NUMBER ADVANTAGE 259
11.1 INTRODUCTION 259 11.2 TUMOR SIGNATURES IN BIOFLUIDS 260 11.3
MITOCHONDRIAL GENOME CHANGES IN BIOFLUIDS OF CANCER PATIENTS 262 11.3.1
BLOOD (SERUM AND PLASMA) 262 11.3.2 SALIVARY RINSES 265 11.3.3
BALANDSPUTUM 266 11.3.4 NIPPLE ASPIRATE FLUID AND DUCTAL LAVAGE 266
11.3.5 URINE 267 11.3.6 CEREBROSPINAL FLUID 268 11.3.7 OTHER BIOFLUIDS
268 11.3.8 EXFOLIATED SKIN CELLS FOR SKIN CANCER DETECTION 269 11.4
CLINICAL UTILITY OF MITOCHONDRIAL DNA CHANGES IN BIOFLUIDS 269 11.5
CONCLUSION 271 REFERENCES 27 1 12 EARLY CANCER DETECTION AND MONITORING
USING CHANGES IN THE MITOCHONDRIAL GENOME AS BIOSENSORS 275 12.1
INTRODUCTION 275 12.2 FIELD CANCERIZATION DEMONSTRATED BY MITOCHONDRIAL
GENOME CHANGES 278 12. CONTENTS XV 12.4.2 RISK ASSESSMENT, EARLY CANCER
DETECTION, CHEMOPREVENTION, AND DISEASE MONITORING 289 12.4.3 TUMOR
MARGINS AND RECURRENCES 291 12.5 CONCLUSION 291 REFERENCES 292 13
ANALYSIS OF MITOCHONDRIAL GENOME ALTERATIONS IN CANCER 297 13.1
INTRODUCTION 297 13.2 PREPARATION OF CLINICAL SAMPLES FOR MITOCHONDRIAL
GENOME ANALYSIS IN CANCER 298 13.3 ANALYSIS OF MITOCHONDRIAL GENOME
POINT MUTATIONS IN CANCER 299 13.3.1 DIAGNOSTIC APPROACHES 299 13.4
ANALYSIS OF MITOCHONDRIAL GENOME DELETIONS AND CONTENT CHANGES 309
13.4.1 SOUTHERN BLOTTING 310 13.4.2 QUANTITATIVE POLYMERASE CHASE
REACTION 310 13.5 QUALITY ASSURANCE ISSUES IN MITOCHONDRIAL DNA ANALYSIS
317 13.6 CONCLUSION 318 REFERENCES 318 14 "MITOCANS": AGENTS TARGETING
MITOCHONDRIA TO KILL CANCER CELLS 321 14.1 INTRODUCTION 321 14.2
CHEMOTHERAPY TARGETS 322 14.2.1 THE INTRINSIC APOPTOTIC PATHWAY 322
14.2.2 TARGETING GLYCOLYSIS TO KILL CANCER CELLS 332 14.2.3 TARGETS OF
REDOX HOMEOSTASIS 335 14.2.4 TARGETING MEMBRANE POTENTIAL CHANGES 336
14.2.5 CANCER MITOCHONDRIAL DNA DEPLETION AS A STRATEGY 336 14.2.6
DELIVERY OF TOXIC COMPOUNDS TO MITOCHONDRIA USING DIFFERENTIAL RECEPTOR
EXPRESSION BY CANCER CELLS 337 14.3 CONCLUSION 338 REFERENCES 338 INDEX
34 |
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| spelling | Dakubo, Gabriel D. Verfasser aut Mitochondrial genetics and cancer Gabriel D. Dakubo Berlin [u.a.] Springer 2010 XV, 356 S. Ill. txt rdacontent n rdamedia nc rdacarrier Mitochondriale DNS (DE-588)4202301-4 gnd rswk-swf Mutation (DE-588)4170883-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Carcinogenese (DE-588)4069853-1 s Mitochondriale DNS (DE-588)4202301-4 s Mutation (DE-588)4170883-0 s DE-604 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3423765&prov=M&dok%5Fvar=1&dok%5Fext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020302296&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dakubo, Gabriel D. Mitochondrial genetics and cancer Mitochondriale DNS (DE-588)4202301-4 gnd Mutation (DE-588)4170883-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Carcinogenese (DE-588)4069853-1 gnd |
| subject_GND | (DE-588)4202301-4 (DE-588)4170883-0 (DE-588)4073781-0 (DE-588)4069853-1 |
| title | Mitochondrial genetics and cancer |
| title_auth | Mitochondrial genetics and cancer |
| title_exact_search | Mitochondrial genetics and cancer |
| title_full | Mitochondrial genetics and cancer Gabriel D. Dakubo |
| title_fullStr | Mitochondrial genetics and cancer Gabriel D. Dakubo |
| title_full_unstemmed | Mitochondrial genetics and cancer Gabriel D. Dakubo |
| title_short | Mitochondrial genetics and cancer |
| title_sort | mitochondrial genetics and cancer |
| topic | Mitochondriale DNS (DE-588)4202301-4 gnd Mutation (DE-588)4170883-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Carcinogenese (DE-588)4069853-1 gnd |
| topic_facet | Mitochondriale DNS Mutation Krebs Medizin Carcinogenese |
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