Influence of formulation variables on in vitro deposition of spray dried, respirable particles:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Aachen
Shaker
2009
|
| Series: | Monographs in pharmaceutics
11 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 225 S. Ill., graph. Darst. 21 cm |
| ISBN: | 9783832287849 |
Staff View
MARC
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Record in the Search Index
| _version_ | 1804142812012216320 |
|---|---|
| adam_text | CONTENTS NOMENCLATURE XI 1 INTRODUCTION 1 2 CASCADE IMPACTION 3 2.1 A
SHORT HISTORY OF CASCADE IMPACTION 3 2.2 BASIC PRINCIPLES OF CASCADE
IMPACTION 11 2.2.1 CONCERNING GAS FLOW 11 2.2.2 INERTIAL IMPACTION 13
2.3 THE ANDERSEN CASCADE IMPACTOR 18 2.4 IN VIVO - IN VITRO CORRELATION
23 2.5 PROCESSING CASCADE IMPACTION DATA 25 2.5.1 COMPENDIAI METHODS 25
2.5.2 NON-COMPENDIAL METHODS 29 3 SPRAY DRYING 33 3.1 SPRAY DRYING OF
PROTEINS 33 3.2 POWDER STICKINESS 36 3.3 DROPLET AND PARTICLE SIZES 43 4
MATERIALS AND METHODS 49 4.1 MATERIALS 49 4.2 METHODS 50 4.2.1 SPRAY
DRYING 50 BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1000544133
DIGITALISIERT DURCH 4.2.2 CASCADE IMPACTION 51 4.2.3
UV/VIS-PHOTOSPECTROMETRY 54 4.2.4 LASER DIFFRACTOMETRY 56 4.2.5 SCANNING
ELECTRON MICROSCOPY 56 4.2.6 WIDE ANGLE X-RAY DIFFRACTOMETRY 56 4.2.7
DIFFERENTIAL SCANNING CALORIMETRY 57 4.2.8 KARL-FISCHER TRITRATION 58 5
RESULTS AND DISCUSSION 59 5.1 INVESTIGATION OF COMMERCIAL DRY POWDER
INHALERS 59 5.2 INFLUENCE OF METHYLENE BLUE ON MANNITOL-SD-PARTICLE
MORPHOLOGY . . . . 68 5.3 DEVELOPMENT OF CASCADE IMPACTION METHOD 78 5.4
DEVELOPMENT OF COATING MATERIAL FOR IMPACTOR STAGE DISCS 96 5.5 DRY
POWDER MIXTURE DEVELOPMENT 99 5.5.1 DEVELOPMENT OF A HOMOGENEOUS MIXTURE
99 5.5.2 AERODYNAMIC PERFORMANCE 107 5.6 EMITTED DOSE DEPENDANCE HI
5.6.1 CAPSULE FILLING ILL 5.6.2 PRESSURE DROP H 4 5.7 MANNITOL BASED
POWDERS 116 5.7.1 5 % METHYLENE BLUE (95M05MB) 117 5.7.2 25 % METHYLENE
BLUE (75M25MB) 120 5.7.3 5 % METHYLENE BLUE -5% TWEEN 80 (90M05MB-T)
122 5.7.4 25 % METHYLENE BLUE - 5 % TWEEN 80 (70M25MB-T) 124 5.7.5
COMPARISON OF MANNITOL RESULTS 127 5.8 TREHALOSE BASED POWDERS 131 5.8.1
5 % METHYLENE BLUE (95T05MB) 133 5.8.2 25 % METHYLENE BLUE (75T25MB) 135
5.8.3 5 % METHYLENE BLUE *+* 5 % TWEEN 80 (90T05MB-T) 138 5.8. CONTENTS
IX 5.8.5 COMPARISON OF TREHALOSE RESULTS 145 5.9 SUCROSE BASED POWDERS
148 5.9.1 5 % METHYLENE BLUE (95S05MB) 149 5.9.2 25 % METHYLENE BLUE
(75S25MB) 151 5.9.3 5 % METHYLENE BLUE - 5 % TWEEN 80 (90S05MB-T) .154
5.9.4 25 % METHYLENE BLUE + 5 % TWEEN 80 (70S25MB-T) 155 5.9.5
COMPARISON OF SUCROSE RESULTS 155 6 CONCLUSIONS 159 6.1 PROSPECTS 163 7
SUMMARY 165 7.1 INTRODUCTION 165 7.2 CASCADE IMPACTION 165 7.3 SPRAY
DRYING 169 7.4 MATERIALS AND METHODS 171 7.5 RESULTS AND DISCUSSION 173
7.6 PROSPECTS 180 8 ZUSAMMENFASSUNG 181 8.1 INTRODUCTION 181 8.2 CASCADE
IMPACTION 181 8.3 SPRAY DRYING 185 8.4 MATERIALS AND METHODS 188 8.5
RESULTS AND DISCUSSION 190 8.6 PROSPECTS 197
|
| any_adam_object | 1 |
| author | Pudritz, Harald 1978- |
| author_GND | (DE-588)140891013 |
| author_facet | Pudritz, Harald 1978- |
| author_role | aut |
| author_sort | Pudritz, Harald 1978- |
| author_variant | h p hp |
| building | Verbundindex |
| bvnumber | BV036421597 |
| classification_rvk | VT 5200 |
| ctrlnum | (OCoLC)624469910 (DE-599)DNB1000544133 |
| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV036421597 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:37:42Z |
| institution | BVB |
| isbn | 9783832287849 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020218437 |
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| owner_facet | DE-29 DE-29T |
| physical | XVII, 225 S. Ill., graph. Darst. 21 cm |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Shaker |
| record_format | marc |
| series | Monographs in pharmaceutics |
| series2 | Monographs in pharmaceutics |
| spelling | Pudritz, Harald 1978- Verfasser (DE-588)140891013 aut Influence of formulation variables on in vitro deposition of spray dried, respirable particles Harald Pudritz Aachen Shaker 2009 XVII, 225 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Monographs in pharmaceutics 11 Zugl.: Erlangen-Nürnberg, Univ., Diss., 2009 Pulverherstellung (DE-588)4228872-1 gnd rswk-swf Aerodynamik (DE-588)4000589-6 gnd rswk-swf Korngrößenverteilung (DE-588)4032495-3 gnd rswk-swf Zerstäubungstrocknung (DE-588)4190759-0 gnd rswk-swf Formulierung Technische Chemie (DE-588)4246877-2 gnd rswk-swf Inhalationsmittel (DE-588)4263866-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Inhalationsmittel (DE-588)4263866-5 s Pulverherstellung (DE-588)4228872-1 s Formulierung Technische Chemie (DE-588)4246877-2 s Zerstäubungstrocknung (DE-588)4190759-0 s Korngrößenverteilung (DE-588)4032495-3 s Aerodynamik (DE-588)4000589-6 s DE-604 Monographs in pharmaceutics 11 (DE-604)BV020836677 11 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020218437&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pudritz, Harald 1978- Influence of formulation variables on in vitro deposition of spray dried, respirable particles Monographs in pharmaceutics Pulverherstellung (DE-588)4228872-1 gnd Aerodynamik (DE-588)4000589-6 gnd Korngrößenverteilung (DE-588)4032495-3 gnd Zerstäubungstrocknung (DE-588)4190759-0 gnd Formulierung Technische Chemie (DE-588)4246877-2 gnd Inhalationsmittel (DE-588)4263866-5 gnd |
| subject_GND | (DE-588)4228872-1 (DE-588)4000589-6 (DE-588)4032495-3 (DE-588)4190759-0 (DE-588)4246877-2 (DE-588)4263866-5 (DE-588)4113937-9 |
| title | Influence of formulation variables on in vitro deposition of spray dried, respirable particles |
| title_auth | Influence of formulation variables on in vitro deposition of spray dried, respirable particles |
| title_exact_search | Influence of formulation variables on in vitro deposition of spray dried, respirable particles |
| title_full | Influence of formulation variables on in vitro deposition of spray dried, respirable particles Harald Pudritz |
| title_fullStr | Influence of formulation variables on in vitro deposition of spray dried, respirable particles Harald Pudritz |
| title_full_unstemmed | Influence of formulation variables on in vitro deposition of spray dried, respirable particles Harald Pudritz |
| title_short | Influence of formulation variables on in vitro deposition of spray dried, respirable particles |
| title_sort | influence of formulation variables on in vitro deposition of spray dried respirable particles |
| topic | Pulverherstellung (DE-588)4228872-1 gnd Aerodynamik (DE-588)4000589-6 gnd Korngrößenverteilung (DE-588)4032495-3 gnd Zerstäubungstrocknung (DE-588)4190759-0 gnd Formulierung Technische Chemie (DE-588)4246877-2 gnd Inhalationsmittel (DE-588)4263866-5 gnd |
| topic_facet | Pulverherstellung Aerodynamik Korngrößenverteilung Zerstäubungstrocknung Formulierung Technische Chemie Inhalationsmittel Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020218437&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV020836677 |
| work_keys_str_mv | AT pudritzharald influenceofformulationvariablesoninvitrodepositionofspraydriedrespirableparticles |