Essential bioimaging methods: reliable Lab solutions
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier/Academic Press
2009
|
| Edition: | 1. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 420 S. Ill., graph. Darst. |
| ISBN: | 9780123750433 0123750431 |
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Record in the Search Index
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| adam_text | Titel: Essential bioimaging methods
Autor: Conn, Patrick Michael
Jahr: 2009
CONTENTS
Contributors xi
Preface xv
PART I Imaging in Animal and Human Models
1. Positron Emission Tomography (PET): Research to Clinical Practice
Rakesh Kumar and Sumanjana
I. Introduction 4
II. Tracers 4
III. Drug Evaluation 5
IV. Biological Function Evaluation 7
V. Clinical Applications 8
VI. Future Perspectives 16
VII. Conclusions 18
References 18
2. Biophysical Basis of Magnetic Resonance Imaging of Small Animals
Bruce M. Damon and John C. Gore
I. Introduction 27
II. Spin Relaxation 28
III. Effects of Exchange and Compartmentation 31
IV. Paramagnetic Relaxation 33
V. Susceptibility Contrast and BOLD Effects 33
VI. Effects of Spin Motion 34
VII. An Illustrative Example: MRI of Exercising Skeletal Muscle 35
References 45
3. Functional Magnetic Resonance Imaging of Macaque Monkeys
Kiyoshi Nakahara
I. Introduction 47
II. Potential of Functional MRI in Macaque Monkeys 48
Contents
III. Brief History of fMRI in Macaque Monkeys 49
IV. Experimental Procedures 50
V. Conclusion 52
References 52
4. Atlas Template Images for Nonhuman Primate Neuroimaging: Baboon and Macaque
Kevin J. Black, Jonathan M. Koller, Abraham Z. Snyder, and Joel S. Perlmutter
I. Introduction 56
II. Methods 57
III. Discussion 64
References 65
5. Magnetic Resonance Imaging of Brain Function
Stuart Clare
I. Update 67
II. Introduction 68
III. Experimental Procedures 69
IV. An Application of Functional MRI 80
V. Discussion and Conclusion 81
References 81
PART II Imaging of Receptors, Small Molecules,
and Protein-Protein Interactions
Positron Emission Tomography Receptor Assay with Multiple Ligand Concentrations:
An Equilibrium Approach
Doris J. Doudet and James E. Holden
I. Update 86
II. Introduction 88
III. Overview of In Vivo Receptor Assay 89
IV. Methods 93
V. Example Applications 98
VI. Conclusions 101
References lol
Contents
7. Estimation of Local Receptor Density, B*m3x, and Other Parameters via
Multiple-Injection Positron Emission Tomography Experiments
Evan D. Morris, Bradley T. Christian, Karmen K. Yoder, and Raymond F. Muzic,Jr.
I. Update 106
II. Introduction 107
III. Theory 109
IV. Experimental Protocol and Considerations 115
V. Models and Data Fitting 120
VI. Results and Interpretation 125
VII. Understanding and Designing M-I Experiments 128
VIII. Conclusion 131
References 132
8. Magnetic Resonance Imaging in Biomedical Research: Imaging of Drugs
and Drug Effects
Markus Rudin, Nicolau Beckmann, and Martin Rausch
I. Introduction 135
II. Drug Imaging and PK Studies 136
III. Noninvasive Assessment of Drug Efficacy/Pharmacodynamic Studies 138
IV. Disease and Efficacy Biomarkers as Bridge Between Preclinical
and Clinical Drug Evaluation 145
V. Conclusion and Outlook 147
References 148
9. Imaging Myocardium Enzymatic Pathways with Carbon-11 Radiotracers
Carmen S. Dence, Pilar Herrero, Sally W. Schwarz, Robert H. Mach, Robert J. Gropler,
and Michael J. Welch
I. Introduction 152
II. Overview of the Production of Carbon-11 153
III. Overview of the Quality Assurance of C-11 Radiopharmaceuticals 163
IV. Dosimetry Calculations 165
V. Conduct of GAP Studies 166
VI. Conclusion 177
References 178
Contents
PART III Disease Models
10. Molecular and Functional Imaging of Cancer: Advances in MRI and MRS
Arvind P. Pathak, Barjor Gimi, Kristine Glunde, Ellen Ackerstaff, Dmitri Artemov,
and Zaver M. Bhujwalla
I. Update 184
II. Introduction 185
III. Vascular Imaging of Tumors with MRI 186
IV. Cellular and Molecular Imaging 200
V. Metabolic and Physiologic Spectroscopy and Spectroscopic
Imaging with MRS and MRSI 214
VI. Examples of Integrated Imaging and Spectroscopy Approaches to
Studying Cancer 222
References 229
11. A Modified Transorbital Baboon Model of Reperfused Stroke
Anthony L. D Ambrosio, Michael E. Sughrue,J. Mocco, William J. Mack,
Ryan G. King, Shivani Agarwal, and E. Sander Connolly, Jr.
I. Update 238
II. Introduction 238
III. Preoperative Care 240
IV. Operative Technique 243
V. Postoperative Care 246
VI. Data Collection and Analysis 246
VII. Model Application: HuEP5C7 249
VIII. Conclusion 249
References 250
12. Structural and Functional Optical Imaging of Angiogenesis in Animal Models
Richard L. Roberts and Pengnian Charles Lin
I. Introduction 251
II. Intravital Microscopy and Animal Window Models 252
HI. Imaging of Tumor-Host Interaction and Angiogenesis
Initiation Using Fluorescent Protein-Labeled Tumor Cells 256
IV. Vascular Reporter Transgenic Mouse Model 260
V. Conclusions 266
References 267
Contents
13. MRI of Animal Models of Brain Disease
Rob Nabuurs, David L. Thomas, John S. Thornton, Mark F. Lythgoe,
and Louise van der Weerd
How to Avoid Pittfalls: Tips and Tricks 270
I. Introduction 270
II. Biophysical Background and Methods 271
III. Applications of MRI to Experimental Neuropathology 284
IV. Conclusion 294
References 295
14. Magnetic Resonance Imaging in Animal Models of Pathologies
Pasquina Marzola, Stefano Tambalo, and Andrea Sbarbati
I. Update 301
II. Introduction 302
III. Bacterial Infections 303
IV. Ischemic Pathologies 309
V. Neoplastic Pathologies 311
VI. Lipid Accumulation in Metabolic-Degenerative Disorders 316
VII. Conclusions 320
References 320
15. Application of Combined Magnetic Resonance Imaging and Histopathologic
and Functional Studies for Evaluation of Aminoguanidine Following
Traumatic Brain Injury in Rats
Jia Lu and Shabbir Moochhala
I. Introduction 325
II. Materials and Methods 326
III. Results and Discussion 334
References 335
PART IV Preparation of Materials
16. Vascular-Targeted Nanoparticles for Molecular Imaging and Therapy
Samira Guccione, King C.P. Li, and Mark D. Bednarski
I. Introduction 339
II. Rationale Behind Choosing a Vascular Target for Molecular Imaging 341
III. Design and Preclinical Studies of a Vascular-Targeted
Molecular Imaging Agent 344
Contents
IV. Molecular Imaging and Vascular-Targeted Therapeutics 351
V. Summary 354
References 355
17. Generation of DOTA-Conjugated Antibody Fragments for Radioimmunoimaging
Peter M. Smith-Jones and David B. Solit
I. Introduction 358
II. Selection of a Radionuclide and Chelating Agent 359
III. Generation of Antibody Fragments 364
IV. Conjugation of DOTA to Intact Antibodies or Fragments 365
V. Radiolabeling of DOTA Conjugates 366
VI. Characterization of DOTA-F(ab )2 Conjugates 367
VII. PET Imaging 369
VIII. Conclusion 369
References 370
PART V General Methods
18. The Application of Magnetic Resonance Imaging and Spectroscopy to Gene Therapy
Po-Wah So, Kishore K. Bhakoo, I.Jane Cox, Simon D. Taylor-Robinson,
and Jimmy D. Bell
I. Introduction 374
II. Magnetic Resonance Techniques 376
III. MR Overview 377
IV. MR Imaging (MRI) 377
V. MR Spectroscopy (MRS) 380
VI. Role of Magnetic Resonance Methods in GT 380
VII. MRI-Based Systems 383
VIII. MRS-Based Systems 387
IX. Conclusions 389
References 390
19. Voxelation Methods for Genome Scale Imaging of Brain Gene Expression
Daniel M. Sforza and Desmond J. Smith
I. Update 399
II. Introduction 400
III. Methods 401
IV. Data Analysis 405
References 408
Index 411
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| spelling | Essential bioimaging methods reliable Lab solutions ed. by P. Michael Conn 1. ed. Amsterdam [u.a.] Elsevier/Academic Press 2009 XV, 420 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Imaging systems in biology Imaging systems in medicine Bildgebendes Verfahren (DE-588)4006617-4 gnd rswk-swf Bildgebendes Verfahren (DE-588)4006617-4 s DE-604 Conn, Patrick Michael 1949-2016 Sonstige (DE-588)136758541 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=019003458&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Essential bioimaging methods reliable Lab solutions Imaging systems in biology Imaging systems in medicine Bildgebendes Verfahren (DE-588)4006617-4 gnd |
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| title | Essential bioimaging methods reliable Lab solutions |
| title_auth | Essential bioimaging methods reliable Lab solutions |
| title_exact_search | Essential bioimaging methods reliable Lab solutions |
| title_full | Essential bioimaging methods reliable Lab solutions ed. by P. Michael Conn |
| title_fullStr | Essential bioimaging methods reliable Lab solutions ed. by P. Michael Conn |
| title_full_unstemmed | Essential bioimaging methods reliable Lab solutions ed. by P. Michael Conn |
| title_short | Essential bioimaging methods |
| title_sort | essential bioimaging methods reliable lab solutions |
| title_sub | reliable Lab solutions |
| topic | Imaging systems in biology Imaging systems in medicine Bildgebendes Verfahren (DE-588)4006617-4 gnd |
| topic_facet | Imaging systems in biology Imaging systems in medicine Bildgebendes Verfahren |
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