Cell signalling:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2010
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| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXII, 341 S. Ill., graph. Darst. |
| ISBN: | 9780199232109 |
Staff View
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Record in the Search Index
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Titel: Cell signalling
Autor: Hancock, John T.
Jahr: 2010
CONTENTS
LIST OF FIGURES xi
LIST OF TABLES xv
LIST OF ABBREVIATIONS xvi
Part 1: An overview of signalling 1
1 Aspects of cellular signalling 3
1.1 Introduction 3
1.2 The main principles of cell signalling 5
1.3 What makes a good signal? 7
1.4 Different ways in which cells signal to each other 9
1.5 Amplification and physical architectures 16
1.6 Coordination of signalling 18
1.7 Domains and modules 21
1.8 Oncogenes 25
Summary 26
Further reading 27
2 Pathways are the key to signalling 29
2.1 Introduction 29
2.2 Simplified examples of signalling pathways 31
Summary 37
Further reading 37
3 A look at some of the history and techniques of cell signalling 38
3.1 A brief history 38
3.2 A brief look at some techniques 42
Summary 50
Further reading 50
Part 2: Components that comprise signalling pathways 53
4 Extracellular signals: hormones, cytokines and growth factors 55
4.1 Introduction 56
4.2 Hormones 56
4.3 Plant hormones 62
4.4 Cytokines 65
4.5 Growth factors 71
4.6 Neurotransmitters 73
4.7 ATP as an extracellular signal 74
4.8 Pheromones 75
Summary 76
Further reading 76
5 Detection of extracellular signals: the role of receptors 78
5.1 Introduction 79
5.2 Types of receptors 80
5.3 Ligand binding to their receptors 92
5.4 Receptor sensitivity and receptor density 96
Summary 101
Further reading 102
6 Protein phosphorylation, kinases and phosphatases 104
6.1 Introduction 105
6.2 Serine/threonine kinases 110
6.3 Tyrosine kinases 127
6.4 Mitogen-activated protein kinases 130
6.5 Histidine phosphorylation 135
6.6 Phosphatases 137
6.7 Other covalent modifications 141
6.8 Ubiquitin-proteasome system 142
Summary 145
Further reading 147
7 Cyclic nucleotides, cyclases and G proteins 150
7.1 Introduction 151
7.2 cAMP 151
7.3 Adenylyl cyclase 154
7.4 Adenylyl cyclase control and the role of G proteins 156
7.5 Other roles of the heterotrimeric G proteins 164
7.6 Guanylyl cyclase 165
7.7 Phosphodiesterases 168
7.8 Compartmentalization of nucleotide signalling 172
7.9 The GTPase superfamily: functions of monomeric G proteins 173
Summary 181
Further reading 182
8 Inositol phosphate metabolism and roles of membrane lipids 184
8.1 Introduction 184
8.2 Events at the membrane 186
8.3 The breakdown of the inositol phosphate lipids 189
8.4 Inositol 1,4,5-trisphosphate and its fate 192
8.5 The role of diacylglycerol 198
8.6 Inositol phosphate metabolism at the nucleus 198
8.7 Other lipids involved in signalling 199
8.8 Related lipid derived signalling molecules 206
Summary 207
Further reading 208
9 Intracellular calcium: its control and role as an intracellular signal 210
9.1 Introduction 211
9.2 Calmodulin 216
9.3 The plasma membrane and its role in calcium
concentration maintenance 219
9.4 Intracellular stores 221
9.5 Gradients, waves and oscillations 229
9.6 Sphingosine-1-phosphate 235
9.7 CyclicADP-ribose 236
9.8 Nicotinate adenine-dinucleotide phosphate 237
9.9 Fluorescence detection and confocal microscopy 237
Summary 239
Further reading 240
10 Reactive oxygen species, reactive nitrogen species and
redox signalling 243
10.1 Introduction 243
10.2 Nitric oxide 245
10.3 Reactive oxygen species: superoxide and hydrogen peroxide 252
10.4 Redox signalling and molecular mechanisms of
hydrogen peroxide signalling 258
10.5 Measuring ROS and RNS 261
10.6 Carbon monoxide and other compounds 262
Summary 262
Further reading 263
Part 3: Selected examples of signalling pathways and events 265
11 Insulin and the signal transduction cascades it invokes 267
11.1 The insulin signalling system 267
Summary 278
Further reading 279
12 Perception of the environment 281
12.1 Introduction 281
12.2 Photodetection in the eye 282
12.3 Other environment perception systems 289
Summary 291
Further reading 291
13 Signalling in development and for the regulation of
gene expression 293
13.1 Introduction 294
13.2 Transcription factors 295
13.3 Transforming growth factor 6 299
13.4 Notch receptor signalling 301
13.5 Hedgehog signalling 303
13.6 Wnt signalling 306
13.7 Toll-like receptor signalling 308
Summary 311
Further reading 311
14 Life, death and apoptosis 314
14.1 Introduction 314
14.2 An overview of apoptosis 315
14.3 Caspases 316
14.4 The intrinsic pathway 318
14.5 The extrinsic pathway 321
Summary 325
Further reading 325
Part 4: Final thoughts 327
15 Cell signalling: importance, complexity and the future 329
15.1 Introduction 329
15.2 Specificity, subtlety and crosstalk 330
15.3 Longer term effects 331
15.4 Thefuture 332
Further reading 333
INDEX 335 |
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| discipline | Biologie |
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| isbn | 9780199232109 |
| language | English |
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| physical | XXII, 341 S. Ill., graph. Darst. |
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| spelling | Hancock, John T. Verfasser (DE-588)1247739163 aut Cell signalling John T. Hancock 3. ed. Oxford [u.a.] Oxford Univ. Press 2010 XXII, 341 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell interaction Cellular signal transduction Signal Transduction physiology Zellkommunikation (DE-588)4136131-3 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zellkommunikation (DE-588)4136131-3 s Signaltransduktion (DE-588)4318717-1 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018936372&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hancock, John T. Cell signalling Cell interaction Cellular signal transduction Signal Transduction physiology Zellkommunikation (DE-588)4136131-3 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4136131-3 (DE-588)4318717-1 (DE-588)4143413-4 |
| title | Cell signalling |
| title_auth | Cell signalling |
| title_exact_search | Cell signalling |
| title_full | Cell signalling John T. Hancock |
| title_fullStr | Cell signalling John T. Hancock |
| title_full_unstemmed | Cell signalling John T. Hancock |
| title_short | Cell signalling |
| title_sort | cell signalling |
| topic | Cell interaction Cellular signal transduction Signal Transduction physiology Zellkommunikation (DE-588)4136131-3 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Cell interaction Cellular signal transduction Signal Transduction physiology Zellkommunikation Signaltransduktion Aufsatzsammlung |
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