Primary cilia:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier, Academic Press
2009
|
| Edition: | 1. ed. |
| Series: | Methods in cell biology
94 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 386 S., [10] Bl. Ill., graph. Darst. |
| ISBN: | 9780123750242 |
Staff View
MARC
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| 245 | 1 | 0 | |a Primary cilia |c ed. by Roger D. Sloboda |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Academic Press |c 2009 | |
| 300 | |a XVI, 386 S., [10] Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Methods in cell biology |v 94 | |
| 650 | 4 | |a Cilia and ciliary motion | |
| 650 | 4 | |a Cilia and ciliary motion |x Health aspects | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-018911285 | ||
Record in the Search Index
| _version_ | 1804141046401073152 |
|---|---|
| adam_text | CONTENTS
Contributors
Preface
SECTION I Background
1.
From Central to Rudimentary to Primary: The History
of an Underappreciated
Organelle
Whose Time Has Come. The Primary Cilium
Robert A. Bloodgood
I. Introduction
4
II. Technical Issues in the Discovery and Study of Primary Cilia
6
HI. Origins:
1844-1910 7
IV. The Henneguy-Lenhossek Hypothesis and the Role of Primary Cilia
19
V. The Middle Period
(1910-1935) 26
VI. Origin of Photoreceptor Connecting Cilia from Primary
Glia
28
VII.
The Dark Ages of Primary Cilia
(1935-1955) 30
VIII.
The
1950s
and
1960s:
Transmission Electron Microscopy
and the Renaissance of the Primary Cilium
31
IX. Primary Cilia and the Cell Cycle
34
X. The Golden Age of Primary Cilia (2000-Onward)
39
XI. Conclusions: The Morals of this Story
42
References
45
2.
Origin of the Cilium: Novel Approaches to Examine a Centriolar
Evolution Hypothesis
Mark C. AUiegro and Peter
Satir
I. Introduction
54
II. Methods
58
III. Viral Relatives of cnRNAs and Other Centriolar
and Centrosomal Components
60
IV. Conclusions
62
References
63
vi
Contents
SECTION
Π
Cell Biology/Biochemistry
3.
Using quantitative PCR to Identify Kinesin-3 Genes
that are Upregulated During Growth Arrest in Mouse NIH3T3 Cells
Rikke I. Thorsteinsson,
Seren
T.
Christensen, and
Lotte
В.
Pedersen
I. Introduction
68
II. Rationale
70
III. Materials
70
IV. Methods
72
V. Results and Discussion
80
VI. Summary
83
References
83
4.
Methods for the Isolation of Sensory and Primary Cilia
—
An Overview
Kimberly A.P. Mitchell,
Gabor Szabo,
and Angela
de S.
Otero
I. Introduction
88
II. Isolation of Olfactory Cilia
88
III. Isolation of Rod Photoreceptor Cilia
91
IV. Isolation of Primary Cilia
92
References
98
5.
Isolation of Primary Cilia for Morphological Analysis
Bing
Huang, Tatyana Masyuk, and Nicholas LaRusso
I. Introduction
104
II. Materials and Instrumentations
105
III. Methods
106
IV. Results and Discussion
110
V. Summary
114
References
114
6.
Analyzing Primary Cilia by Multiphoton Microscopy
Cornelia E. Famum, Rebecca M. Williams, and Eve Donnelly
I. Introduction
118
II. Materials and Solutions
120
HI. Methods
121
IV. Results and Discussion
128
References
133
Contents
7.
Primary Cilia and the Cell Cycle
Olga
V. Plotnikova, Elena
N.
Pugacheva, and Erica A. Goiemis
I. Introduction
138
II. Signaling Systems Regulating Ciliary Protusion and
Resorption 141
III. Methods
150
References
154
SECTION III Function
8.
Utilization of Conditional
Alíeles
to Study the Role
of the Primary Cilium in Obesity
Robert A. Kesterson, Nicolas F.
herbari,
Raymona
С.
Pasek,
and Bradley
Κ. Υ
oder
I. Introduction
164
II. CNS Mechanisms of Energy Balance
164
III. Human Ciliopathies and Obesity
165
IV. Cilia Mutant Mouse Models of Obesity
167
V.
Neuronal
Cilia
171
VI. Strategies and Methods of Analyzing Obesity
in Cilia Mouse Models
172
References
176
9.
Using Nucleofection of siRNA Constructs for Knockdown
of Primary Cilia in P19.CL6 Cancer Stem Cell Differentiation
into Cardiomyocytes
Christian A. Clement, Lars A.
harsen,
and
Seren
T. Christensen
I. Introduction
182
II. Rationale
184
III. Materials
184
IV. Methods
186
V. Results and Discussion
190
VI. Summary
195
References
196
10.
The Primary Cilium as a Hedgehog Signal Transduction Machine
Sarah C. Goetz, PollonealJ.R. Ocbina, and Kathryn V. Anderson
I. Introduction
200
II. Summary
215
References
216
Contents
11.
Detecting the Surface Localization and Cytoplasmic
Cleavage of Membrane-Bound Proteins
Hannah C.
Chapín,
Vanathy Rajendran, Anna
Capasse,
and Michael].
Captan
I. Introduction
224
II. Assay Rationale and History
225
III. Materials
228
IV. Methods
230
V. Discussion
236
VI. Summary
238
References
238
12.
Assay for In Vitro Budding of Ciliary-Targeted Rhodopsin
Transport Carriers
Dusanka
Deretic
and
Jana Mazelova
I. Introduction
242
II. Methods
243
III. Materials
249
IV. Results and Discussion
250
V. Summary
255
References
255
13.
Immunoelectron Microscopy of Vesicle Transport to the Primary
Cilium of Photoreceptor Cells
Tina
Sedmak,
Elisabeth
Sehn,
and
Uwe
Wolfium
I. Introduction and Rationale
260
II. Materials
262
III. Methods and Procedures
264
IV. Results and Discussion
267
References
270
14.
Polycystic Kidney Disease, Cilia, and Planar Polarity
Luis F.
Menezes
and Gregory G.
Germino
I. Cystic Kidney Diseases
274
II. The Primary Cilium and Cystic Kidney Diseases
276
III. Explanatory Models for Cystic Kidney Diseases
279
IV. Final Remarks
292
References
292
Contents
15. Constructing
and Deconstructing Roles for the Primary
Cilium in Tissue Architecture and Cancer
E. Scott Seeley and Maxence V. Nachury
I. Introduction
300
II. Sensory Modalities
300
III. Flow and Mechanosensation
301
IV. Low-Abundance Ligands
301
V. Concentration Shifts
304
VI. Ciliary Receptors
304
VII.
Growth Factor Receptors
304
VIII.
Morphogens
305
IX. Hormone and G-Protein-Coupled Receptors
306
X. Tissue Homeostasis and Architecture
306
XI. Cancer
307
XII.
Summary
310
References
311
SECTION IV Posttranslational Modifications
16.
Polyglutamylation and the fleer Gene
Narendra
H.
Pattiak
and Iain
Α.
Drummond
I. Introduction
317
II. Significance of Polyglutamylation
318
III. Biochemistry of Tubulin Glutamylation
319
IV. Functional Significance of Tubulin Glutamylase
319
V. The Zebrafish fleer Mutant as a Paradigm for Analysis
of Cilia Tubulin Glutamylation
320
VI. Situs Inversus in fleer is Caused by Motility and Length
Defects ofKupffer s Vesicle Cilia
322
VII.
Pronephric Cysts in fleer Result from Defects of Cilia
Motility and Length
322
VIII.
Olfactory
Piacodé
Cilia
325
IX. Abnormal Otolith Numbers are Caused by Defects
of Motile Otic
Piacode
Cilia
325
X. Retinal Degeneration in fleer Results from Defects
of the Connecting Cilium in Photoreceptors
326
XI. fleer-Like
Phenotypes
in Other Species
326
XII.
Methods
327
References
330
Contents
17. Regulation
of Cilia assembly, Disassembly, and Length by Protein
Phosphorylation
Muqing
Cao,
Guihua Li, andjunmin Pan
I. Introduction
334
II. Protein Phosphorylation in Cilia Assembly
335
III. Protein Phosphorylation in Cilia Disassembly
338
IV. Protein Phosphorylation in Cilia Length Control
340
V. Conclusion
342
References
343
18.
Posttranslational Protein Modifications in Cilia and
Flagella
Roger
D. Sloboda
I. Introduction
348
II. Posttranslational Protein Modification in Cilia and
Flagella
350
III. Methods for the Detection of PTM in Cilia and
Flagella
using the Electron Microscope
354
References
360
Index
365
Volume in Series
379
|
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| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.67 |
| dewey-search | 571.67 |
| dewey-sort | 3571.67 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1. ed. |
| format | Book |
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| institution | BVB |
| isbn | 9780123750242 |
| language | English |
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| physical | XVI, 386 S., [10] Bl. Ill., graph. Darst. |
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| series | Methods in cell biology |
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| spelling | Primary cilia ed. by Roger D. Sloboda 1. ed. Amsterdam [u.a.] Elsevier, Academic Press 2009 XVI, 386 S., [10] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in cell biology 94 Cilia and ciliary motion Cilia and ciliary motion Health aspects Primäre Zilie (DE-588)7690953-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Primäre Zilie (DE-588)7690953-0 s b DE-604 Sloboda, Roger D. Sonstige oth Methods in cell biology 94 (DE-604)BV002534878 94 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018911285&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Primary cilia Methods in cell biology Cilia and ciliary motion Cilia and ciliary motion Health aspects Primäre Zilie (DE-588)7690953-0 gnd |
| subject_GND | (DE-588)7690953-0 (DE-588)4143413-4 |
| title | Primary cilia |
| title_auth | Primary cilia |
| title_exact_search | Primary cilia |
| title_full | Primary cilia ed. by Roger D. Sloboda |
| title_fullStr | Primary cilia ed. by Roger D. Sloboda |
| title_full_unstemmed | Primary cilia ed. by Roger D. Sloboda |
| title_short | Primary cilia |
| title_sort | primary cilia |
| topic | Cilia and ciliary motion Cilia and ciliary motion Health aspects Primäre Zilie (DE-588)7690953-0 gnd |
| topic_facet | Cilia and ciliary motion Cilia and ciliary motion Health aspects Primäre Zilie Aufsatzsammlung |
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