Quantitation and mass spectrometric data of drugs and isotopically labeled analogs:
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| Main Authors: | , , |
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| Format: | Book |
| Language: | English |
| Published: |
Boca Raton
CRC Press
2010
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XII, 498 S. überwieg. graph. Darst. |
| ISBN: | 9781420094978 |
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MARC
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| 245 | 1 | 0 | |a Quantitation and mass spectrometric data of drugs and isotopically labeled analogs |c Ray H. Liu ; Sheng-Meng Wang ; Dennis V. Canfield |
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| 300 | |a XII, 498 S. |b überwieg. graph. Darst. | ||
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| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Drugs |x Analysis | |
| 650 | 4 | |a Central nervous system |x Effect of drugs on | |
| 650 | 4 | |a Radiolabeling | |
| 650 | 4 | |a Mass spectrometry | |
| 650 | 4 | |a Pharmaceutical Preparations |x analysis | |
| 650 | 4 | |a Central Nervous System Agents |x chemistry | |
| 650 | 4 | |a Isotope Labeling | |
| 650 | 4 | |a Mass Spectrometry |x methods | |
| 700 | 1 | |a Wang, Sheng-Meng |e Verfasser |4 aut | |
| 700 | 1 | |a Canfield, Dennis V. |e Verfasser |4 aut | |
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Record in the Search Index
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| adam_text | QUANTITATION AND MASS SPECTROMETRIC DATA OF DRUGS AND ISOTOPICALLY
LABELED ANALOGS RAY H. LIU SHENG-MENG WANG DENNIS V. CANFIELD WILH THE
ASSISTANCE OF MENG-YAN WU AND BUD-GEN CHEN FOOYIN UNIVERSITY AND ROBERT
J. LEWIS AND ROXANE M. RITTER U.S. FAA CIVIL AEROSPACE MEDICAL INSTITUTE
CRC PRESS TAYLOR F. I R»NF N GROUP ( R( PRR N »O I NPRINT RT( TLW
CONTENTS FOREWORD VII PREFACE IX ABOUT THE AUTHORS XI PART ONE
ISOTOPICALLY LABELED ANALOG AS INTERNAL STANDARD FOR DRUG QUANTITATION *
METHODOLOGY CHAPTER 1. QUANTITATION OF DRUG IN BIOLOGICAL SPECIMEN *
ISOTOPICALLY LABELED ANALOG OF THE ANALYTE AS INTERNAL STANDARD 3
INTRODUCTION 3 SIGNIFICANCEOF ACCURATE QUANTITATION 3 PREFERRED
CALIBRATION METHOD 4 I. INTERNAL STANDARD AND QUANTITATION IONS 4 A.
INADEQUATE ISOTOPIC PURITY * AN EXTRINSIC FACTOR 4 B. CROSS-CONTRIBUTION
DERIVED FROM ION FRAGMENTATION MECHANISM * AN INTRINSIC FACTOR 5 II.
FITTING CALIBRATION DATA 6 III. 2 H- VERSUS 13 C-ANALOGS AS INTERNAL
STANDARDS 7 CONCLUDING REMARKS 9 REFERENCES 10 CHAPTER 2. ISOTOPICALLY
LABELED ANALOG OF THE ANALYTE AS INTERNAL STANDARD FOR DRUG QUANTITATION
* CHEMICAL DERIVATIZATION AND DATA COLLECTION AND EVALUATION 11
INTRODUCTION H I. CHEMICAL DERIVATIZATION 12 A. PRODUCTION OF MOST
FAVORABLE ION-PAIRS FOR DRUG QUANTITATION 12 B. EXEMPLAR STUDIES 12 C.
ISOTOPICALLY LABELED ANALOGS AND CHEMICAL DERIVATIZATION GROUPS 13 II.
ION INTENSITY CROSS-CONTRIBUTION DATA 13 A. FULL-SCAN MASS SPECTRA 17 B.
SELECTED ION MONITORING AND CALCULATION OF ION CROSS-CONTRIBUTION DATA
18 1. DIRECT MEASUREMENT 18 2. NORMALIZED DIRECT MEASUREMENT 19 3.
INTERNAL STANDARD METHOD 20 4. STANDARD ADDITION METHOD 20 C. ASSESSING
THE ACCURACY OF EMPIRICALLY DETERMINED CROSS-CONTRIBUTION DATA 21 1.
EMPIRICALLY OBSERVED CONCENTRATION 22 2. THEORETICALLY CALCULATED
CONCENTRATION 24 3. COMPARING EMPIRICALLY OBSERVED AND THEORETICALLY
CALCULATED CONCENTRA- TIONS * GRAPHIC PRESENTATION 25 4. SUMMARY 26 III.
COMPILATION OF FULL-SCAN MASS SPECTRA AND ION INTENSITY
CROSS-CONTRIBUTION TABLES 26 A. DERIVATIZATION PROCEDURES,
INSTRUMENTATION, AND ANALYTICAL PARAMETERS 26 B. COLLECTION OF MASS
SPECTROMETRIC DATA 26 C. ION INTENSITY CROSS-CONTRIBUTION DATA 27
CONCLUDING REMARKS 28 REFERENCES 28 PART TWO MASS SPECTRA OF COMMONLY
ABUSED DRUGS AND THEIR ISOTOPICALLY LABELED ANALOGS IN VARIOUS
DERIVATIZATION FORMS TABLE OF CONTENTS FOR APPENDIX ONE 33 FIGUREL.
STIMULANTS 35 FIGURE II. OPIOIDS 129 FIGURE III. HALLUCINOGENS 217
FIGURE IV. DEPRESSANTS/HYPNOTICS 251 FIGURE V. ANTIANXIETY AGENTS 273
FIGURE VI. ANTIDEPRESSANTS 327 FIGURE VII. OTHERS 349 PART THREE
CROSS-CONTRIBUTIONS OF ION INTENSITY BETWEEN ANALYTES AND THEIR
ISOTOPICALLY LABELED ANALOGS IN VARIOUS DERIVATIZATION FORMS TABLE OF
CONTENTS FOR APPENDIX TWO 375 TABLE I. STIMULANTS 377 TABLE II. OPIOIDS
409 TABLE III. HALLUCINOGENS 437 TABLE IV. DEPRESSANTS/HYPNOTICS 449
TABLE V. ANTIANXIETY AGENTS 459 TABLE VI. ANTIDEPRESSANTS 477 TABLE VII.
OTHERS 485 INDEX 493
|
| any_adam_object | 1 |
| author | Liu, Ray H. Wang, Sheng-Meng Canfield, Dennis V. |
| author_facet | Liu, Ray H. Wang, Sheng-Meng Canfield, Dennis V. |
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| building | Verbundindex |
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| callnumber-first | R - Medicine |
| callnumber-label | RS189 |
| callnumber-raw | RS189.5.S65 |
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| callnumber-subject | RS - Pharmacy |
| classification_rvk | VS 5300 |
| ctrlnum | (OCoLC)423572434 (DE-599)BVBBV035966567 |
| dewey-full | 615/.1901 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.1901 |
| dewey-search | 615/.1901 |
| dewey-sort | 3615 41901 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV035966567 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:08:42Z |
| institution | BVB |
| isbn | 9781420094978 |
| language | English |
| lccn | 2009026283 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018860657 |
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| physical | XII, 498 S. überwieg. graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Liu, Ray H. Verfasser aut Quantitation and mass spectrometric data of drugs and isotopically labeled analogs Ray H. Liu ; Sheng-Meng Wang ; Dennis V. Canfield Boca Raton CRC Press 2010 XII, 498 S. überwieg. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Drugs Analysis Central nervous system Effect of drugs on Radiolabeling Mass spectrometry Pharmaceutical Preparations analysis Central Nervous System Agents chemistry Isotope Labeling Mass Spectrometry methods Wang, Sheng-Meng Verfasser aut Canfield, Dennis V. Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018860657&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Liu, Ray H. Wang, Sheng-Meng Canfield, Dennis V. Quantitation and mass spectrometric data of drugs and isotopically labeled analogs Drugs Analysis Central nervous system Effect of drugs on Radiolabeling Mass spectrometry Pharmaceutical Preparations analysis Central Nervous System Agents chemistry Isotope Labeling Mass Spectrometry methods |
| title | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs |
| title_auth | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs |
| title_exact_search | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs |
| title_full | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs Ray H. Liu ; Sheng-Meng Wang ; Dennis V. Canfield |
| title_fullStr | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs Ray H. Liu ; Sheng-Meng Wang ; Dennis V. Canfield |
| title_full_unstemmed | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs Ray H. Liu ; Sheng-Meng Wang ; Dennis V. Canfield |
| title_short | Quantitation and mass spectrometric data of drugs and isotopically labeled analogs |
| title_sort | quantitation and mass spectrometric data of drugs and isotopically labeled analogs |
| topic | Drugs Analysis Central nervous system Effect of drugs on Radiolabeling Mass spectrometry Pharmaceutical Preparations analysis Central Nervous System Agents chemistry Isotope Labeling Mass Spectrometry methods |
| topic_facet | Drugs Analysis Central nervous system Effect of drugs on Radiolabeling Mass spectrometry Pharmaceutical Preparations analysis Central Nervous System Agents chemistry Isotope Labeling Mass Spectrometry methods |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018860657&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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