Industrial biotechnology: sustainable growth and economic success
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| Format: | Book |
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| Language: | English |
| Published: |
Weinheim
Wiley-VCH
2010
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| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Item Description: | Hier auch alle unveränd. Nachdr. |
| Physical Description: | XXI, 499 S. Ill., graph. Darst. |
| ISBN: | 9783527314423 |
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CONTENTS PREFACE XV LIST OF CONTRIBUTORS XVII THE SCOPE AND IMPACT OF
INDUSTRIAL BIOTECHNOLOGY 1 WIM SOETAERT AND ERICKJ. VANDAMME 1 HISTORY
OF INDUSTRIAL BIOTECHNOLOGY 17 ARNOLD L DEMAIN 1.1 EARLY HISTORY 17 1.2
THE PENICILLIN STORY 22 1.3 THE COMING OF THE CEPHALOSPORINS 29 1.4 THE
WAKSMAN ERA 31 1.5 STRAIN IMPROVEMENT 33 1.6 SEMI-SYNTHETIC ANTIBIOTICS
TO COMBAT RESISTANT MICROBES 35 1.7 THE PRIMARY METABOLITES 36 1.7.1
AMINO ACIDS 36 1.7.2 NUCLEOTIDES 39 1.7.3 VITAMINS 39 1.7.4 ORGANIC
ACIDS 41 1.7.5 ALCOHOLS 43 1.7.6 POLYMERS 45 1.7.7 SPECIALTY SUGARS,
SUGAR ALCOHOLS, L-SUGARS, OLIGOSUGARS, NOVEL EXTRACELLULAR
POLYSACCHARIDES, BIOPIGMENTS, COSMETICS INCLUDING FRAGRANTS, AND
MICROBIAL ENZYMES FOR CHIRAL SYNTHESIS AND OTHER APPLICATIONS 46 1.8 THE
SHIFT FROM ANTIBIOTICS TO PHARMACOLOGICAL AGENTS 46 1.8.1 ENZYME
INHIBITORS 47 1.8.2 IMMUNOSUPPRESSANTS 49 BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/997573333 DIGITALISIERT DURCH VI CONTENTS 1.9.1 HUMAN
INSULIN (NOVOLIN, HUMULIN) 57 1.9.2 ERYTHROPOIETIN (EPOGEN, PROCRIT) 58
1.9.3 INTERFERONS 58 1.9.4 HUMAN GROWTH HORMONE (SOMATOTROPIN,
SOMATROPIN; HUMATROPE, NUTROPIN, PROTROPIN, SOMATREN, SEROSTIM) 58 1.9.5
TISSUE PLASMINOGEN ACTIVATOR (ACTIVASE, ALTEPLASE) 58 1.9.6 INTERLEUKINS
59 1.9.7 FACTOR VIII 59 1.9.8 COLONY-STIMULATING FACTORS 59 1.9.9 HUMAN
DNASE (PULMOZYME) 59 1.9.10 GLUCOCEREBROSIDASE (CEREZYME) 59 1.9.11
MONOCLONAL ANTIBODIES 60 1.9.12 ADDITIONAL BIOPHARMACEUTICALS 60 1.10
RECOMBINANT HOSTS 61 1.10.1 E. COLI 61 1.10.2 YEASTS 62 1.10.3 MOLDS 62
1.10.4 INSECT CELLS 63 1.10.5 MAMMALIAN CELLS 63 1.10.6 TRANSGENIC
ANIMALS 63 1.10.7 TRANSGENIC PLANTS 64 1.11 ENZYMES 64 1.12
BIOCONVERSIONS 67 1.13 VACCINES 67 1.14 SYSTEMS MICROBIOLOGY 67
REFERENCES 68 2 INDUSTRIAL SYSTEMS BIOLOGY 79 CONTENTS VII 2.8
CONCLUSION AND FUTURE PERSPECTIVES 131 REFERENCES 234 3 FERMENTATION
TECHNOLOGY 249 YUSUFCHISTI 3.1 INTRODUCTION 249 3.2 TYPES OF
FERMENTATIONS 249 3.3 FERMENTATION PROCESS 250 3.3.1 INOCULUM GENERATION
152 3.3.2 GROWTH AND PRODUCT FORMATION 252 3.4 FERMENTATION MEDIUM
DESIGN 254 3.5 STERILIZATION OF AIR AND FERMENTATION MEDIUM 155 3.6
ENVIRONMENTAL FACTORS 256 3.7 FERMENTATION KINETICS 257 3.7.1 BATCH
FERMENTATION 157 3.7.2 CONTINUOUS CULTURE 258 3.8 FERMENTATION EQUIPMENT
259 3.8.1 SUBMERGED FERMENTATION 159 3.8.1.1 STIRRED TANK FERMENTER 159
3.8.1.2 BUBBLE COLUMN 159 3.8.1.3 AIRLIFT FERMENTERS 260 3.8.1.4
FLUIDIZED BED FERMENTER 260 3.8.1.5 TRICKLE-BED FERMENTER 162 3.8.2
SOLID-STATE FERMENTATION 265 3.8.2.1 TRAY FERMENTER 265 3.8.2.2 STATIC
BED FERMENTER 267 3.8.2.3 TUNNEL FERMENTER 267 3.8.2.4 ROTARY DISK
FERMENTER 268 3.8.2.5 ROTARY DRUM FERMENTER 268 3.8.2.6 AGITATED TANK
FERMENTER 268 3.8.2.7 CONTINUOUS SCREW FERMENTER 268 3.9 RECOVERY OF
FERMENTATION PRODUCTS 269 3.10 CONCLUDING REMARKS 270 REFERENCES 270 4
DIRECTED EVOLUTION OF INDUSTRIAL BIOCATALYSTS 273 MARIEN VILI CONTENTS
4.3.1.1 DISPLAY TECHNIQUES 180 4.3.1.2 IN VIVO SELECTION 282 4.3.2
SCREENING 282 4.3.2.1 HYDROLASE ASSAYS 182 4.3.2.2 OXIDOREDUCTASE ASSAYS
284 4.3.2.3 HYDROXYNITRILE LYASE ASSAYS 285 4.4 EXAMPLES 286 4.4.1
ESTERASES, LIPASES, AND PHOSPHOLIPASES 186 A A.I NITRILASE 188 4.4.3
HALOHYDRIN DEHALOGENASE 289 4.4.4 P450 MONOOXYGENASE 290 4.4.5 ALDOLASES
290 4.5 CONCLUSIONS 292 REFERENCES 297 5 THE INDUSTRIAL PRODUCTION OF
ENZYMES 207 REETA RANI SINGHANIA, ANIL KUMAR PATEL, AND ASHOK PANDEY 5.1
INTRODUCTION 207 5.2 ENZYME PRODUCTION 208 5.2.1 SELECTION OF A SUITABLE
ENZYME 209 5.2.2 SELECTION OF A SUITABLE PRODUCTION STRAIN 209 5.2.3
PRODUCTION METHODOLOGY 210 5.2.3.1 SUBMERGED FERMENTATION 210 5.2.3.2
SOLID-STATE FERMENTATION 222 5.2.4 DOWNSTREAM PROCESSING 222 5.3 ENZYME
IMPROVEMENT 213 5.3.1 RECOMBINANT DNA TECHNOLOGY 214 5.3.2 PROTEIN
ENGINEERING 225 5.4 LARGE-SCALE ENZYME APPLICATIONS 226 5.4. CONTENTS IX
6 APPLIED BIOCATALYSIS: AN OVERVIEW 227 PEDRO FERNANDES ANDJOAQUIM M.S.
CABRAI 6.1 INTRODUCTION 227 6.2 THE DESIGN OF THE BIOCONVERSION SYSTEM
229 6.2.1 THE BIOCATALYST 229 6.2.1.1 SELECTION 229 6.2.1.2 WHOLE CELLS
OR ISOLATED ENZYMES? 230 6.2.1.3 IMMOBILIZATION OF BIOCATALYSTS 232
6.2.2 THE BIOCONVERSION MEDIUM 237 6.2.2.1 ORGANIC SOLVENTS 237 6.2.2.2
IONIC LIQUIDS 240 6.2.2.3 TWO-PHASE AQUEOUS SYSTEMS 241 6.2.2.4 SOLID
RESINS 242 6.2.2.5 SOLID-GAS SYSTEMS 242 6.2.2.6 SUPERCRITICAL FLUIDS
242 6.3 BIOREACTORS 243 6.3.1 BATCH REACTORS 243 6.3.2 FED-BATCH
REACTORS 243 6.3.3 CONTINUOUS REACTORS 244 6.4 RATIONALIZING AND
SPEEDING UP THE DEVELOPMENT AND CHARACTERIZATION OF A BIOCONVERSION
PROCESS 244 6.4.1 COMPUTATIONAL METHODS 245 6.4.2 MICROSCALE PROCESSING
METHODS 245 X 1 CONTENTS 7.6 7.6.1 7.6.2 7.6.3 7.6.4 7.6.5 7.7 PROCESSES
AND DEVICES 266 NANOMACHINES 266 BIOSENSORS AND BIOCHIPS 269 BIOREACTORS
269 CATALYSTS 270 SCAFFOLDS 271 OUTLOOK 272 REFERENCES 272 8 DOWNSTREAM
PROCESSING IN INDUSTRIAL BIOTECHNOLOGY 279 RAJNI HATTI-KAUL 8.1
INTRODUCTION 279 8.2 SEPARATIONS IN INDUSTRIAL BIOTECHNOLOGY 281 8.2.1
SEPARATION OF SOLID PARTICLES 281 8.2.1.1 FILTRATION 282 8.2.1.2
MICROFILTRATION 283 8.2.1.3 CENTRIFUGATION 284 8.2.1.4 HYDROCYCLONE 286
8.2.1.5 FLOTATION AND EXTRACTION 286 8.2.2 CELL DISRUPTION FOR RELEASE
OF CELL-ASSOCIATED PRODUCTS 287 8.2.3 SIZE-BASED SEPARATION OF MOLECULES
288 8.2.3.1 MEMBRANE FILTRATION 288 8.2.3.2 SIZE EXCLUSION
CHROMATOGRAPHY 292 8.2.4 SEPARATIONS BASED ON PRODUCT VOLATILITY 292
8.2.4.1 DISTILLATION 293 CONTENTS XI 8.3.8 POLYHYDROXYALKANOATES 318
ACKNOWLEDGMENTS 328 REFERENCES 329 9 INDUSTRIAL BIOTECHNOLOGY IN THE
CHEMICAL AND PHARMACEUTICAL INDUSTRIES 323 MAURICE C. R. FRANSSEN,
MANFRED KIRCHER, AND ROLAND WOHLGEMUTH 9.1 INTRODUCTION 323 9.2
BIOCATALYTIC PROCESSES: SCIENTIFIC AND TECHNOLOGICAL PERSPECTIVES 324
9.2.1 BETA-LACTAM ANTIBIOTICS 324 9.2.1.1 THE NUCLEUS 324 9.2.1.2 THE
SIDE-CHAINS 325 9.2.1.3 ENZYMATIC SEMI-SYNTHESIS 327 9.2.2 CHIRAL
BUILDING BLOCKS 327 9.2.3 BUILDING BLOCKS FOR POLYMERS 328 9.2.4 FINE
CHEMICALS: STATINS 330 9.2.5 AMINO ACIDS 334 9.2.6 INDIGOTIN 336 9.3
BIOCATALYTIC PROCESSES: BUSINESS AND COMMERCIAL PERSPECTIVE 338 9.4
SAFETY, HEALTH, AND THE ENVIRONMENTAL PERSPECTIVE 342 9.5 OUTLOOK 342
ACKNOWLEDGMENTS 348 REFERENCES 348 10 INDUSTRIAL BIOTECHNOLOGY IN THE
FOOD AND FEED SECTOR 352 PIERRE MONSAN AND MICHAELJ. O'DONOHUE 10. XII
CONTENTS 10.2.4.1 MALTING 358 10.2.4.2 PREVENTION OF CHILL HAZE IN BEER
359 10.2.5 FRUIT PROCESSING 359 10.2.5.1 PECTINASES 359 10.2.5.2
ENZYMATIC MACERATION OF FRUIT 360 10.2.5.3 GRAPES AND THE WINE INDUSTRY
361 10.3 FOOD AND FEED APPLICATIONS 362 10.3.1 PROBIOTICS 361 10.3.2
PREBIOTICS 363 10.3.2.1 INULIN 363 10.3.2.2 FRUCTOOLIGOSACCHARIDES 364
10.3.2.3 GALACTOOLIGOSACCHARIDES 364 10.3.2.4 GLUCOOLIGOSACCHARIDES 366
10.3.2.5 RESISTANT STARCH 368 10.4 FEED APPLICATIONS 370 10.4.1 PHYTATE
HYDROLYSIS 370 10.4.2 CARBOHYDRATE HYDROLYSIS 372 10.4.3 AMINO ACID
PRODUCTION 373 REFERENCES 374 11 INDUSTRIAL BIOTECHNOLOGY IN THE PAPER
AND PULP SECTOR 385 LIISA VIIKARI, STINA CROENQVIST, KRISTIINA KRUUS,
JAAKKO PERE, MATTI SIIKA-AHO, AND ANNA SUURNAEKKI 11.1 INTRODUCTION 385
11.2 ENZYMES FOR THE PULP AND PAPER INDUSTRY 387 11.2.1 CELLULASES 388
11.2. CONTENTS XIII 11.5 BIOREFMERY CONCEPTS 403 11.6 CONCLUSIONS 404
REFERENCES 405 12 BIOFUELS: PRODUCTION AND APPLICATIONS 413 ALEXANDRE
ROJEY AND FREDERIC MONOT 12.1 A RENEWED INTEREST IN BIOFUELS 413 12.2
PRESENT CONVERSION PATHWAYS 413 12.3 BIODIESEL PRODUCTION FROM VEGETABLE
OILS AND FATS 416 12.3.1 ESTERIFICATION PROCESSES 416 12.3.2 PROPERTIES
OF VEGETABLE OIL ESTERS 417 12.3.3 HYDROGENATION PROCESSES 418 12.4
ETHANOL AND ETBE PRODUCTION 419 12.4.1 ETHANOL PRODUCTION FROM SUGAR AND
STARCH 419 12.4.2 ETBE PRODUCTION 420 12 A3 PROPERTIES OF ETHANOL AND
ETBE 420 12.5 THE NEED FOR NEW DEVELOPMENTS 421 12.6 LIGNOCELLULOSIC
BIOMASS RESOURCES 422 12.7 PRODUCTION OF ETHANOL FROM LIGNOCELLULOSIC
BIOMASS 422 12.7.1 OVERALL CONVERSION SCHEME 422 12.7.2 BIOMASS
PRETREATMENT 423 12.7.3 ENZYMATIC HYDROLYSIS 424 IV CONTENTS 13.2.2.4
LIFE CYCLE INVENTORY 441 13.2.2.5 ENVIRONMENTAL INDICATORS 442 13.2.3
PROCESS ECONOMICS 442 13.2.3.1 PRICES OF FERMENTABLE SUGARS 444 13.2.3.2
PRICES OF UTILITIES AND AUXILIARIES 444 13.3 OVERALL RESULTS 444 13.3.1
RESULTS OF ENVIRONMENTAL ANALYSIS 444 13.3.2 RESULTS OF ECONOMIC
ANALYSIS 447 13.4 CONCLUSIONS 451 REFERENCES 452 14 SOCIETAL ISSUES IN
INDUSTRIAL BIOTECHNOLOGY 457 PATRICIA OSSEWEIJER, KLAUS AMMANN, AND
JULIAN KINDERLERER 14.1 INTRODUCTION 457 14.2 THE IMPACT OF INDUSTRIAL
BIOTECHNOLOGY 459 14.2.1 HOW DOES THIS INFLUENCE OUR SOCIETY? 459 14.2.2
WHAT ARE THE POLITICAL, INDUSTRIAL, ECONOMIC, AND SCIENTIFIC DRIVERS AND
OBSTACLES? 460 14.3 PUBLIC PERCEPTIONS OF INDUSTRIAL BIOTECHNOLOGY 462
14.3.1 WHAT IS THE PRESENT PUBLIC PERCEPTION OF INDUSTRIAL
BIOTECHNOLOGY? 462 14.3.2 WHAT IS THE IMPACT OF PUBLIC PERCEPTION TO
POLICY DEVELOPMENT? 463 14.3.3 INDUSTRIAL REACTIONS TO LABELING OF GM
FOOD PRODUCTS 465 14.3.4 DEVELOPMENT OF PUBLIC INTERACTION 467 14. |
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| spellingShingle | Industrial biotechnology sustainable growth and economic success Umwelt Biotechnology industries Biotechnology Economic aspects Biotechnology Environmental aspects Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| subject_GND | (DE-588)4307166-1 |
| title | Industrial biotechnology sustainable growth and economic success |
| title_auth | Industrial biotechnology sustainable growth and economic success |
| title_exact_search | Industrial biotechnology sustainable growth and economic success |
| title_full | Industrial biotechnology sustainable growth and economic success ed. by Wim Soetaert ... |
| title_fullStr | Industrial biotechnology sustainable growth and economic success ed. by Wim Soetaert ... |
| title_full_unstemmed | Industrial biotechnology sustainable growth and economic success ed. by Wim Soetaert ... |
| title_short | Industrial biotechnology |
| title_sort | industrial biotechnology sustainable growth and economic success |
| title_sub | sustainable growth and economic success |
| topic | Umwelt Biotechnology industries Biotechnology Economic aspects Biotechnology Environmental aspects Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| topic_facet | Umwelt Biotechnology industries Biotechnology Economic aspects Biotechnology Environmental aspects Bioverfahrenstechnik |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3367545&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018804081&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT soetaertwim industrialbiotechnologysustainablegrowthandeconomicsuccess |