Cell line development:
Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This book deals with the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity a...
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Dordrecht [u.a.]
Springer
2009
|
| Series: | Cell engineering
6 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Summary: | Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This book deals with the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity and improve cell function. |
| Physical Description: | VIII, 253 S. Ill., graph. Darst. |
| ISBN: | 9789048122448 |
Staff View
MARC
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Record in the Search Index
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| adam_text | Contents
Use of MAR Elements to Increase the Production
of
Recombinant
Proteins
................................................................................. 1
Cori
Gorman,
Salina
Агоре,
Melanie Grandjean,
Pierre-Alain Girod, and Nicolas Mermod
Expression Engineering -
The IE2 Promoter/Enhancer
from Mouse CMV
............................................................................................ 33
Markus
O. Imhof,
Philippe Chatellard, Michel
Kobr,
Renata Pankiewicz, Valerie Duverger, Leonard Bagnoud,
Christophe Sauvage, and Christine Mossu
Defeating Randomness - Targeted
Integration
as a Boost for Biotechnology
........................................................................... 53
L. Gama-Norton, P.
Riemer,
U.
Sandhu,
К.
Nehlsen,
R. Schucht, H.
Hauser,
and
D.
Wirth
Importance of Genetic Environment
for
Recombinant
Gene Expression
................................................................. 83
Alan J.
Dickson
Expression Vector Engineering
for
Recombinant
Protein Production
............................................................. 97
Helen Kim, John Laudemann, Jennitte Stevens, and Michelle Wu
Cell Xpress ™ Applications in Development and Characterization
of Biopharmaceutical
Recombinant
Protein Producing Cell Lines
109
Jennifer R, Cresswel!, Nan Lin,
Genova
A. Richardson,
and Kevin J. Kayser
Selection Methods for High-Producing Mammalian Cell Lines
.................. 127
S.M. Browne and M. AL-Rubeai
viii Contents
Engineering Mammalian Cells for
Recombinant
Monoclonal Antibody Production
.................................................................. 153
Sarah L. Davies and David C. James
Engineering Cell Function by
RNA
Interference
.......................................... 175
Joseph A. Gredell, Hemant K.
Kini,
and S. Patrick Walton
Apoptosis and Autophagy Cell Engineering
.................................................. 195
Chaya
Mohan, Yeon-Gu Kim, and Gyun
Min Lee
Glycoengineering and Modeling of Protein N-Glycosylation
...................... 217
Sandra V. Bennun, Frederick J.
Krambeck,
and Michael J. Betenbaugh
Engineering the Secretory Pathway in Mammalian Cells
........................... 233
Ren-Wang Peng and Martin Fussenegger
Index
.................................................................................................................. 249
Mammalian cell lines command an effective monopoly for the production of
therapeutic proteins that require post-translational modifications. This unique
advantage outweighs the costs associated with mammalian cell culture, which are
far greater in terms of development time and manufacturing when compared to
microbial culture,
lhe
development of cell lines has undergone several advances
over the years, essentially to meet the requirement to cut the time and costs
associated with using such a complex hosts as production platforms.
This book provides a comprehensive guide to the methodology involved in
the development of cell lines and the cell engineering approach that can be
employed to enhance productivity, improve cell function, glycosylation and
secretion and control apoptosis. It presents an overall picture of the current
topics central to expression engineering including such topics as epigenetics and
the use of technologies to overcome positional dependent inactivation, the use
of promoter and enhancer sequences for expression of various
transgenes,
site
directed engineering of defined chromosomal sites, and examination of the role
of eukaryotic nucleus as the controller of expression of genes that are introduced
for production of a desired product. It includes a review of selection methods
for high producers and an application developed by a major biopharmaceuticai
industry to expedite the cell line development process. The potential of cell
engineering approach to enhance cell lines through the manipulation of single
genes that play important roles in key metabolic and regulatory pathways is also
explored throughout.
|
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| building | Verbundindex |
| bvnumber | BV035873881 |
| callnumber-first | T - Technology |
| callnumber-label | TP248 |
| callnumber-raw | TP248.27.A53 |
| callnumber-search | TP248.27.A53 |
| callnumber-sort | TP 3248.27 A53 |
| callnumber-subject | TP - Chemical Technology |
| classification_rvk | WE 2600 WX 6600 |
| ctrlnum | (OCoLC)310400323 (DE-599)DNB992368189 |
| dewey-full | 660.6 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 660 - Chemical engineering |
| dewey-raw | 660.6 |
| dewey-search | 660.6 |
| dewey-sort | 3660.6 |
| dewey-tens | 660 - Chemical engineering |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Book |
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| id | DE-604.BV035873881 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:06:31Z |
| institution | BVB |
| isbn | 9789048122448 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018731616 |
| oclc_num | 310400323 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | VIII, 253 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| series | Cell engineering |
| series2 | Cell engineering |
| spelling | Cell line development ed. by Mohamed Al-Rubeai Dordrecht [u.a.] Springer 2009 VIII, 253 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell engineering 6 Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This book deals with the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity and improve cell function. Animal cell biotechnology Zelllinie (DE-588)4231928-6 gnd rswk-swf Labortechnik (DE-588)4123602-6 gnd rswk-swf Zelllinie (DE-588)4231928-6 s Labortechnik (DE-588)4123602-6 s b DE-604 Al-Rubeai, Mohamed Sonstige oth Erscheint auch als Online-Ausgabe 978-90-481-2245-5 Cell engineering 6 (DE-604)BV013305149 6 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731616&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731616&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Cell line development Cell engineering Animal cell biotechnology Zelllinie (DE-588)4231928-6 gnd Labortechnik (DE-588)4123602-6 gnd |
| subject_GND | (DE-588)4231928-6 (DE-588)4123602-6 |
| title | Cell line development |
| title_auth | Cell line development |
| title_exact_search | Cell line development |
| title_full | Cell line development ed. by Mohamed Al-Rubeai |
| title_fullStr | Cell line development ed. by Mohamed Al-Rubeai |
| title_full_unstemmed | Cell line development ed. by Mohamed Al-Rubeai |
| title_short | Cell line development |
| title_sort | cell line development |
| topic | Animal cell biotechnology Zelllinie (DE-588)4231928-6 gnd Labortechnik (DE-588)4123602-6 gnd |
| topic_facet | Animal cell biotechnology Zelllinie Labortechnik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731616&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731616&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV013305149 |
| work_keys_str_mv | AT alrubeaimohamed celllinedevelopment |