Cellular senescence and tumor suppression:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Springer
2010
|
| Online Access: | Inhaltsverzeichnis Klappentext |
| Item Description: | Auch angekündigt u.d.T.: Senescence and cancer |
| Physical Description: | XIII, 272 S. Ill., graph. Darst. |
| ISBN: | 9781441910745 9781441910752 |
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MARC
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| 245 | 1 | 0 | |a Cellular senescence and tumor suppression |c Peter D. Adams ... ed. |
| 246 | 1 | 3 | |a Senescence and cancer |
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Record in the Search Index
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|---|---|
| adam_text | Contents
Introduction
..................................................................................................... ix
John M.
Sedivy
Section
1
Senescence Signals
1
Telomere Biology and Biochemistry
........................................................ 3
Laura Gardano and Lea Harrington
2
Role of RecQ
Helicases
in Nuclear
DNA
Repair and Telomere
Maintenance
.............................................................................................. 45
Avik Ghosh, Yie Liu, and
Vilhelm
A. Bohr
3
Oncogene-Induced Senescence
(OIS) as a
Cellular Response
to Oncogenic Stresses
................................................................................ 63
Véronique
Bourdeau and
Gerardo
Ferbeyre
4
Stress-Induced Senescence
....................................................................... 85
Peter J. Hornsby
Section
2
The Senescent Phenotype
5
The
Secretome
of Senescent Cells
............................................................ 109
Gowrishankar Banumathy and Peter D. Adams
6
Chromatin Structure in Senescent Cells
................................................. 125
Hunter W. Richards and
Estela
E. Medrano
7
A Comparison of Senescence in Mouse and Human Cells
.................... 175
Vera Gorbunova
and Andrei Seluanov
vi
Contents
Section
3
The Physiological Consequences of Senescence
8
Replicative
Senescence as an Intrinsic Tumor-Suppressor
Mechanism
............................................................................................... 201
Sandy Chang
9
Telomere Dysfunction and Senescence in Stem Cell
and Tissues Aging
................................................................................... 219
Kodandaramireddy Nalapareddy and K. Lenhard Rudolph
10
Mining Cellular Senescence for Drug Targets
...................................... 235
Alan E.
Bilsland
and W.
Nicol
Keith
Index
................................................................................................................. 267
Cellular Senescence and Tumor Suppression
Peter D. Adams
·
John (VS. Sedivy Editors
Leonard Hayflick and colleagues coined the term cellular senescence to describe the in¬
evitable and irreversible proliferation arrest of primary human cells in culture. Specifically,
Hayflick and coworkers reported the phenomenon of
replicative
senescence in primary
human
fibroblasts,
showing that these cells can proliferate in vitro for about
55
population
doublings before their proliferative capacity succumbs to irreversible proliferation arrest.
Since those original observations, major advances in our understanding have come
in several areas. We now know that several other triggers, in addition to proliferative ex¬
haustion, can trigger the senescence program. One important class of senescence trig¬
gers, and a focus of this volume, are activated oncogenes in primary untransformed cells.
There is now good evidence to indicate that senescence in response to this cue is a potent
tumor suppressor mechanism, through its ability to block proliferation of incipient can¬
cer cells. However, senescence is not simply a passive proliferation arrest that impacts
only the senescent cell itself, but rather, senescent cells influence their environment and
neighboring cells through an active secretory program. This secretory program appears
to facilitate senescence as a tumor suppression process.
Cellular Senescence and Tumor Suppression collects a number of chapters from leaders
in the field to review the molecular basis of senescence and its physiological functions,
with a particular emphasis on the role of senescence in tumor suppression.
|
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| id | DE-604.BV035873594 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:06:31Z |
| institution | BVB |
| isbn | 9781441910745 9781441910752 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018731333 |
| oclc_num | 635239278 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | XIII, 272 S. Ill., graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Springer |
| record_format | marc |
| spelling | Cellular senescence and tumor suppression Peter D. Adams ... ed. Senescence and cancer New York [u.a.] Springer 2010 XIII, 272 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Auch angekündigt u.d.T.: Senescence and cancer Adams, Peter D. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731333&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731333&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Cellular senescence and tumor suppression |
| title | Cellular senescence and tumor suppression |
| title_alt | Senescence and cancer |
| title_auth | Cellular senescence and tumor suppression |
| title_exact_search | Cellular senescence and tumor suppression |
| title_full | Cellular senescence and tumor suppression Peter D. Adams ... ed. |
| title_fullStr | Cellular senescence and tumor suppression Peter D. Adams ... ed. |
| title_full_unstemmed | Cellular senescence and tumor suppression Peter D. Adams ... ed. |
| title_short | Cellular senescence and tumor suppression |
| title_sort | cellular senescence and tumor suppression |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731333&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018731333&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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