Mechanisms of memory:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier Acad. Press
2010
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 343 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9780123749512 |
Staff View
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| 100 | 1 | |a Sweatt, J. David |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Mechanisms of memory |c J. David Sweatt |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier Acad. Press |c 2010 | |
| 300 | |a XVII, 343 S. |b Ill., graph. Darst. |c 24 cm | ||
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Record in the Search Index
| _version_ | 1804140802527461376 |
|---|---|
| adam_text | Contents
Foreword to First Edition
xi
Preface to First Edition
xiii
Preface to Second Edition
xv
Acknowledgements
xvii
I.
Introduction
The Basics of Psychological Learning
and Memory Theory
3
I. Introduction
3
A. Categories of Learning and Memory
4
B. Memory Exhibits Long-Term and Short-Term
Forms
7
II. Short-Term Memory
10
A. Sensory Memory and Short-Term Storage
10
B. Working Memory
10
C. The Prefrontal Cortex and Working
Memory
11
D. Reverberating Circuit Mechanisms Contrast
with Molecular Storage Mechanisms for
Long-
Term
Memory
12
III. Unconscious Learning
12
A. Simple Forms of Learning
12
B. Unconscious Learning and Unconscious
Recall
14
C. Unconscious Learning and Subject to Conscious
Recall
15
D.
Operant
Conditioning
18
E. Currently Popular Associative Learning
Paradigms
18
IV. Conscious Learning
—
Subject to Conscious and
Unconscious Recall
20
A. Declarative Learning
20
B. Spatial Learning
21
V. Summary
21
Further Reading
22
Journal Club Articles
22
References
22
2.
Studies of Human Learning and Memory
25
I. Introduction
—
Historical Precedents with Studies of
Human Subjects
25
A. Amnesias
25
B. Memory Consolidation
26
II. The Hippocampus in Human Declarative, Episodic,
and Spatial Memory
28
A. Anatomy of the Hippocampal Formation
29
B. Lesion Studies in Human Memory
Formation
31
C. Imaging Studies
34
III. Motor Learning
38
A. Anatomy
38
B. Habits
39
C. Stereotyped Movements
39
D. Sequence Learning
40
IV. Prodigious Memory
42
A. Mnemonists
42
B. Savant Syndrome
43
C. You are a Prodigy
44
V. Summary
45
Further Reading
45
Journal Club Articles
46
References
46
3.
Non-Associative Learning and Memory
49
I. Introduction
—
The Rapid Turnover of
Biomolecules
49
II. Short-Term, Long-Term, and Ultralong-Term Forms
of Learning
52
III. Use of Invertebrate Preparations to Study Simple
Forms of Learning
53
A. The Cellular Basis of Synaptic Facilitation in
Aplysia
54
vii
VIU
CONTENTS
IV. Short-Term Facilitation in Aplysia is Mediated
by Changes in the Levels of Intracellular Second
Messengers
57
V. Long-Term Facilitation in Aplysia Involves Altered
Gene Expression and Persistent Protein Kinase
Activation
—
A Second Category of Reaction
58
VI. Long-Term Synaptic Facilitation in Aplysia
Involves Changes in Gene Expression and
Resulting Anatomical Changes
65
VII.
Attributes of Chemical Reactions Mediating
Memory
69
VIII.
Sensitization in Mammals
71
IX. Summary
—
A General Biochemical Model for
Memory
72
Further Reading
74
Journal Club Articles
74
References
74
4.
Rodent Behavioral Learning and Memory
Models
77
I. Introduction
77
II. Behavioral Assessments in Rodents
78
A. Assessing General Activity and Sensory
Perception
78
B. Fear Conditioning
82
C. Avoidance Conditioning
86
D. Eye-Blink Conditioning
87
E. Simple Maze Learning
88
F. Spatial Learning
89
G. Taste Learning
92
H. Novel Object Recognition
94
I. Studying Memory
Reconsolidation
Using a
Fear Conditioning Protocol
95
III. Modern Experimental Uses of Rodent Behavioral
Models
96
A. The Four Basic Types of Experiments
97
B. Use of Behavioral Paradigms in Block and
Measure Experiments
98
IV. Summary
102
Further Reading
102
Journal Club Articles
102
References
103
5.
Associative Learning and Unlearning
105
I. Introduction
105
A. Classical Associative Conditioning
106
II. Fear Conditioning and the Amygdala
110
A. Long-Term Potentiation in Cued Fear
Conditioning
112
III. Eye-Blink Conditioning and the Cerebellum
114
IV. Positive Reinforcement Learning
118
A. Reward and Human Psychopathology
120
B. Positive Reinforcement Learning
120
C.
Operant
Conditioning of Positive
Reinforcement
122
V. Memory Suppression
—
Forgetting Versus Extinction,
and Latent Inhibition
123
VI. Summary
125
Further Reading
126
Journal Club Articles
126
References
126
6.
Hippocampal Function in Cognition
129
I. Introduction
129
II. Studying the Hippocampus
130
A. Hippocampal Anatomy
130
III. Hippocampal Function in Cognition
131
A. Space
132
B. Timing
135
C.
Multimodal
Associations
—
The Hippocampus
as a Generalized Association Machine and
Multimodal
Sensory Integrator
139
D. The Hippocampus is also Required for Memory
Consolidation
147
IV. Summary
147
Further Reading
147
Journal Club Articles
148
References
148
7·
Long-Term
Potentiation
—
A Candidate Cellular
Mechanism for Information Storage in the Central
Nervous System
151
I. Hebb s Postulate
152
IL A
Breakthrough Discovery
—
Long-Term
Potentiation in the Hippocampus
152
A. The Hippocampal Circuit and Measuring
Synaptic Transmission in the Hippocampal
Slice
155
B. Long-Term Potentiation of Synaptic
Responses
156
C. Short-Term Plasticity
—
Paired-Pulse Facilitation
and Post-Tetanic Potentiation
157
III. NMDA
Receptor-Dependence of Long-Term
Potentiation
159
A. Pairing Long-Term Potentiation
160
B. Dendritic Action Potentials
162
IV. NMDA Receptor-Independent Long-Term
Potentiation
164
A.
200
Hz Long-Term Potentiation
164
B. Tetra-Ethyl Ammonium Long-Term
Potentiation
165
C. Mossy Fiber Long-Term Potentiation in Area
CA3
165
V. A Role for Calcium Influx in NMDA Receptor-
Dependent Long-Term Potentiation
165
VI. Pre-Synaptic Versus Post-Synaptic
Mechanisms
165
CONTENTS
ЇХ
VII.
Long-Term Potentiation can
Include
an Increased
Action Potential Firing Component
168
VIII.
Long-Term Potentiation can be Divided into
Phases
169
A. Early-Long-Term Potentiation and Late-Long-
Term Potentiation
—
Types Versus Phases
170
IX. Modulation of Long-Term Potentiation
Induction
171
X. Depotentiation and Long-Term Depression
172
XI. A Role for Long-Term Potentiation in
Hippocampal Information Processing,
Hippocampus-Dependent Timing, and
Consolidation of Long-Term Memory
177
A. Long-Term Potentiation in Hippocampal
Information Processing
177
B. Timing-Dependent Information Storage in the
Hippocampus
180
C. Consolidation
—
Storage of Information within
the Hippocampus for Down-Loading to the
Cortex
182
D. A Model for Long-Term Potentiation in
Consolidation of Long-Term Memory
182
XII.
Summary
186
Further Reading
186
Journal Club Articles
186
References
187
8.
The NMDA Receptor
191
I. Introduction
191
A. Structure of the NMDA Receptor
193
II. NMDA Receptor Regulatory Component
1—
Mechanisms Upstream of the NMDA Receptor
that Directly Regulate NMDA Receptor
Function
196
A. Kinase Regulation of the NMDA Receptor
197
B. Redox
Regulation of the NMDA Receptor
198
C. Polyamine
Regulation of the NMDA
Receptor
198
III. NMDA Receptor Regulatory Component
2—
Mechanisms Upstream of the NMDA Receptor
that Control Membrane Depolarization
198
A. Dendritic Potassium Channels
—
A-type
Currents
200
B. Voltage-Dependent Sodium Channels
200
C. АМРА
Receptor Function
200
D. GABA
Receptors
201
IV. NMDA Receptor Regulatory Component
3—
The
Components of the Synaptic Infrastructure that
are Necessary for the NMDA Receptor and the
Synaptic Signal Transduction Machinery to
Function Normally
201
A. Cell Adhesion Molecules and the Actin
Matrix
201
B. Pre-Synaptic Processes
201
C. Anchoring and Interacting Proteins of the Post-
Synaptic Compartment
—
Post-Synaptic Density
Proteins
201
D. AMPA
Receptors
204
E. CaMKII
—
the Calcium/Calmodulin-Dependent
Protein Kinase II
204
V. Summary
204
Further Reading
205
Journal Club Articles
205
References
206
9.
Biochemical Mechanisms for Information Storage
at the Cellular Level
209
I. Targets of the Calcium Trigger
210
A. CaMKII
212
B. Two Additional Targets of CaM
—
Adenylyl
Cyclase and Nitric Oxide Synthase
215
С
Another Major Target of Calcium
—
PKC
215
D. Section Summary
—
Mechanisms for Generating
Persisting Signals in Long-Term Potentiation and
Memory
221
II. Targets of the Persisting Signals
222
A. AMPA Receptors in E-LTP
223
B. Direct Phosphorylation of the AMPA
Receptor
223
С
Regulation of Steady-State Levels of AMPA
Receptors
224
D. Silent Synapses
226
E. Pre-Synaptic Changes
—
Increased
Release
226
F. Post-Synaptic Changes in Excitability?
226
III. Dendritic Protein Synthesis
227
IV. An Overview of the Role of Protein Synthesis in
Memory
230
V. Summary
231
Further Reading
232
Journal Club Articles
232
References
233
10.
Molecular Genetic Mechanisms for Long-Term
Information Storage at the Cellular Level
237
I. Introduction
237
II. Altered Gene Expression in Late-Long-Term
Potentiation and Long-Term Memory
238
III. Signaling Mechanisms
240
A. A Core Signal Transduction Cascade Linking
Calcium to the Transcription Factor CREB
241
B.
Modulatory
Influences that Impinge on this
Cascade
242
С
Additional Transcription Factors besides CREB
that are Involved in Memory Formation
244
D. Gene Targets in Late-Long-Term
Potentiation
245
E. mRNA Targeting and Transport
247
CONTENT?
F.
Effects of the Gene Products on Synaptic
Structure
249
IV. Experience-Dependent Epigenetic Modifications in
the Central Nervous System
251
A. What is
Epigeneticsľ
252
B.
What are Epigenetic Marks and What do
they do
ľ
253
C.
Epigenetic Tagging of Histones
255
D. Signaling Systems that Control Histone
Modifications
257
E. Epigenetic Mechanisms in Learning and
Memory
258
E
Environmental Enrichment and Recovery of Lost
Memories
259
G. Section Summary
261
V. Neurogenesis in the Adult Central Nervous
System
261
VI. Summary
262
Further Reading
262
Journal Club Articles
263
References
263
I1.
Inherited Disorders of Human Memory
—
Mental
Retardation Syndromes
269
I. Neurofibromatosis, Coffin-Lowry Syndrome,
and the ras/ERK Cascade
271
II.
Angelman
Syndrome
276
III. Fragile X Syndromes
281
A. Fragile X Mental Retardation Syndrome
Type
1 281
B. Fragile X Mental Retardation Type
2 285
IV. Summary
287
Further Reading
289
Journal Club Articles
289
References
289
12.
Aging-Related Memory Disorders
—
Alzheimer s
Disease
293
I. Aging-Related Memory Decline
293
A. Mild Cognitive Impairment
294
B. Age-Related Dementias
294
II. What is Alzheimer s Disease?
294
A. Stages of Alzheimer s Disease
295
B. Pathological Hallmarks of Alzheimer s
Disease
299
C. АЛ42
as the Cause of Alzheimer s Disease
305
III. Genes
—
Familial and Late-Onset Alzheimer s
Disease
306
A. APP Mutations
307
B. Presenilin Mutations
308
C. ApoE4
Alleies in
Alzheimer s Disease
308
IV. Apolipoprotein
E in
the Nervous System
309
V. Mouse Models for Alzheimer s Disease
310
A. The Tg2576 Mouse
311
VI. Summary
314
Further Reading
315
Journal Club Articles
315
References
315
Appendix
321
I. Introduction
321
II. Introduction to Hypothesis Testing
322
A. Theories
322
B. Models
322
C. Hypotheses
323
III. The Four Basic Types of Experiments
325
IV. An Example of a Hypothesis and How to
Test it
327
A. Some Real-life Examples of Hypothesis
Testing
330
V. Some Additional Terminology of Hypothesis
Testing
330
A. Hypothesis Versus Prediction
331
B. Accuracy, Precision, and Reproducibility
331
C. Type I and Type II Errors
332
VI. Summary
334
References
335
Index
337
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T22:05:46Z |
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| language | English |
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| spelling | Sweatt, J. David Verfasser aut Mechanisms of memory J. David Sweatt 2. ed. Amsterdam [u.a.] Elsevier Acad. Press 2010 XVII, 343 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Memory Physiological aspects Memory physiology Psychologie (DE-588)4047704-6 gnd rswk-swf Gedächtnis (DE-588)4019614-8 gnd rswk-swf Psychologie (DE-588)4047704-6 s Gedächtnis (DE-588)4019614-8 s b DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018695191&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sweatt, J. David Mechanisms of memory Memory Physiological aspects Memory physiology Psychologie (DE-588)4047704-6 gnd Gedächtnis (DE-588)4019614-8 gnd |
| subject_GND | (DE-588)4047704-6 (DE-588)4019614-8 |
| title | Mechanisms of memory |
| title_auth | Mechanisms of memory |
| title_exact_search | Mechanisms of memory |
| title_full | Mechanisms of memory J. David Sweatt |
| title_fullStr | Mechanisms of memory J. David Sweatt |
| title_full_unstemmed | Mechanisms of memory J. David Sweatt |
| title_short | Mechanisms of memory |
| title_sort | mechanisms of memory |
| topic | Memory Physiological aspects Memory physiology Psychologie (DE-588)4047704-6 gnd Gedächtnis (DE-588)4019614-8 gnd |
| topic_facet | Memory Physiological aspects Memory physiology Psychologie Gedächtnis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018695191&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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