Verfügbarkeit: Systems biology and bioinformatics

Systems biology and bioinformatics: a computational approach

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Najarian, Kayvan (VerfasserIn), Najarian, Siamak (VerfasserIn), Gharibzadeh, Shahriar (VerfasserIn), Eichelberger, Christopher N. (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Boca Raton ; London ; New York CRC Press, Taylor & Francis Group [2009]
Schlagworte:	Bio-informatique Biologie systémique Bioinformatics Systems biology Computational biology Computational Biology Systems Biology Systembiologie Mathematische Methode Bioinformatik Einführung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	xxiii, 166 Seiten Diagramme
ISBN:	9781420046502

Internformat

MARC


LEADER	00000nam a2200000 c 4500
001	BV035814196
003	DE-604
005	20160722
007	t
008	091107s2009 \|\|\|\| \|\|\|\| 00\|\|\| eng d
010			\|a 2009009352
020			\|a 9781420046502 \|c hardcover : alk. paper \|9 978-1-4200-4650-2
035			\|a (OCoLC)312625448
035			\|a (DE-599)BVBBV035814196
040			\|a DE-604 \|b ger \|e rda
041	0		\|a eng
049			\|a DE-355 \|a DE-19 \|a DE-578
050		0	\|a QH324.2
082	0		\|a 570.285
084			\|a WC 7700 \|0 (DE-625)148144: \|2 rvk
084			\|a QU 26.5 \|2 nlm
100	1		\|a Najarian, Kayvan \|e Verfasser \|4 aut
245	1	0	\|a Systems biology and bioinformatics \|b a computational approach \|c Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger
264		1	\|a Boca Raton ; London ; New York \|b CRC Press, Taylor & Francis Group \|c [2009]
264		4	\|c © 2009
300			\|a xxiii, 166 Seiten \|b Diagramme
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
505	8		\|a Includes bibliographical references and index
650		4	\|a Bio-informatique
650		4	\|a Biologie systémique
650		4	\|a Bioinformatics
650		4	\|a Systems biology
650		4	\|a Computational biology
650		4	\|a Computational Biology
650		4	\|a Systems Biology
650	0	7	\|a Systembiologie \|0 (DE-588)4809615-5 \|2 gnd \|9 rswk-swf
650	0	7	\|a Mathematische Methode \|0 (DE-588)4155620-3 \|2 gnd \|9 rswk-swf
650	0	7	\|a Bioinformatik \|0 (DE-588)4611085-9 \|2 gnd \|9 rswk-swf
655		7	\|a Einführung \|2 gnd \|9 rswk-swf
689	0	0	\|a Systembiologie \|0 (DE-588)4809615-5 \|D s
689	0	1	\|a Mathematische Methode \|0 (DE-588)4155620-3 \|D s
689	0	2	\|a Einführung \|A f
689	0		\|5 DE-604
689	1	0	\|a Bioinformatik \|0 (DE-588)4611085-9 \|D s
689	1	1	\|a Mathematische Methode \|0 (DE-588)4155620-3 \|D s
689	1	2	\|a Einführung \|A f
689	1		\|C b \|5 DE-604
700	1		\|a Najarian, Siamak \|e Verfasser \|0 (DE-588)1067772138 \|4 aut
700	1		\|a Gharibzadeh, Shahriar \|e Verfasser \|0 (DE-588)1107777968 \|4 aut
700	1		\|a Eichelberger, Christopher N. \|e Verfasser \|0 (DE-588)1107779499 \|4 aut
856	4	2	\|m Digitalisierung UB Regensburg \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018673063&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
999			\|a oai:aleph.bib-bvb.de:BVB01-018673063

Datensatz im Suchindex

_version_	1804140767097126912
adam_text	Contents Preface ......................................................................................................................xv Acknowledgment ....................................................................................................xxi Authors .................................................................................................................xxiii Chapter 1 Cell Biology ...............................................................................................................1 1.1 Introduction and Overview ...............................................................................1 1.2 An Introduction to Cell Structure .....................................................................1 1.2.1 Plasma Membrane ................................................................................1 1.2.1.1 Membrane Phospholipids .......................................................1 1.2.1.2 Proteins ..................................................................................1 1.2.1.3 Fluidity ...................................................................................2 1.2.1.4 Stability ..................................................................................2 1.2.1.5 Capacitive Property ................................................................2 1.2.1.6 Surface for Protein Attachment .............................................2 1.2.1.7 Control of Passage of Different Substances ...........................2 1.2.2 Cytoplasm .............................................................................................3 1.2.2.1 Mitochondria ..........................................................................3 1.2.2.2 Endoplasmic Retícula ............................................................3 1.2.2.3 Golgi Apparatus .....................................................................3 1.2.2.4 Lysosomes ..............................................................................3 1.2.2.5 Ribosomes ..............................................................................3 1.2.3 Nucleus .................................................................................................3 1.3 Proteins as Tools of the Cell .............................................................................4 1.3.1 Structure of Proteins .............................................................................4 1.3.1.1 Higher Levels of Protein Organization ..................................4 1.3.2 Functions of Different Proteins ............................................................4 1.3.2.1 Structural Proteins .................................................................4 1.3.2.2 Transport Proteins ..................................................................5 1.3.2.3 Receptors ...............................................................................5 1.3.2.4 Immunological Proteins .........................................................5 1.3.2.5 Blood Carrier Proteins ...........................................................6 1.3.2.6 Enzymes .................................................................................6 1.4 Genes: Directors of the Cell .............................................................................6 1.4.1 Introduction to Inheritance ...................................................................6 1.4.2 The Structure of Genes .........................................................................6 1.4.2.1 Chromosomes and Chromatin ...............................................7 1.4.2.2 Genetic Code ..........................................................................8 1.4.3 DNA Replication ..................................................................................8 1.4.3.1 Initiation .................................................................................8 VII viii Contents 1.4.3.2 Elongation ..............................................................................9 1.4.3.3 Termination .......................................................................... Ю 1.4.4 Transcription ....................................................................................... Ю 1.4.4.1 Three Kinds of RNA ........................................................... H 1.4.4.2 tRNA Anticodons ................................................................ H 1.4.5 Translation ..........................................................................................12 1.5 Cell Cycle ........................................................................................................12 1.5.1 Cell Cycle: An Overview ....................................................................12 1.5.2 Mitosis ................................................................................................12 1.5.2.1 Mitotic Apparatus ................................................................12 1.5.2.2 Four Stages of Mitosis .........................................................13 1.6 Summary ........................................................................................................13 1.7 Problems .........................................................................................................13 Chapter 2 Bioassays ..................................................................................................................15 2.1 Introduction and Overview .............................................................................15 2.2 Southern Blotting ............................................................................................15 2.3 Fluorescent In Situ Hybridization ...................................................................15 2.4 Sanger (Dideoxy) Method ...............................................................................16 2.5 Polymerase Chain Reaction ............................................................................16 2.6 Analyzing Protein Structure and Function .....................................................17 2.6.1 X-ray Crystallography ........................................................................17 2.6.2 NMR Spectroscopy ............................................................................17 2.6.3 Affinity Chromatography ...................................................................17 2.6.4 Immunoprecipitation ..........................................................................17 2.6.5 Two-Hybrid Systems ...........................................................................18 2.6.6 Phage Display Method ........................................................................18 2.6.7 DNA Footprint Analysis .....................................................................18 2.7 Studying Gene Expression and Function —DNA Microarrays......................18 2.7.1 Spotted Microarrays ...........................................................................19 2.7.2 Oligonucleotide Microarrays ..............................................................19 2.7.3 SNP Microarrays ................................................................................19 2.8 Summary ........................................................................................................19 2.9 Problems .........................................................................................................20 Chapter 3 Review of Some Computational Methods ...............................................................21 3.1 Introduction and Overview .............................................................................21 3.2 Introduction to Probability and Stochastic Processes Theories .....................21 3.2.1 Metrics for Stochastic Processes ........................................................22 3.2.1.1 Probability Density Function ...............................................22 3.2.1.2 Mean and Variance ..............................................................23 3.2.1.3 Expectation Function ...........................................................23 Contents ¡x 3.2.3 Gaussian Distribution.........................................................................24 3.2.4 Correlation Function ...........................................................................24 3.2.5 Stationary and Ergodic Stochastic Processes .....................................26 3.3 Bayesian Theory .............................................................................................28 3.3.1 From Binary Networks to Bayesian Networks ...................................28 3.4 Test of Hypothesis ..........................................................................................29 3.4.1 ŕ Test ....................................................................................................30 3.5 Expectation Maximization Method ................................................................31 3.6 Maximum Likelihood Theory ........................................................................31 3.6.1 Kullback-Leibler Distance ..................................................................32 3.6.2 Log-Likelihood Function ....................................................................32 3.6.3 Akaike s Information Criterion ..........................................................33 3.6.4 Bayesian Information Criterion ..........................................................33 3.7 System Identification Theory ..........................................................................34 3.7.1 Autoregressive Exogenous Model .......................................................34 3.7.2 Least Square Estimation .....................................................................37 3.8 Summary ........................................................................................................38 3.9 Problems .........................................................................................................39 Chapter 4 Computational Structural Biology. Protein Structure Prediction ............................41 4.1 Introduction and Overview .............................................................................41 4.2 Protein Structure Prediction Methods ............................................................42 4. 2.1 Ab Initio Methods: Molecular Dynamics ...........................................42 4.2.2 Comparative Methods .........................................................................42 4.2.2.1 Homology-Based Methods ...................................................43 4.2.2.2 Threading Methods ..............................................................43 4.2.3 Hybrid/Informed Methods ..................................................................43 4.2.3.1 Artificial Neural Networks ..................................................43 4.2.3.2 Hidden Markov Models .......................................................44 4.2.3.3 Support Vector Machines ....................................................45 4.2.3.4 Clustering Methods ..............................................................45 4.2.3.5 Blended Methods .................................................................45 4.3 Data Resources ...............................................................................................46 4.3.1 Protein Sequence and Raw Structure Databases ................................46 4.3.2 Protein Structure Classification Databases .........................................47 4.3.2.1 The SCOP Database .............................................................47 4.3.2.2 Class, Architecture, Topology, and Homologous Superfamily ..............................................-...........................47 4.3.2.3 Molecular Modeling Database .............................................48 4.3.2.4 Fold Classification Based on Structure-Structure Alignment of Proteins (FSSP/DALI) Database ...................48 4.3.2.5 Spatial Arrangement of Backbone Fragments Database ...............................................................................49 4.3.2.6 InterPro ................................................................................49 x Contents 4.4 Summary ........................................................................................................50 4.5 Problems .........................................................................................................50 References ................................................................................................................50 Chapter 5 Computational Structural Biology: Protein Sequence Analysis ..............................51 5.1 Introduction ....................................................................................................51 5.2 Pairwise Sequence Matching ..........................................................................52 5.2.1 Pairwise Background ..........................................................................52 5.2.2 Sequence Matching Methods ..............................................................52 5.2.2.1 Dot Plot Visualization Method ............................................53 5.2.2.2 Dynamic Programming .......................................................53 5.2.2.3 Word Methods ......................................................................54 5.2.2.4 Bayesian Methods ................................................................55 5.2.3 Statistical Significance ........................................................................55 5.3 Multiple Sequence Alignment ........................................................................55 5.3.1 Dynamic Programming ......................................................................56 5.3.2 Progressive Methods ...........................................................................56 5.3.3 Iterative Strategies ..............................................................................56 5.4 Summary ........................................................................................................56 5.5 Problems .........................................................................................................57 Chapter 6 Genomics and Proteomics .......................................................................................59 6.1 Introduction and Overview .............................................................................59 6.2 Genomics ........................................................................................................59 6.2.1 Genetic Sequence Data .......................................................................59 6.2.2 Genetic Annotations ...........................................................................60 6.2.3 Genomic Analysis ...............................................................................60 6.2.4 Metagenomics .....................................................................................61 6.3 Proteomics ......................................................................................................61 6.3.1 Protein Sequence Data ........................................................................62 6.3.2 Protein Annotations ............................................................................62 6.3.3 Proteomic Analysis .............................................................................63 6.4 Summary ........................................................................................................63 6.5 Problems .........................................................................................................64 Chapter 7 Methods for Identification of Differentially Expressed Genes or Proteins .................................................................................65 7.1 Introduction and Overview .............................................................................65 7.2 Why f Test Is Not Enough? .............................................................................65 7.3 Mixture Model Method ..................................................................................66 Contents xi 7.3.1 Basic Formulations .............................................................................66 7.3.2 More Advanced Versions ....................................................................68 7.4 Genes Involved in Leukemia: A Case Study ..................................................70 7.5 Summary ........................................................................................................72 7.6 Problems .........................................................................................................72 References ................................................................................................................72 Chapter 8 Binary and Bayesian Networks as Static Models of Regulatory Pathways .............................................................................................73 8.1 Introduction and Overview .............................................................................73 8.2 Binary Regulator Pathways ............................................................................73 8.3 Bayesian Networks: Algorithm .......................................................................73 8.4 Applications and Practical Considerations .....................................................74 8.5 Summary ........................................................................................................76 8.6 Problems .........................................................................................................76 Chapter 9 Metabolic Control Theory for Static Modeling of Metabolic Pathways ..................77 9.1 Introduction and Overview .............................................................................77 9.2 Basic Ideas ......................................................................................................77 9.3 Main Concepts in Metabolic Control Theory ................................................79 9.3.1 Stepl ..................................................................................................79 9.3.2 Step 2..................................................................................................81 9.3.3 Step 3..................................................................................................82 9.4 Mason Method ................................................................................................83 9.5 Metabolic Control Model for Galactose Regulation Pathway: A Case Study ...............................................................................................................86 9.6 Summary ........................................................................................................92 9.7 Problems .........................................................................................................93 References ................................................................................................................93 Chapter 10 System Identification and Control Theory for Dynamic Modeling of Biological Pathways ...............................................................................................95 10.1 Introduction and Overview ...........................................................................95 10.2 Methodology .................................................................................................95 10.2.1 Nonlinear Factor Analysis ...............................................................97 10.2.2 ARX Model .....................................................................................98 10.2.3 Linearized Model: Extracting Pathway Links from Nonlinear Model ...........................................................................101 10.3 Modeling of Cell Cycle: A Case Study .......................................................102 10.3.1 Stability Analysis of System .........................................................103 x¡¡ Contents 10.4 Summary .....................................................................................................106 10.5 Problems .....................................................................................................106 References ..............................................................................................................107 Chapter 11 Gene Silencing for Systems Biology ......................................................................109 11.1 Introduction and Overview .........................................................................109 11.2 A Brief Review of RNA Interference, Small Interfering RNA, and Gene Silencing Mechanisms ................................................................109 11.2.1 Pretranscriptional Gene Silencing ................................................109 11.2.2 Posttranscriptional Gene Silencing ...............................................110 11.2.3 RNA Interference ..........................................................................110 11.3 Pathway Perturbation Using Gene Silencing .............................................. Ill 11.3.1 Overexpression .............................................................................. Ill 11.3.2 Gene Silencing ..............................................................................112 11.3.3 Model Improvement and Validation .............................................112 11.4 Summary .....................................................................................................113 11.5 Problems .....................................................................................................113 References ..............................................................................................................113 Chapter 12 Simulation and Systems Biology ...........................................................................115 12.1 Introduction and Overview .........................................................................115 12.2 What Is Simulation? ....................................................................................115 12.2.1 Power of Expression ......................................................................116 12.2.2 Economy of Form .........................................................................116 12.3 Challenges to Effective Simulation .............................................................117 12.3.1 Identifying Meaningful Themes ...................................................117 12.3.2 Detail Selection and Rejection ......................................................118 12.3.3 Validation ......................................................................................119 12.3.3.1 Measuring Quality Once ...............................................119 12.3.3.2 Handling Stochastic Results .........................................119 12.4 CaseStudies ................................................................................................120 12.4.1 Simulated Protein Folding: Rosetta@Home .................................120 12.4.1.1 Generally How It Works ...............................................121 12.4.1.2 Details to Use or Discard ..............................................121 12.4.1.3 Computing Power .........................................................122 12.4.1.4 Future Goals .................................................................123 12.4.2 Simulated Protein Computing .......................................................124 12.4.2.1 Generally How It Works ...............................................124 12.4.2.1 Details to Use or Discard ..............................................125 12.4.2.3 Computing Power .........................................................128 12.4.2.4 Future Goals .................................................................128 Contents xüi 12.5 Summary .....................................................................................................129 12.6 Problems.....................................................................................................129 References and Notes.............................................................................................129 Chapter 13 Software, Databases, and Other Resources for Systems Biology ..........................131 13.1 Introduction and Overview .........................................................................131 13.2 Databases ....................................................................................................132 13.2.1 Nucleotide Databases ....................................................................132 13.2.1.1 GenBank .......................................................................132 13.2.1.2 DNA Data Bank of Japan .............................................132 13.2.1.3 European Molecular Biology Laboratory .....................132 13.2.1.4 International Sequence Database ..................................132 13.2.2 Protein Database ...........................................................................133 13.2.2.1 Swiss-Prot .....................................................................133 13.2.2.2 Protein Information Resource .......................................133 13.2.2.3 Translated EMBL .........................................................133 13.2.2.4 Universal Protein Resource ..........................................133 13.3 Scoring Matrix ............................................................................................134 13.3.1 Point Accepted Mutation ...............................................................134 13.3.2 Blocks Substitution Matrix ...........................................................134 13.4 Analysis Software .......................................................................................135 13.4.1 FASTA ...........................................................................................135 13.4.1.1 FASTA Algorithm .........................................................135 13.4.1.2 FASTA Variants ............................................................137 13.4.2 BLAST ..........................................................................................138 13.4.2.1 BLAST Algorithm ........................................................138 13.4.2.2 BLAST Variants ............................................................140 13.5 Bioinformatics in MATLAB .......................................................................140 13.5.1 Sequence Analysis ........................................................................140 13.5.2 Sequence Alignment .....................................................................141 13.6 Summary .....................................................................................................141 13.7 Problems .....................................................................................................141 References ..............................................................................................................141 Chapter 14 Future Directions ...................................................................................................143 14.1 Introduction and Overview .........................................................................143 14.2 Single-Cell Microarray and Systems Biology ............................................143 14.2.1 Microarrays to Identify Single Cells .............................................143 14.2.2 Microarray Analysis of a Single Cell ............................................145 14.3 High-Throughput Protein Assays and Systems Biology .............................146 14.4 Integration of Molecular Data with Higher-Level Datasets ........................147 xiv Contents 14.4.1 Higher-Level Data Sets and Publishers .........................................148 14.4.2 Tools to Navigate Metadata ...........................................................149 14.4.3 Role of Higher-Level Data in Systems Biology ............................149 14.5 Identifying Genes Controlling Macrolevel Changes ..................................150 14.5.1 Generate Candidate Markers ........................................................151 14.5.2 Correlate Markers with Phenotype ...............................................151 14.5.3 Infer Genes or Gene Expression Patterns .....................................152 14.6 Molecular-Level Image Systems and Systems Biology ..............................153 14.6.1 Molecular-Level Imaging ..............................................................153 14.6.2 Visual Analytics ............................................................................154 14.7 Summary .....................................................................................................155 14.8 Problems .....................................................................................................155 References and Notes .............................................................................................156 Index ......................................................................................................................159
any_adam_object	1
author	Najarian, Kayvan Najarian, Siamak Gharibzadeh, Shahriar Eichelberger, Christopher N.
author_GND	(DE-588)1067772138 (DE-588)1107777968 (DE-588)1107779499
author_facet	Najarian, Kayvan Najarian, Siamak Gharibzadeh, Shahriar Eichelberger, Christopher N.
author_role	aut aut aut aut
author_sort	Najarian, Kayvan
author_variant	k n kn s n sn s g sg c n e cn cne
building	Verbundindex
bvnumber	BV035814196
callnumber-first	Q - Science
callnumber-label	QH324
callnumber-raw	QH324.2
callnumber-search	QH324.2
callnumber-sort	QH 3324.2
callnumber-subject	QH - Natural History and Biology
classification_rvk	WC 7700
contents	Includes bibliographical references and index
ctrlnum	(OCoLC)312625448 (DE-599)BVBBV035814196
dewey-full	570.285
dewey-hundreds	500 - Natural sciences and mathematics
dewey-ones	570 - Biology
dewey-raw	570.285
dewey-search	570.285
dewey-sort	3570.285
dewey-tens	570 - Biology
discipline	Biologie
format	Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02429nam a2200613 c 4500</leader><controlfield tag="001">BV035814196</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20160722 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">091107s2009 \|\|\|\| \|\|\|\| 00\|\|\| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2009009352</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781420046502</subfield><subfield code="c">hardcover : alk. paper</subfield><subfield code="9">978-1-4200-4650-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)312625448</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV035814196</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH324.2</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">570.285</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 7700</subfield><subfield code="0">(DE-625)148144:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">QU 26.5</subfield><subfield code="2">nlm</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Najarian, Kayvan</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Systems biology and bioinformatics</subfield><subfield code="b">a computational approach</subfield><subfield code="c">Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boca Raton ; London ; New York</subfield><subfield code="b">CRC Press, Taylor & Francis Group</subfield><subfield code="c">[2009]</subfield></datafield><datafield tag="264" ind1=" " ind2="4"><subfield code="c">© 2009</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xxiii, 166 Seiten</subfield><subfield code="b">Diagramme</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bio-informatique</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biologie systémique</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bioinformatics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Systems biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Computational biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Computational Biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Systems Biology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Systembiologie</subfield><subfield code="0">(DE-588)4809615-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Mathematische Methode</subfield><subfield code="0">(DE-588)4155620-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Bioinformatik</subfield><subfield code="0">(DE-588)4611085-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="a">Einführung</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Systembiologie</subfield><subfield code="0">(DE-588)4809615-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Mathematische Methode</subfield><subfield code="0">(DE-588)4155620-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Einführung</subfield><subfield code="A">f</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Bioinformatik</subfield><subfield code="0">(DE-588)4611085-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Mathematische Methode</subfield><subfield code="0">(DE-588)4155620-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">Einführung</subfield><subfield code="A">f</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Najarian, Siamak</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1067772138</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gharibzadeh, Shahriar</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1107777968</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eichelberger, Christopher N.</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1107779499</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018673063&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-018673063</subfield></datafield></record></collection>
genre	Einführung gnd
genre_facet	Einführung
id	DE-604.BV035814196
illustrated	Not Illustrated
indexdate	2024-07-09T22:05:12Z
institution	BVB
isbn	9781420046502
language	English
lccn	2009009352
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-018673063
oclc_num	312625448
open_access_boolean
owner	DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-578
owner_facet	DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-578
physical	xxiii, 166 Seiten Diagramme
publishDate	2009
publishDateSearch	2009
publishDateSort	2009
publisher	CRC Press, Taylor & Francis Group
record_format	marc
spelling	Najarian, Kayvan Verfasser aut Systems biology and bioinformatics a computational approach Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger Boca Raton ; London ; New York CRC Press, Taylor & Francis Group [2009] © 2009 xxiii, 166 Seiten Diagramme txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Bio-informatique Biologie systémique Bioinformatics Systems biology Computational biology Computational Biology Systems Biology Systembiologie (DE-588)4809615-5 gnd rswk-swf Mathematische Methode (DE-588)4155620-3 gnd rswk-swf Bioinformatik (DE-588)4611085-9 gnd rswk-swf Einführung gnd rswk-swf Systembiologie (DE-588)4809615-5 s Mathematische Methode (DE-588)4155620-3 s Einführung f DE-604 Bioinformatik (DE-588)4611085-9 s b DE-604 Najarian, Siamak Verfasser (DE-588)1067772138 aut Gharibzadeh, Shahriar Verfasser (DE-588)1107777968 aut Eichelberger, Christopher N. Verfasser (DE-588)1107779499 aut Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018673063&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Najarian, Kayvan Najarian, Siamak Gharibzadeh, Shahriar Eichelberger, Christopher N. Systems biology and bioinformatics a computational approach Includes bibliographical references and index Bio-informatique Biologie systémique Bioinformatics Systems biology Computational biology Computational Biology Systems Biology Systembiologie (DE-588)4809615-5 gnd Mathematische Methode (DE-588)4155620-3 gnd Bioinformatik (DE-588)4611085-9 gnd
subject_GND	(DE-588)4809615-5 (DE-588)4155620-3 (DE-588)4611085-9
title	Systems biology and bioinformatics a computational approach
title_auth	Systems biology and bioinformatics a computational approach
title_exact_search	Systems biology and bioinformatics a computational approach
title_full	Systems biology and bioinformatics a computational approach Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger
title_fullStr	Systems biology and bioinformatics a computational approach Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger
title_full_unstemmed	Systems biology and bioinformatics a computational approach Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger
title_short	Systems biology and bioinformatics
title_sort	systems biology and bioinformatics a computational approach
title_sub	a computational approach
topic	Bio-informatique Biologie systémique Bioinformatics Systems biology Computational biology Computational Biology Systems Biology Systembiologie (DE-588)4809615-5 gnd Mathematische Methode (DE-588)4155620-3 gnd Bioinformatik (DE-588)4611085-9 gnd
topic_facet	Bio-informatique Biologie systémique Bioinformatics Systems biology Computational biology Computational Biology Systems Biology Systembiologie Mathematische Methode Bioinformatik Einführung
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018673063&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT najariankayvan systemsbiologyandbioinformaticsacomputationalapproach AT najariansiamak systemsbiologyandbioinformaticsacomputationalapproach AT gharibzadehshahriar systemsbiologyandbioinformaticsacomputationalapproach AT eichelbergerchristophern systemsbiologyandbioinformaticsacomputationalapproach

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Inhaltsverzeichnis

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge