Pseudomonas: model organism, pathogen, cell factory
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Wiley-VCH
2008
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| ISBN: | 9783527319145 352731914X |
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| 245 | 1 | 0 | |a Pseudomonas |b model organism, pathogen, cell factory |c ed. by Bernd H. A. Rehm |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2008 | |
| 300 | |a XXI, 402 S. |b Ill., graph. Darst. |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Pseudomonas | |
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| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Pseudomonas |0 (DE-588)4210233-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Rehm, Bernd H. A. |e Sonstige |4 oth | |
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Contents
Preface
XV
List of Contributors
XVII
1
Comparative Cenomics of Pseudomonas
1
Kristoffer
KHI,
Tim
T.
B'mnewies, Harmi
Willenbrock,
Susse Kirkelund
Hansen,
Lei Yang, Larsjelsbak, David W. Ussery, and Carsten Friis
1.1
Introduction
1
1.1.1
Other Species of Pseudomonas
2
1.1.2
Obtaining Sequence Data on Pseudomonas
4
1.2
Pan/Core Genome of Pseudomonas
4
1.3
Phylogeny of Pseudomonas
6
1.4
Blast Atlas of Pseudomonas Genomes
б
1.4.1
Region
5 243 000-5 361 000 12
1.4.2
Region
713 000-785 000 14
1.5
Functional Categories
14
1.6
Codon Usage and Expression
17
1.7
Future Outlook
20
References
21
2
Clinical Relevance of Pseudomonas aeruginosa: A Master of Adaptation
and Survival Strategies
25
Niels
H0Íby,
Helle Krogh Johansen, Claus Moser,
and Oana Ciofu
2.1
Introduction
25
2.2
CF
26
2.3
Survival of P. aeruginosa by Adaptation to the Inflammatory
Defense System
27
2.4
Conductive and the Respiratory Zones of the Lungs
31
2.5
Survival of P. aeruginosa by Adaptation to the Respiratory Zone
of the Lungs
32
VI Contents
2.6
Survival of P. aeruginosa by Adaptation to the Conductive Zone
of the Lungs
33
2.7
Survival of P. aeruginosa by Adaptation to the Antibiotic Therapy
35
2.8
Evolutionary Implications of the Adaptability of P. aeruginosa
37
References
37
3
Adherence of Pseudomonas aeruginosa
45
Randall T. Irvin
3.1
Introduction
45
3.2
What is Adherence?
46
3.3
Role of Adherence in Infection
46
3.4
How is Bacterial Adherence Associated with Virulence?
47
3.5
P. aeruginosa Adhesins
50
3.6
Surface Receptor Requirements of the Pilus Adhesin
52
3.7
How Does PilA Mediate Attachment to Human Mucosal Surfaces?
53
3.8
X-ray Crystallograpbic Structural Studies of the
Pilin
Structural
Protein
56
3.9
Structure of the Pilus Fiber
60
3.10
Structure of the Receptor-Binding Domain and Location
on the Pilus
63
3.11
Structural Nature of the Receptor-Binding Domain
66
3.12
Twitching Motility
68
3.13
How Does the Pilus Attach to a Solid Surface?
69
3.14
The Monkey-Bar Swing Paradox
72
3.15
Molecular Basis for Receptor-binding Domain Interaction with
Steel Surfaces
73
3.16
Pili
as Nanowires for
Redox
Reactions
76
3.17
What is the Most Important Role of Adherence to P. aeruginosa
76
References
77
4
Flagella
and
Pili
of Pseudomonas aeruginosa
85
Jeevanjyot and Reuben
Ramphal
4.1
Introduction
85
4.2
Flagellum of P. aeruginosa
85
4.2.1
Structure of the P. aeruginosa Flagellum
86
4.2.2
Chromosomal Organization of the
Flagellar
Genes of P. aeruginosa
86
4.2.3
Transcriptional Hierarchy of the
Flagellar
Genes
90
4.2.4
Model Proposed for
Flagellar
Assembly in P. aeruginosa
91
4.2.5
Environmental/Nonflagellar Regulators of
Flagellar
Expression
92
4.2.6
Posttranslational Modification of Flagellin
93
4.2.6.1
Flagellar
Glycosylation Islands (GIs) in P. aeruginosa
93
4.2.6.2
Polymorphism of the P. aeruginosa
a-type GI
94
4.2.7
Role of
Flagella in
Inflammation
95
4.2.8
Role of Flagellum in Pathogenesis
95
4.3
Pili
of P. aeruginosa
96
Contents
VII
4.3.1
Structure of P.
«eruginoso
Pilus
97
4.3.2
Pilus/Fimbrial Genes of P. aeruginosa
97
4.3.3
Regulation of Pilus Assembly and Twitching Motility
99
4.3.4
Assembly of Type IV
Pili
100
4.3.5
Pilin
Classification
100
4.3.5.1
Type IV a and
b
Pilins
100
4.3.5.2
Group I-V Pilins
101
4.3.6
Pseudopilins
101
4.3.7
Chaperone-Usher Pathways
101
4.3.8
flp-tad-rcp Gene Cluster
202
4.3.9
Posttranslational Modifications of
Pilin
103
4.3.10
Role of
Pili
in Pathogenesis
103
4-А
Conclusions
104
References
304
5
Pseudomonas Motility and Chemotaxis
109
Junichi
Kato
5.1
Introduction
209
5.2
Chemotaxis Assay Methods
209
5.3
Ecological Aspects of Chemotaxis
222
5.3.1
Host-Microbe Interactions
222
5.3.2
Nitrogen Cycle
113
5.3.3
Bioremediation and Chemotaxis Toward Environmental Pollutants
113
5.4
Molecular Biology of Chemotaxis in Pseudomonas
114
5.4.1
Molecular Mechanism of Bacterial Chemotaxis
224
5.4.2
MCPs in Pseudomonas
115
5.4.3
Che Proteins in Pseudomonas
123
5.4.4
Polar Localization of MCPs and Che Proteins
224
5.5
Pseudomonas as Model Microorganisms for Chemotaxis Research
225
References
226
6
Iron Transport and Signaling in Pseudomonads
229
Francesco
Imperi,
Karla
A. Mettrkk, Matt Shirley,
Federica
Tiburzi,
Richard
С
Draper, Paolo
Visca
and lain
L Lamont
6.1
Introduction
129
6.2
Siderophores Used by Pseudomonads
131
6.2.1
Chemical Diversity of Siderophores
131
6.2.2
Endogenous Siderophores of Pseudomonads
133
6.2.2.1
Pyoverdines
133
6.2.2.2
Pyochelin
134
6.2.2.3
Other Endogenous Siderophores
134
6.2.3
Exogenous Siderophores Utilized by Pseudomonads
235
6.2.3.1
Enterobactin
135
6.2.3.2
Desferrioxamines
236
6.2.3.3
Ferrichromes
236
VIII Contents
6.2.3.4
Aerobactin
136
6.2.3.5
Citrate
136
6.3
Siderophore Synthesis
136
6.3.1
Nonribosomal
Peptide
Synthesis
136
6.3.2
Pyoverdine Biosynthetic Pathways
137
6.3.3
Synthesis of other Pseudomonas Siderophores
141
6.4
Ferri-
Siderophore Transport
142
6.4.1
Overview
142
6.4.2
Outer Membrane
Ferri-
Siderophore Receptors
142
6.4.3
TonB Complex
144
6.4.4
Transport of
Ferri-
Siderophores into the Periplasm
145
6.4.5
Iron Transport Across the Cytoplasmic Membrane
146
6.5
Regulation of Siderophore Synthesis and Transport
146
6.5.1
Fur Protein as Master
Repressor
146
6.5.2
ECF
σ
Factors
148
6.5.3
QS and Expression of Iron Transport Genes
149
6.6
Introduction to Signaling
150
6.6.1
Pyoverdine-Mediated Signaling
150
6.6.1.1
FpvA and Pyoverdine
150
6.6.1.2
Transfer of Signal: Role of FpvR
151
6.6.2
Pyochelin: An Alternative Signaling Mechanism
152
6.6.3
Enterobactm
153
6.6.4
Multiplicity of Heterologous Siderophore Signaling Systems
in Pseudomonads
154
6.7
Concluding Remarks and Future Perspectives
154
References
156
7
Quorum Sensing in Pseudomonads
167
S.P. Diggle, S. HeebJ.F. Dubern, M.P. Fletcher,
S.A.
Crusz, P. Williams, and
M.
Cámara
7.1
Introduction to Quorum Sensing
167
7.2
AHL QS in Pseudomonas aeruginosa
168
7.3
AHL-Dependent QS in Other Pseudomonads
172
7.4
AHQ-Dependent QS in Pseudomonads
174
7.4.1
Regulation and Biosynthesis of AHQs
175
1'.4.2
Function of AHQs in P. aeruginosa
176
7.4.3
AHQs in Other Pseudomonads
178
7.5
Gac/Rsm System in Pseudomonads
178
7.5.1
Gac/Rsm as the Principal QS System
179
7.5.2
Gac/Rsm as a QS Fine-tuning System
180
7.6
QS and Infection
182
7.6.1
Role of QS in the Pathogenesis of P. aeruginosa Infections
182
7.6.2
Evidence for QS In vivo
182
7.6.3
QS and
Biofilms
in P. aeruginosa
183
7.6.4
QS Molecules and the Host
185
Contents
7.6.5
Disruption of QS Represents a Novel Approach for Managing
P. aeruginosa Infections
186
7.7
Conclusions
187
References
188
8
Regulatory Networks in Pseudomonas aeruginosa: Role
of
Cyclic-diß'.S'J-Guanylic
Acid
195
Ute Römling and Susanne Haussier
8.1
Introduction - The History of
Cydic-diß'.S'J-Guanylic
Acid Detection
195
8.2
Principles of c-di-GMP Signaling
196
8.2.1
Transition between Motility and Sessility
196
8.2.2
Di-guanylate Cyclases
298
8.2.3
Phosphodiesterases
198
8.2.4
Principle Concepts of c-di-GMP Signaling
199
8.3
GGDEF and EAL Domain Proteins in P. aeruginosa
199
8.4
c-di-GMP Signaling in
Biofilm
Formation
199
8.5
c-di-GMP Signaling in Fimbrial Biogenesis
202
8.6
c-di-GMP Signaling in Exopolysaccharide Production
203
8.7
c-di-GMP Signaling and Motility
203
8.8
c-di-GMP Signaling in the Formation of Small Colony Variants
204
8.9
c-di-GMP Signaling in Virulence
205
8.10
c-di-GMP-Binding Proteins in P. aeruginosa
206
8.11
Perspectives
207
References
208
9
Pseudomonas aeruginosa: A Model for
Biofilm
Formation
215
Diane McDougald, Janosch Klebensberger, Tim Tolker-Nielsen,
Jeremy
5.
Webb, Tim Conibear, Scott A. Rice, Sylvia M. Kirov,
Carsten Matz,
and
Staffan Kjelleberg
9.1
Introduction
215
9.2
Biofilm
Development
216
9.2.1
Early Attachment and Colonization Events
217
9.2.1.1
Translocation
and Attachment to Surfaces
217
9.2.1.2
Role of
Flagella
and Fimbriae in Reversible and Irreversible
Attachment
218
9.2.2
Extracellular Matrix
219
9.2.2.1
Polysaccharide
219
9.2.2.2
Protein
220
9.2.2.3 DNA 221
9.2.3
Phenotypic and
Genotypie
Diversification in Pseudomonas
Biofilms
223
9.2.3.1
Ecological and Genetic Causes of Diversity in Pseudomonas
Biofilms
223
9.2.3.2
Colony Morphology Variation in P. Aeruginosa
Biofilms
224
X
Contents
9.2.3.3 GacS Sensor Kinase 224
9.2.3.4 Bacteriophage and SCVs 225
9.2.4 Biofilm
Dispersal
226
9.2.4.1
Role ofc-di-GMP in Dispersal
226
9.2.4.2 Denitrifkation,
Nitric
Oxide
and Dispersal
in P. aeruginosa 226
9.2.4.3 Microcolony-based
Biofilm
Dispersal
228
9.3
Regulatory Mechanisms of P. ae.rugi.nosa
Biofilms
229
9.3.1
c-di-GMP
229
9.3.1.1
c-di-GMP Regulation of SCVs
230
9.3.1.2 Autoaggregation
and c-di-GMP
231
9.3.1.3
Motility
231
9.3.1.4
Environmental Stimuli and Targets ofc-di-GMP Signaling
232
9.3.2
QS and P. aeruginosa
Biofilms
233
9.3.2.1
Effect of Nutrient on QS Regulation of
Biofilm
Formation
233
9.3.2.2
QS, Central Metabolism and
Biofilm
Gradients
235
9.3.2.3
QS and Chronic Infection
236
9.4
Biofilm/
Eukaryote Interactions
237
9.4.1
Clinical P.
aeruginosa
Biofilm
Infections
237
9.4.1.1
Chronic Lung Infections in
C F
237
9.4.1.2
Conversion to Mucoidy and Anaerobic Growth
238
9.4.1.3
Phenotypic and
Genotypie
Analyses of P. aeruginosa
in CF Infection
239
9.4.2
Similarities Across P. aeruginosa Biofilm-Host Interactions
241
9.4.2.1
Interactions with Host Immune Cells
241
9.4.2.2
Interactions with Free-living Protozoa
242
9.4.2.3
Interactions with Fungi
243
9.5
Future Perspectives
244
References
246
10
Bacteriophages of Pseudomonas
255
Kirsten Hertveldt
and Rob Lavigne
10.1
Introduction
255
10.1.1
Bacteriophage Propagation Cycle
255
10.1.1.1
Temperate versus Lytic Phages
255
10.1.1.2
Lytic Infection Cycle
256
10.1.2
Phage Classification
259
10.1.3
Phages of Pseudomonas Spp.
259
10.1.4
Applications of Pseudomonas Bacteriophages
263
10.2
Pseudomonas Phage Representatives
263
10.2.1
Introduction
263
10.2.1.1
Tailed Phages
264
10.2.1.2
Tailless Phages
264
10.2.2
Pseiidomonas-Infecting
Myoviridae
264
10.2.2.1
Phage
фСТХ
264
10.2.2.2
Giant Virulent Pseudomonas Phages
265
Contents XI
10.2.3
Pseudomonas-lníecúng
Siphoviridae
268
10.2.3.1
ОЗШ/ВЗ-ііке
Pseudomonas Phages
268
10.2.3.2
Bacteriophage D3
272
10.2.4
Pseudomonas-lnfecting Podoviridae
275
10.2.4.1
gh-1:
A
17-
like Member of the Podoviridae
275
10.2.4.2
φΚΜν
-Like
Viruses
277
10.2.4.3
Pseudomonas Phage
РаРЗ
278
10.2.4.4
Pseudomonas Phage F116
279
10.2.5
Pseudomonas-lníecting Levivirídae
279
10.2.6
Pseudomonas-lníecting Cystoviridae
282
10.2.6.1
Bacteriophage
ф6
282
10.2.6.2
Bacteriophages
ф8, ф12
and
фіЗ
283
10.2.7
Pseudomonas-Infecting Inoviridae
284
10.2.7.1
Introduction
284
10.2.7.2
Phages Pfl and Pf3
285
10.2.8
Prophage Sequences in Pseudomonas Bacterial Chromosomes
286
References
286
11
Pseudomonas Plasmids
293
Christopher M. Thomas, Anthony S.
Haines, Irina
A. Kosheieva, and
Alexander Boronin
11.1
Introduction
293
11.2 Plasmid
Groups in
Pseudomonas 294
11.3
Defining Characteristics of
Pseudomonas Plasmids 303
11.4 Isolation
of
Plasmids 304
11.5
Use of PCR
Primers and Associated
Probes for
Pseudomonas
Plasmids 306
11.6 Plasmid
Replication
306
11.7 Plasmid
Maintenance
309
11.8
Determinants of Incompatibility
312
11.9
Determinants of Host Range
ЗІЗ
11.10
Plasmid Transfer
326
11.11
Phenotypic Cargo of Pseudomonas Plasmids
318
11.12
Conclusions
319
References
320
12
Biosynthesis and Regulation of Phenazine Compounds in
Pseudomonas spp.
331
Dmitri V. Mavrodi, Linda S. Thomashow, and
Wulf
Blankenfeldt
12.1
Introduction
331
12.2
Diversity of Phenazine Compounds Produced
by Pseudomonas spp
331
12.3
Biosynthesis of Phenazines and Evolution of Pathways
333
12.3.1
Core Biosynthetic Pathway and Assembly
of the Phenazine Scaffold
333
XII Contents
12.3.2
Phenazine-Modifying
Genes
337
12.3.3 Evolution
of Phenazine Pathways
338
12.4
Regulation of Phenazine Production in Pseudomonas Spp.
339
12.4.1
Phenazine Biosynthesis and N-Acyl-Homoserine Lactone
(Acyl-HSLj-Based Quorum Sensing (QS)
339
12.4.2
Global Regulation
340
12.5
Biological Activity and Role of Phenazine Compounds
from Pseudomonas Spp.
340
12.5.1
Spectrum of Biological Activity of Phenazines
340
12.5.2
Mode of Action and Mechanisms of Self-Defense
341
12.5.3
Redox
Homeostasis and Other Physiological Roles
343
12.6
Conclusions
344
References
344
13
Pseudomonas-Plant Interactions
353
S.H. Miller, C.L Mark, A. Franks, and F. O'Cara
13.1
Introduction
353
13.2
Beneficial Pseudomonas-Plant Interactions
354
13.2.1
Biocontrol
358
13.2.2
ISR
359
13.2.3
Biofertilization
359
13.2.4
Phytostimulation
360
13.2.5
Rhizoremediation
361
13.3
Pseudomonas-Plant Signaling
362
13.3.1
Plant Root Exudates
362
13.3.2
Plant-Derived Signals and Bacterial Gene Expression
364
13.3.3
N-Acyl-Homoserine Lactone (AHL) Signaling
364
13.3.4
Pathogen-Associated Molecular Patterns (PAMPs)
366
13.4
Current and Future Prospects for the Study of Pseudomonas-Plant
Interactions
367
13.4.1
Transcriptomics
367
13.4.2
Proteomics
367
13.4.3
Metabolomics
368
13.4.4
In Situ Analysis of Pseudomonas-Plant Interactions
368
13.4.5
Plant-Beneficial Microbial
Consortia
369
13.5
Conclusions
370
References
370
14
Biotechnological Relevance of Pseudomonads
377
Bernd H.A. Rehm
14.1
Introduction
377
14.2 Biodegradation 377
14.2.1
Microbial Degradation of PAHs
378
14.2.2
Metabolic Engineering of Strains for
Biodegradation 379
14.3
Biotransformation/Bioconversion
381
Contents XIII
14.4
Low-molecular-weight Compounds: Microbial Production
of Biosurfactants
383
14
A.I Rhamnolipids as Biosurfactants
384
14.4.1.1
Rhamnolipid Biosynthesis
385
14.5 Biopolymer
Production
386
14.5.1
Alginate Biosynthesis
386
14.5.1.1
Applications
388
14.5.2
Elastomeric
Bioplastics:
Medium-chain-length PHAs
388
14.5.2.1
Biosynthesis of Medium-chain-length PHAs
388
14.5.2.2
Potential Applications of Medium-chain-length PHAs
389
14.6
Recombinant
Protein Production
389
14.7
Biocontrol Agents: Plant Growth Promotion
390
14.8
Outlook
391
References
391
Index
397
I he pseudomonads comprise bacterial species which emerged as
model organisms to study important microbial processes such as
biofilm
formation, plant-growth promotion and
biodégradation.
The use
of Pseudomonas bacteria in biotechnological production has exponen¬
tially increased over the past few years.
Pseudomonas-relateå
products
and services are found across a wide range of industrial areas, including
the manufacture of chemicals, biopharmaceuticals and biocatalysts.
Concise and up-to-date, this handy guide fills a gap in the literature
by providing the essential knowledge for everyone with an interest in
the topic. The result is a comprehensive overview of the most important
model organism in applied and medical microbiology that covers basic
biology, pathology and biotechnological applications.
Bernd
Rehm is Professor and Chair of Microbiology at Massey
University in New Zealand. Having obtained his academic
degrees at the Universities of
Bochum
and
Münster
(Germa¬
ny), he spent two years at the University of British Columbia
(Canada), before establishing his own research program at ifie
University of
Münster. In 2003,
he took up his present
appointment at Massey University.
Bernd Rehm
authored and co-authored over ninety scientific
publications. He is sole editor of three books, co-organizer of
the international symposium on biological polyester and
member of the editorial board for several scientificjournals. |
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| building | Verbundindex |
| bvnumber | BV035721631 |
| callnumber-first | Q - Science |
| callnumber-label | QR82 |
| callnumber-raw | QR82.P78 |
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| callnumber-sort | QR 282 P78 |
| callnumber-subject | QR - Microbiology |
| classification_rvk | WF 5700 WF 8300 XD 5100 YD 2700 |
| ctrlnum | (OCoLC)180478869 (DE-599)DNB985851058 |
| dewey-full | 579.332 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 579 - Microorganisms, fungi & algae |
| dewey-raw | 579.332 |
| dewey-search | 579.332 |
| dewey-sort | 3579.332 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV035721631 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T10:19:02Z |
| institution | BVB |
| isbn | 9783527319145 352731914X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017998401 |
| oclc_num | 180478869 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | XXI, 402 S. Ill., graph. Darst. 25 cm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Pseudomonas model organism, pathogen, cell factory ed. by Bernd H. A. Rehm Weinheim Wiley-VCH 2008 XXI, 402 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Pseudomonas Pseudomonas (DE-588)4210233-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Pseudomonas (DE-588)4210233-9 s DE-604 Rehm, Bernd H. A. Sonstige oth text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3008955&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017998401&sequence=000005&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017998401&sequence=000006&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Pseudomonas model organism, pathogen, cell factory Pseudomonas Pseudomonas (DE-588)4210233-9 gnd |
| subject_GND | (DE-588)4210233-9 (DE-588)4143413-4 |
| title | Pseudomonas model organism, pathogen, cell factory |
| title_auth | Pseudomonas model organism, pathogen, cell factory |
| title_exact_search | Pseudomonas model organism, pathogen, cell factory |
| title_full | Pseudomonas model organism, pathogen, cell factory ed. by Bernd H. A. Rehm |
| title_fullStr | Pseudomonas model organism, pathogen, cell factory ed. by Bernd H. A. Rehm |
| title_full_unstemmed | Pseudomonas model organism, pathogen, cell factory ed. by Bernd H. A. Rehm |
| title_short | Pseudomonas |
| title_sort | pseudomonas model organism pathogen cell factory |
| title_sub | model organism, pathogen, cell factory |
| topic | Pseudomonas Pseudomonas (DE-588)4210233-9 gnd |
| topic_facet | Pseudomonas Aufsatzsammlung |
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