Anandamide an endogenous cannabinoid:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier
2009
|
| Series: | Vitamins and hormones
81 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Einzelaufn. eines Zeitschr.-H. |
| Physical Description: | XXII, 513 S. |
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| 245 | 1 | 0 | |a Anandamide an endogenous cannabinoid |c ed-in-chief: Gerald Litwack |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2009 | |
| 300 | |a XXII, 513 S. | ||
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| 490 | 0 | |a Vitamins and hormones |v 81 | |
| 500 | |a Einzelaufn. eines Zeitschr.-H. | ||
| 650 | 4 | |a Arachidonic Acids | |
| 650 | 4 | |a Cannabinoids | |
| 650 | 4 | |a Endocannabinoids | |
| 650 | 4 | |a Polyunsaturated Alkamides | |
| 650 | 4 | |a Receptors, Cannabinoid | |
| 700 | 1 | |a Litwack, Gerald |e Sonstige |4 oth | |
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Record in the Search Index
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| adam_text | Titel: Anandamide an endogenous cannabinoid
Autor: Litwack, Gerald
Jahr: 2009
Contents
Contributors xv
Preface xxi
1. Enzymatic Formation of Anandamide 1
Yasuo Okamoto, Kazuhito Tsuboi, and Natsuo Ueda
I. The Transacylation-Phosphodiesterase Pathway for
Anandamide Formation 2
II. NAT 4
III. NAPE-PLD 9
IV. Alternative Pathways Forming NAEs from NAPEs 15
V. Conclusions 18
References 19
2. Organized Trafficking of Anandamide and Related Lipids 25
Maria L. Yates and Eric L. Barker
I. AEA and the Endocannabinoid System 26
II. AEA Transport 31
Acknowledgment 45
References 45
3. Biosynthesis of Oleamide 55
Gregory P. Mueller and William J. Driscoll
I. Introduction 56
II. Fatty Acid Amide Messengers: Structural Considerations 56
III. Natural Occurrence of Oleamide 57
IV. Biologic Actions of Oleamide 58
V. Proposed Mechanisms for the Biosynthesis of Oleamide 59
VI. Oleamide Biosynthesis by Peptidyiglycine Alpha-amidating
Monooxygenase 60
VII. Discovery of Cytochrome c as an Oleamide Synthase 62
VIII. Cytochrome c also Catalyzes the Formation of Oleoylglycine
and Other Long-Chain Fatty Acylamino Acids 64
IX. Proposal for an Oleamide Synthesome 66
vii
vjjj Contents
X. Apoptosis: A Model for the Mechanism and Regulation
of Oleamide Biosynthesis 67
XI. Considerations for the Investigation of Oleamide Biosynthesis 70
XII. Future Directions and Concluding Remarks 70
References 71
4. Anandamide Receptor Signal Transduction 79
Catherine E. Goodfellow and Michelle Glass
I. Introduction 80
II. Cannabinoid Receptor 1 81
III. Cannabinoid Receptor 2 89
IV. Transient Receptor Potential Vanilloid 1 90
V. Evidence for Additional Receptors 92
VI. Concluding Remarks 98
References 99
5. Is GPR55 an Anandamide Receptor? tu
Andrew J. Brown and C. Robin Hiley
I. A9-Tetrahydrocannabinol, CB1( and CB2 Receptors 112
II. Functional Evidence for Novel Cannabinoid Receptors 113
III. Genomics of G Protein-Coupled Cannabinoid Receptors 116
IV. The Orphan Receptor GPR55 117
V. Endogenous Ligands for GPR55 121
VI. GPR55 Cellular Signaling Pathways 123
VII. Interactions Between GPR55 and CB! Receptors 126
VIII. Conclusion: GPR55 as an Anandamide Receptor 128
References 133
6. The Endocannabinoid System During Development:
Emphasis on Perinatal Events and Delayed Effects 139
Ester Fride, Nikolai Gobshtis, Hodaya Dahan, Aron Weller,
Andrea Giuffrida, and Shimon Ben-Shabat
I. Introduction 140
II. Early Gestation i^t
III. Neural Development 146
IV. Postnatal Development 147
V. Effects of Developmental Manipulation of the
ECS System on the Offspring 150
VI. Conclusions ^^
Acknowledgments 153
References 153
Contents f.
7. CannaMnoid Receptor CBi Antagonists: State of the
Art and Challenges t$$
Maurizio Bifulco, Antonietta Santoro, Chiara Laezza, and
Anna Maria Malfitano
I. Introduction X(,o
II. Endocannabinoid System: Control of Energy Balance 16*
III. Cannabinoid CBi Receptors and CBi Antagonists x§?
IV. C0a Antagonists in the Treatment of Obesity and
Related Comorbidities x§g
V. Other Emerging Effects of CBi Antagonists Xy$
VI. Therapeutic Prospects Xyg
VII. conclusions 1§ j
Acknowledgments ;gi
References %i
8. Novel Endogenous /V-Acyl Glycines: Identification
and Characterization 19*
Heather B. Bradshaw, Neta Rimmerman, Sherry S.-J. Hu,
Sumner Burstein, and J. Michael Walker
I. Historical View of Lipid Signaling Discoveries 19?
II. The Identification of Endogenous Signaling Lipids
with cannabimimetic Activity 19?
III. Identification of Additional W-Acyl Amides 193
IV. W-Arachidonoyl Glycine Biological Activity 194
V. /V-Arachidonoyl Glycine Biosynthesis 194
VI. N-Palrriitoyl Glycine Biological Activity 195
VII. W-Palrnitoyl Glycine Biosynthesis x^
VIII. PalGly Metabolism I97
IX. Identification and Characterization of Additional Member^
of the W-Acyl Glycines 198
X. Biological Activity of Novel W-Acyl Glycines 2qo
XI. Conclusions 2oj
References 20;j
9. The Endocannabinoid Anandamide: From ImmunomoduWj.^11
to Neuroprotection. Implications for Multiple Sclerosis 207
Fernando G. Correa, Leyre Mestre, Fabian Docagne,
Jose Borreli, and Carmen Guaza
I. Introduction 2 jg
II. AEA as a Neuroimmune Signal al2
x Contents
III. Anandamide and Multiple Sclerosis 219
IV. Concluding Remarks 223
Acknowledgment 224
References 224
10. Modulation of the Endocannabinoid-Degrading Enzyme
Fatty Acid Amide Hydrolase by Follicle-Stimulating Hormone 231
Paola Grimaldi, Gianna Rossi, Giuseppina Catanzaro, and Mauro Maccarrone
I. Follicle-Stimulating Hormone: Signal Transduction and
Molecular Targets 232
II. Sertoli Cells: Activities and Biological Relevance 237
III. Overview of the Endocannabinoid System 239
IV. The ECS in Sertoli Cells 241
V. Regulation of FAAH by FSH in Sertoli Cells 243
VI. FAAH Is an Integrator of Fertility Signals 244
VII. Conclusions 25^
Acknowledgments 255
References 255
11. Glucocorticoid-Regulated Crosstalk Between Arachidonic
Acid and Endocannabinoid Biochemical Pathways Coordinates
Cognitive-, Neuroimmune-, and Energy Homeostasis-Related
Adaptations to Stress 263
Renato Malcher-Lopes and Marcelo Buzzi
I. Introduction 264
II. The Arachidonic Acid Cascade 266
III. Glucocorticoid-Mediated Inhibition of cPLA2-Dependent
AA Release from Membrane Phospholipids 269
IV. Biosynthesis of the AA-Containing Endocannabinoids
AEA and 2-AG 271
V. Nongenomic Glucocorticoid-lnduced Activation of
Endocannabinoid Biosynthesis 274
VI. Endocannabinoids Metabolization 278
VII. Crosstalk Between GCs and COX2 in the Control of
Neuroinflammation and Neuroprotection 282
VIII. Crosstalk Between GCs and COX2 in the Control of
Synaptic Plasticity and Learning Processes 285
IX. Coordination of GC-Mediated Control of the Neuroimmune
Response and Energy Homeostasis Control 288
Acknowledgments 295
References 295
Contents xi
12. Modulation of the Cys-Loop Ligand-Gated Ion Channels
by Fatty Acid and Cannabinoids 315
Li Zhang and Wei Xiong
I. CB Receptor-Dependent and -Independent Effects
of Endocannabinoids 316
II. Structure and Function of the Cys-Loop LGICs 317
III. Inhibition of 5-HT3 Receptors by Cannabinoids 318
IV. Modulation of Gly Receptor Function by Cannabinoids 324
V. Inhibition of nACh Receptors by Endocannabinoids 328
VI. Modulation of GABAA Receptor Function by Fatty Acids 329
VII. Concluding Discussion 330
References 331
13. Endogenous Cannabinoids and Neutrophil Chemotaxis 337
Douglas McHugh and Ruth A. Ross
I. Cellular Motility and Neutrophils 338
II. The Endogenous Cannabinoid System 339
III. Cannabinoids Modulate Cell Migration 342
IV. Endocannabinoid Effects on Basal Locomotion of Neutrophils 343
V. Endocannabinoid Effects on Induced Migration of Neutrophils 343
VI. Cannabinoid Receptor Expression in Neutrophils 344
VII. inhibition of Induced Migration: Which Receptors are Involved? 345
VIII. Inhibitory Signal Transduction Mechanisms: Receptor Crosstalk 350
IX. Inhibitory Signal Transduction Mechanisms: Disruption
of the Actin Cytoskeleton 351
X. Conclusion 356
References 357
14. CBi Activity in Male Reproduction: Mammalian
and Nonmammalian Animal Models 367
Riccardo Pierantoni, Gilda Cobellis, Rosaria Meccariello,
Giovanna Cacciola, Rosanna Chianese, Teresa Chioccarelli,
and Silvia Fasano
I. Introduction 368
II. Receptor Properties 368
III. Brain-Pituitary Axis 371
IV. Testis 374
V. Excurrent Duct System 379
VI. Concluding Remarks 382
References 382
xjj Contents
15. Anandamide and the Vanilloid Receptor (TRPV1) 389
Attila Toth, Peter M. Blumberg, and judit Boczan
I. Cannabinoid and Vanilloid Receptors 39°
II. Biochemistry of Anandamide 392
III. Anandamide as Vanilloid Receptor (TRPVi) Ligand 396
IV. Other Anandamide Receptors 4°4
V. Physiological Actions of Anandamide on TRPVa 4°4
VI. Future Directions 410
References 4
16. Endocannabinoid System and Fear Conditioning 421
Leonardo B. M. Resstel, Fabrfcio A. Moreira, and Francisco S. Guimaraes
I. Introduction 421
II. Fear Conditioning 423
III. Influence of Endocannabinoids on Fear Conditioning 426
IV. Brain Regions in which Endocannabinoids may Modulate
Fear Conditioning 429
V. Conclusion 433
References 433
17. Regulation of Gene Transcription and Keratinocyte
Differentiation by Anandamide 441
Nicoletta Pasquariello, Sergio Oddi, Marinella Malaponti,
and Mauro Maccarrone
I. Introduction 442
II. Epidermis 445
Hi. Transcriptional Control of Skin Differentiation 453
IV. Endocannabinoid System in Epidermis 455
V. Modulation of the Endocannabinoid System in
Differentiating Keratinocytes 456
VI. Repression of Gene Transcription by Anandamide 457
VII. Conclusions 459
Acknowledgments 460
References 461
18. Changes in the Endocannabinoid System May Give Insight
into new and Effective Treatments for Cancer 469
Gianfranco Alpini and Sharon DeMorrow
I. Introduction 47o
II. Changes in the Endocannabinoid System in Cancer 471
Contents xiii
III. Antiproliferative Effects of Anandamide 473
IV. Effects of AEA on Migration, Invasion, and Angiogenesis 476
V. targeting Degradation Enzymes of Cannabinoids as an
Anticancer Therapy 479
VI. Tumor Promoting Effects of Anandamide 480
VII. Conclusions 480
Acknowledgments 481
References 481
19. Use of Cannabinoids as a Novel Therapeutic Modality
Against Autoimmune Hepatitis 487
Rupal Pandey, Venkatesh L. Hegde, Narendra P. Singh, Lome Hofseth,
Uday Singh, Swapan Ray, Mitzi Nagarkatti, and Prakash S. Nagarkatti
I. introduction 488
II. The Endogenous Cannabinoid System 489
III. The Biosynthesis of Endocannabinoids 490
IV. Endocannabinoid System is Autoprotective 490
V. Autoimmune Hepatitis 492
VI. Treatment Drawbacks 494
VII. Cannabinoid/Endocannabinoid System in Hepatitis 494
VIII. Conclusions and Future Directions 499
Acknowledgments 500
References 500
Index 505
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| series2 | Vitamins and hormones |
| spelling | Anandamide an endogenous cannabinoid ed-in-chief: Gerald Litwack Amsterdam [u.a.] Elsevier 2009 XXII, 513 S. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 81 Einzelaufn. eines Zeitschr.-H. Arachidonic Acids Cannabinoids Endocannabinoids Polyunsaturated Alkamides Receptors, Cannabinoid Litwack, Gerald Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017749450&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Anandamide an endogenous cannabinoid Arachidonic Acids Cannabinoids Endocannabinoids Polyunsaturated Alkamides Receptors, Cannabinoid |
| title | Anandamide an endogenous cannabinoid |
| title_auth | Anandamide an endogenous cannabinoid |
| title_exact_search | Anandamide an endogenous cannabinoid |
| title_full | Anandamide an endogenous cannabinoid ed-in-chief: Gerald Litwack |
| title_fullStr | Anandamide an endogenous cannabinoid ed-in-chief: Gerald Litwack |
| title_full_unstemmed | Anandamide an endogenous cannabinoid ed-in-chief: Gerald Litwack |
| title_short | Anandamide an endogenous cannabinoid |
| title_sort | anandamide an endogenous cannabinoid |
| topic | Arachidonic Acids Cannabinoids Endocannabinoids Polyunsaturated Alkamides Receptors, Cannabinoid |
| topic_facet | Arachidonic Acids Cannabinoids Endocannabinoids Polyunsaturated Alkamides Receptors, Cannabinoid |
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