Neoplastic hematopathology:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Philadelphia, PA
Saunders
2009
|
| Series: | Hematology, oncology clinics of North America
23,4 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII S., S. 634 - 948 Ill., graph. Darst. |
| ISBN: | 9781437712261 1437712266 |
Staff View
MARC
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| 245 | 1 | 0 | |a Neoplastic hematopathology |c guest ed. Randy D. Gascoyne |
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| 650 | 4 | |a Hematologic Neoplasms | |
| 650 | 4 | |a Leukemia | |
| 650 | 4 | |a Lymphoma | |
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Record in the Search Index
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| adam_text | Neoplastic Hematopathology
Contents
Preface
xi
Randy
D.
Gascoyne
Acute Myeloìd
Leukemia
633
Amy Heerema-McKenney and Daniel A. Arber
The evolution of acute myeloid leukemia (AML) classification reflects
greater understanding of the AML pathogenesis. The
2008
World Health
Organization classification incorporated cytogenetic and molecular
genetic findings and introduced important prognostic correlations. In
this article, the authors discuss the different types of AML and their
diagnoses.
Acute Lymphoblastic Leukemia
655
Mihaela Onciu
Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute
a family of genetically heterogeneous lymphoid neoplasms derived from
B- and T-lymphoid progenitors. Diagnosis is based on morphologic, im-
munophenotypic, and genetic features that allow differentiation from nor¬
mal progenitors and other hematopoietic and nonhematopoietic
neoplasms. Current intensive chemotherapy regimens have accomplished
overall cure rates of
85%
to
90%
in children and
40%
to
50%
in adults,
with outcomes depending on the genetic subtype of disease and clinical
features at presentation. Therapy is optimized using minimal residual dis¬
ease studies that employ flow cytometric and molecular methodologies,
and are important determinants of prognosis. Genetic analyses currently
underway are likely to provide insight into biology, mechanisms of relapse,
pharmacogenetics, and new potential therapeutic targets, which should
aid in further improvement of outcome in this disease.
The Myelodysplastic Syndromes
675
Phuong L. Nguyen
Myelodysplastic syndromes (MDS) are a heterogeneous group of bone
marrow disorders that affect mostly the elderly and have a variable
probability of progression to acute leukemia. The diagnosis of MDS
rests largely on a critical morphologic review of blood and bone mar¬
row slides, with careful correlation with other clinical and essential lab¬
oratory data, including cytogenetics. This article discusses the
epidemiology and clinical and pathologic features of MDS and pertinent
diagnostic and prognostic classifications, with a brief overview of treat¬
ment options. Other considerations in the differential diagnosis are also
briefly outlined.
Contents
The
Myeloproliferatìve
Neoplasms: Insights into Molecular Pathogenesis
and Changes in WHO Classification and Criteria for Diagnosis
693
John Anastasi
In the
2008
World Health Organization-sponsored classification of hema-
topoietic and lymphoid malignancies, changes were made in the classifi¬
cation and criteria for the diagnosis of some of the myeloproliferative
disorders. These changes were initiated by recent insights into the molec¬
ular pathogenesis of these disorders. In this article, the changes made to
the myeloproliferative neoplasm and the basis of the new classification
and altered diagnostic criteria are summarized and discussed.
Plasma Cell Myeloma
709
Pei Lin
Plasma cell myeloma is a heterogenous disease with variable clinical pre¬
sentation and outcome. The prognosis is largely determined by tumor bi¬
ology. Newer therapeutic agents are rapidly changing the survival outlook
of myeloma patients.
Atypical Lymphoid Hyperplasia Mimicking Lymphoma
729
David J. Good and Randy D. Gascoyne
The distinction between reactive and neopiastic lymphoid infiltrates is
a common problem in clinical practice and can be problematic. The clinical
implications for both the patient and the treating clinician are profound. In
this article, we discuss six of the common entities that can present as atyp¬
ical lymphoid hyperplasia and thus can mimic malignant lymphomas, with
emphasis on morphologic features, immunophenotypic findings, and mo¬
lecular correlates that help distinguish these disorders from neopiastic con¬
ditions. The six conditions to be discussed in detail include reactive foilicuiar
hyperplasia versus foilicuiar lymphoma; progressive transformation of ger¬
minal centers versus nodular lymphocyte predominant
Hodgkin
lymphoma;
immunoblastic proliferations versus diffuse large B-cell lymphomas; variant
forms of Castleman disease that may mimic a number of lymphoid cancers;
Kikuchi s disease versus large cell lymphomas; and finally, dermatopathic
lymphadenopathy and its distinction from lymph nodes showing early in¬
volvement by cutaneous
Т
-cell
lymphoma (Mycosis fungoides).
Hodgkin
Lymphoma
747
Bertram
Schnitzer
Hodgkin
disease was first described more than
175
years ago. Clinically
and histomorphologically, the features of
Hodgkin
lymphoma are unusual
for a lymphoma or for other malignancies. The incidence of
Hodgkin
lym¬
phoma is estimated to be
7400
new cases per year in the United States,
resulting in an age-adjusted yearly rate of
2.7
per
100,000
per year. There
have been numerous classifications of non-Hodgkin lymphoma over the
years, but the organizational schemes of
Hodgkin
lymphoma have been
stable. This article reviews the diagnosis of the various types of
Hodgkin
lymphoma classification, diagnosis and differential.
Contents
Indolent Lymphomas
of Mature
В
Lymphocytes
769
Paul
J.
Kurtin
The lymphomas of small
В
lymphocytes are a biologically diverse group of
В
cell derived neoplasms that includes
В
cell small lymphocytic lym-
phoma/chronic lymphocytic leukemia; mantle cell lymphoma; follicular
lymphoma; nodal, splenic and extranodal marginal zone lymphomas;
and lymphoplasmacytic lymphoma. They are distinguished from one an¬
other on clinical, morphological, phenotypic and genetic grounds. This ar¬
ticle reviews the essential diagnostic and biologic features of these
clinically indolent
В
cell malignancies.
Diffuse Large B-Cell Lymphomas and Burkitt Lymphoma
791
Laurence
de Levai
and Robert Paul Hasserjian
Diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphoma (BL) ac¬
count for the majority of aggressive lymphomas in adults and children.
DLBCLs exhibit marked biological heterogeneity and variable clinical pre¬
sentation and clinical course. Conversely, BL is genetically relatively ho¬
mogeneous but associated with variable clinicopathological features. In
this article, the authors summarize the recent advances pertaining to these
B-cell neoplasms, following the latest World Health Organization classifi¬
cation and focusing on changes introduced since the previous edition.
These changes include the addition of variants and subgroups of DLBCLs
and borderline categories for high-grade B-cell neoplasms that show
features intermediate between DLBCL and classical
Hodgkin
lymphoma,
or between DLBCL and BL. In particular, the diagnostic and therapeutic
problems related to neoplasms with features intermediate between
DLBCL and BL will be discussed.
Peripheral
Т
-Cell
Lymphomas
829
William R. Macon
Peripheral
Т
-cell
lymphomas (PTCLs) are malignancies of immunologically
mature
Т
-cells that arise in peripheral lymphoid tissues such as lymph no¬
des, spleen, gastrointestinal tract, and skin. These lymphomas are uncom¬
mon as compared with the incidence of B-cell lymphomas, and they
comprise only
5%
to
10%
of non-Hodgkin lymphomas in North America
and Western Europe. A variety of specific disease entities have been rec¬
ognized among PTCLs, and they tend to have lymph node, extranodal/cu-
taneous, or mixed leukemic/lymphomatous presentations. Most PTCLs
have an aggressive clinical course. The clinicopathologic features of the
various PTCLs are described herein.
The
Leukémiás
of Mature Lymphocytes
843
Eric D. Hsi
The
leukémiás
of mature
В
cells and
T
cells are a limited set of diseases in
which biood and bone marrow are the primary sites of involvement.
Contents
Although they may superficially resemble one another, they have distinct
clinical and pathologic features and must be distinguished from one an¬
other. In this article, the major clinical, morphologic, phenotypic, and mo¬
lecular genetic features of the mature B- and
Т
-cell
leukémiás
are
reviewed, and differential diagnostic considerations are discussed.
Bone Marrow Involvement by
Hodgkin
and Non-Hodgkin Lymphomas
873
Qian-Yun Zhang and Kathryn Foucar
Bone marrow evaluation plays a critical role in staging and predicting prog¬
nosis in patients with
Hodgkin
Iymphoma or non-Hodgkin Iymphoma.
Bone marrow can be the initial site of detection of Iymphoma in patients
with unexplained symptoms or cytopenias. A comprehensive evaluation
of bone marrow includes complete blood counts, blood morphology,
bone marrow aspirate, and generous core biopsy sections. Specialized
testing should be used in a logical fashion on a case by case basis.
Molecular Diagnosis of Hematopoietic and Lymphoid Neoplasms
903
Dragan
Jevremovic and David S. Viswanatha
This chapter summarizes the significance and molecular diagnostic detec¬
tion of genetic abnormalities commonly associated with hematolymphoid
neoplasms.
Methodologie
aspects of laboratory diagnosis are presented,
as well as discussion of multiparameter genotyping of tumors for progno¬
sis and the role of minimal residual disease monitoring in specific
neoplasms.
Index
935
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| spelling | Neoplastic hematopathology guest ed. Randy D. Gascoyne Philadelphia, PA Saunders 2009 XII S., S. 634 - 948 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Hematology, oncology clinics of North America 23,4 Hematologic Neoplasms Leukemia Lymphoma Lymphomas Blutkrankheit (DE-588)4007281-2 gnd rswk-swf Leukämie (DE-588)4035487-8 gnd rswk-swf Blutbildendes Gewebe (DE-588)4239650-5 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Blutkrankheit (DE-588)4007281-2 s Leukämie (DE-588)4035487-8 s DE-604 Blutbildendes Gewebe (DE-588)4239650-5 s Krebs Medizin (DE-588)4073781-0 s b DE-604 Gascoyne, Randy D. Sonstige oth Hematology, oncology clinics of North America 23,4 (DE-604)BV000625446 23,4 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017739580&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neoplastic hematopathology Hematology, oncology clinics of North America Hematologic Neoplasms Leukemia Lymphoma Lymphomas Blutkrankheit (DE-588)4007281-2 gnd Leukämie (DE-588)4035487-8 gnd Blutbildendes Gewebe (DE-588)4239650-5 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4007281-2 (DE-588)4035487-8 (DE-588)4239650-5 (DE-588)4073781-0 (DE-588)4143413-4 |
| title | Neoplastic hematopathology |
| title_auth | Neoplastic hematopathology |
| title_exact_search | Neoplastic hematopathology |
| title_full | Neoplastic hematopathology guest ed. Randy D. Gascoyne |
| title_fullStr | Neoplastic hematopathology guest ed. Randy D. Gascoyne |
| title_full_unstemmed | Neoplastic hematopathology guest ed. Randy D. Gascoyne |
| title_short | Neoplastic hematopathology |
| title_sort | neoplastic hematopathology |
| topic | Hematologic Neoplasms Leukemia Lymphoma Lymphomas Blutkrankheit (DE-588)4007281-2 gnd Leukämie (DE-588)4035487-8 gnd Blutbildendes Gewebe (DE-588)4239650-5 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Hematologic Neoplasms Leukemia Lymphoma Lymphomas Blutkrankheit Leukämie Blutbildendes Gewebe Krebs Medizin Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017739580&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT gascoynerandyd neoplastichematopathology |