Diabetic metabolism with high and low diets:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Washington, DC
Carnegie Institution
1923
|
| Series: | Publication / Carnegie Institution <Washington, DC>
323 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VIII, 334 S. |
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| 245 | 1 | 0 | |a Diabetic metabolism with high and low diets |c by Elliott P. Joslin |
| 264 | 1 | |a Washington, DC |b Carnegie Institution |c 1923 | |
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| 490 | 1 | |a Publication / Carnegie Institution <Washington, DC> |v 323 | |
| 650 | 4 | |a Diabetes |x Metabolism | |
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DIABETIC METABOLISM WITH
HIGH AND LOW DIETS
BY
ELLIOTT P JOSLIN
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PUBLISHED BY THE CARNEGIE INSTITUTION OF WASHINGTON
WASHINGTON; 1923
, CONTENTS
PAGE
Introduction 1
Bibliography of recent research on1 metabolism in diabetes 1
General history and plan of research - 1 jl 2
Apparatus employed for-determining themetabolism of diabetics 5
Clinical tests 6
Description of diabetic cases ! 7
Sex * 7
Age , 7
Maximum body-weight in diabetes aiid its etiological significance 12
Greatest loss in weight of diabetic patients ! 13
Extreme loss in weight 14
Loss in weight of pancreas 1 15
Duration of diabetes ! 16
Severity of diabetes !:T 20
Acidosis - J 1 ! 21
Causes of death ! 1 22
Treatment : ,1 24
Composition of diet 26
Detailed protocols for individual diabetics : 1 26
Discussion of results 1 I : 28
Pulse-rate in diabetes : 28
s Methods used for recording pulse-rate VI 29
Summary of previous data upon pulse-rate in diabetes 30
Pulse-rate of diabetic patients treated before and since June, :i914 31
Relation between loss in weight; and pulse-rate ! 32
Effect of loss in-weight on pulse-rate of normal individuals 32
Factors influencing relation between pulse-rate and loss in, weight 34
Effect of loss in weight on pulse-rate of diabetics; and comparison with
: normals- , i 35
Effect of sex upon pulse-rate 36
Relation between food and pulse-rate 7J1 V 37
Relation between food and pulse-rate with normal individuals 38
Relation between food and pulse-rate with diabetics1 39
Effect of levul amp;ie upon pulse-rate of diabetics: : 40
Comparison of effect of food on pulse-rate of normals and diabetics 40
Variations in pulse-rate with certain individuals * 40
Relation of severity of diabetes to pulse-rate 41
• Relation of acidosis to pulse-rate 1 42
Relation of blood sugar and blood fat to pulse-rate 44
Metabolism of diabetics without food : 45
Normal standards j 45
Computation of basal metabolism 47
Varying metabolism in diabetes l: 48
Metabolism of diabetic patients before and after June, 1914 J : 49
Effect on metabolism of Using different types! of apparatus, including changes
in position I1! i! 50
High and low metabolism*in diabetes 51
Changes in metabolism during intervals of more than one year 54
Relation of age to metabolism of diabetics- 56
Sex and metabolism in diabetes i - 58
Pulse-rate as a measure of basal-metabolism in diabetes ; 59
Relation between pulse-rate^and metabolism of different individuals 60
Metabolism and-pulse-rate in disease |! 62
Pulse-rate and metabolism in diabetes 63
I-0
vI • V „ !ill-
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VI CONTENTS
Discussion of results—Continued PAGE
Metabolism of diabetics without, food-r-Cpntinued »
Variations in body-weight and their relation to calculations of the metabolism
during observation 65
Edema and calculations of metabolism , 65
Caloric value of a, kilogram ofjbody-weight and1 hypothetical estimations
connected therewith i ( 68
Effect of sudden change in body-weight on calculation of metabolism 69
Relation of loss in body-weight to metabolism in diabetes 72
Relation of severity of diabetes to metabolism 74
Relation of acidosis to metabolism of diabetics 77
Variations in same individual of acidosis and metabolism 79
Acidosis, pulse-rate, and metabolism i 83
Acidosis, severity!of the diabetes, and metabolism ,|t • 83
Acidosis and metabolism of individual diabetics 85
Metabolism of young female diabetics without food 90
Variations in metabolism of diabetic girls, with influencing factors 95
Influence of liberal diet upon metabolism of severe cases 95
Influence of restricted diet upon metabolism of severe cases 96
Influence of acidosis upon metabolism of severe cases!; 97
Metabolism of moderately severe cases 1 97
Comparison of standards 1 i1: i 98
Relation between pulse-rate and metabolism of diabetic girls 1 99
Comparison of metabolism and urinary nitrogen of diabetic girls 100
Respiratory quotients of diabetic girls ! j J| J 101
Comparison of respiratory quotients and urinary nitrogen of diabetic
girls ji 102
Body-weight of jdiabetic girls] |i 103
Relation of various constituent^ of blood and urine to metabolism in diabetes 105
Relation between;metabolism a nd,percentage of,sugar in the blood 105
Fat in the bloodj of diabetics J; , 106
Relation ofjblood fat and severity,of diabetes / 107
Relation between blood fat and acidosis j 107
Relation between blood fat and metabolism 107
Relation between metabolism anc^ non-protein nitrogen in the blood 109
Relation between metabolisin and urinary, sugar ; HI
Nitrogen excretion in jthe urine 112
Individual variations in excretion,of urinaryinitrogen , 114
Low nitrogen excretion ; 114
High nitrogen excretion , ,•••••, 116
Relation of excretion of urinary nitrogen in periods of overnutritionand
undernutrition,to severity of diabetes;; ; • • • • • 117
Relation of excretion of urinary nitrogen ;to acidosis : 118
Relation between acidosis, urinary nitrogen,,and body-weight 119
Relation of excretion of urinary nitrogen to basal metabolism 120
Heat-production per kilogram of body-weight as index of, caloric needs of
diabetics 124
Fasting and undernutrition in health ! 127
Metabolism, of, a healthy incjividual during a prolonged fast 127
Metabolism of a healthy young woman undergoing the routine under
nutrition treatment of a diabetic | 131
Changes in body-weight ; | 134
Pulse-rate ,•••!••• -j- 135
Volume of urine :;; 135
Excretion|of urinary^ nitrogen e 136
Blood sugar, ,;:i 137
Acidosis : 138
Basal metabolism , - 140
Respiratory quotient 140
Materials) katabolized 141
Summary, of results with healthy woman under diabetic regime 141
CONTENTS; -:VII
Discussion of results—Continued, ;• t • • I, PAGE
Metabolism of diabetics without food—Continued •• : |i II• •
Effect of extraneous factors upon metabolism] in diabetes | 142
Influence of catamenia, the menopause, and o variotomy i upon the
metabolism of diabetic patients, j ) ;- • • - ••• | •; - 142
Diabetes during pregnancy J 143
Observations with Case No: 436 i; ;i 143
Observations with Case No; 1070 ;;i| j: it 145
Observations with Case No: i232 it ; :, 150
Conclusions regarding metabolism tin diabetes with pregnancy 151
Enlarged thyroid gland r 1; ; 151
Jaundice i-j !j 151
Influence of sodium bicarbonate upon the metabolism | 152
Effect of overweight on metabolism of diabetics ancLnbrma 1 individuals 153
Metabolism of diabetic patients within a month and a, half of death 156
Metabolism of diabetics on vergejof coma preceding death 158
Factors of influence in theiprognosis of diabetes ; : ,j |: : J 160
Severity of diabetes and duratiori|pf life |jitp 162
Acidosis and duration,,of life tJk l| 163
Duration of life and;body-weight V i: 164
Respiratory quotient in diabetes J 165
Relation between respiratory quotient and metabolism „of diabetics 165
Clinical importance of relation between respiratory quotient and metabolism 167 v
Low and high respiratory [quotients 169
Low respiratory quotients in diabetes } 1 171
Extremely low respiratory quotients in the literature 171
Extremely low respiratory quotients in this: Laboratory 173
High respiratory, quotients in diabetes ;I 178
Respiratory quotients with men of same height but of varying weight 187
Respiratory quotient in relation to the different types of severity 1S7
Respiratory quotient in relation to the degree of acidosis v;189
Respiratory quotient in relation to pulse-rate of diabetics 191
Respiratory quotient in relation to the glycosuria of; preceding 24 hours 191
Relation between respiratory quotient and carbohydrate balance 193
Relation of constituents of the blood and respiratory quotient i : 194
Respiratory quotientjin relation to blood sugar : 194
Relation between respiratory quotient,and blood fat • 197
Effect of administering levulose, and other foods i to diabetics 198
General factors influencing normal metabolism 198
Increase in metabolism due to exercise ,; j 198
Increase in metabolism due to ingestion of food ; 199
Effect of coffee upon metabolism • 201
Factors decreasing the metabolism::ii 202
Variations in metabolism, due to pathological conditions |u 203
Effect of food on respiratory quotient of normal individuals 204
Effect of ingestion of, carbohydrate upon respiratory quotients of normal
individuals !jj 206
Methods employed in studying effect of foodiupon metabolism in diabetes 208
Comparison with basal metabolism, ij 208
Clinical details ; i, r; j: : ij 209
Quality and quantitjjjof foods administered: ,t; i; J f 209
Character of information jsupplied by experiments after food to 210
Experiments following ingestion of levulose W -j|: 211
Observations with diabetics after levulose in present research 212
Utilization of levulose by diabetics 214
Effect of ingestion of, levulose upon metabolism • I ,j 214
Effect upon metabolism of variation in amounts of leyulose 214
Effect , of levulose, in diabetes of ^different; degrees of severity 215
Effect of levulose on metabolism with varying degrees of acidosis 217
||,I I !! HI - - I
,,itI • i • i i •
VIII •CONTENTS
Discussion of results—Continued , : PACE
Effect of administering levulose aiid other foocls itb^diabetics—Continued
Experiments following ingestion of levulose—Continued
Effect of ingestion of levulose upon respiratory quotient 217
Effect of levulose with basal iquotientslof different levels 217
Variations in quotients in different periods of basal experiments 221
Variations in quotients in different periods of levulose experiments 221
Comparison of basal respiratory quotients of diabetics with respira
tory quotients after ingestion of levulose 222
Effect on respiratory-1 quotient of varying amounts of levulose per
kilogram of body-weight 222
Effect of levulose on the respiratory quotient in successive half-hour
periods •[ VlV jI ! 225
Levulose experiments iri which this respiratory quotient remained
unchanged or fell! i1 230
High respiratory quotients obtained after administration of levulose 231
Effect of)levulose given on different occasions1 to the same patient 235
Carbohydrate balance in levulose experiments 237
Relationl between metabolism and variations in excretion of sugar in
urine of diabetics afterilevulose H 238
Effect of severity of diabetes on respiratory quotient after ingestion
• of levulose i lL |: • 240
Effect of acidosis on respiratory quotient after ingestion of levulose 240
Blood sugarland ingestion of levulose |t • : 240
Effect of levulose on metabolism1 and respiratory, (quotient with varying
percentages of sugar in thejblood J j 245 ,
Relation, of ((urinary nitrogeni to metabolism anil respiratory quotient
of diabetics in levulose experiments « 246
Relation of tnon-protein nitrogen in the blood to total metabolism and
respiratory quotient of diabetics irilevulose experiments 247
Relation of blood fat to total metabolism and respiratory quotient after
administration of levulose to diabetics 1 248
Effect of ingestion of various^carbohydrates : 249
Orange juice: 249
Dextrose;i J-1r;i I249
Levulose j: 1 250
Sucrose111 _251
Effect of dextrose and bread on the metabolism of diabetics 251
Effect on diabetics of ingestion of carbohydrate with butter or olive oil 251
Effect on diabetics of ingestion of protein J I1 253
Effect of ingestion of protein and fat J IJ ! • 254
Effect of ingestion of beefsteak (protein) and fat Iby diabetics 256
Increases in heat-production1 inI various food experiments at different
levels of basal metabolism 1 257
Effect of oatmeal on metabolism of diabetics C i 261
Oatmeai without fat : U 261
Oatmeal with fat 261
Metabolism on oatmea) days—-single observations 262
Metabolism on oatmeal days —multiple observations 263
Conclusions upon experiments with oatmeal! 267
• Metabolism of diabetics after ingestioh of mixed diets 268
Metabcilism of diabetics after first meal of day (breakfast or dinner) 268
Metabolism of diabetics after nooii meal preceded by breakfast 270
Metabolism of diabetics after-two or three meals 271
Metabolism of diabetics after noon nieal of carbohydrates and
protein^ *! • v - 272
Summary rr 1 ,T A jl - Ji 274
Appendix I Abstract of clinical data land protocols of experiments with 113
cases of diabetes mellitus i#i : J 281
Appendix II Sugar, fat and non-protein nitrogen in blood of diabetics in
post-absorptive condition 331
|
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| spelling | Joslin, Elliott P. 1869-1962 Verfasser (DE-588)172172268 aut Diabetic metabolism with high and low diets by Elliott P. Joslin Washington, DC Carnegie Institution 1923 VIII, 334 S. txt rdacontent n rdamedia nc rdacarrier Publication / Carnegie Institution <Washington, DC> 323 Diabetes Metabolism Carnegie Institution <Washington, DC> Publication 323 (DE-604)BV035415500 323 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017676676&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Joslin, Elliott P. 1869-1962 Diabetic metabolism with high and low diets Diabetes Metabolism |
| title | Diabetic metabolism with high and low diets |
| title_auth | Diabetic metabolism with high and low diets |
| title_exact_search | Diabetic metabolism with high and low diets |
| title_full | Diabetic metabolism with high and low diets by Elliott P. Joslin |
| title_fullStr | Diabetic metabolism with high and low diets by Elliott P. Joslin |
| title_full_unstemmed | Diabetic metabolism with high and low diets by Elliott P. Joslin |
| title_short | Diabetic metabolism with high and low diets |
| title_sort | diabetic metabolism with high and low diets |
| topic | Diabetes Metabolism |
| topic_facet | Diabetes Metabolism |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017676676&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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