The cell: a molecular approach
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| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Washington, DC
ASM Press [u.a.]
2009
|
| Edition: | 5. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIX, 820 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9780878933006 |
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MARC
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| 100 | 1 | |a Cooper, Geoffrey M. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The cell |b a molecular approach |c Geoffrey M. Cooper ; Robert E. Hausman |
| 250 | |a 5. ed. | ||
| 264 | 1 | |a Washington, DC |b ASM Press [u.a.] |c 2009 | |
| 300 | |a XIX, 820 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cell Biology | |
| 650 | 4 | |a Cells | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Molecular biology | |
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| _version_ | 1804139226710671361 |
|---|---|
| adam_text | Titel: The cell
Autor: Cooper, Geoffrey M.
Jahr: 2009
Brief Contents
PARTI Introduction 1
Chapter 1 An Overview of Cells and Cell Research 3
Chapter 2 The Composition of Cells 43
Chapter 3 Cell Metabolism 73
Chapter 4 Fundamentals of Molecular Biology 103
PART II The Flow of Genetic Information 153
Chapter 5 The Organization and Sequences of Cellular Genomes 155
Chapter 6 Replication, Maintenance, and Rearrangements of Cenomic DNA 201
Chapter 7 RNA Synthesis and Processing 251
Chapter 8 Protein Synthesis, Processing, and Regulation 309
PART III Cell Structure and Function 353
Chapter 9 The Nucleus 355
Chapter 10 Protein Sorting and Transport:
The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes 383
Chapter 11 Bioenergetics and Metabolism:
Mitochondria, Chloroplasts, and Peroxisomes 433
Chapter 12 The Cytoskeleton and Cell Movement 473
Chapter 13 The Plasma Membrane 529
Chapter 14 Cell Walls, the Extracellular Matrix, and Cell Interactions 571
PART IV Cell Regulation 601
Chapter 15 Cell Signaling 603
Chapter 16 The Cell Cycle 653
Chapter 17 Cell Death and Cell Renewal 693
Chapter 18 Cancer 725
Contents
Preface xiii
Organization and Features of The Cell
Media and Supplements to Accompar
PA
IAn Overview of Cells
and Cell Research 3
The Origin and Evolution
of Ceils 4
The First Cell 4
The Evolution of Metabolism 6
Present-Day Prokaryotes 8
Eukaryotic Cells 8
The Origin of Eukaryotes 9
The Development of Multicellular
Organisms 12
Cells as Experimental
Models 16
E.coli 16
Yeasts 17
Caenorhabditis elegans 18
Drosophila melanogaster 18
Arabidopsis thaliana 19
Vertebrates 19
Tools of Cell Biology 21
Light Microscopy 21
Electron Microscopy 28
Subcellular Fractionation 30
Growth of Animal Cells in Culture 33
Culture of Plant Cells 36
Viruses 37
KEY EXPERIMENT
Animal Cell Culture 34
MOLECULAR MEDICINE
Viruses and Cancer 37
XV
ly The Cell xvii
RTI INTRODUCTI
Summary and Key Terms 39
Questions 41
References and Further Reading 42
2 The Composition
of Cells 43
The Molecules
of Cells 43
Carbohydrates 44
Lipids 46
Nucleic Acids 49
Proteins 52
Cell Membranes 58
Membrane Lipids 58
Membrane Proteins 60
Transport across Cell Membranes 63
Proteomics: Large-Scale
Analysis of Cell Proteins 64
Identification of Cell Proteins 65
Global Analysis of Protein
Localization 67
Protein Interactions 68
KEY EXPERIMENT
The Folding of Polypeptide Chains 54
KEY EXPERIMENT
The Structure of Cell Membranes 60
Summary and Key Terms 70
Questions 71
References and Further Reading 71
ON
J Cell Metabolism 73
The Central Role of Enzymes as
Biological Catalysts 73
The Catalytic Activity of Enzymes 73
Mechanisms of Enzymatic Catalysis 74
Coenzymes 76
Regulation of Enzyme Activity 79
Metabolic Energy 81
Free Energy and ATP 81
The Generation of ATP from
Glucose 84
The Derivation of Energy from Other
Organic Molecules 89
Photosynthesis 89
The Biosynthesis of Cell
Constituents 91
Carbohydrates 92
Lipids 93
Proteins 94
Nucleic Acids 96
MOLECULAR MEDICINE
Phenylketonuria 97
KEY EXPERIMENT
Antimetabolites and Chemotherapy 98
Summary and Key Terms 99
Questions 100
References and Further Reading 101
4 Fundamentals
of Molecular
Biology 103
Heredity, Genes,
andDNA 103
Genes and Chromosomes 104
Genes and Enzymes 105
Identification of DNA as the Genetic
Material 107
The Structure of DNA 108
Replication of DNA 109
Expression of Genetic
Information 110
Colinearity of Genes and Proteins 111
The Role of Messenger RNA 112
PART II THE
The Organization
5 and Sequences
of Cellular
Genomes 155
The Complexity of Eukaryotic
Genomes 155
Intronsand Exons 157
Repetitive DNA Sequences 161
Gene Duplication and
Pseudogenes 164
The Composition of Higher Eukaryotic
Genomes 165
Chromosomes and
Chromatin 166
Chromatin 166
Centromeres 170
Telomeres 174
The Genetic Code 113
RNA Viruses and Reverse
Transcription 115
Recombinant DNA 118
Restriction Endonucleases 118
Generation of Recombinant DNA
Molecules 120
Vectors for Recombinant DNA 121
DNA Sequencing 124
Expression of Cloned Genes 124
Detection of Nucleic Acids
and Proteins 127
Amplification of DNA by the Polymerase
Chain Reaction 128
Nucleic Acid Hybridization 130
Antibodies as Probes for Proteins 133
¦FLOW OF GENETIC
The Sequences of Complete
Genomes 176
Prokaryotic Genomes 177
The Yeast Genome 178
The Genomes of Caenorhabditis
elegans, Drosophila melanogaster
and Other Invertebrates 180
Plant Genomes 182
The Human Genome 184
The Genomes of Other Vertebrates 188
Bioinformatics and Systems
Biology 191
Systematic Screens of Gene Function
191
Regulation of Gene Expression 192
Variation among Individuals and
Genomic Medicine 194
KEY EXPERIMENT
The Discovery of Introns 158
CONTENTS V
Gene Function in
Eukaryotes 136
Genetic Analysis in Yeasts 136
Gene Transfer in Plants and
Animals 137
Mutagenesis of Cloned DNAs 140
Introducing Mutations into Cellular
Genes 141
Interfering with Cellular Gene
Expression 143
KEY EXPERIMENT
The DNA Provirus Hypothesis 116
KEY EXPERIMENT
RNA Interference 146
Summary and Key Terms 148
Questions ISO
References and Further Reading ISO
INFORMATION
KEY EXPERIMENT
The Human Genome 186
Summary and Key Terms 195
Questions 198
References and Further Reading 198
Replication,
6 Maintenance, and
Rearrangements of
Genomic DNA 201
DNA Replication 201
DNA Polymerases 202
The Replication Fork 203
The Fidelity of Replication 210
Origins and the Initiation
of Replication 211
Telomeres and Telomerase: Maintaining
the Ends of Chromosomes 214
Viii CONTENTS
DNA Repair 216
Direct Reversal of DNA Damage 216
Excision Repair 219
Translesion DNA Synthesis 224
Repair of Double-Strand Breaks 226
Recombination between
Homologous DNA
Sequences 227
Models of Homologous
Recombination 228
Enzymes Involved in Homologous
Recombination 229
DNA Rearrangements 233
Site-Specific Recombination 234
Transposition via DNA
Intermediates 240
Transposition via RNA
Intermediates 242
Gene Amplification 245
MOLECULAR MEDICINE
Colon Cancer and DNA Repair 225
KEY EXPERIMENT
Rearrangement of Immunoglobulin
Genes 236
Summary and Key Terms 247
Questions 249
References and Further Reading 249
7 RNA Synthesis and
Processing 251
Transcription in
Prokaryotes 251
RNA Polymerase and Transcription 252
Repressors and Negative Control of
Transcription 256
Positive Control of Transcription 258
Eukaryotic RNA Polymerases
and General Transcription
Factors 258
Eukaryotic RNA Polymerases 259
General Transcription Factors and
Initiation of Transcription by RNA
Polymerasell 259
Transcription by RNA Polymerases I
and III 263
Regulation of Transcription
in Eukaryotes 265
c/s-Acting Regulatory Sequences:
Promoters and Enhancers 265
Transcription Factor Binding Sites 269
Transcriptional Regulatory Proteins 270
Structure and Function of
Transcriptional Activators 273
Eukaryotic Repressors 276
Regulation of Elongation 278
Relationship of Chromatin Structure to
Transcription 278
Regulation of Transcription by
Noncoding RNAs 285
DNA Methylation 286
RNA Processing and
Turnover 287
Processing of Ribosomal and Transfer
RNAs 288
Processing of mRNA in Eukaryotes 290
Splicing Mechanisms 293
Alternative Splicing 298
RNA Editing 300
RNA Degradation 301
KEY EXPERIMENT
Isolation of a Eukaryotic Transcription
Factor 272
KEY EXPERIMENT
The Discovery of snRNPs 294
Summary and Key Terms 303
Questions 305
References and Further Reading 306
8 Protein Synthesis,
Processing, and
Regulation 309
Translation of mRNA 309
Transfer RNAs 310
The Ribosome 311
The Organization of mRNAs and the
Initiation of Translation 317
The Process of Translation 318
Regulation of Translation 323
Protein Folding and
Processing 329
Chaperones and Protein Folding 330
Enzymes that Catalyze Protein
Folding 332
Protein Cleavage 333
Clycosylation 335
Attachment of Lipids 337
Regulation of Protein
Function 340
Regulation by Small Molecules 340
Protein Phosphorylation 341
Protein-Protein Interactions 343
Protein Degradation 345
The Ubiquitin-Proteasome
Pathway 345
Lysosomai Proteolysis 348
KEY EXPERIMENT
Catalytic Role of Ribosomal RNA 316
KEY EXPERIMENT
The Discovery of Protein-Tyrosine
Kinases 344
Summary and Key Terms 349
Questions 351
References and Further Reading 351
PART III (
J The Nucleus 355
The Nuclear Envelope and
Traffic between the Nucleus
and the Cytoplasm 355
Structure of the Nuclear Envelope 356
The Nuclear Pore Complex 360
Selective Transport of Proteins to and
from the Nucleus 361
Regulation of Nuclear Protein
Import 367
Transport of RNAs 368
Internal Organization of
the Nucleus 369
Chromosomes and Higher-Order
Chromatin Structure 370
Sub-Compartments within the
Nucleus 372
The Nucleolus and rRNA
Processing 374
Ribosomal RNA Genes and the
Organization of the Nucleolus 375
Transcription and Processing
of rRNA 376
Ribosome Assembly 378
MOLECULAR MEDICINE
Nuclear Lamina Diseases 358
KEY EXPERIMENT
Identification of Nuclear Localization
Signals 362
Summary and Key Terms 379
Questions 381
References and Further Reading 381
:ell structure ani
III Protein Sorting
I v and Transport:
The Endoplasmic Reticulum,
Golgi Apparatus, and
Lysosomes 383
The Endoplasmic
Reticulum 383
The Endoplasmic Reticulum and Protein
Secretion 384
Targeting Proteins to the Endoplasmic
Reticulum 386
Insertion of Proteins into the ER
Membrane 391
Protein Folding and Processing
in the ER 396
Quality Control in the ER 398
The Smooth ER and Lipid Synthesis 402
Export of Proteins and Lipids from
the ER 405
The Golgi Apparatus 408
Organization of the Golgi 408
Protein Clycosylation within
the Golgi 410
Lipid and Polysaccharide Metabolism
in the Golgi 412
Protein Sorting and Export from the
Golgi Apparatus 413
The Mechanism of Vesicular
Transport 416
Experimental Approaches to Under¬
standing Vesicular Transport 416
Cargo Selection, Coat Proteins, and
Vesicle Budding 418
Vesicle Fusion 420
Lysosomes 423
Lysosomal Acid Hydrolases 423
CONTENTS ix
) FUNCTION
Endocytosis and Lysosome Formation 426
Phagocytosis and Autophagy 426
KEY EXPERIMENT
The Signal Hypothesis 388
MOLECULAR MEDICINE
Gaucher Disease 425
Summary and Key Terms 429
Questions 431
References and Further Reading 431
1j Bioenergetics and
I Metabolism:
Mitochondria, Chloroplasts,
and Peroxisomes 433
Mitochondria 433
Organization and Function of
Mitochondria 434
The Genetic System of Mitochondria 435
Protein Import and Mitochondrial
Assembly 437
The Mechanism of Oxidative
Phosphorylation 445
The Electron Transport Chain 445
Chemiosmotic Coupling 446
Transport of Metabolites across the
Inner Membrane 450
Chloroplasts and Other
Plastids 452
The Structure and Function
of Chloroplasts 452
The Chloroplast Genome 454
Import and Sorting of Chloroplast
Proteins 455
Other Plastids 457
Photosynthesis 459
Electron Flow through Photosystems I
and I! 460
Cyclic Electron Flow 463
ATP Synthesis 464
Peroxisomes 464
Functions of Peroxisomes 465
Peroxisome Assembly 467
MOLECULAR MEDICINE
Diseases of Mitochondria: Leber s
Hereditary Optic Neuropathy 438
KEY EXPERIMENT
The Chemiosmotic Theory 448
Summary and Key Terms 469
Questions 471
References and Further Reading 471
m a The Cytoskeleton
1 J and Cell
£m Movement 473
Structure and Organization of
Actin Filaments 473
Assembly and Disassembly of Actin
Filaments 474
Organization of Actin Filaments 479
Association of Actin Filaments with the
Plasma Membrane 481
Protrusions of the Ceil Surface 485
Actin, Myosin, and Cell
Movement 487
Muscle Contraction 487
Contractile Assemblies of Actin and
Myosin in Nonmuscle Cells 492
Nonmusde Myosins 493
Formation of Protrusions and Cell
Movement 494
Intermediate Filaments 496
Intermediate Filament Proteins 496
Assembly of Intermediate Filaments 498
Intracellular Organization of
Intermediate Filaments 499
Functions of Keratins and
Neurofilaments: Diseases of the Skin
and Nervous System 501
Microtubules 504
Structure and Dynamic Organization
of Microtubules 504
Assembly of Microtubules 507
Organization of Microtubules within
Cells 509
Microtubule Motors and
Movement 511
Identification of Microtubule Motor
Proteins 511
Cargo Transport and Intracellular
Organization 515
Cilia and Flagella 516
Reorganization of Microtubules
during Mitosis 519
Chromosome Movement 520
KEY EXPERIMENT
Expression of Mutant Keratin Causes
Abnormal Skin Development 502
KEY EXPERIMENT
The Isolation of Kinesin 512
Summary and Key Terms 522
Questions 525
References and Further Reading 525
13 The Plasma
J Membrane 529
Structure of the Plasma
Membrane 529
The Phospholipid Bilayer 529
Membrane Proteins 533
Mobility of Membrane Proteins 538
The Glycocalyx 540
Transport of Small
Molecules 540
Passive Diffusion 541
Facilitated Diffusion and Carrier
Proteins 542
Ion Channels 544
Active Transport Driven by ATP
Hydrolysis 551
Active Transport Driven by Ion
Gradients 555
Endocytosis 557
Phagocytosis 557
Receptor-Mediated Endocytosis 558
Protein Trafficking in Endocytosis 563
MOLECULAR MEDICINE
Cystic Fibrosis 554
KEY EXPERIMENT
The LDL Receptor 560
Summary and Key Terms 567
Questions 568
References and Further Reading 568
Cell Walls, the
m m Extracellular
1 j Matrix, and Cell
Inr Interactions 571
Cell Walls 571
Bacterial Cell Walls 571
Eukaryotic Cell Walls 572
The Extracellular Matrix and
Cell-Matrix Interactions 577
Matrix Structural Proteins 578
Matrix Polysaccharides 581
Matrix Adhesion Proteins 582
Cell-Matrix Interactions 583
Cell-Cell Interactions 587
Adhesion Junctions 587
Tight Junctions 590
Gap Junctions 591
Plasmodesmata 595
KEY EXPERIMENT
The Characterization of Integrins 584
MOLECULAR MEDICINE
Cap Junction Diseases 594
Summary and Key Terms 596
Questions 598
References and Further Reading 598
PAR
IS Cell Signaling
J 603
Signaling Molecules and
Their Receptors 603
Modes of Cell-Cell Signaling 604
Steroid Hormones and the Nuclear
Receptor Superfamily 605
Nitric Oxide and Carbon
Monoxide 607
Neurotransmitters 608
Peptide Hormones and Growth
Factors 609
Eicosanoids 610
Plant Hormones 612
Functions of Cell Surface
Receptors 613
G Protein-Coupled Receptors 613
Receptor Protein-Tyrosine Kinases 615
Cytokine Receptors and Nonreceptor
Protein-Tyrosine Kinases 620
Receptors Linked to Other Enzymatic
Activities 620
Pathways of Intracellular
Signal Transduction 621
The cAMP Pathway: Second Messengers
and Protein Phosphorylation 622
Cyclic GMP 624
Phospholipids and Ca2+ 625
The PI 3-Kinase/Akt and mTOR
Pathways 628
MAP Kinase Pathways 630
The JAK/STAT and TGF-j3/Smad
Pathways 636
NF-jcB Signaling 637
The Hedgehog, Wnt, and Notch
Pathways 638
T IV CELL REGULA
Signal Transduction and
the Cytoskeleton 641
Integrins and Signal Transduction 641
Regulation of the Actin
Cytoskeleton 642
Signaling Networks 644
Feedback and Crosstalk 644
Networks of Cellular Signal
Transduction 646
KEY EXPERIMENT
C Protein-Coupled Receptors and Odor
Detection 616
MOLECULAR MEDICINE
Cancer: Signal Transduction and the
rasOncogenes 633
Summary and Key Terms 647
Questions 650
References and Further Reading 650
1 £ The Cell
IU Cycle 653
The Eukaryotic Cell
Cycle 653
Phases of the Cell Cycle 654
Regulation of the Cell Cycle by Cell
Growth and Extracellular Signals 655
Cell Cycle Checkpoints 657
Restricting DNA Replication to Once
per Cell Cycle 659
Regulators of Cell Cycle
Progression 659
Protein Kinases and Cell Cycle
Regulation 659
Families of Cyclins and Cyclin-
Dependent Kinases 664
CONTENTS Xi
noN
Growth Factors and the Regulation
of G, Cdk s 667
DNA Damage Checkpoints 670
The Events of M Phase 672
Stages of Mitosis 672
Cdki /Cyclin B and Progression to
Metaphase 675
The Spindle Assembly Checkpoint and
Progression to Anaphase 678
Cytokinesis 680
Meiosis and Fertilization 681
The Process of Meiosis 681
Regulation of Oocyte Meiosis 684
Fertilization 687
KEY EXPERIMENT
The Discovery of MPF 660
KEY EXPERIMENT
The Identification of Cyclin 663
Summary and Key Terms 688
Questions 690
References and Further Reading 691
17 Cell Death and
I I Cell Renewal 693
Programmed Cell Death 693
The Events of Apoptosis 694
Caspases: The Executioners
of Apoptosis 697
Central Regulators of Apoptosis:
The Bcl-2 Family 699
Signaling Pathways that Regulate
Apoptosis 701
Alternative Pathways of Programmed
Cell Death 705
X CONTENTS
Photosynthesis 459
Electron Flow through Photosystems I
and II 460
Cyclic Electron Flow 463
ATP Synthesis 464
Peroxisomes 464
Functions of Peroxisomes 465
Peroxisome Assembly 467
MOLECULAR MEDICINE
Diseases of Mitochondria: Leber s
Hereditary Optic Neuropathy 438
KEY EXPERIMENT
The Chemiosmotic Theory 448
Summary and Key Terms 469
Questions 471
References and Further Reading 471
m a The Cytoskeleton
1 J and Cell
£m Movement 473
Structure and Organization of
Actin Filaments 473
Assembly and Disassembly of Actin
Filaments 474
Organization of Actin Filaments 479
Association of Actin Filaments with the
Plasma Membrane 481
Protrusions of the Cell Surface 485
Actin, Myosin, and Cell
Movement 487
Muscle Contraction 487
Contractile Assemblies of Actin and
Myosin in Nonmuscle Cells 492
Nonmuscle Myosins 493
Formation of Protrusions and Cell
Movement 494
Intermediate Filaments 496
Intermediate Filament Proteins 496
Assembly of Intermediate Filaments 498
Intracellular Organization of
Intermediate Filaments 499
Functions of Keratins and
Neurofilaments: Diseases of the Skin
and Nervous System 501
Microtubules 504
Structure and Dynamic Organization
of Microtubules 504
Assembly of Microtubules 507
Organization of Microtubules within
Cells 509
Microtubule Motors and
Movement 511
Identification of Microtubule Motor
Proteins 511
Cargo Transport and Intracellular
Organization 515
Cilia and Flagella 516
Reorganization of Microtubules
during Mitosis 519
Chromosome Movement 520
KEY EXPERIMENT
Expression of Mutant Keratin Causes
Abnormal Skin Development 502
KEY EXPERIMENT
The Isolation of Kinesin 512
Summary and Key Terms 522
Questions 525
References and Further Reading 525
1 rf The Plasma
U Membrane 529
Structure of the Plasma
Membrane 529
The Phospholipid Bilayer 529
Membrane Proteins 533
Mobility of Membrane Proteins 538
The Glycocalyx 540
Transport of Small
Molecules 540
Passive Diffusion 541
Facilitated Diffusion and Carrier
Proteins 542
Ion Channels 544
Active Transport Driven by ATP
Hydrolysis 551
Active Transport Driven by Ion
Gradients 555
Endocytosis 557
Phagocytosis 557
Receptor-Mediated Endocytosis 558
Protein Trafficking in Endocytosis 563
MOLECULAR MEDICINE
Cystic Fibrosis 554
KEY EXPERIMENT
The LDL Receptor 560
Summary and Key Terms 567
Questions 568
References and Further Reading 568
Cell Walls, the
m m Extracellular
1 #1 Matrix, and Cell
iHr Interactions 571
Cell Walls 571
Bacterial Cell Walls 571
Eukaryotic Cell Walls 572
The Extracellular Matrix and
Cell-Matrix Interactions 577
Matrix Structural Proteins 578
Matrix Polysaccharides 581
Matrix Adhesion Proteins 582
Cell-Matrix Interactions 583
Cell-Cell Interactions 587
Adhesion junctions 587
Tight Junctions 590
Gap Junctions 591
Plasmodesmata 595
KEY EXPERIMENT
The Characterization of Integrins 584
MOLECULAR MEDICINE
Cap Junction Diseases 594
Summary and Key Terms 596
Questions 598
References and Further Reading 598
PAR
11% Cell Signaling
J 603
Signaling Molecules and
Their Receptors 603
Modes of Cell-Cell Signaling 604
Steroid Hormones and the Nuclear
Receptor Superfamily 605
Nitric Oxide and Carbon
Monoxide 607
Neurotransmitters 608
Peptide Hormones and Growth
Factors 609
Eicosanoids 610
Plant Hormones 612
Functions of Cell Surface
Receptors 613
C Protein-Coupled Receptors 613
Receptor Protein-Tyrosine Kinases 615
Cytokine Receptors and Nonreceptor
Protein-Tyrosine Kinases 620
Receptors Linked to Other Enzymatic
Activities 620
Pathways of Intracellular
Signal Transduction 621
The cAMP Pathway: Second Messengers
and Protein Phosphorylation 622
Cyclic GMP 624
Phospholipids and Ca2+ 625
The PI 3-Kinase/Akt and mTOR
Pathways 628
MAP Kinase Pathways 630
The JAK/STAT and TGF-j3/Smad
Pathways 636
NF-k-B Signaling 637
The Hedgehog, Wnt, and Notch
Pathways 638
T IV CELL REGULA1
Signal Transduction and
the Cytoskeleton 641
Integrins and Signal Transduction 641
Regulation of the Actin
Cytoskeleton 642
Signaling Networks 644
Feedback and Crosstalk 644
Networks of Cellular Signal
Transduction 646
KEY EXPERIMENT
G Protein-Coupled Receptors and Odor
Detection 616
MOLECULAR MEDICINE
Cancer: Signal Transduction and the
ras Oncogenes 633
Summary and Key Terms 647
Questions 650
References and Further Reading 650
i £ The Cell
IV Cycle 653
The Eukaryotic Cell
Cycle 653
Phases of the Cell Cycle 654
Regulation of the Cell Cycle by Cell
Growth and Extracellular Signals 655
Cell Cycle Checkpoints 657
Restricting DNA Replication to Once
per Cell Cycle 659
Regulators of Cell Cycle
Progression 659
Protein Kinases and Cell Cycle
Regulation 659
Families of Cyclins and Cyclin-
Dependent Kinases 664
CONTENTS XI
noN
Growth Factors and the Regulation
of G, Cdk s 667
DNA Damage Checkpoints 670
The Events of M Phase 672
Stages of Mitosis 672
Cdki/Cyclin B and Progression to
Metaphase 675
The Spindle Assembly Checkpoint and
Progression to Anaphase 678
Cytokinesis 680
Meiosis and Fertilization 681
The Process of Meiosis 681
Regulation of Oocyte Meiosis 684
Fertilization 687
KEY EXPERIMENT
The Discovery of MPF 660
KEY EXPERIMENT
The Identification of Cyclin 663
Summary and Key Terms 688
Questions 690
References and Further Reading 691
17 Cell Death and
I I Cell Renewal 693
Programmed Cell Death 693
The Events of Apoptosis 694
Caspases: The Executioners
of Apoptosis 697
Central Regulators of Apoptosis:
The Bcl-2 Family 699
Signaling Pathways that Regulate
Apoptosis 701
Alternative Pathways of Programmed
Cell Death 705
xii CONTENTS
Stem Cells and the
Maintenance of Adult
Tissues 705
Proliferation of Differentiated Cells 706
Stem Cells 708
Medical Applications of Adult
Stem Cells 713
Embryonic Stem Cells and
Therapeutic Cloning 714
Embryonic Stem Cells 716
Somatic Cell Nuclear Transfer 718
Induced Pluripotent Stem Cells 719
KEY EXPERIMENT
Identification of Genes Required for
Programmed Cell Death 696
KEY EXPERIMENT
Culture of Embryonic Stem Cells 715
Summary and Key Terms 720
Questions 722
References and Further Reading 722
10 Cancer 725
The Development and Causes
of Cancer 725
Types of Cancer 725
The Development of Cancer 727
Causes of Cancer 729
Properties of Cancer Cells 730
Transformation of Cells in Culture 734
Tumor Viruses 735
Hepatitis B and C Viruses 735
SV40 and Polyomavims 736
Papillomaviruses 737
Adenoviruses 737
Herpesviruses 738
Retroviruses 738
Oncogenes 739
Retroviral Oncogenes 739
Proto-Oncogenes 740
Oncogenes in Human Cancer 743
Functions of Oncogene Products 747
Tumor Suppressor
Genes 752
Identification of Tumor Suppressor
Genes 752
Functions of Tumor Suppressor Gene
Products 756
Roles of Oncogenes and Tumor
Suppressor Genes in Tumor
Development 759
Molecular Approaches to
Cancer Treatment 761
Prevention and Early Detection 761
Molecular Diagnosis 762
Treatment 763
KEY EXPERIMENT
The Discovery of Proto-Oncogenes 742
MOLECULAR MEDICINE
Imatinib: Cancer Treatment Targeted
against the bcr/abl Oncogene 766
Summary and Key Terms 767
Questions 769
References and Further Reading 770
Answers to Questions 773
Glossary 783
Index 799
|
| any_adam_object | 1 |
| author | Cooper, Geoffrey M. Hausman, Robert E. |
| author_facet | Cooper, Geoffrey M. Hausman, Robert E. |
| author_role | aut aut |
| author_sort | Cooper, Geoffrey M. |
| author_variant | g m c gm gmc r e h re reh |
| building | Verbundindex |
| bvnumber | BV035572522 |
| callnumber-first | Q - Science |
| callnumber-label | QH581 |
| callnumber-raw | QH581.2 |
| callnumber-search | QH581.2 |
| callnumber-sort | QH 3581.2 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | WD 4150 WE 1000 WE 2400 |
| ctrlnum | (OCoLC)310075904 (DE-599)OBVAC07110333 |
| dewey-full | 571.6 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.6 |
| dewey-search | 571.6 |
| dewey-sort | 3571.6 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 5. ed. |
| format | Book |
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| genre_facet | Lehrbuch |
| id | DE-604.BV035572522 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:40:43Z |
| institution | BVB |
| isbn | 9780878933006 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017628075 |
| oclc_num | 310075904 |
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| physical | XIX, 820 S. zahlr. Ill., graph. Darst. |
| publishDate | 2009 |
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| publisher | ASM Press [u.a.] |
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| spelling | Cooper, Geoffrey M. Verfasser aut The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman 5. ed. Washington, DC ASM Press [u.a.] 2009 XIX, 820 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell Biology Cells Cytology Molecular Biology Molecular biology Cytologie (DE-588)4070177-3 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf CD-ROM (DE-588)4139307-7 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Zelle (DE-588)4067537-3 s Molekularbiologie (DE-588)4039983-7 s CD-ROM (DE-588)4139307-7 s 1\p DE-604 Cytologie (DE-588)4070177-3 s 2\p DE-604 Hausman, Robert E. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017628075&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cooper, Geoffrey M. Hausman, Robert E. The cell a molecular approach Cell Biology Cells Cytology Molecular Biology Molecular biology Cytologie (DE-588)4070177-3 gnd Zelle (DE-588)4067537-3 gnd CD-ROM (DE-588)4139307-7 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4070177-3 (DE-588)4067537-3 (DE-588)4139307-7 (DE-588)4039983-7 (DE-588)4123623-3 |
| title | The cell a molecular approach |
| title_auth | The cell a molecular approach |
| title_exact_search | The cell a molecular approach |
| title_full | The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman |
| title_fullStr | The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman |
| title_full_unstemmed | The cell a molecular approach Geoffrey M. Cooper ; Robert E. Hausman |
| title_short | The cell |
| title_sort | the cell a molecular approach |
| title_sub | a molecular approach |
| topic | Cell Biology Cells Cytology Molecular Biology Molecular biology Cytologie (DE-588)4070177-3 gnd Zelle (DE-588)4067537-3 gnd CD-ROM (DE-588)4139307-7 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Cell Biology Cells Cytology Molecular Biology Molecular biology Cytologie Zelle CD-ROM Molekularbiologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017628075&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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