Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart:
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2008
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VII, 56 S. Ill., graph. Darst. 21 cm |
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| adam_text | Titel: Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5 -nucleotidase in
Autor: Falk, Melanie
Jahr: 2008
Tabie of contents j v j
Table of contents
Table of contents v
List of figures vii
List of tables vii
Abbreviations viii
1. Introduction 1
1.1 Acute myocardial infarction 1
1.2 Ischemic preconditioning 2
1.3 Role of adenosine generation and signaling in cardioprotection 5
1.4 Murine studies of myocardial infarction and IP 8
1.5 Myocardial ischemia, CD73 and IP 9
2. Materialand Methods 10
2.1 Anesthesia, ventilatory support and monitoring 10
2.2 Technique of coronary artery occlusion 11
2.3 Determination of the area at risk (AAR) and myocardial infarct size 14
2.4 Cardiac enzyme measurement 16
2.5 Adenosine therapeutics 17
2.6 Genotyping 17
3. Results 20
3.1 Influence of ischemia time on myocardial infarct size 20
3.2 Influence of reperfusion time on myocardial infarct size
by TTC staining 21
3.3 Influence of body temperature on myocardial infarct size 23
3.4 Myocardial infarct size reduction by IP 24
3.5 Influence of different IP cycle numbers on myocardial infarct size ... 26
3.6 Correlation between infarct size and plasma troponin I levels 27
3.7 Haemodynamic Monitoring 28
3.8 Cardioprotection by IP is abolished in cd73J mice 29
3.9 IP in A1 AFT , A2AARV-, A2BAR* and A3ARJ mice 33
Table of contents I vi |
4. Discussion 34
4.1 Murine model of IP 34
4.2 RoleofCD73andA2BARinlP 37
5. Summary 39
Bibliography 40
Acknowledgment 53
Curriculum Vitae 55
List of figures and tables [ vit j
List of figures
Figure 1: Original experiments from Murry et al 2
Figure2: Set-up 11
Figure 3: Occluding mechanism 12
Figure 4: Determination of myocardial infarction 13
Figure 5: Model of a heart with representative slices of infarct staining 15
Figure6: Genotyping results 19
Figure 7: Different ischemia times in myocardial infarction 21
Figure 8: Different reperfusion times in myocardial infarction 22
Figure 9: Different body temperatures in myocardial infarction 23
Figure 10: IP Model 25
Figure 11: Different IP cycle numbers in myocardial infarction 26
Figure 12: Troponin measurement 27
Figure 13: Correlation between infarct size and troponin plasma levels 28
Figure 14: IP in cd 73+mice 30
Figure 15: Reconstitutional treatment with adenosine 31
Figure 16: Reconstitutional treatment with ecto-5 -nucleotidase 32
Figure 17: IP in adenosine receptor KO mice 33
List of tables
Table 1: Triggers, mediators and effectors in IP 4
Table2: Genotyping primers 18
Table 3: Haemodynamic monitoring 29
|
| any_adam_object | 1 |
| author | Falk, Melanie 1981- |
| author_GND | (DE-588)136989055 |
| author_facet | Falk, Melanie 1981- |
| author_role | aut |
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| bvnumber | BV035544051 |
| ctrlnum | (OCoLC)314789598 (DE-599)DNB992283426 |
| dewey-full | 616.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.1 |
| dewey-search | 616.1 |
| dewey-sort | 3616.1 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| spelling | Falk, Melanie 1981- Verfasser (DE-588)136989055 aut Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart vorgelegt von Melanie Falk 2008 VII, 56 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Tübingen, Univ., Diss., 2008 (DE-588)4113937-9 Hochschulschrift gnd-content HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017600064&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Falk, Melanie 1981- Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart |
| subject_GND | (DE-588)4113937-9 |
| title | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart |
| title_auth | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart |
| title_exact_search | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart |
| title_full | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart vorgelegt von Melanie Falk |
| title_fullStr | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart vorgelegt von Melanie Falk |
| title_full_unstemmed | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart vorgelegt von Melanie Falk |
| title_short | Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart |
| title_sort | evaluation of a novel model of cardiac ischemic preconditioning and role of ecto 5 nucleotidase in ischemic preconditioning of the heart |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017600064&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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