Neuroanatomy and pathology of sporadic Parkinson's disease:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2009
|
| Series: | Advances in anatomy, embryology and cell biology
201 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VI, 119 S. |
| ISBN: | 9783540798491 |
Staff View
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV035464891 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 090504s2009 |||| 00||| eng d | ||
| 020 | |a 9783540798491 |9 978-3-540-79849-1 | ||
| 035 | |a (OCoLC)300465686 | ||
| 035 | |a (DE-599)BVBBV035464891 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-20 | ||
| 050 | 0 | |a QL801 | |
| 082 | 0 | |a 616.83307 |2 22/ger | |
| 100 | 1 | |a Braak, Heiko |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Neuroanatomy and pathology of sporadic Parkinson's disease |c Heiko Braak and Kelly Del Tredici |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2009 | |
| 300 | |a VI, 119 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in anatomy, embryology and cell biology |v 201 | |
| 650 | 7 | |a Parkinson-Krankheit |2 swd | |
| 650 | 7 | |a Pathologische Anatomie |2 swd | |
| 650 | 4 | |a Parkinson Disease |x physiopathology | |
| 650 | 4 | |a Parkinson's disease | |
| 700 | 1 | |a Del Tredici, Kelly |d 1951- |e Verfasser |0 (DE-588)128986417 |4 aut | |
| 830 | 0 | |a Advances in anatomy, embryology and cell biology |v 201 |w (DE-604)BV002528506 |9 201 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017384663&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-017384663 | ||
Record in the Search Index
| _version_ | 1804138921453420544 |
|---|---|
| adam_text | List of Contents
1 Prologue 1
1.1 sPD and Parkinsonism 2
1.2 sPD Is a Proteinopathy Linked to the Development of Abnormal
Intraneuronal Inclusions (Lewy Pathology: Lewy Neurites, Lewy bodies,
Lewy plaques) 3
2 Morphology of Lewy Pathology 8
2.1 The Protein a-Synuclein 8
2.2 Protein Misfolding and Abnormal Aggregation of a-Synuclein 9
2.3 Light Microscopic Visualization of Lewy Pathology 10
2.3.1 Lewy Neurites 12
2.3.2 Granular Aggregations 13
2.3.3 Pale Bodies and Lewy Bodies 13
2.3.4 Lewy Plaques 14
2.4 Degradation of Lewy Pathology 14
2.5 Lewy Pathology Can Co-occur with Pathology Related to Other Disorders . 15
3 The Evolving Distribution Pattern of Lewy Pathology Associated
with sPD Renders Neuropathological Staging Possible 15
3.1 Incidental Lewy Pathology 15
3.2 Presymptomatic and Symptomatic Phases 15
3.3 Vulnerable Regions are Interconnected Anatomically 18
4 Stage 1 20
4.1 Pathology in Olfactory Structures 20
4.2 Basic Organization of the Medullary Autonomic Region 21
4.3 Involvement of Preganglionic Parasympathetic Projection Neurons 21
4.4 Pathology in the Enteric Nervous System 23
4.5 Is sPD Inducible by a Neurotropic Pathogen Akin to a Slow Virus? 23
4.6 Involvement of Preganglionic and Postganglionic Sympathetic
Projection Neurons 29
4.7 Pathology in Lamina I of the Spinal Cord 29
5 Stage 2 32
5.1 Involvement of the Medulla Oblongata and Pontine Tegmentum 32
5.2 Basic Organization of the Gain Setting System 35
5.2.1 Lower Raphe Nuclei 35
5.2.2 Magnocellular Reticular Nuclei 35
5.2.3 Coeruleus-Subcoeruleus Complex 36
5.3 Potential Functional Consequences of the Lesions 37
vi List of Contents
6 Stage 3 38
6.1 Involvement of the Mesencephalic Tegmentum and Basal Forebrain 38
6.1.1 Central Subnucleus of the Amygdala 38
6.1.2 Substantia Nigra and Adjoining Nuclei 40
6.2 Basic Organization of Nonthalamic Nuclei with Diffuse Projections 43
6.2.1 Magnocellular Nuclei of the Basal Forebrain 44
6.2.2 Pedunculopontine Tegmental Nucleus 44
6.2.3 Tuberomamillary Nucleus 45
6.2.4 Upper Raphe Nuclei 45
6.3 Potential Functional Consequences of the Lesions 46
7 Stage 4 48
7.1 Involvement of the Amygdala and Thalamus 49
7.1.1 Amygdala 49
7.1.2 Thalamus 50
7.2 Basic Organization of the Cerebral Cortex and Limbic Circuit 52
7.2.1 Allocortex and Neocortex 52
7.2.2 Mesocortex 57
7.2.3 Limbic Circuit 58
7.3 Involvement of the Temporal Mesocortex and Hippocampal Formation ... 59
7.3.1 Temporal Mesocortex 59
7.3.2 Hippocampal Formation 60
7.4 Involvement of Insular, Subgenual, and Anterior Cingulate Areas 60
7.5 Potential Functional Consequences of the Lesions 61
8 Stages 5 and 6 64
8.1 Involvement of Neocortex and Basal Ganglia 65
8.1.1 Neocortex 65
8.1.2 Basal Ganglia 67
8.2 Basic Organization of the Basal Ganglia and Striatal Circuit 69
8.2.1 Striatum 69
8.2.2 Pallidum 71
8.2.3 Subthalamic Nucleus 72
8.2.4 Claustrum 73
8.3 Dot-Like Inclusions and Abnormally Altered Astrocytes in the Forebrain .. 73
8.4 Disruption of the Striatal Circuit 80
8.5 Potential Functional Consequences of Lesions 84
8.6 Pathologically Changed Components of the Cerebellar Circuit 85
9 The Progression of the Cortical Lesions Mimics the Pattern
of Myelination in Reverse Order 88
10 The Staging Hypothesis: Assumptions, Challenges, Potential 89
|
| any_adam_object | 1 |
| author | Braak, Heiko Del Tredici, Kelly 1951- |
| author_GND | (DE-588)128986417 |
| author_facet | Braak, Heiko Del Tredici, Kelly 1951- |
| author_role | aut aut |
| author_sort | Braak, Heiko |
| author_variant | h b hb t k d tk tkd |
| building | Verbundindex |
| bvnumber | BV035464891 |
| callnumber-first | Q - Science |
| callnumber-label | QL801 |
| callnumber-raw | QL801 |
| callnumber-search | QL801 |
| callnumber-sort | QL 3801 |
| callnumber-subject | QL - Zoology |
| ctrlnum | (OCoLC)300465686 (DE-599)BVBBV035464891 |
| dewey-full | 616.83307 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.83307 |
| dewey-search | 616.83307 |
| dewey-sort | 3616.83307 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01451nam a2200373 cb4500</leader><controlfield tag="001">BV035464891</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">090504s2009 |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783540798491</subfield><subfield code="9">978-3-540-79849-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)300465686</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV035464891</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-20</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QL801</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.83307</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Braak, Heiko</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Neuroanatomy and pathology of sporadic Parkinson's disease</subfield><subfield code="c">Heiko Braak and Kelly Del Tredici</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2009</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">VI, 119 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Advances in anatomy, embryology and cell biology</subfield><subfield code="v">201</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parkinson-Krankheit</subfield><subfield code="2">swd</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pathologische Anatomie</subfield><subfield code="2">swd</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Parkinson Disease</subfield><subfield code="x">physiopathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Parkinson's disease</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Del Tredici, Kelly</subfield><subfield code="d">1951-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)128986417</subfield><subfield code="4">aut</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Advances in anatomy, embryology and cell biology</subfield><subfield code="v">201</subfield><subfield code="w">(DE-604)BV002528506</subfield><subfield code="9">201</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017384663&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-017384663</subfield></datafield></record></collection> |
| id | DE-604.BV035464891 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T21:35:52Z |
| institution | BVB |
| isbn | 9783540798491 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017384663 |
| oclc_num | 300465686 |
| open_access_boolean | |
| owner | DE-20 |
| owner_facet | DE-20 |
| physical | VI, 119 S. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| series | Advances in anatomy, embryology and cell biology |
| series2 | Advances in anatomy, embryology and cell biology |
| spelling | Braak, Heiko Verfasser aut Neuroanatomy and pathology of sporadic Parkinson's disease Heiko Braak and Kelly Del Tredici Berlin [u.a.] Springer 2009 VI, 119 S. txt rdacontent n rdamedia nc rdacarrier Advances in anatomy, embryology and cell biology 201 Parkinson-Krankheit swd Pathologische Anatomie swd Parkinson Disease physiopathology Parkinson's disease Del Tredici, Kelly 1951- Verfasser (DE-588)128986417 aut Advances in anatomy, embryology and cell biology 201 (DE-604)BV002528506 201 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017384663&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Braak, Heiko Del Tredici, Kelly 1951- Neuroanatomy and pathology of sporadic Parkinson's disease Advances in anatomy, embryology and cell biology Parkinson-Krankheit swd Pathologische Anatomie swd Parkinson Disease physiopathology Parkinson's disease |
| title | Neuroanatomy and pathology of sporadic Parkinson's disease |
| title_auth | Neuroanatomy and pathology of sporadic Parkinson's disease |
| title_exact_search | Neuroanatomy and pathology of sporadic Parkinson's disease |
| title_full | Neuroanatomy and pathology of sporadic Parkinson's disease Heiko Braak and Kelly Del Tredici |
| title_fullStr | Neuroanatomy and pathology of sporadic Parkinson's disease Heiko Braak and Kelly Del Tredici |
| title_full_unstemmed | Neuroanatomy and pathology of sporadic Parkinson's disease Heiko Braak and Kelly Del Tredici |
| title_short | Neuroanatomy and pathology of sporadic Parkinson's disease |
| title_sort | neuroanatomy and pathology of sporadic parkinson s disease |
| topic | Parkinson-Krankheit swd Pathologische Anatomie swd Parkinson Disease physiopathology Parkinson's disease |
| topic_facet | Parkinson-Krankheit Pathologische Anatomie Parkinson Disease physiopathology Parkinson's disease |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017384663&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002528506 |
| work_keys_str_mv | AT braakheiko neuroanatomyandpathologyofsporadicparkinsonsdisease AT deltredicikelly neuroanatomyandpathologyofsporadicparkinsonsdisease |